Obinutuzumab plus fludarabine/cyclophosphamide or bendamustine in the initial therapy of CLL patients: the phase 1b GALTON trial.

abstract：:A male neonate with Down's syndrome and congenital myeloproliferative disorder was studied. His blood picture showed the unique coexistence of leukocytosis with matured cells and a large number of blast cells. The in vitro proliferation and differentiation of blast cells into various lineages in the presence of phytoh...

journal_title：Blood

authors： Suda J,Eguchi M,Akiyama Y,Iwama Y,Furukawa T,Sato Y,Miura Y,Suda T,Saito M

更新日期：1987-02-01 00:00:00

abstract：:X-linked hyper IgM syndrome (XHM) is a combined immune deficiency disorder caused by genetic alterations in CD40 ligand. The purpose of this study was to investigate the safety and efficacy of recombinant CD40 ligand (rCD40L) in the treatment of the disease. Three children were administered rCD40L subcutaneously 3 tim...

journal_title：Blood

authors： Jain A,Kovacs JA,Nelson DL,Migueles SA,Pittaluga S,Fanslow W,Fan X,Wong DW,Massey J,Hornung R,Brown MR,Spinner JJ,Liu S,Davey V,Hill HA,Ochs H,Fleisher TA

更新日期：2011-10-06 00:00:00

abstract：:Adult T-cell leukemia/lymphoma (ATLL) is an incurable disease where most patients succumb within the first year of diagnosis. Both standard chemotherapy regimens and mAbs directed against ATLL tumor markers do not alter this aggressive clinical course. Therapeutic development would be facilitated by the discovery of g...

journal_title：Blood

authors： Elliott NE,Cleveland SM,Grann V,Janik J,Waldmann TA,Davé UP

更新日期：2011-10-06 00:00:00

abstract：:Erythropoiesis-inhibiting factors (EIF) have been demonstrated in plasma from hypertransfused animals and from polycythemic individuals during periods of hyperoxia, but there is a decided discrepancy in the data published. In the present paper methodologic variations of a bioassay for demonstrating the erythropoiesis-...

journal_title：Blood

authors： Lindemann R

更新日期：1976-01-01 00:00:00

abstract：:The human CD11a molecule is expressed specifically on lymphocytes, monocyte/macrophages, and neutrophils, in which it mediates important adhesion-related functions. We used 1.7 kb of regulatory sequences upstream from the human CD11a gene transcription start site to drive expression of a modified human CD4 reporter ge...

journal_title：Blood

authors： Ritchie KA,Aprikian A,Gollahon KA,Hickstein DD

更新日期：1995-07-01 00:00:00

abstract：:Fibrillar collagens are among the most potent activators of platelets and play an important role in the initiation of thrombosis. The glycoprotein VI (GPVI)/FcRgamma-chain complex is a central collagen receptor and inhibitors of GPVI produce a major defect in arterial thrombogenesis. In this study we have examined art...

journal_title：Blood

authors： Mangin P,Yap CL,Nonne C,Sturgeon SA,Goncalves I,Yuan Y,Schoenwaelder SM,Wright CE,Lanza F,Jackson SP

更新日期：2006-06-01 00:00:00

abstract：:The diagnosis of recurrent ipsilateral deep vein thrombosis (DVT) is challenging, because persistent intravascular abnormalities after previous DVT often hinder a diagnosis by compression ultrasonography. Magnetic resonance direct thrombus imaging (MRDTI), a technique without intravenous contrast and with a 10-minute ...

journal_title：Blood

authors： van Dam LF,Dronkers CEA,Gautam G,Eckerbom Å,Ghanima W,Gleditsch J,von Heijne A,Hofstee HMA,Hovens MMC,Huisman MV,Kolman S,Mairuhu ATA,Nijkeuter M,van de Ree MA,van Rooden CJ,Westerbeek RE,Westerink J,Westerlund E,Krof

更新日期：2020-04-16 00:00:00

abstract：:Neutrophil dysfunction consequent to influenza A virus infection has been described in vivo and in vitro and may contribute to the serious bacterial sequelae which occur in influenza-infected hosts. On the premise that such dysfunction may represent a form of "deactivation," we sought to characterize neutrophil activa...

