Obinutuzumab plus fludarabine/cyclophosphamide or bendamustine in the initial therapy of CLL patients: the phase 1b GALTON trial.

abstract：:Different biologic features have been associated with a more or less aggressive clinical course in chronic lymphocytic leukemia (CLL). In the present study, 20 patients with highly stable CLL observed at a single institution over a period of 10 to 23 years and who never required treatment were extensively characterize...

journal_title：Blood

authors： Guarini A,Gaidano G,Mauro FR,Capello D,Mancini F,De Propris MS,Mancini M,Orsini E,Gentile M,Breccia M,Cuneo A,Castoldi G,Foa R

更新日期：2003-08-01 00:00:00

abstract：:Hemophilia B is a bleeding disorder caused by a deficiency of clotting factor IX (FIX). A colony of FIX deficient Lhasa Apso dogs has been established and the molecular basis of hemophilia B has been determined. The plasma factor IX levels were < 1% of normal canine levels in affected dogs. A complex deletion mutation...

journal_title：Blood

authors： Mauser AE,Whitlark J,Whitney KM,Lothrop CD Jr

更新日期：1996-11-01 00:00:00

abstract：:MEIS1 is a three-amino acid loop extension class homeodomain-containing homeobox (HOX) cofactor that plays key roles in normal hematopoiesis and leukemogenesis. Expression of Meis1 is rate-limiting in MLL-associated leukemias and potently interacts with Hox and NUP98-HOX genes in leukemic transformation to promote sel...

journal_title：Blood

authors： Argiropoulos B,Yung E,Xiang P,Lo CY,Kuchenbauer F,Palmqvist L,Reindl C,Heuser M,Sekulovic S,Rosten P,Muranyi A,Goh SL,Featherstone M,Humphries RK

更新日期：2010-05-20 00:00:00

abstract：:Emerging successful clinical data on gene therapy using adeno-associated viral (AAV) vector for hemophilia B (HB) showed that the risk of cellular immune response to vector capsid is clearly dose dependent. To decrease the vector dose, we explored AAV-8 (1-3 × 10(12) vg/kg) encoding a hyperfunctional factor IX (FIX-Pa...

journal_title：Blood

authors： Crudele JM,Finn JD,Siner JI,Martin NB,Niemeyer GP,Zhou S,Mingozzi F,Lothrop CD Jr,Arruda VR

更新日期：2015-03-05 00:00:00

abstract：:Haploinsufficiency of ribosomal proteins (RPs) has been proposed to be the common basis for the anemia observed in Diamond-Blackfan anemia (DBA) and myelodysplastic syndrome with loss of chromosome 5q [del(5q) MDS]. We have modeled DBA and del(5q) MDS in zebrafish using antisense morpholinos to rps19 and rps14, respec...

journal_title：Blood

authors： Payne EM,Virgilio M,Narla A,Sun H,Levine M,Paw BH,Berliner N,Look AT,Ebert BL,Khanna-Gupta A

更新日期：2012-09-13 00:00:00

abstract：:In addition to its importance in transfusion, Kell protein is a member of the M13 family of zinc endopeptidases and functions as an endothelin-3-converting enzyme. To obtain information on the structure of Kell protein we built a model based on the crystal structure of the ectodomain of neutral endopeptidase 24.11 (NE...

journal_title：Blood

authors： Lee S,Debnath AK,Redman CM

更新日期：2003-10-15 00:00:00

abstract：:Dendritic cells (DCs) are a key cell type in the initiation of the adaptive immune response. Recently, an additional role for DCs in suppressing myeloproliferation was discovered. Myeloproliferative disorder (MPD) was observed in murine studies with constitutive depletion of DCs, as well as in patients with congenital...

journal_title：Blood

authors： Humblet-Baron S,Barber JS,Roca CP,Lenaerts A,Koni PA,Liston A

更新日期：2019-01-24 00:00:00

abstract：:Although small deletions, splice site abnormalities, missense, and nonsense mutations have been identified in patients with factor VII deficiency, there have been no reports of mutations in the factor VII promoter. We investigated a girl with factor VII levels that were less than 1% of normal in association with a sev...

journal_title：Blood

authors： Arbini AA,Pollak ES,Bayleran JK,High KA,Bauer KA

更新日期：1997-01-01 00:00:00

abstract：:To evaluate the relationship between myeloperoxidase (MPO) gene expression and specific lineages of hematopoietic differentiation, we analyzed expression of the MPO gene in a variety of normal and leukemic human cells. As a first step, we synthesized several oligonucleotide probes and isolated cDNA clones for the MPO ...

journal_title：Blood

authors： Zaki SR,Austin GE,Swan D,Srinivasan A,Ragab AH,Chan WC

更新日期：1989-11-01 00:00:00

abstract：:Following antigen acquisition and maturation, dendritic cells (DCs) disengage from the extracellular matrix, cross basement membranes, and travel to draining lymph nodes to activate T cells. CCR7 expression is necessary but not sufficient for the directional migration of DCs. Prostaglandin E2 (PGE2), present in inflam...

