当前位置： SCI文献检索 > BLOOD期刊下所有文献 > Sialyl Lewis(x) (sLe(x)) and an sLe(x) mimetic, CGP69669A, disrupt E-selectin-dependent leukocyte rolling in vivo.

Sialyl Lewis(x) (sLe(x)) and an sLe(x) mimetic, CGP69669A, disrupt E-selectin-dependent leukocyte rolling in vivo.

Abstract：

:Leukocyte rolling is the earliest observable even in their recruitment from the circulation to inflamed tissue. This rolling is mediated largely by interaction between the selectin family of adhesion molecules and their glycosylated ligands. Although the nature of these ligands and their interaction with the selectins is not fully understood, it is accepted that expression of fucosylated sialylated glycans such as sialyl Lewis(x) (sLe(x)) is required for function. Despite findings that sLe(x) inhibits binding of leukocytes to E-selectin in vitro, and has beneficial effects in inflammatory disease models, inhibition of E-selectin-dependent leukocyte rolling in vivo has not been described. Functional overlap between the selectins has been noted and reduction of rolling by E-selectin antibodies only occurs if P-selectin is absent or blocked. We demonstrate that leukocyte rolling velocity in tumor necrosis factor alpha (TNF alpha)-stimulated mouse cremaster is increased following treatment with either sLe(x) or the sLe(x)-mimetic CGP69669A and that rolling is dramatically reduced if CGP69669A is applied in the presence of anti-P-selectin antibody. These effects are characteristic of E-selectin antagonism. In contrast, surgically stimulated (L- or P-selectin-dependent) rolling is unaffected by either sLe(x) or CGP69669A. Our data demonstrate that CGP69669A is an effective and selective antagonist of E-selectin in vivo.

journal_name

Blood

journal_title

Blood

authors

Norman KE,Anderson GP,Kolb HC,Ley K,Ernst B

subject

Has Abstract

pub_date

1998-01-15 00:00:00

pages

475-83

issue

2

eissn

0006-4971

issn

1528-0020

journal_volume

91

pub_type

杂志文章

相关文献

BLOOD文献大全
  • Bcl-x(L) prevents apoptosis of late-stage erythroblasts but does not mediate the antiapoptotic effect of erythropoietin.

    abstract：:The long form of B-cell lymphoma-x (Bcl-x(L)), an outer mitochondrial membrane protein, has been proposed to mediate the antiapoptotic action of erythropoietin on erythroid progenitor cells and to be necessary for heme synthesis in erythroblasts. Mice with conditional knockout of Bcl-x(L) (conditional bcl-x(-/-) mice)...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2004-11-4344

    authors： Rhodes MM,Kopsombut P,Bondurant MC,Price JO,Koury MJ

    更新日期：2005-09-01 00:00:00

  • Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump.

    abstract：:Imatinib mesylate (STI571), a potent tyrosine kinase inhibitor, is successfully used in the treatment of chronic myelogenous leukemia and gastrointestinal stromal tumors. However, the intended chronic oral administration of imatinib may lead to development of cellular resistance and subsequent treatment failure. Indee...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2004-04-1398

    authors： Burger H,van Tol H,Boersma AW,Brok M,Wiemer EA,Stoter G,Nooter K

    更新日期：2004-11-01 00:00:00

  • Self-renewal in late-stage erythropoiesis.

    abstract：:Extensive in vitro self-renewal of proerythroblasts from the earliest period of definitive erythropoiesis, as reported by England and co-investigators in this issue of Blood, expands the potential role of self-renewal in mammalian hematopoiesis and suggests a possible source of blood cells for clinical treatments. ...

    journal_title：Blood

    pub_type： 评论,杂志文章

    doi：10.1182/blood-2010-12-324319

    authors： Koury MJ

    更新日期：2011-03-03 00:00:00

  • Integrative analysis of spontaneous CLL regression highlights genetic and microenvironmental interdependency in CLL.

    abstract：:Spontaneous regression is a recognized phenomenon in chronic lymphocytic leukemia (CLL) but its biological basis remains unknown. We undertook a detailed investigation of the biological and clinical features of 20 spontaneous CLL regression cases incorporating phenotypic, functional, transcriptomic, and genomic studie...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood.2019001262

    authors： Kwok M,Oldreive C,Rawstron AC,Goel A,Papatzikas G,Jones RE,Drennan S,Agathanggelou A,Sharma-Oates A,Evans P,Smith E,Dalal S,Mao J,Hollows R,Gordon N,Hamada M,Davies NJ,Parry H,Beggs AD,Munir T,Moreton P,Paneesha

