Tissue-type plasminogen activator (t-PA) induces stromelysin-1 (MMP-3) in endothelial cells through activation of lipoprotein receptor-related protein.

abstract：:Three recipients of HLA-identical bone marrow transplants developed chronic graft-versus-host disease (cGVHD) and hypergammaglobulinemia. All three had evidence of abnormal B-lymphocyte function, including a polyclonal increase in immunoglobulins (Ig), antinuclear antibodies, rheumatoid factor, lymphocytotoxins, and i...

journal_title：Blood

authors： Saxon A,McIntyre RE,Stevens RH,Gale RP

更新日期：1981-10-01 00:00:00

abstract：:The granulocyte-macrophage colony-stimulating factor (GM-CSF)/interleukin (IL)-3/IL-5 receptor family regulates the production and function of myeloid cells. These cytokines signal through receptor complexes that consist of unique ligand-binding alpha-chains and common signaling beta-chains. IL-5 is distinct from IL-3...

journal_title：Blood

authors： Beekman JM,Verhagen LP,Geijsen N,Coffer PJ

更新日期：2009-10-29 00:00:00

abstract：:Although a number of studies have indicated correlations between histologic subtypes of tumors and certain nonrandom chromosome changes, cytogenetic studies of lymphoma are in an early stage compared to those of leukemia. No comprehensive analysis of available data has so far been attempted in the literature either. H...

journal_title：Blood

authors： Koduru PR,Filippa DA,Richardson ME,Jhanwar SC,Chaganti SR,Koziner B,Clarkson BD,Lieberman PH,Chaganti RS

更新日期：1987-01-01 00:00:00

abstract：:In this issue of Blood, Whyte et al describe how under flow conditions, phosphatidylserine-expressing platelets modulate the lysis of whole blood clots by providing direct and indirect binding sites for plasminogen. ...

journal_title：Blood

authors： Kim PY

更新日期：2015-04-16 00:00:00

abstract：:Pediatric-type follicular lymphoma (PTFL) is a variant of follicular lymphoma (FL) with distinctive clinicopathological features. Patients are predominantly young males presenting with localized lymphadenopathy; the tumor shows high-grade cytology and lacks both BCL2 expression and t(14;18) translocation. The genetic ...

journal_title：Blood

authors： Schmidt J,Gong S,Marafioti T,Mankel B,Gonzalez-Farre B,Balagué O,Mozos A,Cabeçadas J,van der Walt J,Hoehn D,Rosenwald A,Ott G,Dojcinov S,Egan C,Nadeu F,Ramis-Zaldívar JE,Clot G,Bárcena C,Pérez-Alonso V,Endris V,Pe

更新日期：2016-08-25 00:00:00

abstract：:Congenital deficiency in coagulation factor XIII is a rare autosomal recessive bleeding disorder. Although the defect was characterized over 30 years ago, little is known about the molecular basis of the disorder. Here, we show two novel point mutations in the gene of the A-subunit of factor XIII in the genetically is...

journal_title：Blood

authors： Mikkola H,Syrjälä M,Rasi V,Vahtera E,Hämäläinen E,Peltonen L,Palotie A

更新日期：1994-07-15 00:00:00

abstract：:Late committed progenitor cells of erythropoiesis, CFU-E (colony-forming unit--erythroid), were isolated from mouse spleens to near homogeneity by a three-step enrichment procedure. The procedure included a four-day pretreatment of bled mice with the antibiotic thiamphenicol, a recovery period of 3 1/2 days, followed ...

journal_title：Blood

authors： Nijhof W,Wierenga PK,Staal GE,Jansen G

更新日期：1984-09-01 00:00:00

abstract：:Interleukin-33 (IL-33), a member of the IL-1 cytokine family, is emerging as a new regulator of immune responses and inflammatory vascular diseases. Although IL-33 and its cognate receptor ST2 appear to be expressed in vascular cells, the precise role of IL-33 in the vasculature has not been determined. In this study,...