journal_title：Blood

authors： Yen JH,Khayrullina T,Ganea D

更新日期：2008-01-01 00:00:00

abstract：:Platelets from patients with Montreal platelet syndrome (MPS) consistently display a defect in the mechanisms that regulate platelet size during shape change and undergo spontaneous aggregation and stir-induced microaggregate formation. We now provide data that the surface glycoprotein composition of MPS platelets is ...

journal_title：Blood

authors： Okita JR,Frojmovic MM,Kristopeit S,Wong T,Kunicki TJ

更新日期：1989-08-01 00:00:00

abstract：:Clonality studies of hematopoietic reconstitution after remission were performed in 24 female patients (pts) with leukemias characterized by specific molecular markers. At diagnosis, 13 pts had promyelocytic leukemia (PML) retinoic acid receptor-alpha (RAR-alpha)-rearranged acute promyelocytic leukemia (APL), 8 Philad...

journal_title：Blood

authors： Lo Coco F,Pelicci PG,D'Adamo F,Diverio D,Alimena G,Montefusco E,Arcese W,Avvisati G,De Felice L,Meloni G

更新日期：1993-07-15 00:00:00

abstract：:Erythropoietin (Ep), insulin, and prostaglandins E1 and A1 (PGE1, PGA1) enhanced heme synthesis by mitochondria isolated from embryonic and adult mouse liver cells. The combination of Ep with PGE1 had an antagonistic effect, while that of Ep with PGA1 gave an additive result. The capability of isolated human platelet ...

journal_title：Blood

authors： Agam G,Djaldetti M

更新日期：1978-06-01 00:00:00

abstract：:Recently various genetic defects in immunity mediated by interferon gamma (IFN-gamma) have been described, including mutations in the IFN-gamma receptor 1 (IFN-gammaR1) and receptor 2 (IFN-gammaR2), signal transducer and activator of transcription 1 (STAT 1), and interleukin 12 receptor beta 1 (IL-12Rbeta1), and IL-12...

journal_title：Blood

authors： Höflich C,Sabat R,Rosseau S,Temmesfeld B,Slevogt H,Döcke WD,Grütz G,Meisel C,Halle E,Göbel UB,Volk HD,Suttorp N

更新日期：2004-01-15 00:00:00

abstract：:Prophylactic fluconazole prevents candidiasis; however, this drug has no activity against molds. We performed a randomized trial to determine whether prophylactic itraconazole prevents invasive mold infections (IMIs). A total of 304 patients receiving allogeneic stem cell transplants (SCT) were randomized to receive f...

journal_title：Blood

authors： Marr KA,Crippa F,Leisenring W,Hoyle M,Boeckh M,Balajee SA,Nichols WG,Musher B,Corey L

更新日期：2004-02-15 00:00:00

abstract：:Glanzmann thrombasthenia (GT) is the most common inherited disorder of platelets. Most of the molecular defects previously identified in GT have been caused by point (or other small) mutations in the genes for glycoprotein (GP) IIb or GPIIIa. We have used single-strand conformation polymorphism (SSCP) analysis to rapi...

journal_title：Blood

authors： Jin Y,Dietz HC,Nurden A,Bray PF

更新日期：1993-10-15 00:00:00

abstract：:We used our recently reported stable, transformed human renal carcinoma cell line as a model system to study the role of 3',5'-adenosine monophosphate (cAMP) in erythropoietin secretion. The erythropoietin produced by these cells is both biologically active and immunologically cross-reactive with purified native human...

journal_title：Blood

authors： Sherwood JB,Burns ER,Shouval D

更新日期：1987-04-01 00:00:00

abstract：:Selectins are carbohydrate-binding adhesion molecules that play important roles in control of leukocyte traffic. Glycosyltransferases involved in selectin ligand biosynthesis include the alpha1,3-fucosyltransferases FucT-VII and FucT-IV, one or more sialyltransferases, and at least one O-linked branching enzyme. Previ...

journal_title：Blood

authors： Snapp KR,Heitzig CE,Ellies LG,Marth JD,Kansas GS

更新日期：2001-06-15 00:00:00

abstract：:Although receptor activator of nuclear factor (NF)-kappaB ligand (RANKL) signaling has been shown to prolong the survival of mature dendritic cells (DCs), the association of RANKL pathway with Fas-mediated apoptosis is obscure. Here, we found that bone marrow-derived DCs (BMDCs) from the Fas-deficient strain MRL/lpr m...

journal_title：Blood

authors： Izawa T,Ishimaru N,Moriyama K,Kohashi M,Arakaki R,Hayashi Y

更新日期：2007-07-01 00:00:00

abstract：:Although the expression of Pitx2, a bicoid family homeodomain transcription factor, is highly regulated during hematopoiesis, its function during this process was not documented; we thus studied hematopoiesis in Pitx2-null mice. We found that Pitx2(-/-) embryos display hypoplastic livers with reduced numbers of hemato...

journal_title：Blood

authors： Kieusseian A,Chagraoui J,Kerdudo C,Mangeot PE,Gage PJ,Navarro N,Izac B,Uzan G,Forget BG,Dubart-Kupperschmitt A

