Abstract：
:Although combination regimens have improved outcomes over monotherapy in chronic lymphocytic leukemia (CLL), patients eventually relapse. Combined fludarabine, cyclophosphamide, and monoclonal anti-CD52 antibody alemtuzumab (FCC) provided synergistic cytotoxicity with effective clearing of minimal residual disease. This phase 2 study determined FCC efficacy and safety in relapsed/refractory CD52(+) B-CLL after ≥ 1 line of treatment. From January 2005 through June 2008, up to 6 courses of oral fludarabine 40 mg/m² per day, oral cyclophosphamide 250 mg/m² per day, and subcutaneous alemtuzumab (Mab-Campath) 10 mg (increased to 20 mg after first 10-patient cohort) were administered days 1 to 3 every 28 days. The primary objective was overall response rate (ORR); secondary objectives included response duration, time to disease progression, and safety and tolerability. ORR was 67% in 43 patients; 30% achieved complete response. ORR significantly improved with 1 versus ≥ 2 prior therapies (P = .018), and without versus with previous monoclonal antibody treatment (P = .003). Median progression-free survival was 24.4 months, not reached in patients achieving complete response. Median overall survival was 33.6 months. Myelosuppression was the most common adverse event, with a low percentage of cytomegalovirus reactivations and manageable infections. However, close vigilance of opportunistic infections is warranted. FCC provides effective immunotherapy in relapsed/refractory CLL, including in patients with poor-risk prognostic factors.
journal_name
Bloodjournal_title
Bloodauthors
Montillo M,Tedeschi A,Petrizzi VB,Ricci F,Crugnola M,Spriano M,Spedini P,Ilariucci F,Uziel L,Attolico I,Vismara E,De Blasio A,Zaccaria A,Morra Edoi
10.1182/blood-2011-05-351833subject
Has Abstractpub_date
2011-10-13 00:00:00pages
4079-85issue
15eissn
0006-4971issn
1528-0020pii
blood-2011-05-351833journal_volume
118pub_type
杂志文章,多中心研究相关文献
BLOOD文献大全abstract：:The purpose of this study was to define, in a phase I study in leukemia, the maximally tolerated dose (MTD), major toxicities, and possible antitumor activity of Topotecan, a new topoisomerase I (topo I) inhibitor. Topotecan was delivered by a 5-day continuous infusion every 3 to 4 weeks to patients with refractory or...
journal_title：Blood
pub_type： 临床试验,杂志文章
doi：
更新日期：1993-03-01 00:00:00
abstract：:Familial hemophagocytic lymphohistiocytosis (FHL) is caused by genetic defects in cytotoxic granule components or their fusion machinery, leading to impaired natural killer cell and/or T lymphocyte degranulation and/or cytotoxicity. This may accumulate into a life-threatening condition known as macrophage activation s...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2013-03-494039
更新日期：2013-07-04 00:00:00
abstract：:The molecular basis for the recently described hereditary hyperferritinemia-cataract syndrome is the presence of a mutation in the iron-responsive element (IRE) of the L ferritin gene, located on chromosome 19q13.3-13.4. Two mutations have been reported so far, altering adjacent nucleotides in the IRE loop, in a regio...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:After invading human red blood cells (RBCs) the malaria parasite Plasmodium falciparum remodels the host cell by trafficking proteins to the RBC compartment. The virulence protein P. falciparum erythrocyte membrane protein 1 (PfEMP1) is responsible for cytoadherence of infected cells to host endothelial receptors. Thi...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2004-12-4666
更新日期：2005-05-15 00:00:00
abstract：:Sickle cell anemia (SCA) is an inherited disorder of beta-globin, resulting in red blood cell rigidity, anemia, painful crises, organ infarctions, and reduced life expectancy. Allogeneic blood or marrow transplantation (BMT) can cure SCA but is associated with an 8% to 10% mortality rate, primarily from complications ...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood.v97.12.3960
更新日期：2001-06-15 00:00:00
abstract：:The PI3K/Akt/mTOR pathway has emerged as a critical regulator of dendritic cell (DC) development and function. The kinase mTOR is found in 2 distinct complexes, mTORC1 and mTORC2. In this study, we show that mTORC1 but not mTORC2 is required for epidermal Langerhans cell (LC) homeostasis. Although the initial seeding ...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2012-06-439786
更新日期：2013-01-10 00:00:00
abstract：:A critical role for the endothelium of yolk sac and dorsal aorta has been shown in embryonic hematopoiesis. A stromal cell line derived from yolk sac, YSCL-72, has been chosen to search for a novel molecule associated with embryonic hematopoiesis. Analysis between YSCL-72 and an adult aorta-derived endothelial cell li...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood.v98.7.2134
更新日期：2001-10-01 00:00:00
abstract：:From October 1987 to December 1990, 101 patients with acute myeloid leukemia (AML) were randomized to be transplanted in first complete remission (CR1). Preparative regimen including Cytoxan (120 mg/kg) with total body irradiation (CYTBI) (N = 50) or busulfan (16 mg/kg) (BUSCY) (N = 51) was followed by allogeneic bone...
