One siRNA pool targeting the λ constant region stops λ light-chain production and causes terminal endoplasmic reticulum stress.

abstract：:Langerhans cell histiocytosis (LCH) is a myeloproliferative disorder characterized by lesions composed of pathological CD207(+) dendritic cells with an inflammatory infiltrate. BRAFV600E remains the only recurrent mutation reported in LCH. In order to evaluate the spectrum of somatic mutations in LCH, whole exome sequ...

journal_title：Blood

authors： Chakraborty R,Hampton OA,Shen X,Simko SJ,Shih A,Abhyankar H,Lim KP,Covington KR,Trevino L,Dewal N,Muzny DM,Doddapaneni H,Hu J,Wang L,Lupo PJ,Hicks MJ,Bonilla DL,Dwyer KC,Berres ML,Poulikakos PI,Merad M,McClain K

更新日期：2014-11-06 00:00:00

abstract：:Azacitidine treatment of myelodysplastic syndromes (MDSs) generally exacerbates thrombocytopenia during the first treatment cycles. A Study of Eltrombopag in Myelodysplastic Syndromes Receiving Azacitidine (SUPPORT), a phase 3, randomized, double-blind, placebo-controlled study, investigated the platelet supportive ef...

journal_title：Blood

authors： Dickinson M,Cherif H,Fenaux P,Mittelman M,Verma A,Portella MSO,Burgess P,Ramos PM,Choi J,Platzbecker U,SUPPORT study investigators.

更新日期：2018-12-20 00:00:00

abstract：:Minimal residual disease (MRD) in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph1 ALL) who received allogeneic (n = 9) or autologous (n = 6) bone marrow transplantation (BMT) was evaluated by the polymerase chain reaction (PCR) for the bcr-abl transcript. Twelve patients received BMT a...

journal_title：Blood

authors： Miyamura K,Tanimoto M,Morishima Y,Horibe K,Yamamoto K,Akatsuka M,Kodera Y,Kojima S,Matsuyama K,Hirabayashi N

更新日期：1992-03-01 00:00:00

abstract：:Graft failure was analyzed in 625 patients receiving allogeneic bone marrow transplants from HLA-identical sibling donors as treatment for severe aplastic anemia. Sixty-eight (11%) had no or only transient engraftment. Second bone marrow transplants were successful in achieving extended survival in 16 of 27 patients w...

journal_title：Blood

authors： Champlin RE,Horowitz MM,van Bekkum DW,Camitta BM,Elfenbein GE,Gale RP,Gluckman E,Good RA,Rimm AA,Rozman C

更新日期：1989-02-01 00:00:00

abstract：:Toll-like receptors (TLRs) and complement are 2 components of innate immunity that are critical for first-line host defense and elicitation of adaptive immune responses. Many pathogen-associated molecular patterns activate both TLR and complement, but whether and how these 2 systems, when coactivated in vivo, interact...

journal_title：Blood

authors： Zhang X,Kimura Y,Fang C,Zhou L,Sfyroera G,Lambris JD,Wetsel RA,Miwa T,Song WC

更新日期：2007-07-01 00:00:00

abstract：:Absorption of iron was studied with a double-isotope technique that allowed differentiation between "mucosal uptake," "mucosal transfer," and ultimate "retention" of iron. A physiologic dose of ferrous sulfate was administered to 25 healthy young adults, 40 active aged persons, and 20 patients with uncomplicated iron ...

journal_title：Blood

authors： Marx JJ

更新日期：1979-02-01 00:00:00

abstract：:The clonal growth of progenitor cells from myelodysplastic syndromes (MDS) can be subdivided into four growth patterns: (1) normal, (2) no growth or low plating efficiency, (3) low colony and high cluster number, and (4) normal or high colony number with a large number of clusters. The former two (1 and 2) can be refe...

journal_title：Blood

authors： Sawada K,Ieko M,Notoya A,Tarumi T,Koizumi K,Kitayama S,Nishio H,Fukada Y,Yasukouchi T,Yamaguchi M,Katoh S,Koike T

更新日期：1996-07-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is a malignant disorder of the hematopoietic stem cell. It has been shown that normal stem cells coexist with malignant stem cells in the bone marrow of patients with chronic-phase CML. To characterize the primitive hematopoietic progenitor cells within CML marrow, CD34+DR- and CD34+DR+ ...

journal_title：Blood

authors： Leemhuis T,Leibowitz D,Cox G,Silver R,Srour EF,Tricot G,Hoffman R

更新日期：1993-02-01 00:00:00

abstract：:Shiga-like toxin-1 (SLT-1) is a bacterial toxin that kills cells by inhibiting protein synthesis. SLT-1 is composed of one cytotoxic A-subunit and five B-subunits that bind to CD77, a cell-surface glycolipid. In the human hematopoietic system, CD77 expression is restricted to a subset of activated B cells and derived ...

journal_title：Blood

authors： LaCasse EC,Saleh MT,Patterson B,Minden MD,Gariépy J

更新日期：1996-09-01 00:00:00

abstract：:The incidence of follicular lymphoma (FL) in industrialized countries has been increasing since the 1950s. Polymorphisms in genes encoding key enzymes controlling folate-methionine metabolism, including methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MS or MTR), serine hydroxymethyltransferase (SHMT)...