    更新日期：2020-02-06 00:00:00

  • Identification of the molecular genetic defect of patients with methemoglobin M-Kankakee (M-Iwate), alpha87 (F8) His --> Tyr: evidence for an electrostatic model of alphaM hemoglobin assembly.

    abstract：:We determined that the molecular defect of 2 patients with hemoglobin (Hb) M-Kankakee [Hb M-Iwate, alpha87 (F8) His --> Tyr] resides in the alpha1-globin gene. The proportion of Hb M observed is higher than that predicted for an alpha1-globin variant. Our evidence suggests that the greater-than-expected proportion of ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Ameri A,Fairbanks VF,Yanik GA,Mahdi F,Thibodeau SN,McCormick DJ,Boxer LA,McDonagh KT

    更新日期：1999-09-01 00:00:00

  • ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes.

    abstract：:Anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma (ALCL) is a CD30-positive T-cell non-Hodgkin lymphoma that morphologically resembles ALK-positive ALCL but lacks chromosomal rearrangements of the ALK gene. The genetic and clinical heterogeneity of ALK-negative ALCL has not been delineated. We p...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2014-04-571091

    authors： Parrilla Castellar ER,Jaffe ES,Said JW,Swerdlow SH,Ketterling RP,Knudson RA,Sidhu JS,Hsi ED,Karikehalli S,Jiang L,Vasmatzis G,Gibson SE,Ondrejka S,Nicolae A,Grogg KL,Allmer C,Ristow KM,Wilson WH,Macon WR,Law ME,Ce

    更新日期：2014-08-28 00:00:00

  • Anomalous function of vimentin in chronic lymphocytic leukemia lymphocytes.

    abstract：:Chronic lymphocytic leukemia (CLL) lymphocytes manifest anomalous motility and cap formation. Since these processes involve cytoskeletal proteins, vimentin from intermediate filaments of normal and CLL lymphocytes was investigated using hetero- and monoclonal antisera. The antisera reacted predominantly with a 60-kD p...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Stark RS,Liebes LF,Shelanski ML,Silber R

    更新日期：1984-02-01 00:00:00

  • Living T9 glioma cells expressing membrane macrophage colony-stimulating factor produce immediate tumor destruction by polymorphonuclear leukocytes and macrophages via a "paraptosis"-induced pathway that promotes systemic immunity against intracranial T9

    abstract：:Cloned T9-C2 glioma cells transfected with membrane macrophage colony-stimulating factor (mM-CSF) never formed subcutaneous tumors when implanted into Fischer rats, whereas control T9 cells did. The T9-C2 cells were completely killed within 1 day through a mechanism that resembled paraptosis. Vacuolization of the T9-C...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2002-01-0174

    authors： Chen Y,Douglass T,Jeffes EW,Xu Q,Williams CC,Arpajirakul N,Delgado C,Kleinman M,Sanchez R,Dan Q,Kim RC,Wepsic HT,Jadus MR

    更新日期：2002-08-15 00:00:00

  • Role of nitric oxide in the anti-tumoral effect of retinoic acid and 1,25-dihydroxyvitamin D3 on human promonocytic leukemic cells.

    abstract：:All trans retinoic acid and vitamin D3 derivatives are well known for their antileukemic activity, while the precise mechanism of this effect remains to be clarified. Using human leukemic U937 and THP-1 promonocytic cell lines, we analyzed the effect of all-trans retinoic acid (RA) and/or 1,25-dihydroxyvitamin D3 (VD)...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Dugas N,Mossalayi MD,Calenda A,Léotard A,Bécherel P,Mentz F,Ouaaz F,Arock M,Debré P,Dornand J,Dugas B

    更新日期：1996-11-01 00:00:00

  • Cyclosporin-A is selectively cytotoxic to human leukemic T cells in vitro.

    abstract：:We have studied the antileukemic effects of cyclosporin-A (CyA) on the cells of a number of human hematopoietic biopsies and established cell lines in vitro. Cya killed the tumor cells but not the nonmalignant control cells from three of four patients with T-lymphocytic leukemia/lymphoma at concentrations comparable t...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Tötterman TH,Danersund A,Nilsson K,Killander A

    更新日期：1982-05-01 00:00:00

  • Cyclin D1 overexpression is a favorable prognostic variable for newly diagnosed multiple myeloma patients treated with high-dose chemotherapy and single or double autologous transplantation.

