Evaluation and clinical correlations of bone marrow angiogenesis in myelofibrosis with myeloid metaplasia.

abstract：:Current treatment strategies for Hodgkin lymphoma result in excellent survival but often confer significant long-term toxicity. We designed ABVE-PC (doxorubicin, bleomycin, vincristine, etoposide, prednisone, cyclophosphamide) to (1) enhance treatment efficacy by dose-dense drug delivery and (2) reduce risk of long-te...

journal_title：Blood

authors： Schwartz CL,Constine LS,Villaluna D,London WB,Hutchison RE,Sposto R,Lipshultz SE,Turner CS,deAlarcon PA,Chauvenet A

更新日期：2009-09-03 00:00:00

abstract：:Clinical trials have been started with the aim of inducing tumor immunity by blocking the immunosuppressive action of indoleamine-2,3-dioxygenase (IDO) with the IDO2-inhibitor dextro-1-methyl-tryptophan (D-1MT). Here we show that human dendritic cells (DCs) express both IDO-1 and IDO-2, but that only IDO1 mediates try...

journal_title：Blood

authors： Lob S,Konigsrainer A,Schafer R,Rammensee HG,Opelz G,Terness P

更新日期：2008-02-15 00:00:00

abstract：:We used in vitro DNA amplification by the polymerase chain reaction and nonradioactive probes for prenatal diagnosis of beta thalassemia in Chinese from the Guangdong province. Exact molecular diagnoses were made in all 20 fetuses studied over a 6-month period. We conclude that this method of prenatal diagnosis for be...

journal_title：Blood

authors： Cai SP,Chang CA,Zhang JZ,Saiki RK,Erlich HA,Kan YW

更新日期：1989-02-01 00:00:00

abstract：:To assess the frequency and significance of nonrandom abnormalities of chromosome 9p in childhood acute lymphoblastic leukemia (ALL), we analyzed our experience with 398 consecutive cases with completely banded karyotypes. Forty cases (10%) with abnormalities of 9p were identified: 26 with deletions, nine with unbalan...

journal_title：Blood

authors： Murphy SB,Raimondi SC,Rivera GK,Crone M,Dodge RK,Behm FG,Pui CH,Williams DL

更新日期：1989-07-01 00:00:00

abstract：:Auxiliary bone marrow cells are required for optimal murine megakaryocyte colony formation in addition to progenitor cells and a colony stimulating activity (CSA) present in WEHI-3 cell conditioned medium. These auxiliary cells are adherent, with a sedimentation rate of 5.8 mm hr-1 and buoyant density of 1.065-1.078 g...

journal_title：Blood

authors： Williams N,Jackson H,Ralph P,Nakoinz I

更新日期：1981-01-01 00:00:00

abstract：:This study demonstrates a unique and crucial role of plasmacytoid dendritic cells (pDCs) and pDC-derived type I interferons (IFNs) in the pathogenesis of mouse coronavirus infection. pDCs controlled the fast replicating mouse hepatitis virus (MHV) through the immediate production of type I IFNs. Recognition of MHV by ...

journal_title：Blood

authors： Cervantes-Barragan L,Züst R,Weber F,Spiegel M,Lang KS,Akira S,Thiel V,Ludewig B

更新日期：2007-02-01 00:00:00

abstract：:Fibrin is essential for hemostasis; however, abnormal fibrin formation is hypothesized to increase thrombotic risk. We previously showed that in situ thrombin generation on a cell's surface modulates the 3-dimensional structure and stability of the fibrin network. Currently, we compared the abilities of extravascular ...

journal_title：Blood

authors： Campbell RA,Overmyer KA,Selzman CH,Sheridan BC,Wolberg AS

更新日期：2009-11-26 00:00:00

abstract：:Proapoptotic Bax and Bak are the key B-cell lymphoma-2 family members mediating apoptosis through the intrinsic pathway. Cells doubly deficient for Bax and Bak are profoundly resistant to apoptotic stimuli originating from multiple stimuli. Here we describe mice in which Bax and Bak have been deleted specifically in T...

journal_title：Blood

authors： Biswas S,Shi Q,Matise L,Cleveland S,Dave U,Zinkel S

更新日期：2010-12-09 00:00:00

abstract：:Human endothelial cells release two forms of a plasminogen activator-specific inhibitor: an active form that readily binds to and inhibits plasminogen activators and an inactive or latent form that has no anti-activator activity but which can be activated by denaturation. Latent and active forms of plasminogen activat...

