Abstract:
:The genetic diversity of the human immunodeficiency virus (HIV) isolated from transfusion-associated AIDS patients has been examined. Restriction enzyme mapping studies of integrated proviral DNA of donor and recipient origin demonstrated genomic variation between isolates. Analysis of the molecularly cloned viral genomes of one donor-recipient pair showed that virus from the recipient had restriction enzyme site differences from the donor, noticeably clustered in the env and orf-2 regions, and also had a greater number of restriction sites in common with the donor as well. These results suggest that HIV may undergo genomic variation in vivo. Comparison of donor-recipient viruses may further the understanding of the molecular basis for AIDS pathogenesis.
journal_name
Bloodjournal_title
Bloodauthors
Srinivasan A,York D,Ranganathan P,Ferguson R,Butler D Jr,Feorino P,Kalyanaraman V,Jaffe H,Curran J,Anand Rsubject
Has Abstractpub_date
1987-06-01 00:00:00pages
1766-70issue
6eissn
0006-4971issn
1528-0020journal_volume
69pub_type
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