Obinutuzumab plus fludarabine/cyclophosphamide or bendamustine in the initial therapy of CLL patients: the phase 1b GALTON trial.


:Obinutuzumab is a type 2, glycoengineered, anti-CD20 antibody recently approved with chlorambucil for the initial therapy of chronic lymphocytic leukemia (CLL). In this nonrandomized, parallel-cohort, phase 1b, multicenter study, we explored the safety and preliminary efficacy of obinutuzumab-bendamustine (G-B) or obinutuzumab fludarabine cyclophosphamide (G-FC) for the therapy of previously untreated fit patients with CLL. Patients received up to 6 cycles of G-B (n = 20) or G-FC (n = 21). The primary end point was safety, with infusion-related reactions (88%, grade 3-4 20%) being the most common adverse event and grade 3-4 neutropenia in 55% on G-B and 48% on G-FC. Mean cycles completed were 5.7 for G-B and 5.1 for G-FC, with 2 and 7 early discontinuations, respectively. The objective response rate (ORR) for G-B was 90% (18/20) with 20% complete response (CR) and 25% CR with incomplete marrow recovery (CRi). The ORR for G-FC was 62% (13/21), with 10% CR and 14% CRi, including 4 patients not evaluable. With a median follow-up of 23.5 months in the G-B cohort and 20.7 months in the G-FC cohort, no patient has relapsed or died. We conclude that obinutuzumab with either B or FC shows manageable toxicity and has promising activity. This study was registered at as #NCT01300247.






Brown JR,O'Brien S,Kingsley CD,Eradat H,Pagel JM,Lymp J,Hirata J,Kipps TJ




Has Abstract


2015-04-30 00:00:00
















  • Differentiation of blast cells from a Down's syndrome patient with transient myeloproliferative disorder.

    abstract::A male neonate with Down's syndrome and congenital myeloproliferative disorder was studied. His blood picture showed the unique coexistence of leukocytosis with matured cells and a large number of blast cells. The in vitro proliferation and differentiation of blast cells into various lineages in the presence of phytoh...


    pub_type: 杂志文章


    authors: Suda J,Eguchi M,Akiyama Y,Iwama Y,Furukawa T,Sato Y,Miura Y,Suda T,Saito M

    更新日期:1987-02-01 00:00:00

  • Partial immune reconstitution of X-linked hyper IgM syndrome with recombinant CD40 ligand.

    abstract::X-linked hyper IgM syndrome (XHM) is a combined immune deficiency disorder caused by genetic alterations in CD40 ligand. The purpose of this study was to investigate the safety and efficacy of recombinant CD40 ligand (rCD40L) in the treatment of the disease. Three children were administered rCD40L subcutaneously 3 tim...


    pub_type: 临床试验,杂志文章


    authors: Jain A,Kovacs JA,Nelson DL,Migueles SA,Pittaluga S,Fanslow W,Fan X,Wong DW,Massey J,Hornung R,Brown MR,Spinner JJ,Liu S,Davey V,Hill HA,Ochs H,Fleisher TA

    更新日期:2011-10-06 00:00:00

  • FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma.

    abstract::Adult T-cell leukemia/lymphoma (ATLL) is an incurable disease where most patients succumb within the first year of diagnosis. Both standard chemotherapy regimens and mAbs directed against ATLL tumor markers do not alter this aggressive clinical course. Therapeutic development would be facilitated by the discovery of g...


    pub_type: 杂志文章


    authors: Elliott NE,Cleveland SM,Grann V,Janik J,Waldmann TA,Davé UP

    更新日期:2011-10-06 00:00:00

  • Erythropoiesis-inhibiting factor(s) (EIF): methodologic studies.

    abstract::Erythropoiesis-inhibiting factors (EIF) have been demonstrated in plasma from hypertransfused animals and from polycythemic individuals during periods of hyperoxia, but there is a decided discrepancy in the data published. In the present paper methodologic variations of a bioassay for demonstrating the erythropoiesis-...


    pub_type: 杂志文章


    authors: Lindemann R

    更新日期:1976-01-01 00:00:00

  • The human leukocyte integrin CD11a promoter directs expression in leukocytes of transgenic mice.