    abstract：:We used a sensitive real-time reverse transcription-polymerase chain reaction assay to quantify cyclin D1 mRNA levels in bone marrow samples collected at diagnosis from 74 newly diagnosed multiple myeloma (MM) patients who were randomized to undergo either single or double autologous peripheral blood stem cell transpl...

    journal_title：Blood

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1182/blood-2002-12-3789

    authors： Soverini S,Cavo M,Cellini C,Terragna C,Zamagni E,Ruggeri D,Testoni N,Tosi P,De Vivo A,Amabile M,Grafone T,Ottaviani E,Giannini B,Cangini D,Bonifazi F,Neri A,Fabris S,Tura S,Baccarani M,Martinelli G

    更新日期：2003-09-01 00:00:00

  • Targeting receptor kinases by a novel indolinone derivative in multiple myeloma: abrogation of stroma-derived interleukin-6 secretion and induction of apoptosis in cytogenetically defined subgroups.

    abstract：:In multiple myeloma (MM), both vascular endothelial (VEGF) and basic fibroblast growth factor (bFGF) promote tumor growth and survival. We have used the novel indolinone BIBF 1000 to study effects of simultaneous inhibition of VEGF, FGF and transforming growth factor-beta on MM cells and their interactions with bone m...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2004-11-4250

    authors： Bisping G,Kropff M,Wenning D,Dreyer B,Bessonov S,Hilberg F,Roth GJ,Munzert G,Stefanic M,Stelljes M,Scheffold C,Müller-Tidow C,Liebisch P,Lang N,Tchinda J,Serve HL,Mesters RM,Berdel WE,Kienast J

    更新日期：2006-03-01 00:00:00

  • Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome.

    abstract：:Mutations in CCAAT/enhancer binding protein alpha (CEBPA) are seen in 5% to 14% of acute myeloid leukemia (AML) and have been associated with a favorable clinical outcome. Most AMLs with CEBPA mutations simultaneously carry 2 mutations (CEBPA(double-mut)), usually biallelic, whereas single heterozygous mutations (CEBP...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2008-09-179895

    authors： Wouters BJ,Löwenberg B,Erpelinck-Verschueren CA,van Putten WL,Valk PJ,Delwel R

    更新日期：2009-03-26 00:00:00

  • Enhanced normal short-term human myelopoiesis in mice engineered to express human-specific myeloid growth factors.

    abstract：UNLABELLED:Better methods to characterize normal human hematopoietic cells with short-term repopulating activity cells (STRCs) are needed to facilitate improving recovery rates in transplanted patients.We now show that 5-fold more human myeloid cells are produced in sublethally irradiated NOD/SCID-IL-2Receptor-γchain-n...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2012-09-456566

    authors： Miller PH,Cheung AM,Beer PA,Knapp DJ,Dhillon K,Rabu G,Rostamirad S,Humphries RK,Eaves CJ

    更新日期：2013-01-31 00:00:00

  • Core 2 branching beta1,6-N-acetylglucosaminyltransferase and high endothelial cell N-acetylglucosamine-6-sulfotransferase exert differential control over B- and T-lymphocyte homing to peripheral lymph nodes.

    abstract：:Blood-borne lymphocyte trafficking to peripheral lymph nodes (PLNs) depends on the successful initiation of rolling interactions mediated by L-selectin binding to sialomucin ligands in high endothelial venules (HEVs). Biochemical analysis of purified L-selectin ligands has identified posttranslational modifications me...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2004-05-1986

    authors： Gauguet JM,Rosen SD,Marth JD,von Andrian UH

    更新日期：2004-12-15 00:00:00

  • Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activity.

    abstract：:We investigated whether atorvastatin (AT) was capable of protecting animals from acute graft-versus-host disease (aGVHD) across major histocompatibility complex (MHC) mismatch barriers. AT treatment of the donor induced a Th-2 cytokine profile in the adoptively transferred T cells and reduced their in vivo expansion, ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2007-08-106005

    authors： Zeiser R,Youssef S,Baker J,Kambham N,Steinman L,Negrin RS

    更新日期：2007-12-15 00:00:00

  • Murine malaria decreases hemopoietic stem cells.

    abstract：:The causes of anemia and immunosuppression, major outcomes of malaria, are not well established. This study was undertaken to investigate whether erythropoietin (EP) production is adequate and whether the hemopoietic stem cells (CFU-S) were affected during the course of infection. Groups of female Balb/c mice infected...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Silverman PH,Schooley JC,Mahlmann LJ

    更新日期：1987-02-01 00:00:00

  • Congenital sideroblastic anemia due to mutations in the mitochondrial HSP70 homologue HSPA9.