journal_title：Blood

authors： Hartshorn KL,Collamer M,White MR,Schwartz JH,Tauber AI

更新日期：1990-01-01 00:00:00

abstract：:Warm autoimmune hemolytic anemia (WAIHA) is characterized by an accelerated clearance of red blood cells (RBCs) associated with the presence of anti-RBC immunoglobulin (Ig)G autoantibodies. In the present study, we analyzed the self-reactive IgG and IgM antibody repertoires of patients with WAIHA using a technique of ...

journal_title：Blood

authors： Stahl D,Lacroix-Desmazes S,Heudes D,Mouthon L,Kaveri SV,Kazatchkine MD

更新日期：2000-01-01 00:00:00

abstract：:Primary effusion lymphoma (PEL) is an aggressive HIV-associated lymphoma with a relatively poor prognosis in the era of effective HIV therapy. Kaposi sarcoma herpesvirus (KSHV) is the etiologic agent, and ∼80% of tumors are coinfected with Epstein-Barr virus (EBV). A better understanding of how KSHV-related immune dys...

journal_title：Blood

authors： Lurain K,Polizzotto MN,Aleman K,Bhutani M,Wyvill KM,Gonçalves PH,Ramaswami R,Marshall VA,Miley W,Steinberg SM,Little RF,Wilson W,Filie AC,Pittaluga S,Jaffe ES,Whitby D,Yarchoan R,Uldrick TS

更新日期：2019-04-18 00:00:00

abstract：:The pp65(495-503) cytotoxic T-lymphocyte (CTL) epitope from cytomegalovirus (CMV) is universally recognized among CMV+ individuals who express an allele of the human leukocyte antigen A (HLA-A*0201). The relative binding affinity of the epitope to HLA-A*0201 is moderate, and its increased activity might prove benefici...

journal_title：Blood

authors： La Rosa C,Krishnan R,Markel S,Schneck JP,Houghten R,Pinilla C,Diamond DJ

更新日期：2001-03-15 00:00:00

abstract：:Chromosome maintenance protein 1 (CRM1) is a nuclear export receptor involved in the active transport of tumor suppressors (e.g., p53 and nucleophosmin) whose function is altered in cancer because of increased expression and overactive transport. Blocking CRM1-mediated nuclear export of such proteins is a novel therap...

journal_title：Blood

authors： Ranganathan P,Yu X,Na C,Santhanam R,Shacham S,Kauffman M,Walker A,Klisovic R,Blum W,Caligiuri M,Croce CM,Marcucci G,Garzon R

更新日期：2012-08-30 00:00:00

abstract：:FTY720 is an immunosuppressant developed to prevent organ transplant rejection. Recent studies indicate an additional role for FTY720 in inducing cell apoptosis. We demonstrate here that FTY720 mediates toxic effects in cell lines representing different B-cell malignancies and primary B cells from patients with chroni...

journal_title：Blood

authors： Liu Q,Zhao X,Frissora F,Ma Y,Santhanam R,Jarjoura D,Lehman A,Perrotti D,Chen CS,Dalton JT,Muthusamy N,Byrd JC

更新日期：2008-01-01 00:00:00

abstract：:The CXC-chemokines interleukin-8 (IL-8), neutrophil-activating peptide-2 (NAP-2), and melanoma growth-stimulatory activity (MGSA) are chemoattractants with high selectivity for neutrophils. Although IL-8 has been shown to act as an extremely potent mediator, reports on NAP-2 and MGSA are still contradictory. Here we s...

journal_title：Blood

authors： Ludwig A,Petersen F,Zahn S,Götze O,Schröder JM,Flad HD,Brandt E

更新日期：1997-12-01 00:00:00

abstract：:Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) affect >200 000 individuals yearly with a 40% mortality rate. Although platelets are implicated in the progression of ALI/ARDS, their exact role remains undefined. Triggering receptor expressed in myeloid cells (TREM)-like transcript 1 (TLT-1) is f...