    abstract::The human CD11a molecule is expressed specifically on lymphocytes, monocyte/macrophages, and neutrophils, in which it mediates important adhesion-related functions. We used 1.7 kb of regulatory sequences upstream from the human CD11a gene transcription start site to drive expression of a modified human CD4 reporter ge...


    pub_type: 杂志文章


    authors: Ritchie KA,Aprikian A,Gollahon KA,Hickstein DD

    更新日期:1995-07-01 00:00:00

  • Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRgamma deficiency.

    abstract::Fibrillar collagens are among the most potent activators of platelets and play an important role in the initiation of thrombosis. The glycoprotein VI (GPVI)/FcRgamma-chain complex is a central collagen receptor and inhibitors of GPVI produce a major defect in arterial thrombogenesis. In this study we have examined art...


    pub_type: 杂志文章


    authors: Mangin P,Yap CL,Nonne C,Sturgeon SA,Goncalves I,Yuan Y,Schoenwaelder SM,Wright CE,Lanza F,Jackson SP

    更新日期:2006-06-01 00:00:00

  • Magnetic resonance imaging for diagnosis of recurrent ipsilateral deep vein thrombosis.

    abstract::The diagnosis of recurrent ipsilateral deep vein thrombosis (DVT) is challenging, because persistent intravascular abnormalities after previous DVT often hinder a diagnosis by compression ultrasonography. Magnetic resonance direct thrombus imaging (MRDTI), a technique without intravenous contrast and with a 10-minute ...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: van Dam LF,Dronkers CEA,Gautam G,Eckerbom Å,Ghanima W,Gleditsch J,von Heijne A,Hofstee HMA,Hovens MMC,Huisman MV,Kolman S,Mairuhu ATA,Nijkeuter M,van de Ree MA,van Rooden CJ,Westerbeek RE,Westerink J,Westerlund E,Krof

    更新日期:2020-04-16 00:00:00

  • Characterization of influenza A virus activation of the human neutrophil.

    abstract::Neutrophil dysfunction consequent to influenza A virus infection has been described in vivo and in vitro and may contribute to the serious bacterial sequelae which occur in influenza-infected hosts. On the premise that such dysfunction may represent a form of "deactivation," we sought to characterize neutrophil activa...


    pub_type: 杂志文章


    authors: Hartshorn KL,Collamer M,White MR,Schwartz JH,Tauber AI

    更新日期:1990-01-01 00:00:00

  • Altered control of self-reactive IgG by autologous IgM in patients with warm autoimmune hemolytic anemia.

    abstract::Warm autoimmune hemolytic anemia (WAIHA) is characterized by an accelerated clearance of red blood cells (RBCs) associated with the presence of anti-RBC immunoglobulin (Ig)G autoantibodies. In the present study, we analyzed the self-reactive IgG and IgM antibody repertoires of patients with WAIHA using a technique of ...


    pub_type: 杂志文章


    authors: Stahl D,Lacroix-Desmazes S,Heudes D,Mouthon L,Kaveri SV,Kazatchkine MD

    更新日期:2000-01-01 00:00:00

  • Viral, immunologic, and clinical features of primary effusion lymphoma.

    abstract::Primary effusion lymphoma (PEL) is an aggressive HIV-associated lymphoma with a relatively poor prognosis in the era of effective HIV therapy. Kaposi sarcoma herpesvirus (KSHV) is the etiologic agent, and ∼80% of tumors are coinfected with Epstein-Barr virus (EBV). A better understanding of how KSHV-related immune dys...


    pub_type: 杂志文章


    authors: Lurain K,Polizzotto MN,Aleman K,Bhutani M,Wyvill KM,Gonçalves PH,Ramaswami R,Marshall VA,Miley W,Steinberg SM,Little RF,Wilson W,Filie AC,Pittaluga S,Jaffe ES,Whitby D,Yarchoan R,Uldrick TS

    更新日期:2019-04-18 00:00:00

  • Enhanced immune activity of cytotoxic T-lymphocyte epitope analogs derived from positional scanning synthetic combinatorial libraries.

    abstract::The pp65(495-503) cytotoxic T-lymphocyte (CTL) epitope from cytomegalovirus (CMV) is universally recognized among CMV+ individuals who express an allele of the human leukocyte antigen A (HLA-A*0201). The relative binding affinity of the epitope to HLA-A*0201 is moderate, and its increased activity might prove benefici...