journal_title：Blood
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1992-05-15 00:00:00
abstract：:Juvenile chronic myelocytic leukemia (JCML) is a rare disorder of early childhood. Characteristic of JCML are the progressive appearance of high levels of fetal hemoglobin (HbF), reflecting a true reversion to a fetal type of erythropoiesis, and the presence of colony-forming cells able to grow in vitro spontaneously ...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1995-07-01 00:00:00
abstract：:Human immunodeficiency virus-1 (HIV-1)-Tat, the transactivating gene product of HIV-1, has been shown to interact with different cell types, inducing gene expression, altering their growth and migratory behavior. In this study we examined whether Tat might affect functions of acquired immunodeficiency syndrome (AIDS)-...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：:Because a pediatric-inspired Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) protocol yielded a markedly improved outcome in adults with Philadelphia chromosome-negative ALL, we aimed to reassess the role of allogeneic stem cell transplantation (SCT) in patients treated in the GRAALL-2003 and GRAALL-...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2014-09-599894
更新日期：2015-04-16 00:00:00
abstract：:Congenital dyserythropoietic anemia type II (CDA-II) is an autosomal recessive disease characterized by anemia, jaundice, splenomegaly, and erythroblast multinuclearity. The natural history of the disease is unknown. The frequency, the relevance of complications, and the use of splenectomy are poorly defined. This stu...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood.v98.4.1258
更新日期：2001-08-15 00:00:00
abstract：:In systemic light-chain amyloidosis, λ light chains produced by clonal plasma cells cause organ damage and early death. In pursuit of novel therapy, we developed 1 pool of short interfering RNA (siRNA) targeting the constant region of λ light chains that substantially and promptly reduces λ-light-chain production and ...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2013-10-535187
更新日期：2014-05-29 00:00:00
abstract：:Expression of B7 family costimulatory molecules on B cells defines their capacity to function as antigen presenting cells (APCs). B cells that do not express B7 costimulatory molecules induce T-cell tolerance. Therefore, the expression of B7 costimulatory molecules on malignant B cells might be critical for their reco...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1997-12-01 00:00:00
abstract：:Mutations within exon 3 of the beta-globin gene are relatively uncommon, and many of these mutations produce a dominant thalassemia-like phenotype. We describe a novel thalassemic hemoglobinopathy caused by a single nucleotide substitution (CTG-->CCG) at codon 114 resulting in a leucine to proline substitution and des...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1994-02-15 00:00:00
abstract：:The mechanism leading to the formation of antiphospholipid antibodies (aPL) is still unknown. Because an in vitro study suggested that aPL may derive from pro-oxidant conditions, we sought a relationship between aPL and isoprostanes, indices of lipid peroxidation in vivo. Thirty patients with systemic lupus erythemato...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1997-11-15 00:00:00
abstract：:Type I interferons (IFNs-alpha and IFN-beta) bind to a common receptor to exert strong antiproliferative activity on a broad range of cell types, including interleukin-6 (IL-6)-dependent myeloma cells. In this study, we investigated the effect of IFN-beta pretreatment on IL-6-stimulated mitogenic signaling in the huma...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:Cancer patients are at increased risk of deep vein thrombosis and pulmonary embolism. The incidence among different groups of cancer patients varies considerably depending on clinical factors, the most important being tumor entity and stage. Biomarkers have been specifically investigated for their capacity of predicti...
