Core 2 branching beta1,6-N-acetylglucosaminyltransferase and high endothelial cell N-acetylglucosamine-6-sulfotransferase exert differential control over B- and T-lymphocyte homing to peripheral lymph nodes.

abstract：:Enhanced tolerance to combination chemotherapy has been cited as an ancillary benefit of staging laparotomy and splenectomy in Hodgkin's disease. Seventeen patients with Hodgkin's disease and 15 with non-Hodgkin's lymphoma were subjected to nontherapeutic splenectomy as part of the staging procedure prior to their ini...

journal_title：Blood

authors： Ihde DC,DeVita VT,Canellos GP,Young RC

更新日期：1976-02-01 00:00:00

abstract：:We determined the role of the heterophilic interaction of alphavbeta3 integrin on endothelial cells with CD31 on leukocytes in mediating leukocyte-endothelial cell interactions. Preincubation of interleukin-4 (IL-4)-stimulated human umbilical vein endothelial cells (HUVECs) with anti-CD31 monoclonal antibodies (MoAbs)...

journal_title：Blood

authors： Chiba R,Nakagawa N,Kurasawa K,Tanaka Y,Saito Y,Iwamoto I

更新日期：1999-08-15 00:00:00

abstract：:Human umbilical vein endothelial cells in culture (HUVEC) express receptors for urokinase-type plasminogen activators (u-PA). The immunochemical nature of this receptor and its relationship to u-PA receptors expressed by other cell types is unknown. Cross-linking active site-blocked u-PA to HUVEC lead to an increase i...

journal_title：Blood

authors： Barnathan ES,Kuo A,Karikó K,Rosenfeld L,Murray SC,Behrendt N,Rønne E,Weiner D,Henkin J,Cines DB

更新日期：1990-11-01 00:00:00

abstract：:The effect of recombinant human erythropoietin (rHuEpo) on megakaryopoiesis remains controversial. Treatment with rHuEpo in renal failure patients has been associated with a slight elevation of platelet counts. In animal studies, high doses of rHuEpo produced an increase of platelet counts followed by a gradual return...

journal_title：Blood

authors： Loo M,Beguin Y

更新日期：1999-05-15 00:00:00

abstract：:Basic fibroblast growth factor or fibroblast growth factor-2 (FGF) has been shown to affect myeloid cell proliferation and hypothesized to stimulate primitive hematopoietic cells. We sought to evaluate the effect of FGF on hematopoietic stem cells and to determine if FGF mediated its effects on progenitor cells direct...

journal_title：Blood

authors： Berardi AC,Wang A,Abraham J,Scadden DT

更新日期：1995-09-15 00:00:00

abstract：:Acquisition of mature T cell function and the T cell antigen receptor repertoire occur in the thymus. In an effort to delineate the cascade of events leading to T cell maturation, we analyzed a series of clonal human precursor T cell neoplasms representing early, middle, and late stages of intrathymic differentiation....

journal_title：Blood

authors： Pittaluga S,Uppenkamp M,Cossman J

更新日期：1987-04-01 00:00:00

abstract：:The SJL/J mouse strain has a high spontaneous incidence of a B-cell neoplasm, reticulum cell neoplasm type B (RCN B). In addition, following irradiation, 10% to 30% of these mice develop acute myelomonocytic leukemia (radiation-induced acute myeloid leukemia [RI-AML]), an incidence that can be increased to 50% by trea...

journal_title：Blood

authors： Haran-Ghera N,Krautghamer R,Lapidot T,Peled A,Dominguez MG,Stanley ER

更新日期：1997-04-01 00:00:00

abstract：:Treatment of AL amyloidosis patients with high-dose melphalan chemotherapy followed by autologous peripheral blood stem cell transplantation (HDM/SCT) can produce hematologic complete responses (CRs) and improvement in organ function. To determine whether these responses are accompanied by improvement in quality of li...

journal_title：Blood

authors： Seldin DC,Anderson JJ,Sanchorawala V,Malek K,Wright DG,Quillen K,Finn KT,Berk JL,Dember LM,Falk RH,Skinner M

