Biomarkers for prediction of venous thromboembolism in cancer.

abstract：:If bone marrow transplantation is to become widely applicable in the treatment of patients with leukemia and aplastic anemia, the necessity to have a perfectly histocompatible donor must be overcome. In an effort to define the roles of HL-A type and mixed lymphocyte culture (MLC) reactivity in the determination of suc...

journal_title：Blood

authors： Feig SA,Opelz G,Winter HS,Falk PM,Neerhout RC,Sparkes R,Gale RP

更新日期：1976-09-01 00:00:00

abstract：:Hepcidin controls systemic iron availability, and its excess contributes to the anemia of chronic diseases, the most prevalent anemia in hospitalized patients. We previously reported that heparins are efficient hepcidin inhibitors both in vitro and in vivo, but their anticoagulant activity limits therapeutic use. We s...

journal_title：Blood

authors： Poli M,Asperti M,Naggi A,Campostrini N,Girelli D,Corbella M,Benzi M,Besson-Fournier C,Coppin H,Maccarinelli F,Finazzi D,Arosio P

更新日期：2014-03-06 00:00:00

abstract：:During an 8-year period, 3,638 children from institutions of the Pediatric Oncology Group (POG) were diagnosed with acute lymphoblastic leukemia (ALL). Fifty-seven patients had Philadelphia chromosome-positive (Ph1) ALL. Blast cells obtained at diagnosis from 13 of these 57 cases (23%) were also found to have partial ...

journal_title：Blood

authors： Russo C,Carroll A,Kohler S,Borowitz M,Amylon M,Homans A,Kedar A,Shuster J,Land V,Crist W

更新日期：1991-03-01 00:00:00

abstract：:We examined the expression of messenger RNA (mRNA) of the human inducible nitric oxide synthase (hiNOS) gene in a panel of human T-cell lines. Reverse transcriptase-polymerase chain reaction showed that human T-cell leukemia virus type-I (HTLV-I)-infected T-cell lines (MT-1, SLB-1, and C5/MJ) expressed mRNA for the hi...

journal_title：Blood

authors： Mori N,Nunokawa Y,Yamada Y,Ikeda S,Tomonaga M,Yamamoto N

更新日期：1999-10-15 00:00:00

abstract：:Bcr-abl fusion peptide-specific CD4+ T-lymphocyte clones have recently been shown to augment colony formation by chronic myelogenous leukemia (CML) cells in a bcr-abl type-specific and HLA class II-restricted manner without addition of exogenous antigen. These findings suggest that CML cells can naturally process and ...

journal_title：Blood

authors： Yasukawa M,Ohminami H,Kojima K,Hato T,Hasegawa A,Takahashi T,Hirai H,Fujita S

更新日期：2001-09-01 00:00:00

abstract：:In this issue of Blood, Donadieu et al present what may be the most encouraging data to date on a group of patients with Langerhans cell histiocytosis (LCH), which historically has poor disease-free survival and poor overall survival. ...

journal_title：Blood

authors： Stine KC

更新日期：2015-09-17 00:00:00

abstract：:Both total metabolic tumor volume (TMTV), computed on baseline positron emission tomography (PET), and end of induction (EOI) PET are imaging biomarkers showing promise for early risk stratification in patients with high-tumor-burden follicular lymphoma. A model was built incorporating these 2 factors in 159 patients ...

journal_title：Blood

authors： Cottereau AS,Versari A,Luminari S,Dupuis J,Chartier L,Casasnovas RO,Berriolo-Riedinger A,Menga M,Haioun C,Tilly H,Tarantino V,Federico M,Salles G,Trotman J,Meignan M

更新日期：2018-05-31 00:00:00

abstract：:Obinutuzumab is a type 2, glycoengineered, anti-CD20 antibody recently approved with chlorambucil for the initial therapy of chronic lymphocytic leukemia (CLL). In this nonrandomized, parallel-cohort, phase 1b, multicenter study, we explored the safety and preliminary efficacy of obinutuzumab-bendamustine (G-B) or obi...

journal_title：Blood

authors： Brown JR,O'Brien S,Kingsley CD,Eradat H,Pagel JM,Lymp J,Hirata J,Kipps TJ

更新日期：2015-04-30 00:00:00

abstract：:Filamin A (FLNa), a dimeric actin cross-linking and scaffold protein with numerous intracellular binding partners, anchors the platelet adhesion glycoprotein (GP) Ib-IX-V receptor to actin cytoskeleton. We mapped the GPIbalpha binding site to a single domain of FLNa and resolved the structure of this domain and its in...

journal_title：Blood

authors： Nakamura F,Pudas R,Heikkinen O,Permi P,Kilpeläinen I,Munday AD,Hartwig JH,Stossel TP,Ylänne J

更新日期：2006-03-01 00:00:00

abstract：:Human immunodeficiency virus-1 (HIV-1)-Tat, the transactivating gene product of HIV-1, has been shown to interact with different cell types, inducing gene expression, altering their growth and migratory behavior. In this study we examined whether Tat might affect functions of acquired immunodeficiency syndrome (AIDS)-...