journal_title：Blood

authors： Niclot S,Pruvot Q,Besson C,Savoy D,Macintyre E,Salles G,Brousse N,Varet B,Landais P,Taupin P,Junien C,Baudry-Bluteau D

更新日期：2006-07-01 00:00:00

abstract：:Outgrowth, long-term self-renewal, and terminal maturation of human erythroid progenitors derived from umbilical cord blood in serum-free medium can be modulated by steroid hormones. Homogeneous erythroid cultures, as characterized by flow cytometry and dependence on a specific mixture of physiologic proliferation fac...

journal_title：Blood

authors： Leberbauer C,Boulmé F,Unfried G,Huber J,Beug H,Müllner EW

更新日期：2005-01-01 00:00:00

abstract：:Recent observations have underscored the biologic relevance of intratumoral angiogenesis and its potential impact on prognosis. Increased bone marrow angiogenesis has been demonstrated in a variety of hematologic disorders, including multiple myeloma. The extent and prognostic significance of bone marrow angiogenesis ...

journal_title：Blood

authors： Mesa RA,Hanson CA,Rajkumar SV,Schroeder G,Tefferi A

更新日期：2000-11-15 00:00:00

abstract：:Autoimmune hemolytic anemia (AIHA) in children is sometimes characterized by a severe course, requiring prolonged administration of immunosuppressive therapy. Rituximab is able to cause selective in vivo destruction of B lymphocytes, with abrogation of antibody production. In a prospective study, we have evaluated the...

journal_title：Blood

authors： Zecca M,Nobili B,Ramenghi U,Perrotta S,Amendola G,Rosito P,Jankovic M,Pierani P,De Stefano P,Bonora MR,Locatelli F

更新日期：2003-05-15 00:00:00

abstract：:Platelet membrane GPIIb is comprised of a disulfide-linked heavy chain (GPIIb(H)) and light chain (GPIIb(L)). We have examined the role of the two chains of GPIIb in the maintenance of the GPIIb-IIIa heterodimer and Arg-Gly-Asp (RGD) peptide-binding function. Lysates of surface radioiodinated platelets were treated wi...

journal_title：Blood

authors： Lam SC,Plow EF,Ginsberg MH

更新日期：1989-05-01 00:00:00

abstract：:We took advantage of the proliferative and permissive environment of the developing preimmune fetus to develop a noninjury large animal model in sheep, in which the transplantation of defined populations of human hematopoietic stem cells resulted in the establishment of human hematopoiesis and led to the formation of ...

journal_title：Blood

authors： Almeida-Porada G,Porada CD,Chamberlain J,Torabi A,Zanjani ED

更新日期：2004-10-15 00:00:00

abstract：:Cell cycle checkpoints ensure orderly progression of events during cell division. A microtubule damage (MTD)-induced checkpoint has been described in G(1) phase of the cell cycle (G(1)MTC) for which little is known. The present study shows that the G(1)MTC is intact in activated T lymphocytes from mice with the p21(wa...

journal_title：Blood

authors： Mantel CR,Braun SE,Lee Y,Kim YJ,Broxmeyer HE

更新日期：2001-03-01 00:00:00

abstract：:Previous studies have implicated activation-induced cytidine deaminase (AID) in B-cell translocations but have failed to identify any association between their chromosomal breakpoints and known AID target sequences. Analysis of 56 unclustered IgH-CCND1 translocations in mantle cell lymphoma across the ~ 344-kb bcl-1 b...

journal_title：Blood

authors： Greisman HA,Lu Z,Tsai AG,Greiner TC,Yi HS,Lieber MR

更新日期：2012-10-04 00:00:00

abstract：:Sickle cell trait (SCT) is unique among the carrier states that are identified during newborn screening. Unlike other heterozygous states for rare recessive diseases, SCT is exceedingly prevalent throughout regions of the world, making sickle cell disease one of the most common monogenetic diseases worldwide. Because ...

journal_title：Blood

authors： Pecker LH,Naik RP

更新日期：2018-11-29 00:00:00

abstract：:Recurrence of the underlying malignancy remains a major cause of treatment failure after autologous bone marrow transplantation (BMT) for patients with lymphoma. In this regard, we have developed an immunotherapeutic approach designed to induce resistance against residual tumor cells persisting after BMT. Previous stu...

journal_title：Blood

authors： Kwak LW,Campbell MJ,Zelenetz AD,Levy R

更新日期：1990-12-01 00:00:00

abstract：:Epstein-Barr virus (EBV)-driven posttransplantation lymphoproliferative disease (PTLD) is a serious complication of immunosuppression after either stem cell transplantation (SCT) or solid organ transplantation (SOT). Adoptive transfer of EBV-specific cytotoxic T lymphocytes (EBV-CTLs) is an effective prophylaxis and t...

journal_title：Blood

authors： Brewin J,Mancao C,Straathof K,Karlsson H,Samarasinghe S,Amrolia PJ,Pule M