    pub_type: 杂志文章


    authors: La Rosa C,Krishnan R,Markel S,Schneck JP,Houghten R,Pinilla C,Diamond DJ

    更新日期:2001-03-15 00:00:00

  • Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia.

    abstract::Chromosome maintenance protein 1 (CRM1) is a nuclear export receptor involved in the active transport of tumor suppressors (e.g., p53 and nucleophosmin) whose function is altered in cancer because of increased expression and overactive transport. Blocking CRM1-mediated nuclear export of such proteins is a novel therap...


    pub_type: 杂志文章


    authors: Ranganathan P,Yu X,Na C,Santhanam R,Shacham S,Kauffman M,Walker A,Klisovic R,Blum W,Caligiuri M,Croce CM,Marcucci G,Garzon R

    更新日期:2012-08-30 00:00:00

  • FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma.

    abstract::FTY720 is an immunosuppressant developed to prevent organ transplant rejection. Recent studies indicate an additional role for FTY720 in inducing cell apoptosis. We demonstrate here that FTY720 mediates toxic effects in cell lines representing different B-cell malignancies and primary B cells from patients with chroni...


    pub_type: 杂志文章


    authors: Liu Q,Zhao X,Frissora F,Ma Y,Santhanam R,Jarjoura D,Lehman A,Perrotti D,Chen CS,Dalton JT,Muthusamy N,Byrd JC

    更新日期:2008-01-01 00:00:00

  • The CXC-chemokine neutrophil-activating peptide-2 induces two distinct optima of neutrophil chemotaxis by differential interaction with interleukin-8 receptors CXCR-1 and CXCR-2.

    abstract::The CXC-chemokines interleukin-8 (IL-8), neutrophil-activating peptide-2 (NAP-2), and melanoma growth-stimulatory activity (MGSA) are chemoattractants with high selectivity for neutrophils. Although IL-8 has been shown to act as an extremely potent mediator, reports on NAP-2 and MGSA are still contradictory. Here we s...


    pub_type: 杂志文章


    authors: Ludwig A,Petersen F,Zahn S,Götze O,Schröder JM,Flad HD,Brandt E

    更新日期:1997-12-01 00:00:00

  • Platelet-derived TLT-1 is a prognostic indicator in ALI/ARDS and prevents tissue damage in the lungs in a mouse model.

    abstract::Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) affect >200 000 individuals yearly with a 40% mortality rate. Although platelets are implicated in the progression of ALI/ARDS, their exact role remains undefined. Triggering receptor expressed in myeloid cells (TREM)-like transcript 1 (TLT-1) is f...


    pub_type: 杂志文章


    authors: Morales-Ortíz J,Deal V,Reyes F,Maldonado-Martínez G,Ledesma N,Staback F,Croft C,Pacheco A,Ortiz-Zuazaga H,Yost CC,Rowley JW,Madera B,John AS,Chen J,Lopez J,Rondina MT,Hunter R,Gibson A,Washington AV

    更新日期:2018-12-06 00:00:00

  • Erythropoietin stimulates a rise in intracellular-free calcium concentration in single BFU-E derived erythroblasts at specific stages of differentiation.

    abstract::Human cord blood progenitor-derived erythroblasts have recently been shown to respond to erythropoietin (Epo) or granulocyte-macrophage colony-stimulating factor (GM-CSF) with a transient increase in intracellular free calcium concentration [Cac]. However, the importance of [Cac] changes in mediating cell proliferatio...


    pub_type: 杂志文章


    authors: Miller BA,Cheung JY,Tillotson DL,Hope SM,Scaduto RC Jr

    更新日期:1989-04-01 00:00:00

  • Cross talk between neutrophils and the microbiota.

    abstract::The microbiota has emerged as an important regulator of the host immunity by the induction, functional modulation, or suppression of local and systemic immune responses. In return, the host immune system restricts translocation and fine tunes the composition and distribution of the microbiota to maintain a beneficial ...


    pub_type: 杂志文章,评审


    authors: Zhang D,Frenette PS

    更新日期:2019-05-16 00:00:00

  • Monoallelic and biallelic inactivation of TP53 gene in chronic lymphocytic leukemia: selection, impact on survival, and response to DNA damage.