journal_title：Blood

authors： Chirivi RG,Taraboletti G,Bani MR,Barra L,Piccinini G,Giacca M,Bussolino F,Giavazzi R

更新日期：1999-09-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is composed of 3% of pediatric leukemias, making evidence-based recommendations difficult. Imatinib has revolutionized the treatment for adult CML by eliminating allogeneic stem cell transplantation for almost all patients in chronic phase. Shown effective in pediatric CML, imatinib and ...

journal_title：Blood

authors： Andolina JR,Neudorf SM,Corey SJ

更新日期：2012-02-23 00:00:00

abstract：:The putative chemokine receptor BLR1 has been identified as the first G-protein-coupled receptor involved in B-cell migration and in microenvironmental homing to B-cell follicles and to germinal centers. In healthy individuals, expression of BLR1 is restricted to all mature recirculating B cells and to a subpopulation...

journal_title：Blood

authors： Förster R,Schweigard G,Johann S,Emrich T,Kremmer E,Nerl C,Lipp M

更新日期：1997-07-15 00:00:00

abstract：:The genetic diversity of the human immunodeficiency virus (HIV) isolated from transfusion-associated AIDS patients has been examined. Restriction enzyme mapping studies of integrated proviral DNA of donor and recipient origin demonstrated genomic variation between isolates. Analysis of the molecularly cloned viral gen...

journal_title：Blood

authors： Srinivasan A,York D,Ranganathan P,Ferguson R,Butler D Jr,Feorino P,Kalyanaraman V,Jaffe H,Curran J,Anand R

更新日期：1987-06-01 00:00:00

abstract：:Adult-onset hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening disease of immune hyperactivation. Unlike pediatric HLH, adult HLH is rarely driven by germline genetic variants. Although numerous precipitating etiologies have been identified, the reason that HLH occurs in only a subset of individuals ...

journal_title：Blood

authors： Miller PG,Sperling AS,Gibson CJ,Viswanathan K,Castellano C,McConkey M,Ceremsak J,Taylor MS,Birndt S,Perner F,Arnason J,Agrawal M,Schram AM,Nikiforow S,Pihan G,Hasserjian RP,Aster JC,La Rosée P,Morgan EA,Berliner N,

更新日期：2020-12-24 00:00:00

abstract：:The administration of cytokines that modulate endogenous or transferred T-cell immunity could improve current approaches to clinical immunotherapy. Interleukin-2 (IL-2) is used most commonly for this purpose, but causes systemic toxicity and preferentially drives the expansion of CD4(+)CD25(+)Foxp3(+) regulatory T cel...

journal_title：Blood

authors： Berger C,Berger M,Hackman RC,Gough M,Elliott C,Jensen MC,Riddell SR

更新日期：2009-09-17 00:00:00

abstract：:The nuclear receptors (NR) retinoid X receptors (RXRs) exert immunomodulatory functions to control inflammation and metabolism via homodimers and heterodimers with several other NRs including retinoic acid receptors. IRX4204 is a novel, highly specific RXR agonist in clinical trials that potently and selectively activ...

journal_title：Blood

authors： Thangavelu G,Wang C,Loschi M,Saha A,Osborn M,Furlan SN,Aoyama K,McDonald-Hyman C,Aguilar EG,Janesick AS,Chandraratna RA,Refaeli Y,Panoskaltsis-Mortari A,MacDonald KP,Hill GR,Zeiser R,Maillard I,Serody J,Murphy WJ,Mu

更新日期：2020-09-24 00:00:00

abstract：:Depressed cellular immune function and increased susceptibility to infection characterize familial erythrophagocytic lymphohistiocytosis (FEL), a usually fatal autosomal recessive disease. One component of the immunodeficiency is plasma-mediated inhibition of lymphocyte proliferation. We have tested whether repeated p...

journal_title：Blood

authors： Ladisch S,Ho W,Matheson D,Pilkington R,Hartman G

更新日期：1982-10-01 00:00:00

abstract：:Human neutrophils exposed to chemotactic concentrations of zymosan-activated serum (ZAS) and a formylated chemotactic peptide (FMLP, 10(-7)--10(-9) M) were markedly enhanced in their ability to generate superoxide (O2-) upon stimulation with either sodium fluoride or phorbol myristate acetate (PMA). For both fluoride ...

journal_title：Blood

authors： English D,Roloff JS,Lukens JN

更新日期：1981-07-01 00:00:00

abstract：:Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a rare primary immunodeficiency caused by gain-of-function mutations in the CXCR4 gene. We report the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of mavorixafor from a phase 2 open-label dose-escalatio...

journal_title：Blood

authors： Dale DC,Firkin F,Bolyard AA,Kelley M,Makaryan V,Gorelick KJ,Ebrahim T,Garg V,Tang W,Jiang H,Skerlj R,Beaussant Cohen S

更新日期：2020-12-24 00:00:00

abstract：:The cells of hematopoietic and vascular endothelial cell lineages are believed to share a common precursor, termed hemangioblast. However, the existence of a growth factor acting relatively specifically on hemangioblasts remains unclear. Here we report the identification of hemangiopoietin (HAPO), a novel growth facto...