journal_title：Blood

authors： Choi YS,Choi HJ,Min JK,Pyun BJ,Maeng YS,Park H,Kim J,Kim YM,Kwon YG

更新日期：2009-10-01 00:00:00

abstract：:Myelotoxic injury in the bone marrow (BM) as a consequence of total body irradiation (TBI) or granulocyte colony-stimulating factor (G-CSF) mobilization results in the deposition of iC3b on BM stroma (stroma-iC3b). In the present study, we have examined how stroma-iC3b interacts with hematopoietic progenitor cells (HP...

journal_title：Blood

authors： Cramer DE,Allendorf DJ,Baran JT,Hansen R,Marroquin J,Li B,Ratajczak J,Ratajczak MZ,Yan J

更新日期：2006-01-15 00:00:00

abstract：:We report a novel chromosome translocation--t(2;5)(p23;q35) or its variant, t(2;5;13)(p23;q35;q12)--in 3 patients with peripheral T-cell lymphoma. All 3 were female children who had peripheral lymphadenopathy without organomegaly and underwent complete remission with or without chemotherapy. Their tumors were characte...

journal_title：Blood

authors： Kaneko Y,Frizzera G,Edamura S,Maseki N,Sakurai M,Komada Y,Sakurai M,Tanaka H,Sasaki M,Suchi T

更新日期：1989-02-15 00:00:00

abstract：:We have analyzed the phenotype, cytokine profile, and mitotic history (telomere length) of monoclonal T-cell expansions in 5 CD3(+) T-cell large granular lymphocyte (TLGL) leukemia patients by fluorescence activated cell sorting (FACS) and single-cell polymerase chain reaction (PCR). We confirm that the common phenoty...

journal_title：Blood

authors： Bigouret V,Hoffmann T,Arlettaz L,Villard J,Colonna M,Ticheli A,Gratwohl A,Samii K,Chapuis B,Rufer N,Roosnek E

更新日期：2003-04-15 00:00:00

abstract：:Incubation of human platelets, human neutrophils, or highly metastatic mouse lymphoma cells with sulfate-labeled extracellular matrix (ECM) results in heparanase-mediated release of labeled heparan sulfate cleavage fragments (0.5 less than Kav less than 0.85 on Sepharose 6B). This degradation was inhibited by native h...

journal_title：Blood

authors： Bar-Ner M,Eldor A,Wasserman L,Matzner Y,Cohen IR,Fuks Z,Vlodavsky I

更新日期：1987-08-01 00:00:00

abstract：:Fanconi anemia (FA) is the most frequent inherited cause of bone marrow failure (BMF). Most FA patients experience hematopoietic stem cell attrition and cytopenia during childhood, which along with intrinsic chromosomal instability, favor clonal evolution and the frequent emergence in their teens or young adulthood of...

journal_title：Blood

authors： Peffault de Latour R,Soulier J

更新日期：2016-06-16 00:00:00

abstract：:Although the potential role of Pim2 as a cooperative oncogene has been well described in lymphoma, its role in leukemia has remained largely unexplored. Here we show that high expression of Pim2 is observed in patients with acute promyelocytic leukemia (APL). To further characterize the cooperative role of Pim2 with p...

journal_title：Blood

authors： Agrawal-Singh S,Koschmieder S,Gelsing S,Stocking C,Stehling M,Thiede C,Thoennissen NH,Köhler G,Valk PJ,Delwel R,Mills K,Bäumer N,Tickenbrock L,Hansen K,Berdel WE,Müller-Tidow C,Serve H

更新日期：2010-06-03 00:00:00

abstract：:This phase 1/2 study assessed parsaclisib (INCB050465), a next-generation, potent, and highly selective phosphatidylinositol 3-kinase δ (PI3Kδ) inhibitor, in patients with relapsed or refractory B-cell malignancies, alone or in combination with a Janus kinase 1 inhibitor (itacitinib) or chemotherapy (rituximab, ifosfa...

journal_title：Blood

authors： Forero-Torres A,Ramchandren R,Yacoub A,Wertheim MS,Edenfield WJ,Caimi P,Gutierrez M,Akard L,Escobar C,Call J,Persky D,Iyer S,DeMarini DJ,Zhou L,Chen X,Dawkins F,Phillips TJ

