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Improvement in quality of life of patients with AL amyloidosis treated with high-dose melphalan and autologous stem cell transplantation.

Abstract：

:Treatment of AL amyloidosis patients with high-dose melphalan chemotherapy followed by autologous peripheral blood stem cell transplantation (HDM/SCT) can produce hematologic complete responses (CRs) and improvement in organ function. To determine whether these responses are accompanied by improvement in quality of life (QOL), we employed the Medical Outcomes Study (MOS) 36-item Short Form General Health Survey (SF-36) questionnaire for 544 patients evaluated between 1994 and 2002. At baseline, the scores were significantly lower on all 8 SF-36 scales compared with age-matched population norms: the composite physical component summary (PCS) for the AL patients was 34.5 versus the population norm of 46.8, and the mental component summary (MCS) was 45.0 versus the norm of 51.5. All SF-36 scores improved at 1 year, with the MCS reaching the population norm. The PCS, though improved, was still lower than normal but was greater in the subgroup of patients who achieved a hematologic CR; the PCS normalized at 2 years in these patients. Thus, treatment of AL amyloidosis patients with HDM/SCT produces measurable and sustained improvements in quality of life, particularly in those patients who achieve hematologic CR.

journal_name

Blood

journal_title

Blood

authors

Seldin DC,Anderson JJ,Sanchorawala V,Malek K,Wright DG,Quillen K,Finn KT,Berk JL,Dember LM,Falk RH,Skinner M

doi

10.1182/blood-2004-01-0089

subject

Has Abstract

pub_date

2004-09-15 00:00:00

pages

1888-93

issue

6

eissn

0006-4971

issn

1528-0020

pii

2004-01-0089

journal_volume

104

pub_type

临床试验,杂志文章

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