    abstract：:The congenital sideroblastic anemias (CSAs) are relatively uncommon diseases characterized by defects in mitochondrial heme synthesis, iron-sulfur (Fe-S) cluster biogenesis, or protein synthesis. Here we demonstrate that mutations in HSPA9, a mitochondrial HSP70 homolog located in the chromosome 5q deletion syndrome 5...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2015-09-659854

    authors： Schmitz-Abe K,Ciesielski SJ,Schmidt PJ,Campagna DR,Rahimov F,Schilke BA,Cuijpers M,Rieneck K,Lausen B,Linenberger ML,Sendamarai AK,Guo C,Hofmann I,Newburger PE,Matthews D,Shimamura A,Snijders PJ,Towne MC,Niemeyer CM,

    更新日期：2015-12-17 00:00:00

  • Role for granulocyte colony-stimulating factor in the generation of human T regulatory type 1 cells.

    abstract：:Granulocyte colony-stimulating factor (G-CSF) may affect T-cell homeostasis by multiple mechanisms, inducing polarization of cytokine secretion, inhibition of T-cell proliferation, and enhancement of T-cell apoptosis. We analyzed the production of interleukin-10 (IL-10) and transforming growth factor-beta1 (TGF-beta1)...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2001-12-0291

    authors： Rutella S,Pierelli L,Bonanno G,Sica S,Ameglio F,Capoluongo E,Mariotti A,Scambia G,d'Onofrio G,Leone G

    更新日期：2002-10-01 00:00:00

  • Second cancers and late toxicities after treatment of aggressive non-Hodgkin lymphoma with the ACVBP regimen: a GELA cohort study on 2837 patients.

    abstract：:The survival of patients with aggressive non-Hodgkin lymphoma (NHL) is increasing, but the incidence of secondary cancer and late toxicity is poorly defined for those treated with cyclophosphamide-hydroxydaunomycin/doxorubicin-Oncovin-prednisone (CHOP)-like chemotherapy. From February 1984 to January 1998, 2837 patien...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2003-04-1124

    authors： André M,Mounier N,Leleu X,Sonet A,Brice P,Henry-Amar M,Tilly H,Coiffier B,Bosly A,Morel P,Haioun C,Gaulard P,Reyes F,Gisselbrecht C,Groupe D'Etude Des Lymphomes De L'Adulte.

    更新日期：2004-02-15 00:00:00

  • Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism.

    abstract：:Chronic graft-versus-host disease (cGVHD) remains a major complication following allogeneic bone marrow transplantation (BMT). The discovery of novel therapeutics is dependent on assessment in preclinical murine models of cGVHD. Rho-associated kinase 2 (ROCK2) recently was shown to be implicated in regulation of inter...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2015-10-678706

    authors： Flynn R,Paz K,Du J,Reichenbach DK,Taylor PA,Panoskaltsis-Mortari A,Vulic A,Luznik L,MacDonald KK,Hill GR,Nyuydzefe MS,Weiss JM,Chen W,Trzeciak A,Serody JS,Aguilar EG,Murphy WJ,Maillard I,Munn D,Koreth J,Cutler CS

    更新日期：2016-04-28 00:00:00

  • Red cell rheology in stomatocyte-echinocyte transformation: roles of cell geometry and cell shape.

    abstract：:The influence of the shape of the red blood cell during stomatocyte-echinocyte transformation on its deformability was studied by microsieving through pores with diameters of 2.6, 4.5, and 6.9 micron. A stomatocytic transformation was produced by chlorpromazine (0.02, 0.1, and 0.5 mmol/L) and an echinocytic transforma...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Reinhart WH,Chien S

    更新日期：1986-04-01 00:00:00

  • Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation.

    abstract：:We examined whether activated protein C (APC) reduces ischemia/reperfusion (I/R)-induced renal injury by inhibiting leukocyte activation. In a rat model, intravenous administration of APC markedly reduced I/R-induced renal dysfunction and histological changes, whereas intravenous administration of dansyl glutamylglycy...

    journal_title：Blood

    pub_type： 杂志文章,收录出版

    doi：

    authors： Mizutani A,Okajima K,Uchiba M,Noguchi T

    更新日期：2000-06-15 00:00:00

  • Overexpression of HOXB4 enhances the hematopoietic potential of embryonic stem cells differentiated in vitro.