更新日期：2019-04-18 00:00:00

abstract：:The regulation of megakaryocytopoiesis and thrombopoiesis appears to be under the control of an array of hematopoietic growth factors. To determine the relationship of endogenous thrombopoietic cytokine levels and circulating platelet (PLT) counts, we measured the levels of thrombo-poietin (TPO), interleukin-11 (IL-11...

journal_title：Blood

authors： Chang M,Suen Y,Meng G,Buzby JS,Bussel J,Shen V,van de Ven C,Cairo MS

更新日期：1996-11-01 00:00:00

abstract：:DNA amplification combined with hybridization with 32P-labeled synthetic oligonucleotide probes has been used to identify base substitutions in the 5' promoter region of the A gamma globin gene in members of eleven families from China, Sardinia, Canada, and the United States who had a heterozygosity for the A gamma-be...

journal_title：Blood

authors： Yang KG,Stoming TA,Fei YJ,Liang S,Wong SC,Masala B,Huang RB,Wei ZP,Huisman TH

更新日期：1988-05-01 00:00:00

abstract：:Recent observations have underscored the biologic relevance of intratumoral angiogenesis and its potential impact on prognosis. Increased bone marrow angiogenesis has been demonstrated in a variety of hematologic disorders, including multiple myeloma. The extent and prognostic significance of bone marrow angiogenesis ...

journal_title：Blood

authors： Mesa RA,Hanson CA,Rajkumar SV,Schroeder G,Tefferi A

更新日期：2000-11-15 00:00:00

abstract：:The pattern of expression of several protein kinase C (PKC) isoforms (alpha, betaI, delta, epsilon, eta, and zeta) during the course of hematopoietic development was investigated using primary human CD34(+) hematopoietic cells and stable cell lines subcloned from the growth factor-dependent 32D murine hematopoietic ce...

journal_title：Blood

authors： Bassini A,Zauli G,Migliaccio G,Migliaccio AR,Pascuccio M,Pierpaoli S,Guidotti L,Capitani S,Vitale M

更新日期：1999-02-15 00:00:00

abstract：:Antibody-mediated pure red cell aplasia is a rare but serious event resulting from the induction of neutralizing erythropoietin (Epo)-specific antibodies provoked by treatment with recombinant Epo. Because of the crucial role of CD4 T cells in humoral response, we have quantified the number of Epo-specific CD4 T cells...

journal_title：Blood

authors： Delluc S,Ravot G,Maillere B

更新日期：2010-11-25 00:00:00

abstract：:Cryoprecipitate has been demonstrated to correct the bleeding abnormality of patients with some congenital (storage pool disease) and acquired (uremia) platelet abnormalities, but the reason for this effect is unknown. We found significant platelet contamination in plasma harvested to prepare fresh frozen plasma and c...

journal_title：Blood

authors： George JN,Pickett EB,Heinz R

更新日期：1986-07-01 00:00:00

abstract：:Using either hexazotized pararosaniline or new fuchsin as coupling agents, we investigated the ultrastructural localization of alpha-naphthyl acetate esterase (ANAE) activity in guinea pig bone marrow and peritoneal exudates, and in human peripheral blood cells. DFP-inhibitable ANAE activity was present on the cell su...

journal_title：Blood

authors： Monahan RA,Dvorak HF,Dvorak AM

更新日期：1981-12-01 00:00:00

abstract：:Adaptor protein-3 (AP-3) is an ubiquitous cytoplasmic complex that shuttles cargo proteins from the trans-Golgi and a tubular-endosomal compartment to endosome-lysosome-related organelles. Lack of the beta3A subunit of this complex causes Hermansky-Pudlak syndrome type 2, an autosomal recessive disease characterized b...

journal_title：Blood

authors： Fontana S,Parolini S,Vermi W,Booth S,Gallo F,Donini M,Benassi M,Gentili F,Ferrari D,Notarangelo LD,Cavadini P,Marcenaro E,Dusi S,Cassatella M,Facchetti F,Griffiths GM,Moretta A,Notarangelo LD,Badolato R