更新日期：2006-01-15 00:00:00

abstract：:Allogeneic bone marrow transplantation is still limited by the morbidity and mortality caused by graft-versus-host disease (GVHD), resulting from host recognition by donor T lymphocytes. It is possible to drastically reduce the T-cell content of the graft. However, transplanted T cells can also have a beneficial effec...

journal_title：Blood

authors： Gallot G,Hallet MM,Gaschet J,Moreau JF,Vivien R,Bonneville M,Milpied N,Vié H

更新日期：1996-08-01 00:00:00

abstract：:The effects of activation of adult murine stem cells on their expression of CD38 were studied using a murine transplantation model. First, the published finding that the majority of long-term engrafting cells from normal adult steady-state marrow are CD38(+) was confirmed. Next, it was determined that the majority of ...

journal_title：Blood

authors： Tajima F,Deguchi T,Laver JH,Zeng H,Ogawa M

更新日期：2001-05-01 00:00:00

abstract：:Retention of lipoproteins within the vasculature is a central event in the pathogenesis of atherosclerosis. However, the signals that mediate this process are only partially understood. Prompted by putative links between inflammation and atherosclerosis, we previously reported that alpha-defensins released by neutroph...

journal_title：Blood

authors： Bdeir K,Cane W,Canziani G,Chaiken I,Weisel J,Koschinsky ML,Lawn RM,Bannerman PG,Sachais BS,Kuo A,Hancock MA,Tomaszewski J,Raghunath PN,Ganz T,Higazi AA,Cines DB

更新日期：1999-09-15 00:00:00

abstract：:Hepcidin controls systemic iron availability, and its excess contributes to the anemia of chronic diseases, the most prevalent anemia in hospitalized patients. We previously reported that heparins are efficient hepcidin inhibitors both in vitro and in vivo, but their anticoagulant activity limits therapeutic use. We s...

journal_title：Blood

authors： Poli M,Asperti M,Naggi A,Campostrini N,Girelli D,Corbella M,Benzi M,Besson-Fournier C,Coppin H,Maccarinelli F,Finazzi D,Arosio P

更新日期：2014-03-06 00:00:00

abstract：:Immunological control may contribute to achievement of deep molecular response in chronic myeloid leukemia (CML) patients on tyrosine kinase inhibitor (TKI) therapy and may promote treatment-free remission (TFR). We investigated effector and suppressor immune responses in CML patients at diagnosis (n = 21), on TKI (im...

journal_title：Blood

authors： Hughes A,Clarson J,Tang C,Vidovic L,White DL,Hughes TP,Yong AS

更新日期：2017-03-02 00:00:00

abstract：:Chronic myeloid leukemia (CML) is a malignant disorder of the hematopoietic stem cell. It has been shown that normal stem cells coexist with malignant stem cells in the bone marrow of patients with chronic-phase CML. To characterize the primitive hematopoietic progenitor cells within CML marrow, CD34+DR- and CD34+DR+ ...

journal_title：Blood

authors： Leemhuis T,Leibowitz D,Cox G,Silver R,Srour EF,Tricot G,Hoffman R

更新日期：1993-02-01 00:00:00

abstract：:The mechanisms by which tumors metastasize to sentinel and distant lymph nodes, and beyond, are poorly understood. We developed transgenic mice that overexpress vascular endothelial growth factor-C (VEGF-C) and green fluorescent protein specifically in the skin and studied the effects of chemically-induced skin carcin...

journal_title：Blood

authors： Hirakawa S,Brown LF,Kodama S,Paavonen K,Alitalo K,Detmar M

更新日期：2007-02-01 00:00:00

abstract：:Eosinophils are important in antibody-mediated immune defense against parasites based on interaction with Ig receptors (FcR). Of the three classes of IgG FcR in humans, hFc gamma RI, II, and III, solely hFc gamma RII (CD32) is expressed on freshly isolated eosinophils. Despite an expression level similar to that found...

journal_title：Blood

authors： Koenderman L,Hermans SW,Capel PJ,van de Winkel JG

更新日期：1993-05-01 00:00:00

abstract：:Human band 3 Walton is an AE1 mutation that results in the deletion of the 11 COOH-terminal amino acids of the protein and is associated with dominant distal renal tubular acidosis. The properties of band 3 Walton expressed with normal band 3 in the heterozygous mutant erythrocytes and the kidney isoform expressed in ...

journal_title：Blood

authors： Toye AM,Bruce LJ,Unwin RJ,Wrong O,Tanner MJ

更新日期：2002-01-01 00:00:00

abstract：:Prothrombin activation can proceed through the intermediates meizothrombin or prethrombin-2. To assess the contributions that these 2 intermediates make to prothrombin activation in tissue factor (Tf)-activated blood, immunoassays were developed that measure the meizothrombin antithrombin (mTAT) and α-thrombin antithr...

journal_title：Blood

authors： Whelihan MF,Zachary V,Orfeo T,Mann KG

更新日期：2012-11-01 00:00:00