更新日期：2004-09-15 00:00:00

abstract：:Under normal conditions, platelets do not adhere to endothelium. However, when platelets or endothelial cells are stimulated by thrombin or cytokines, respectively, platelets bind avidly to endothelium. Because there is accumulating evidence that endothelial cells may become apoptotic under certain proinflammatory or ...

journal_title：Blood

authors： Bombeli T,Schwartz BR,Harlan JM

更新日期：1999-06-01 00:00:00

abstract：:The polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes (POEMS) syndrome is a rare multisystemic disorder associated with osteosclerotic myeloma and multicentric Castleman's disease (MCD). Human herpesvirus type 8 (HHV-8) DNA sequences have been detected in lymph nodes of about 40% of human immunodef...

journal_title：Blood

authors： Bélec L,Mohamed AS,Authier FJ,Hallouin MC,Soe AM,Cotigny S,Gaulard P,Gherardi RK

更新日期：1999-06-01 00:00:00

abstract：:GVHD is still one of the major complications after allogeneic stem cell transplantation. Whereas murine data have clearly shown the beneficial effects of regulatory T cells (Tregs) on the prevention of GVHD, data from the human system are rare. Here, we present a comparative dynamic analysis of CD4(+)CD25(hi)CD127(lo/...

journal_title：Blood

authors： Ukena SN,Velaga S,Geffers R,Grosse J,Baron U,Buchholz S,Stadler M,Bruder D,Ganser A,Franzke A

更新日期：2011-09-29 00:00:00

abstract：:At present, one of the most sensitive assays for human erythropoietin (Ep) is a bioassay that measures the Ep-dependent proliferation of spleen cells from phenylhydrazine-treated mice after 24 hours in culture. We describe how this assay can be used as the basis of a very sensitive method for detecting mouse antibodie...

journal_title：Blood

authors： Wognum AW,Lansdorp PM,Eaves CJ,Krystal G

更新日期：1988-06-01 00:00:00

abstract：:Fibrinogen, coagulation factor VII (FVII), and factor VIII (FVIII) and its carrier von Willebrand factor (vWF) play key roles in hemostasis. Previously identified common variants explain only a small fraction of the trait heritabilities, and additional variations may be explained by associations with rarer variants wi...

journal_title：Blood

authors： Huffman JE,de Vries PS,Morrison AC,Sabater-Lleal M,Kacprowski T,Auer PL,Brody JA,Chasman DI,Chen MH,Guo X,Lin LA,Marioni RE,Müller-Nurasyid M,Yanek LR,Pankratz N,Grove ML,de Maat MP,Cushman M,Wiggins KL,Qi L,Sennb

更新日期：2015-09-10 00:00:00

abstract：:The influence of the shape of the red blood cell during stomatocyte-echinocyte transformation on its deformability was studied by microsieving through pores with diameters of 2.6, 4.5, and 6.9 micron. A stomatocytic transformation was produced by chlorpromazine (0.02, 0.1, and 0.5 mmol/L) and an echinocytic transforma...

journal_title：Blood

authors： Reinhart WH,Chien S

更新日期：1986-04-01 00:00:00

abstract：:Hepatitis C virus (HCV) is associated with the B-cell lymphoproliferative disorders mixed cryoglobulinemia (MC) and non-Hodgkin lymphoma. We have previously reported that HCV(+)MC(+) patients have clonal expansions of hypermutated, rheumatoid factor-bearing marginal zone-like IgM(+)CD27(+) peripheral B cells using the...

journal_title：Blood

authors： Charles ED,Brunetti C,Marukian S,Ritola KD,Talal AH,Marks K,Jacobson IM,Rice CM,Dustin LB

更新日期：2011-05-19 00:00:00

abstract：:Natural killer (NK) cell activity is severely impaired in untreated patients with hairy cell leukemia (HCL). In an attempt to investigate whether this impairment is related to a defect at the target cell binding and/or at the post target cell binding level, we evaluated the peripheral blood mononuclear cells (PBMC) of...