journal_title：Blood

authors： Morales-Ortíz J,Deal V,Reyes F,Maldonado-Martínez G,Ledesma N,Staback F,Croft C,Pacheco A,Ortiz-Zuazaga H,Yost CC,Rowley JW,Madera B,John AS,Chen J,Lopez J,Rondina MT,Hunter R,Gibson A,Washington AV

更新日期：2018-12-06 00:00:00

abstract：:Human cord blood progenitor-derived erythroblasts have recently been shown to respond to erythropoietin (Epo) or granulocyte-macrophage colony-stimulating factor (GM-CSF) with a transient increase in intracellular free calcium concentration [Cac]. However, the importance of [Cac] changes in mediating cell proliferatio...

journal_title：Blood

authors： Miller BA,Cheung JY,Tillotson DL,Hope SM,Scaduto RC Jr

更新日期：1989-04-01 00:00:00

abstract：:The microbiota has emerged as an important regulator of the host immunity by the induction, functional modulation, or suppression of local and systemic immune responses. In return, the host immune system restricts translocation and fine tunes the composition and distribution of the microbiota to maintain a beneficial ...

journal_title：Blood

authors： Zhang D,Frenette PS

更新日期：2019-05-16 00:00:00

abstract：:Deletion of TP53 gene, under routine assessment by fluorescence in situ hybridization analysis, connects with the worst prognosis in chronic lymphocytic leukemia (CLL). The presence of isolated TP53 mutation (without deletion) is associated with reduced survival in CLL patients. It is unclear how these abnormalities a...

journal_title：Blood

authors： Malcikova J,Smardova J,Rocnova L,Tichy B,Kuglik P,Vranova V,Cejkova S,Svitakova M,Skuhrova Francova H,Brychtova Y,Doubek M,Brejcha M,Klabusay M,Mayer J,Pospisilova S,Trbusek M

更新日期：2009-12-17 00:00:00

abstract：:To investigate underlying mechanisms of thrombocytopenia in myelodysplastic syndrome (MDS), radiolabeled platelet studies were performed in 30 MDS patients with platelet counts less than 100 x 10(9)/L. Furthermore, plasma thrombopoietin and glycocalicin index (a parameter of platelet or megakaryocyte destruction) were...

journal_title：Blood

authors： Houwerzijl EJ,Blom NR,van der Want JJ,Louwes H,Esselink MT,Smit JW,Vellenga E,de Wolf JT

更新日期：2005-05-01 00:00:00

abstract：:The effects of alpha 2-antiplasmin and fibrin on the activation of plasminogen by recombinant staphylokinase (STAR) were studied in an effort to elucidate further the molecular basis of the fibrin-specificity of this fibrinolytic agent. In purified systems consisting of 1.5 mumol/L intact or low-M(r) plasminogen and 3...

journal_title：Blood

authors： Silence K,Collen D,Lijnen HR

更新日期：1993-08-15 00:00:00

abstract：:Cyclophosphamide (CTX), a commonly used chemotherapeutic agent can enhance immune responses. The ability of CTX to promote the proliferation of effector T cells and abrogate the function of regulatory T cells (Tregs) has been described. In this study, we examined the effects of CTX treatment on dendritic cell (DC) sub...

journal_title：Blood

authors： Nakahara T,Uchi H,Lesokhin AM,Avogadri F,Rizzuto GA,Hirschhorn-Cymerman D,Panageas KS,Merghoub T,Wolchok JD,Houghton AN

更新日期：2010-06-03 00:00:00

abstract：:Although infants with acute lymphoblastic leukemia (ALL) and a germline MLL gene have a better prognosis than comparable infants with a rearranged MLL gene, their optimal therapy is controversial. In 2 consecutive studies, conducted between 1996 and 2002, we treated 22 cases of infant ALL with germline MLL using chemo...

journal_title：Blood

authors： Nagayama J,Tomizawa D,Koh K,Nagatoshi Y,Hotta N,Kishimoto T,Takahashi Y,Kuno T,Sugita K,Sato T,Kato K,Ogawa A,Nakahata T,Mizutani S,Horibe K,Ishii E,Japan Infant Leukemia Study Group.