    abstract::Deletion of TP53 gene, under routine assessment by fluorescence in situ hybridization analysis, connects with the worst prognosis in chronic lymphocytic leukemia (CLL). The presence of isolated TP53 mutation (without deletion) is associated with reduced survival in CLL patients. It is unclear how these abnormalities a...


    pub_type: 杂志文章


    authors: Malcikova J,Smardova J,Rocnova L,Tichy B,Kuglik P,Vranova V,Cejkova S,Svitakova M,Skuhrova Francova H,Brychtova Y,Doubek M,Brejcha M,Klabusay M,Mayer J,Pospisilova S,Trbusek M

    更新日期:2009-12-17 00:00:00

  • Increased peripheral platelet destruction and caspase-3-independent programmed cell death of bone marrow megakaryocytes in myelodysplastic patients.

    abstract::To investigate underlying mechanisms of thrombocytopenia in myelodysplastic syndrome (MDS), radiolabeled platelet studies were performed in 30 MDS patients with platelet counts less than 100 x 10(9)/L. Furthermore, plasma thrombopoietin and glycocalicin index (a parameter of platelet or megakaryocyte destruction) were...


    pub_type: 杂志文章


    authors: Houwerzijl EJ,Blom NR,van der Want JJ,Louwes H,Esselink MT,Smit JW,Vellenga E,de Wolf JT

    更新日期:2005-05-01 00:00:00

  • Regulation by alpha 2-antiplasmin and fibrin of the activation of plasminogen with recombinant staphylokinase in plasma.

    abstract::The effects of alpha 2-antiplasmin and fibrin on the activation of plasminogen by recombinant staphylokinase (STAR) were studied in an effort to elucidate further the molecular basis of the fibrin-specificity of this fibrinolytic agent. In purified systems consisting of 1.5 mumol/L intact or low-M(r) plasminogen and 3...


    pub_type: 杂志文章


    authors: Silence K,Collen D,Lijnen HR

    更新日期:1993-08-15 00:00:00

  • Cyclophosphamide enhances immunity by modulating the balance of dendritic cell subsets in lymphoid organs.

    abstract::Cyclophosphamide (CTX), a commonly used chemotherapeutic agent can enhance immune responses. The ability of CTX to promote the proliferation of effector T cells and abrogate the function of regulatory T cells (Tregs) has been described. In this study, we examined the effects of CTX treatment on dendritic cell (DC) sub...


    pub_type: 杂志文章


    authors: Nakahara T,Uchi H,Lesokhin AM,Avogadri F,Rizzuto GA,Hirschhorn-Cymerman D,Panageas KS,Merghoub T,Wolchok JD,Houghton AN

    更新日期:2010-06-03 00:00:00

  • Infants with acute lymphoblastic leukemia and a germline MLL gene are highly curable with use of chemotherapy alone: results from the Japan Infant Leukemia Study Group.

    abstract::Although infants with acute lymphoblastic leukemia (ALL) and a germline MLL gene have a better prognosis than comparable infants with a rearranged MLL gene, their optimal therapy is controversial. In 2 consecutive studies, conducted between 1996 and 2002, we treated 22 cases of infant ALL with germline MLL using chemo...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Nagayama J,Tomizawa D,Koh K,Nagatoshi Y,Hotta N,Kishimoto T,Takahashi Y,Kuno T,Sugita K,Sato T,Kato K,Ogawa A,Nakahata T,Mizutani S,Horibe K,Ishii E,Japan Infant Leukemia Study Group.

    更新日期:2006-06-15 00:00:00

  • Caspase-independent cell death in AML: caspase inhibition in vitro with pan-caspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis.

    abstract::Survivin and XIAP, members of the protein family known as the inhibitors of apoptosis, interfere with the activation of caspases, called the "cell death executioners." We examined Survivin (n = 116) and XIAP (n = 172) expression in primary acute myeloid leukemia (AML) blasts and assessed the impact of their expression...


    pub_type: 杂志文章


    authors: Carter BZ,Kornblau SM,Tsao T,Wang RY,Schober WD,Milella M,Sung HG,Reed JC,Andreeff M

    更新日期:2003-12-01 00:00:00

  • Mouse and human HSPC immobilization in liquid culture by CD43- or CD44-antibody coating.