journal_title：Blood

authors： Trentin L,Zambello R,Agostini C,Ambrosetti A,Chisesi T,Raimondi R,Bulian P,Pizzolo G,Semenzato G

更新日期：1990-04-01 00:00:00

abstract：:Although small deletions, splice site abnormalities, missense, and nonsense mutations have been identified in patients with factor VII deficiency, there have been no reports of mutations in the factor VII promoter. We investigated a girl with factor VII levels that were less than 1% of normal in association with a sev...

journal_title：Blood

authors： Arbini AA,Pollak ES,Bayleran JK,High KA,Bauer KA

更新日期：1997-01-01 00:00:00

abstract：:This phase 2 study evaluated the efficacy and safety of the oral farnesyltransferase inhibitor tipifarnib in adults with refractory or relapsed acute myeloid leukemia (AML). Patients (n=252) received tipifarnib 600 mg twice a day for 21 days in 28-day cycles. Median age was 62 years; 99 (39%) patients were 65 years or...

journal_title：Blood

authors： Harousseau JL,Lancet JE,Reiffers J,Lowenberg B,Thomas X,Huguet F,Fenaux P,Zhang S,Rackoff W,De Porre P,Stone R,Farnesyltransferase Inhibition Global Human Trials (FIGHT) Acute Myeloid Leukemia Study Group.

更新日期：2007-06-15 00:00:00

abstract：:In 65 patients with hemophagocytic lymphohistiocytosis (HLH), we found an as yet undescribed heterogeneity of defects in cellular cytotoxicity when assay conditions were modified by the incubation time, the presence of mitogen, or interleukin-2 (IL-2). The standard 4-hour natural killer (NK) test against K562 targets ...

journal_title：Blood

authors： Schneider EM,Lorenz I,Müller-Rosenberger M,Steinbach G,Kron M,Janka-Schaub GE

更新日期：2002-10-15 00:00:00

abstract：:Monocytes/macrophages exert a series of important functions in vivo. To facilitate detailed investigation of their functional capacity and the mechanism leading to their differentiation, several cell lines have been established from primary material. We present here a new human monoblastic cell line, designated UG3. U...

journal_title：Blood

authors： Ikeda T,Sasaki K,Ikeda K,Yamaoka G,Kawanishi K,Kawachi Y,Uchida T,Takahara J,Irino S

更新日期：1998-06-15 00:00:00

abstract：:We assessed frequency and predictive factors for major cardiovascular (CV) events in 707 patients with primary myelofibrosis (PMF) followed in 4 European institutions. A total of 236 deaths (33%) were recorded for an overall mortality of 7.7% patient-years (pt-yr). Fatal and nonfatal thromboses were registered in 51 (...

journal_title：Blood

authors： Barbui T,Carobbio A,Cervantes F,Vannucchi AM,Guglielmelli P,Antonioli E,Alvarez-Larrán A,Rambaldi A,Finazzi G,Barosi G

更新日期：2010-01-28 00:00:00

abstract：:Glycoprotein (GP) Ibalpha, a member of the leucine-rich repeat (LRR) protein family, mediates platelet adhesion to immobilized von Willebrand factor (VWF). We investigated the role in VWF binding of charged residues in the LRR region of GP Ibalpha that are conserved in human, canine, and murine proteins. Substitution ...

journal_title：Blood

authors： Peng Y,Shrimpton CN,Dong JF,López JA

更新日期：2005-09-15 00:00:00

abstract：:We conducted a genome-wide association study to identify novel associations between genetic variants and circulating plasminogen activator inhibitor-1 (PAI-1) concentration, and examined functional implications of variants and genes that were discovered. A discovery meta-analysis was performed in 19 599 subjects, foll...