更新日期：2006-06-15 00:00:00

abstract：:Survivin and XIAP, members of the protein family known as the inhibitors of apoptosis, interfere with the activation of caspases, called the "cell death executioners." We examined Survivin (n = 116) and XIAP (n = 172) expression in primary acute myeloid leukemia (AML) blasts and assessed the impact of their expression...

journal_title：Blood

authors： Carter BZ,Kornblau SM,Tsao T,Wang RY,Schober WD,Milella M,Sung HG,Reed JC,Andreeff M

更新日期：2003-12-01 00:00:00

abstract：:Keeping track of individual cell identifications is imperative to the study of dynamic single-cell behavior over time. Highly motile hematopoietic stem and progenitor cells (HSPCs) migrate quickly and do not adhere, and thus must be imaged very frequently to keep cell identifications. Even worse, they are also flushed...

journal_title：Blood

authors： Loeffler D,Wang W,Hopf A,Hilsenbeck O,Bourgine PE,Rudolf F,Martin I,Schroeder T

更新日期：2018-03-29 00:00:00

abstract：:The outcome of patients with acute myeloid leukemia who are older than 60 years has remained poor because of unfavorable disease characteristics and patient-related factors. The randomized German-Austrian AML Study Group 06-04 protocol was designed on the basis of in vitro synergistic effects of valproic acid (VPA) an...

journal_title：Blood

authors： Tassara M,Döhner K,Brossart P,Held G,Götze K,Horst HA,Ringhoffer M,Köhne CH,Kremers S,Raghavachar A,Wulf G,Kirchen H,Nachbaur D,Derigs HG,Wattad M,Koller E,Brugger W,Matzdorff A,Greil R,Heil G,Paschka P,Gaidzik

更新日期：2014-06-26 00:00:00

abstract：:Persistent fibrin deposition in tissues characterizes the early pathology of many types of injury. In an animal model of bleomycin-induced lung fibrosis, increased expression of type 1 plasminogen activator inhibitor (PAI-1) is associated with accumulation of fibrin in fibroproliferative lesions. Plasmin proteolysis o...

journal_title：Blood

authors： Hagood JS,Olman MA,Godoy JA,Rivera KE,Fuller GM

更新日期：1996-05-01 00:00:00

abstract：:The conjunctival microcirculation of 18 homozygous sickle cell disease (SCD) patients during steady-state, painful crisis, and postcrisis conditions was recorded on high-resolution videotapes using intravital microscopy. Selected videotape sequences were subsequently coded, frame-captured, studied, and blindly analyze...

journal_title：Blood

authors： Cheung AT,Chen PC,Larkin EC,Duong PL,Ramanujam S,Tablin F,Wun T

更新日期：2002-06-01 00:00:00

abstract：:Previous studies have implicated activation-induced cytidine deaminase (AID) in B-cell translocations but have failed to identify any association between their chromosomal breakpoints and known AID target sequences. Analysis of 56 unclustered IgH-CCND1 translocations in mantle cell lymphoma across the ~ 344-kb bcl-1 b...

journal_title：Blood

authors： Greisman HA,Lu Z,Tsai AG,Greiner TC,Yi HS,Lieber MR

更新日期：2012-10-04 00:00:00

abstract：:The malignant monoclonal population in hairy cell leukemia (HCL) has been variously ascribed to be of myeloid, B, or even T cell origin. Recent data have been interpreted as suggesting that hairy cells (HC) may concomitantly or serially express both B and T surface determinants, a phenomenon which, if verified, would ...

journal_title：Blood

authors： Han T,Dadey B,Pollard C,Barcos M,Bloom ML,Minowada J,Ozer H

更新日期：1984-04-01 00:00:00

abstract：:Chromosomal translocations involving the platelet-derived growth factor beta receptor (PDGFbetaR) gene have been reported in some patients with chronic myelomonocytic leukemia (CMML). The resultant fusion proteins have constitutive PDGFbetaR tyrosine kinase activity, but the partner genes previously reported (tel, Hun...

journal_title：Blood

authors： Magnusson MK,Meade KE,Brown KE,Arthur DC,Krueger LA,Barrett AJ,Dunbar CE

更新日期：2001-10-15 00:00:00