更新日期：2009-11-26 00:00:00

abstract：:Minimal residual disease (MRD) negativity, defined as <1 chronic lymphocytic leukemia (CLL) cell detectable per 10 000 leukocytes, has been shown to independently predict for clinical outcome in patients receiving combination chemoimmunotherapy in the frontline setting. However, the long-term prognostic value of MRD s...

journal_title：Blood

authors： Kwok M,Rawstron AC,Varghese A,Evans PA,O'Connor SJ,Doughty C,Newton DJ,Moreton P,Hillmen P

更新日期：2016-12-15 00:00:00

abstract：:Little is known about the ontogeny of naturally occurring CD4(+)CD25(+) regulatory/suppressor T cells that play a major role in maintaining self-tolerance in mice and humans. In rodents, thymectomy on day 3 of life leads to multiple organ-specific autoimmune diseases that can be prevented by adoptive transfer of regul...

journal_title：Blood

authors： Darrasse-Jèze G,Marodon G,Salomon BL,Catala M,Klatzmann D

更新日期：2005-06-15 00:00:00

abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) has previously been shown to stimulate granulocyte, macrophage, and megakaryocyte lineages to act as an erythroid burst-promoting activity and to stimulate limited replication of spleen colony-forming cells. Here we demonstrate that murine GM-CSF alone or in co...

journal_title：Blood

authors： McNiece IK,Robinson BE,Quesenberry PJ

更新日期：1988-07-01 00:00:00

abstract：:Coculture of nurse-like cells (NLCs) with chronic lymphocytic leukemia (CLL) cells induced leukemia cell phosphorylation of STAT3 (pSTAT3), which could be blocked by anti-Wnt5a antibodies or the anti-ROR1 monoclonal antibody, cirmtuzumab. Time-course studies revealed Wnt5a could induce activation of NF-κB within 30 mi...

journal_title：Blood

authors： Chen Y,Chen L,Yu J,Ghia EM,Choi MY,Zhang L,Zhang S,Sanchez-Lopez E,Widhopf GF 2nd,Messer K,Rassenti LZ,Jamieson C,Kipps TJ

更新日期：2019-09-26 00:00:00

abstract：:The evolutionarily conserved immune system of the zebrafish (Danio rerio), in combination with its genetic tractability, position it as an excellent model system in which to elucidate the origin and function of vertebrate immune cells. We recently reported the existence of antigen-presenting mononuclear phagocytes in ...

journal_title：Blood

authors： Wittamer V,Bertrand JY,Gutschow PW,Traver D

更新日期：2011-06-30 00:00:00

abstract：:Activated protein C is a potent anticoagulant and profibrinolytic enzyme that can be derived from the vitamin-K-dependent serine protease zymogen, protein C, by the action of thrombin. Protein C antigen concentration was determined in plasmas from normals (n = 40) and from 38 patients with intravascular coagulation as...

journal_title：Blood

authors： Griffin JH,Mosher DF,Zimmerman TS,Kleiss AJ

更新日期：1982-07-01 00:00:00

abstract：:Human umbilical vein endothelial cells in culture (HUVEC) express receptors for urokinase-type plasminogen activators (u-PA). The immunochemical nature of this receptor and its relationship to u-PA receptors expressed by other cell types is unknown. Cross-linking active site-blocked u-PA to HUVEC lead to an increase i...

journal_title：Blood

authors： Barnathan ES,Kuo A,Karikó K,Rosenfeld L,Murray SC,Behrendt N,Rønne E,Weiner D,Henkin J,Cines DB

更新日期：1990-11-01 00:00:00

abstract：:To investigate the tropism of the T-lymphotropic human herpesvirus 7 (HHV-7) for hematopoietic progenitors, cord blood CD34(+) cells were inoculated in vitro with HHV-7 and then induced to differentiate along the granulocytic and erythroid lineages by the addition of appropriate cytokine cocktails. In semisolid assays...

journal_title：Blood

authors： Mirandola P,Secchiero P,Pierpaoli S,Visani G,Zamai L,Vitale M,Capitani S,Zauli G

更新日期：2000-07-01 00:00:00

abstract：:Adherent cell layers and their associated extracellular matrices form when human marrow is incubated in cultures containing hydrocortisone and horse serum. These stromal layers contain cells positive for alkaline phosphatase; secrete collagens types I and III and fibronectin, bind the anti-actin monoclonal antibodies ...

journal_title：Blood

authors： Liesveld JL,Abboud CN,Duerst RE,Ryan DH,Brennan JK,Lichtman MA

更新日期：1989-05-15 00:00:00

abstract：:Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic anemia characterized by the presence of abnormal subpopulations of blood cells that are deficient in surface expression of glycosylphosphatidylinositol (GPI)-anchored proteins. Recent studies showed that the gene termed PIG-A, which participates in the...

journal_title：Blood

authors： Iida Y,Takeda J,Miyata T,Inoue N,Nishimura J,Kitani T,Maeda K,Kinoshita T

更新日期：1994-06-01 00:00:00