    abstract::Keeping track of individual cell identifications is imperative to the study of dynamic single-cell behavior over time. Highly motile hematopoietic stem and progenitor cells (HSPCs) migrate quickly and do not adhere, and thus must be imaged very frequently to keep cell identifications. Even worse, they are also flushed...


    pub_type: 杂志文章


    authors: Loeffler D,Wang W,Hopf A,Hilsenbeck O,Bourgine PE,Rudolf F,Martin I,Schroeder T

    更新日期:2018-03-29 00:00:00

  • Valproic acid in combination with all-trans retinoic acid and intensive therapy for acute myeloid leukemia in older patients.

    abstract::The outcome of patients with acute myeloid leukemia who are older than 60 years has remained poor because of unfavorable disease characteristics and patient-related factors. The randomized German-Austrian AML Study Group 06-04 protocol was designed on the basis of in vitro synergistic effects of valproic acid (VPA) an...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Tassara M,Döhner K,Brossart P,Held G,Götze K,Horst HA,Ringhoffer M,Köhne CH,Kremers S,Raghavachar A,Wulf G,Kirchen H,Nachbaur D,Derigs HG,Wattad M,Koller E,Brugger W,Matzdorff A,Greil R,Heil G,Paschka P,Gaidzik

    更新日期:2014-06-26 00:00:00

  • Regulation of type I plasminogen activator inhibitor by fibrin degradation products in rat lung fibroblasts.

    abstract::Persistent fibrin deposition in tissues characterizes the early pathology of many types of injury. In an animal model of bleomycin-induced lung fibrosis, increased expression of type 1 plasminogen activator inhibitor (PAI-1) is associated with accumulation of fibrin in fibroproliferative lesions. Plasmin proteolysis o...


    pub_type: 杂志文章


    authors: Hagood JS,Olman MA,Godoy JA,Rivera KE,Fuller GM

    更新日期:1996-05-01 00:00:00

  • Microvascular abnormalities in sickle cell disease: a computer-assisted intravital microscopy study.

    abstract::The conjunctival microcirculation of 18 homozygous sickle cell disease (SCD) patients during steady-state, painful crisis, and postcrisis conditions was recorded on high-resolution videotapes using intravital microscopy. Selected videotape sequences were subsequently coded, frame-captured, studied, and blindly analyze...


    pub_type: 杂志文章


    authors: Cheung AT,Chen PC,Larkin EC,Duong PL,Ramanujam S,Tablin F,Wun T

    更新日期:2002-06-01 00:00:00

  • IgH partner breakpoint sequences provide evidence that AID initiates t(11;14) and t(8;14) chromosomal breaks in mantle cell and Burkitt lymphomas.

    abstract::Previous studies have implicated activation-induced cytidine deaminase (AID) in B-cell translocations but have failed to identify any association between their chromosomal breakpoints and known AID target sequences. Analysis of 56 unclustered IgH-CCND1 translocations in mantle cell lymphoma across the ~ 344-kb bcl-1 b...


    pub_type: 杂志文章


    authors: Greisman HA,Lu Z,Tsai AG,Greiner TC,Yi HS,Lieber MR

    更新日期:2012-10-04 00:00:00

  • Lack of T cell antigen expression on hairy cells of B cell origin after in vitro exposure to PHA.

    abstract::The malignant monoclonal population in hairy cell leukemia (HCL) has been variously ascribed to be of myeloid, B, or even T cell origin. Recent data have been interpreted as suggesting that hairy cells (HC) may concomitantly or serially express both B and T surface determinants, a phenomenon which, if verified, would ...


    pub_type: 杂志文章


    authors: Han T,Dadey B,Pollard C,Barcos M,Bloom ML,Minowada J,Ozer H

    更新日期:1984-04-01 00:00:00

  • Rabaptin-5 is a novel fusion partner to platelet-derived growth factor beta receptor in chronic myelomonocytic leukemia.

    abstract::Chromosomal translocations involving the platelet-derived growth factor beta receptor (PDGFbetaR) gene have been reported in some patients with chronic myelomonocytic leukemia (CMML). The resultant fusion proteins have constitutive PDGFbetaR tyrosine kinase activity, but the partner genes previously reported (tel, Hun...


    pub_type: 杂志文章


    authors: Magnusson MK,Meade KE,Brown KE,Arthur DC,Krueger LA,Barrett AJ,Dunbar CE

    更新日期:2001-10-15 00:00:00