更新日期：2006-06-15 00:00:00

abstract：:The nuclear receptors (NR) retinoid X receptors (RXRs) exert immunomodulatory functions to control inflammation and metabolism via homodimers and heterodimers with several other NRs including retinoic acid receptors. IRX4204 is a novel, highly specific RXR agonist in clinical trials that potently and selectively activ...

journal_title：Blood

authors： Thangavelu G,Wang C,Loschi M,Saha A,Osborn M,Furlan SN,Aoyama K,McDonald-Hyman C,Aguilar EG,Janesick AS,Chandraratna RA,Refaeli Y,Panoskaltsis-Mortari A,MacDonald KP,Hill GR,Zeiser R,Maillard I,Serody J,Murphy WJ,Mu

更新日期：2020-09-24 00:00:00

abstract：:It has been proposed that CD4 T-cell responses to Staphylococcus aureus (SA) can inadvertently enhance neoplastic progression in models of skin cancer and cutaneous T-cell lymphoma (CTCL). In this prospective study, we explored the effect of transient antibiotic treatment on tumor cells and disease activity in 8 patie...

journal_title：Blood

authors： Lindahl LM,Willerslev-Olsen A,Gjerdrum LMR,Nielsen PR,Blümel E,Rittig AH,Celis P,Herpers B,Becker JC,Stausbøl-Grøn B,Wasik MA,Gluud M,Fredholm S,Buus TB,Johansen C,Nastasi C,Peiffer L,Kubat L,Bzorek M,Eriksen JO,K

更新日期：2019-09-26 00:00:00

abstract：:Epidemiologic studies have correlated elevated plasma fibrinogen (hyperfibrinogenemia) with risk of cardiovascular disease and arterial and venous thrombosis. However, it is unknown whether hyperfibrinogenemia is merely a biomarker of the proinflammatory disease state or is a causative mechanism in the etiology. We ra...

journal_title：Blood

authors： Machlus KR,Cardenas JC,Church FC,Wolberg AS

更新日期：2011-05-05 00:00:00

abstract：:Src activation involves the coordinated regulation of positive and negative tyrosine phosphorylation sites. The mechanism whereby receptor tyrosine kinases, cytokine receptors, and integrins activate Src is not known. Here, we demonstrate that granulocyte colony-stimulating factor (G-CSF) activates Lyn, the predominan...

journal_title：Blood

authors： Futami M,Zhu QS,Whichard ZL,Xia L,Ke Y,Neel BG,Feng GS,Corey SJ

更新日期：2011-07-28 00:00:00

abstract：:Although NPM1 gene mutations leading to aberrant cytoplasmic expression of nucleophosmin (NPMc(+)) are the most frequent genetic lesions in acute myeloid leukemia, there is yet no experimental model demonstrating their oncogenicity in vivo. We report the generation and characterization of a transgenic mouse model expr...

journal_title：Blood

authors： Cheng K,Sportoletti P,Ito K,Clohessy JG,Teruya-Feldstein J,Kutok JL,Pandolfi PP

更新日期：2010-04-22 00:00:00

abstract：:We have previously reported on a unique patient in whom homozygosity for a mutation at IRF8 (IRF8(K108E)) causes a severe immunodeficiency. Laboratory evaluation revealed a highly unusual myeloid compartment, remarkable for the complete absence of CD141 and CD161 monocytes, absence of CD11c1 conventional dendritic cel...

journal_title：Blood

authors： Salem S,Langlais D,Lefebvre F,Bourque G,Bigley V,Haniffa M,Casanova JL,Burk D,Berghuis A,Butler KM,Leahy TR,Hambleton S,Gros P

更新日期：2014-09-18 00:00:00

abstract：:We infused six human immunodeficiency virus (HIV)-seropositive subjects with autologous CD8+ cytotoxic T cells (CTLs) enriched for HIV-specific cytotoxicity targeted against a diversity of HIV epitopes in gp120, gag p17 and p24, and nef. There was no toxicity and no subject deteriorated clinically. In the first 2 week...

journal_title：Blood

authors： Lieberman J,Skolnik PR,Parkerson GR 3rd,Fabry JA,Landry B,Bethel J,Kagan J

更新日期：1997-09-15 00:00:00