journal_title：Blood

authors： Liu YJ,Lu SH,Xu B,Yang RC,Ren Q,Liu B,Li B,Lu M,Yan FY,Han ZB,Han ZC

更新日期：2004-06-15 00:00:00

abstract：:Overexpression of transcription factors runt-related transcription factor 1 (RUNX1) and nuclear factor, erythroid-derived 2 (NF-E2) was reported in granulocytes of patients with polycythemia vera and other myeloproliferative neoplasms (MPNs). Further, a transgenic mouse overexpressing the NF-E2 transgene was reported ...

journal_title：Blood

authors： Kapralova K,Lanikova L,Lorenzo F,Song J,Horvathova M,Divoky V,Prchal JT

更新日期：2014-01-16 00:00:00

abstract：:To understand the hematopoietic and nonhematopoietic responses to interleukin-3 (IL-3), expression of cell-surface IL-3 receptors (IL-3R) was examined on bone marrow (BM) cells and peripheral blood (PB) cells of rhesus monkeys during the course of in vivo IL-3 treatment. Whereas IL-3R expression is low in untreated mo...

journal_title：Blood

authors： van Gils FC,van Teeffelen ME,Neelis KJ,Hendrikx J,Burger H,van Leen RW,Knol E,Wagemaker G,Wognum AW

更新日期：1995-07-15 00:00:00

abstract：:Recent studies suggest plasmacytoid predendritic cells (pDCs) and myeloid dendritic cells (mDCs) have the functional plasticity to produce similar amounts of type 1 interferons (IFNs) and interleukin-12 (IL-12), challenging the concept and existence of DC subsets with distinct function. In this study, we demonstrate t...

journal_title：Blood

authors： Ito T,Kanzler H,Duramad O,Cao W,Liu YJ

更新日期：2006-03-15 00:00:00

abstract：:In this issue of Blood, Bromberg et al and Greenbaum et al delete the gene encoding the cell adhesion molecule N-cadherin in osteoblastic cells forming the hematopoietic stem cell (HSC) niche to demonstrate that N-cadherin has no role in regulating hematopoiesis. ...

journal_title：Blood

authors： Levesque JP

更新日期：2012-07-12 00:00:00

abstract：:We investigated 17 patients (12 males and 5 females, ages 2 to 57 years old) with posttransfusion non-A, non-B hepatitis to determine relationships between clinical courses and hepatitis C virus (HCV) markers. The patients were grouped according to time course of abnormal serum alanine aminotransferase (ALT) levels in...

journal_title：Blood

authors： Shibata M,Morishima T,Kudo T,Maki T,Maki S,Nagai Y

更新日期：1991-03-15 00:00:00

abstract：:An estimated 22 350 patients had multiple myeloma diagnosed in 2013, representing 1.3% of all new cancers; 10 710 deaths are projected, representing 1.8% of cancer deaths. Approximately 0.7% of US men and women will have a myeloma diagnosis in their lifetime, and with advances in therapy, 77 600 US patients are living...

journal_title：Blood

authors： Gertz MA,Dingli D

更新日期：2014-08-07 00:00:00

abstract：:In patients with common variable immunodeficiency (CVI), we have previously defined a subgroup of patients (CVIHyper) characterized by decreased numbers of CD4+ lymphocytes in peripheral blood, splenomegaly, and persistent immune activation in vivo, particularly of monocytes/macrophages. To further characterize this h...

journal_title：Blood

authors： Aukrust P,Lien E,Kristoffersen AK,Müller F,Haug CJ,Espevik T,Frøland SS

更新日期：1996-01-15 00:00:00

abstract：:A cone and plate viscometer and Coulter Counter were used to study platelet modulation of polymorphonuclear leukocyte (PMNL) aggregation caused by controlled shear stress. As an index of aggregation, the large-particle percentage (LPP) was calculated. This represents the ratio of aggregated cell count to total cell co...

journal_title：Blood

authors： Rhee BG,Hall ER,McIntire LV

更新日期：1986-01-01 00:00:00

abstract：:Peripheral blood and bone marrow mononuclear cells from patients with refractory anemia (RA) or RA with sideroblasts (defined according to the revised French-American-British classification with less than 5% blast cells in the bone marrow) were analyzed using a panel of monoclonal antibodies directed against leukocyte...

journal_title：Blood

authors： Hokland P,Kerndrup G,Griffin JD,Ellegaard J

更新日期：1986-04-01 00:00:00

abstract：:Attempts to maintain or expand primitive hematopoietic stem cells in vitro without the concomitant loss of their differentiative and proliferative potential in vivo have largely been unsuccessful. To investigate this problem, we compared the ability of three cloned bone marrow (BM) stromal cell lines to support the gr...

journal_title：Blood

authors： Szilvassy SJ,Weller KP,Lin W,Sharma AK,Ho AS,Tsukamoto A,Hoffman R,Leiby KR,Gearing DP

更新日期：1996-06-01 00:00:00