Cirmtuzumab blocks Wnt5a/ROR1 stimulation of NF-κB to repress autocrine STAT3 activation in chronic lymphocytic leukemia.

abstract：:Human invariant natural killer T (iNKT) cells are a rare innate-like lymphocyte population that recognizes glycolipids presented on CD1d. Studies in mice have shown that these cells are heterogeneous and are capable of enacting diverse functions, and the composition of iNKT cell subsets can alter disease outcomes. In ...

journal_title：Blood

authors： Erkers T,Xie BJ,Kenyon LJ,Smith B,Rieck M,Jensen KP,Ji X,Basina M,Strober S,Negrin RS,Maecker HT,Meyer EH

更新日期：2020-03-12 00:00:00

abstract：:Juvenile myelomonocytic leukemia (JMML) is a rare pediatric myeloid neoplasm characterized by excessive proliferation of myelomonocytic cells. Somatic mutations in genes involved in GM-CSF signal transduction, such as NRAS, KRAS, PTPN11, NF1, and CBL, have been identified in more than 70% of children with JMML. In the...

journal_title：Blood

authors： Doisaki S,Muramatsu H,Shimada A,Takahashi Y,Mori-Ezaki M,Sato M,Kawaguchi H,Kinoshita A,Sotomatsu M,Hayashi Y,Furukawa-Hibi Y,Yamada K,Hoshino H,Kiyoi H,Yoshida N,Sakaguchi H,Narita A,Wang X,Ismael O,Xu Y,Nishio N

更新日期：2012-08-16 00:00:00

abstract：:In this issue of Blood, Hong et al advocate for use of additional US Food and Drug Administration (FDA)–approved safety measures for transfusion. Most patients transfused with contaminated platelets do not show immediate clinical signs. Active surveillance suggests patient risk 10- to 40-fold higher than passive hemov...

journal_title：Blood

authors： Benjamin RJ

更新日期：2016-01-28 00:00:00

abstract：:Hand mirror cells are a morphological configuration that are seen in immunologically stimulated lymphocytes and can be induced by antigen--antibody complexes. Therefore, the bone marrow and peripheral blood plasma of two patients with acute lymphoblastic leukemia--hand mirror variant were evaluated for the presence of...

journal_title：Blood

authors： Stass SA,Phillips TM,Weislow OS,Perlin E,Schumacher HR

更新日期：1980-10-01 00:00:00

abstract：:To assess the influence of graft-versus-host disease (GVHD) on recurrent leukemia and survival after allogeneic marrow transplantation, we studied 1,202 patients with acute nonlymphocytic leukemia (ANL), acute lymphocytic leukemia (ALL), and chronic myelogenous leukemia (CML) given unmodified marrow grafts from HLA-id...

journal_title：Blood

authors： Sullivan KM,Weiden PL,Storb R,Witherspoon RP,Fefer A,Fisher L,Buckner CD,Anasetti C,Appelbaum FR,Badger C

更新日期：1989-05-01 00:00:00

abstract：:In this issue of Blood, Jitschin et al demonstrate a microenvironmental glycolytic shift in chronic lymphocytic leukemia (CLL) cells mediated by Notch-c-Myc signaling. Interfering in the Notch-c-Myc pathway and reprogramming glycolytic metabolism could contribute to overcoming drug resistance in CLL. ...

journal_title：Blood

authors： Moreno C

更新日期：2015-05-28 00:00:00

abstract：:Macrophage inflammatory protein-1 alpha (MIP-1 alpha) and its human homologue GOS19.1/LD78 are members of the C-C chemokine/intercrine family of secreted proteins. They have proinflammatory properties and also inhibit cell cycle progression of hematopoietic stem cells. Characterization of MIP-1 alpha receptor(s) has b...

journal_title：Blood

authors： Avalos BR,Bartynski KJ,Elder PJ,Kotur MS,Burton WG,Wilkie NM

更新日期：1994-09-15 00:00:00

abstract：:Plasmacytoid dendritic cells (PDCs) are crucial effectors in innate immunity. In this study, we show that imatinib, a potent inhibitor of BCR/ABL tyrosine kinase activity, in the presence of Flt3-Ligand, could induce CD34+ progenitors from chronic myeloid leukemia (CML) to give rise in vitro to typical BDCA-2+ type I ...

journal_title：Blood

authors： Mohty M,Jourdan E,Mami NB,Vey N,Damaj G,Blaise D,Isnardon D,Olive D,Gaugler B

更新日期：2004-06-15 00:00:00

abstract：:Somatic mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) were recently demonstrated in acute myeloid leukemia (AML), but their prevalence and prognostic impact remain to be explored in large extensively characterized AML series, and also in various other hematologic malignancies. Here, we demonstrate in 8...

journal_title：Blood

authors： Abbas S,Lugthart S,Kavelaars FG,Schelen A,Koenders JE,Zeilemaker A,van Putten WJ,Rijneveld AW,Löwenberg B,Valk PJ

更新日期：2010-09-23 00:00:00

abstract：:Positron emission tomography (PET) using F-18 fluorodeoxyglucose (FDG) was performed in non-Hodgkin's lymphoma (NHL), which is known to be highly responsive to chemotherapy, but also yields variable treatment results to answer the following questions: (1) What is the extent and time course of changes in FDG utilizatio...