    abstract：:Little is known about the molecular mechanisms controlling primitive hematopoietic stem cells, especially during embryogenesis. Homeobox genes encode a family of transcription factors that have gained increasing attention as master regulators of developmental processes and recently have been implicated in the differen...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Helgason CD,Sauvageau G,Lawrence HJ,Largman C,Humphries RK

    更新日期：1996-04-01 00:00:00

  • Reconstitution of dendritic and natural killer-cell subsets after allogeneic stem cell transplantation: effects of endogenous flt3 ligand.

    abstract：:Recovery of dendritic cells (DCs) and natural killer (NK) cells after allogeneic stem cell transplantation (SCT) is important for allograft responses and antitumor immunity and thus for treatment outcome. Regulation of this regenerative process is not well understood. We investigated the influence of endogenous cytoki...

    journal_title：Blood

    pub_type： 临床试验,杂志文章

    doi：10.1182/blood-2003-04-1200

    authors： Chklovskaia E,Nowbakht P,Nissen C,Gratwohl A,Bargetzi M,Wodnar-Filipowicz A

    更新日期：2004-05-15 00:00:00

  • Lenalidomide targets clonogenic side population in multiple myeloma: pathophysiologic and clinical implications.

    abstract：:Recurrence of multiple myeloma (MM) after therapy suggests the presence of tumor-initiating subpopulations. In our study, we performed flow cytometry-based Hoechst 33342 staining to evaluate the existence of a MM population with stem-like features known as side population (SP) cells. SP cells exhibit substantial heter...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2010-02-267344

    authors： Jakubikova J,Adamia S,Kost-Alimova M,Klippel S,Cervi D,Daley JF,Cholujova D,Kong SY,Leiba M,Blotta S,Ooi M,Delmore J,Laubach J,Richardson PG,Sedlak J,Anderson KC,Mitsiades CS

    更新日期：2011-04-28 00:00:00

  • How I treat acute lymphoblastic leukemia in older adolescents and young adults.

    abstract：:At the intersection between children and older adults, the care of adolescent and young adult (AYA) patients with acute lymphoblastic leukemia (ALL) poses unique challenges and issues beyond those faced by other age groups. Although the survival of AYA patients is inferior to younger children, growing evidence suggest...

    journal_title：Blood

    pub_type： 杂志文章,评审

    doi：10.1182/blood-2014-11-551481

    authors： Curran E,Stock W

    更新日期：2015-06-11 00:00:00

  • Phase 1 study of weekly dosing with the investigational oral proteasome inhibitor ixazomib in relapsed/refractory multiple myeloma.

    abstract：:Proteasome inhibition is an effective treatment strategy for multiple myeloma. With improving survival, attention is increasingly focusing on ease of administration and toxicity profile. Ixazomib is an investigational, orally bioavailable 20S proteasome inhibitor. Sixty patients with relapsed and/or refractory multipl...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2014-01-548941

    authors： Kumar SK,Bensinger WI,Zimmerman TM,Reeder CB,Berenson JR,Berg D,Hui AM,Gupta N,Di Bacco A,Yu J,Shou Y,Niesvizky R

    更新日期：2014-08-14 00:00:00

  • OSU-T315: a novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cells.

    abstract：:Aberrant regulation of endogenous survival pathways plays a major role in progression of chronic lymphocytic leukemia (CLL). Signaling via conjugation of surface receptors within the tumor environmental niche activates survival and proliferation pathways in CLL. Of these, the phosphoinositide 3-kinase (PI3K)/protein k...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2014-06-583518

    authors： Liu TM,Ling Y,Woyach JA,Beckwith K,Yeh YY,Hertlein E,Zhang X,Lehman A,Awan F,Jones JA,Andritsos LA,Maddocks K,MacMurray J,Salunke SB,Chen CS,Phelps MA,Byrd JC,Johnson AJ

    更新日期：2015-01-08 00:00:00

  • All-trans retinoic acid for the treatment of newly diagnosed acute promyelocytic leukemia. Japan Adult Leukemia Study Group.

    abstract：:We conducted a multicenter trial of treatment with all-trans retinoic acid (ATRA) for newly diagnosed acute promyelocytic leukemia (APL) in the AML-92 study and compared it with our previous study with standard intensive chemotherapy, the AML-89 study, in the view of complete remission (CR) rate, incidence of early de...

    journal_title：Blood

    pub_type： 临床试验,杂志文章,多中心研究

    doi：

    authors： Kanamaru A,Takemoto Y,Tanimoto M,Murakami H,Asou N,Kobayashi T,Kuriyama K,Ohmoto E,Sakamaki H,Tsubaki K

    更新日期：1995-03-01 00:00:00