journal_title：Blood
pub_type： 杂志文章,评审
doi：10.1182/blood-2013-04-460147
更新日期：2013-09-19 00:00:00
abstract：:Natural killer (NK) cells contribute to host immunity, including tumor surveillance, through the production of interferon gamma (IFN-gamma). Although there is some knowledge about molecular mechanisms that induce IFN-gamma in NK cells, considerably less is known about the mechanisms that reduce its expression. Here, w...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2006-10-050096
更新日期：2007-03-15 00:00:00
abstract：:The CD14-dependent and -independent dendritic cell (DC) pathways are instituted simultaneously when CD34(+) progenitor cells are treated with granulocyte-macrophage colony-stimulating factor (GM-CSF)/tumor necrosis factor (TNF) +/- stem cell factor (SCF) (GTS). If TNF activity is neutralized within 48 hours of cytokin...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1998-08-01 00:00:00
abstract：:The anemia of chronic disease (ACD) results from 3 major processes: slightly shortened red cell survival, impaired reticuloendothelial system iron mobilization, and impaired erythropoiesis. Hepcidin is an acute-phase protein with specific iron regulatory properties, which, along with the anemia seen with increased hep...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2005-07-2854
更新日期：2006-04-01 00:00:00
abstract：:A gamma-chain variant with a lower molecular weight than the normal gamma chain was detected in a new congenital abnormal fibrinogen with impaired polymerization of the fibrin monomer and with normal release of fibrinopeptides A and B in a 45-year-old male. Purified fibrinogen analyzed on SDS-polyacrylamide gel electr...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1986-09-01 00:00:00
abstract：:Current immunotherapeutic trials for patients with multiple myeloma (MM) focus on the idiotype (Id) as a tumor-specific antigen for active immunization. To bypass the need for the identification of shared MM-associated antigens and the characterization of possible immunogenic T-cell epitopes in a human leukocyte antig...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2002-04-1273
更新日期：2003-02-01 00:00:00
abstract：:We treated 109 patients with adult acute lymphoblastic leukemia (ALL) diagnosed by histochemical and immunologic techniques. Patients were excluded only for age greater than 50 years and Burkitt's leukemia. Treatment included a four-drug remission induction phase followed by alternating cycles of noncrossresistant che...
journal_title：Blood
pub_type： 临床试验,杂志文章
doi：
更新日期：1991-12-01 00:00:00
abstract：:Human neutrophil elastase (NE), a 29-Kd potent serine protease stored in azurophilic granules of mature neutrophils, is coded for by the NE gene, a single copy gene with 5 exons spanning a 6-kb segment of chromosome 11 at q14. With the knowledge that the NE gene expression is limited to early myeloid cell differentiat...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1992-05-15 00:00:00
abstract：:The ontogeny of a 57-Kd cationic antimicrobial protein (CAP57) that has substantial similarities to bactericidal permeability increasing protein (BPI) has been determined immunocytochemically. CAP57 was detected in the granules of mature peripheral blood neutrophils. However, it was absent from other cells of the peri...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1990-08-15 00:00:00
abstract：:Langerhans cell histiocytosis (LCH) is a rare histiocytic neoplasm associated with somatic mutations in the genes involved in the RAF/MEK/extracellular signal-regulated kinase (ERK) signaling pathway. Recently, oncogenic mutations in NRAS/KRAS, upstream regulators of the RAF/MEK/ERK pathway, have been reported in pulm...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2017-02-770149
更新日期：2017-07-27 00:00:00
abstract：:The presence of mast cell precursors in peripheral blood was examined. The beige C57BL/6 (bgj/bgj, Chediak-Higashi syndrome) mouse was parabiosed with the normal C57BL/6 mouse. Mast cells containing giant granules and originating in the beige partner appeared in the normal parabiont. A comparable proportion of normal-...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1979-06-01 00:00:00
abstract：:In an effort to discover specific markers to isolate human hematopoietic stem cells, Jokubaitis and colleagues report that the monoclonal antibody BB9 reacts with hematopoietic cells displaying morphologic, phenotypic, and/or functional properties of stem and progenitor cells throughout human ontogeny. ...
journal_title：Blood
pub_type： 评论,杂志文章
doi：10.1182/blood-2007-12-126672
更新日期：2008-04-15 00:00:00
abstract：:Fanconi anemia is a genetic disorder associated with diverse congenital abnormalities, progressive bone marrow failure, and increased risk of leukemia and other cancers. Affected persons often die before 30 years of age. Bone marrow transplantation is an effective treatment, but there are few data regarding factors as...
journal_title：Blood
pub_type： 临床试验,杂志文章
doi：
更新日期：1995-10-01 00:00:00