journal_title：Blood

authors： Römer W,Hanauske AR,Ziegler S,Thödtmann R,Weber W,Fuchs C,Enne W,Herz M,Nerl C,Garbrecht M,Schwaiger M

更新日期：1998-06-15 00:00:00

abstract：:We prepared a heterohybrid cell line that secretes a human IgM monoclonal autoantibody that recognizes an antigen found on thrombin-activated or stored platelets. The surface expression of the epitope recognized by this autoantibody, 5E5, increases with time as platelets age in vitro, suggesting that it may represent ...

journal_title：Blood

authors： Nugent DJ,Kunicki TJ,Berglund C,Bernstein ID

更新日期：1987-07-01 00:00:00

abstract：:Hematopoietic stem and progenitor cells were previously found to express Toll-like receptors (TLRs), suggesting that bacterial/viral products may influence blood cell formation. We now show that common lymphoid progenitors (CLPs) from mice with active HSV-1 infection are biased to dendritic cell (DC) differentiation, ...

journal_title：Blood

authors： Welner RS,Pelayo R,Nagai Y,Garrett KP,Wuest TR,Carr DJ,Borghesi LA,Farrar MA,Kincade PW

更新日期：2008-11-01 00:00:00

abstract：:Human herpesvirus 8 (HHV-8) is the causative agent of Kaposi sarcoma (KS) and multicentric Castleman disease (MCD), a life-threatening, virally induced B-cell lymphoproliferative disorder. HHV-8 is a B-lymphotropic γ-herpesvirus closely related to the Epstein-Barr virus (EBV). Invariant natural killer T (iNKT) cells a...

journal_title：Blood

authors： Sbihi Z,Dossier A,Boutboul D,Galicier L,Parizot C,Emarre A,Hoareau B,Dupin N,Marcelin AG,Oudin A,Fieschi C,Agbalika F,Autran B,Oksenhendler E,Carcelain G

更新日期：2017-02-16 00:00:00

abstract：:Vascular endothelial growth factor receptor 2 (VEGFR2) plays a key role in physiologic and pathologic angiogenesis. Plasma membrane (PM) levels of VEGFR2 are regulated by endocytosis and secretory transport through the Golgi apparatus. To date, the mechanism whereby the VEGFR2 traffics through the Golgi apparatus rema...

journal_title：Blood

authors： Manickam V,Tiwari A,Jung JJ,Bhattacharya R,Goel A,Mukhopadhyay D,Choudhury A

更新日期：2011-01-27 00:00:00

abstract：:In a previous study, we described a form of nondeletion alpha-thalassemia (alpha T Saudi alpha) found in subjects of Saudi Arabian origin. In the current study, using synthetic oligoprobe hybridization and restriction enzyme analysis, we have demonstrated that the molecular basis of alpha T Saudi alpha is due solely t...

journal_title：Blood

authors： Thein SL,Wallace RB,Pressley L,Clegg JB,Weatherall DJ,Higgs DR

更新日期：1988-02-01 00:00:00

abstract：:Essential thrombocythemia (ET) and polycythemia vera (PV) are characterized by persistent platelet activation. The mechanisms involved in their clearance are poorly characterized. In the present study, we report that leukocytes were actively involved in platelet disposal in 51 patients with ET and 30 with PV, but not ...

journal_title：Blood

authors： Maugeri N,Malato S,Femia EA,Pugliano M,Campana L,Lunghi F,Rovere-Querini P,Lussana F,Podda G,Cattaneo M,Ciceri F,Manfredi AA

更新日期：2011-09-22 00:00:00

abstract：:With the introduction of genomic technologies, more hereditary cancer syndromes with hematologic malignancies are being described. Up to 10% of hematologic malignancies in children and adults may be the result of an underlying inherited genetic risk. Managing these patients with hereditary hematologic malignancies, in...

journal_title：Blood

authors： Kohlmann W,Schiffman JD

更新日期：2016-11-24 00:00:00

abstract：:Activation of p38 MAP kinase (p38) as well as JNK/SAPK has been described as being induced by a variety of environmental stresses such as osmotic shock, ultraviolet radiation, and heat shock, or the proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1 (IL-1). We found that the hematopoietic cytokine...

journal_title：Blood

authors： Nagata Y,Moriguchi T,Nishida E,Todokoro K

更新日期：1997-08-01 00:00:00

abstract：:Epidemiologic studies have correlated elevated plasma fibrinogen (hyperfibrinogenemia) with risk of cardiovascular disease and arterial and venous thrombosis. However, it is unknown whether hyperfibrinogenemia is merely a biomarker of the proinflammatory disease state or is a causative mechanism in the etiology. We ra...

journal_title：Blood

authors： Machlus KR,Cardenas JC,Church FC,Wolberg AS

更新日期：2011-05-05 00:00:00

abstract：:All-trans retinoic acid (ATRA) has previously been shown to inhibit the growth of OPM-2 human myeloma cells. The growth inhibition was postulated to result from a transcriptional downregulation of interleukin-6 receptor alpha (IL-6Ralpha) with IL-6Rbeta (gp130) unaffected. To formally test this hypothesis, an expressi...

