Hematopoietic cell-derived microparticle tissue factor contributes to fibrin formation during thrombus propagation.

Abstract:

:Tissue factor (TF) is expressed on nonvascular cells and cells within the vessel wall and circulates in blood associated with microparticles. Although blood-borne TF accumulates into the developing thrombus during thrombus formation, the contribution of blood-borne TF and vessel wall TF to thrombin generation in vivo following vessel injury is unknown. To determine the source and role of blood-borne microparticle TF, we studied arterial thrombus formation in a living mouse using intravital microscopy. Platelet, TF, and fibrin accumulation in the developing thrombus was compared in wild-type and low TF mice. Compared to wild-type mice, low TF mice formed very small platelet thrombi lacking TF or fibrin. Wild-type and low TF mice received transplants of bone marrow from wild-type and low TF mice. Arterial thrombi in low TF bone marrow/wild-type chimeric mice had decreased size and decreased TF and fibrin levels. Arterial thrombi in wild-type bone marrow/low TF chimeric mice showed decreased platelet thrombus size but normal TF and fibrin levels. This demonstrates that blood-borne TF associated with hematopoietic cell-derived microparticles contributes to thrombus propagation.

journal_name

Blood

journal_title

Blood

authors

Chou J,Mackman N,Merrill-Skoloff G,Pedersen B,Furie BC,Furie B

doi

10.1182/blood-2004-03-0935

subject

Has Abstract

pub_date

2004-11-15 00:00:00

pages

3190-7

issue

10

eissn

0006-4971

issn

1528-0020

pii

2004-03-0935

journal_volume

104

pub_type

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