journal_title：Blood

authors： Huang J,Sabater-Lleal M,Asselbergs FW,Tregouet D,Shin SY,Ding J,Baumert J,Oudot-Mellakh T,Folkersen L,Johnson AD,Smith NL,Williams SM,Ikram MA,Kleber ME,Becker DM,Truong V,Mychaleckyj JC,Tang W,Yang Q,Sennblad B,M

更新日期：2012-12-06 00:00:00

abstract：:Normal human B cell proliferation is controlled by various immunoregulatory signals including the T cell-derived lymphokine B cell growth factor (BCGF). The role of BCGF in the regulation of malignant B cell proliferation is unclear. Therefore, we studied the proliferative response of purified chronic lymphocytic leuk...

journal_title：Blood

authors： Perri RT

更新日期：1986-04-01 00:00:00

abstract：:The plasminogen activator inhibitor PAI-1 is markedly elevated in vivo and in vitro upon exposure to the inflammatory mediators tumor necrosis factor alpha (TNF alpha), interleukin-1 (IL-1), and bacterial lipopolysaccharide. Here we report that the isoflavone compound genistein prevents the increase in synthesis of PA...

journal_title：Blood

authors： van Hinsbergh VW,Vermeer M,Koolwijk P,Grimbergen J,Kooistra T

更新日期：1994-11-01 00:00:00

abstract：:An unbalanced translocation der(1;7)(q10; p10) is a nonrandom chromosomal aberration commonly observed in myelodysplastic syndrome and acute myeloid leukemia. We molecularly analyzed the breakpoints of der(1;7)(q10;p10) by quantitative fluorescent in situ hybridization (FISH) analyses using centromeric satellite DNAs ...

journal_title：Blood

authors： Wang L,Ogawa S,Hangaishi A,Qiao Y,Hosoya N,Nanya Y,Ohyashiki K,Mizoguchi H,Hirai H

更新日期：2003-10-01 00:00:00

abstract：:Nucleophosmin-mutated acute myeloid leukemia (NPM1mut-AML) patients have a high rate of complete remission (CR) to induction chemotherapy. However, the mechanisms responsible for such effects are unknown. Because miR-10 family members are expressed at high levels in NPM1mut-AML, we evaluated whether these microRNAs co...

journal_title：Blood

authors： Havelange V,Ranganathan P,Geyer S,Nicolet D,Huang X,Yu X,Volinia S,Kornblau SM,Andreeff M,Croce CM,Marcucci G,Bloomfield CD,Garzon R

更新日期：2014-04-10 00:00:00

abstract：:While the interferon (IFN)-inducible double-stranded RNA (dsRNA)-dependent protein kinase PKR is reported to initiate apoptosis in some instances, the mechanism by which diverse stress stimuli activate PKR remains unknown. Now we report that RAX, the only known cellular activator for PKR, initiates PKR activation in r...

journal_title：Blood

authors： Bennett RL,Blalock WL,Abtahi DM,Pan Y,Moyer SA,May WS

更新日期：2006-08-01 00:00:00

abstract：:The enhancement of in vitro human hematopoiesis by the addition of a noncytotoxic monoclonal antibody, 9.1C3, is described. Enhancement of all aspects of in vitro hematopoiesis was observed on addition of 9.1C3 antibody to cultures of mononuclear cells from normal bone marrow, cord blood, and peripheral blood from bet...

journal_title：Blood

authors： Kannourakis G,Johnson GR,Begley CG,Werkmeister JA,Burns GF

更新日期：1988-10-01 00:00:00

abstract：:MicroRNAs (miRNAs) regulate cell physiology by altering protein expression, but the biology of platelet miRNAs is largely unexplored. We tested whether platelet miRNA levels were associated with platelet reactivity by genome-wide profiling using platelet RNA from 19 healthy subjects. We found that human platelets expr...

journal_title：Blood

authors： Nagalla S,Shaw C,Kong X,Kondkar AA,Edelstein LC,Ma L,Chen J,McKnight GS,López JA,Yang L,Jin Y,Bray MS,Leal SM,Dong JF,Bray PF

更新日期：2011-05-12 00:00:00