journal_title：Blood

authors： Chen YH,Lavelle D,DeSimone J,Uddin S,Platanias LC,Hankewych M

更新日期：1999-07-01 00:00:00

abstract：:Discoveries during the past decade have revolutionized our understanding of idiopathic thrombotic thrombocytopenic purpura (TTP). Most cases in adults are caused by acquired autoantibodies that inhibit ADAMTS13, a metalloprotease that cleaves von Willebrand factor within nascent platelet-rich thrombi to prevent hemoly...

journal_title：Blood

authors： Sadler JE

更新日期：2008-07-01 00:00:00

abstract：:We have investigated the utility of the green fluorescent protein (GFP) to serve as a marker to assess retroviral gene transfer into hematopoietic cells and as a tool to identify and enrich for cells expressing high levels of the vector-encoded transcript. GFP, by virtue of a naturally occurring chromophore encoded in...

journal_title：Blood

authors： Persons DA,Allay JA,Allay ER,Smeyne RJ,Ashmun RA,Sorrentino BP,Nienhuis AW

更新日期：1997-09-01 00:00:00

abstract：:Ly6G is a glycosylphosphatidylinositol (GPI)-anchored protein of unknown function that is commonly targeted to induce experimental neutrophil depletion in mice. In the present study, we found that doses of anti-Ly6G Abs too low to produce sustained neutropenia remained capable of inhibiting experimental arthritis, lea...

journal_title：Blood

authors： Wang JX,Bair AM,King SL,Shnayder R,Huang YF,Shieh CC,Soberman RJ,Fuhlbrigge RC,Nigrovic PA

更新日期：2012-08-16 00:00:00

abstract：:Although small deletions, splice site abnormalities, missense, and nonsense mutations have been identified in patients with factor VII deficiency, there have been no reports of mutations in the factor VII promoter. We investigated a girl with factor VII levels that were less than 1% of normal in association with a sev...

journal_title：Blood

authors： Arbini AA,Pollak ES,Bayleran JK,High KA,Bauer KA

更新日期：1997-01-01 00:00:00

abstract：:The localization of memory T cells to human skin is essential for long-term immune surveillance and the maintenance of barrier integrity. Although the mechanisms controlling memory T-cell migration to peripheral tissues are poorly understood, the current paradigm includes the localized secretion of "imprinting" signal...

journal_title：Blood

authors： McCully ML,Ladell K,Hakobyan S,Mansel RE,Price DA,Moser B

更新日期：2012-11-29 00:00:00

abstract：:At present, one of the most sensitive assays for human erythropoietin (Ep) is a bioassay that measures the Ep-dependent proliferation of spleen cells from phenylhydrazine-treated mice after 24 hours in culture. We describe how this assay can be used as the basis of a very sensitive method for detecting mouse antibodie...

journal_title：Blood

authors： Wognum AW,Lansdorp PM,Eaves CJ,Krystal G

更新日期：1988-06-01 00:00:00

abstract：:The evidence for a regulatory role of acidic isoferritins on hemopoiesis is not entirely consistent with our knowledge of ferritin biochemistry, and no clear picture of this phenomeonon has emerged. In the present study, we have been unable to confirm a consistent effect of purified heart (acidic), spleen (basic), or ...

journal_title：Blood

authors： Sala G,Worwood M,Jacobs A

更新日期：1986-02-01 00:00:00

abstract：:Recent advances in molecular biology have led to the identification of hematopoietic growth factors that support and influence the proliferation of hematopoietic progenitor cells in vitro and in vivo. Although these factors have been extensively studied, little is known of their role in the regulation of cell-cycling ...

journal_title：Blood

authors： Tanaka R,Katayama N,Ohishi K,Mahmud N,Itoh R,Tanaka Y,Komada Y,Minami N,Sakurai M,Shirakawa S

更新日期：1995-07-01 00:00:00

abstract：:The canonical role of the hemostatic and fibrinolytic systems is to maintain vascular integrity. Perturbations in either system can prompt primary pathological end points of hemorrhage or thrombosis with vessel occlusion. However, fibrin(ogen) and proteases controlling its deposition and clearance, including (pro)thro...

journal_title：Blood

authors： Luyendyk JP,Schoenecker JG,Flick MJ

更新日期：2019-02-07 00:00:00

abstract：:Donor-derived T cells have been proposed to play a role in pathogenesis of chronic graft-versus-host disease (cGVHD). The impact of ex vivo T-cell depletion (TCD) on cGVHD was analyzed in a randomized multicenter trial involving unrelated donor marrow transplants. A total of 404 patients diagnosed with hematologic mal...

journal_title：Blood

authors： Pavletic SZ,Carter SL,Kernan NA,Henslee-Downey J,Mendizabal AM,Papadopoulos E,Gingrich R,Casper J,Yanovich S,Weisdorf D,National Heart, Lung, and Blood Institute Unrelated Donor Marrow Transplantation Trial.

更新日期：2005-11-01 00:00:00