journal_title：Blood

authors： Levin EG

更新日期：1986-05-01 00:00:00

abstract：:Erythropoiesis was investigated in 32 children wih short stature and in eight children with skeletal dysplasia by studying blood hemoglobin in relation to growth and to serum concentrations of insulin-like growth factor I (IGF-I), IGF binding protein-3 (IGFBP-3), and erythropoietin (EPO) before, during, and after 12 m...

journal_title：Blood

authors： Vihervuori E,Virtanen M,Koistinen H,Koistinen R,Seppälä M,Siimes MA

更新日期：1996-03-01 00:00:00

abstract：:Thrombohemorrhagic complications are a major cause of morbidity and mortality in patients with essential thrombocythemia (ET) and polycythemia vera (PV). The pathogenesis of these complications is not completely clarified. Several studies have described abnormalities of red blood cells and platelets in these patients....

journal_title：Blood

authors： Falanga A,Marchetti M,Evangelista V,Vignoli A,Licini M,Balicco M,Manarini S,Finazzi G,Cerletti C,Barbui T

更新日期：2000-12-15 00:00:00

abstract：:Reduced lymphopoiesis during aging contributes to declines in immunity, but little consideration has been given to its effect on the development of hematologic disease. This report demonstrates that age-related defects in lymphopoiesis underlie the myeloid dominance of adult leukemia. Using a murine model of chronic m...

journal_title：Blood

authors： Signer RA,Montecino-Rodriguez E,Witte ON,McLaughlin J,Dorshkind K

更新日期：2007-09-15 00:00:00

abstract：:The timely clearance of apoptotic neutrophils from inflammation sites is an important function of macrophages; however, the role of macrophages in maintaining neutrophil homeostasis under steady-state conditions is less well understood. By conditionally deleting the antiapoptotic gene cellular FLICE-like inhibitory pr...

journal_title：Blood

authors： Gordy C,Pua H,Sempowski GD,He YW

更新日期：2011-01-13 00:00:00

abstract：:Endogenous cytokines are thought to mediate numerous biologic processes and may account for some adverse effects experienced following the administration of recombinant proteins. This study describes the pattern of endogenous cytokine exposure following high-dose chemotherapy. Blood concentrations of interleukin-6 (IL...

journal_title：Blood

authors： Rabinowitz J,Petros WP,Stuart AR,Peters WP

更新日期：1993-05-01 00:00:00

abstract：:Autoimmune lymphoproliferative syndrome (ALPS) caused by impaired FAS-mediated apoptosis of lymphocytes is characterized by lymphoproliferation, autoimmunity, but also an increased risk of invasive bacterial infection, notably following splenectomy. We surveyed a cohort of 100 ALPS patients (including 33 splenectomize...

journal_title：Blood

authors： Neven B,Bruneau J,Stolzenberg MC,Meyts I,Magerus-Chatinet A,Moens L,Lanzarotti N,Weller S,Amiranoff D,Florkin B,Bader-Meunier B,Leverger G,Ferster A,Chantrain C,Blanche S,Picard C,Molina TJ,Brousse N,Durandy A,Rizzi

更新日期：2014-09-04 00:00:00

abstract：:The natural history of lymphoid infiltrates of the orbit and conjunctiva is poorly understood. To determine if immunohistologic features could predict clinical outcome, these features were evaluated in 61 patients with orbital and conjunctival lymphoid infiltrates, including 44 patients with lesions localized to one o...

journal_title：Blood

authors： Medeiros LJ,Harmon DC,Linggood RM,Harris NL

更新日期：1989-11-01 00:00:00

abstract：:Adeno-associated virus (AAV)-based gene therapies can restore endogenous factor VIII (FVIII) expression in hemophilia A (HA). AAV vectors typically use a B-domain-deleted FVIII transgene, such as human FVIII-SQ in valoctocogene roxaparvovec (AAV5-FVIII-SQ). Surprisingly, the activity of transgene-produced FVIII-SQ was...

journal_title：Blood

authors： Rosen S,Tiefenbacher S,Robinson M,Huang M,Srimani J,Mackenzie D,Christianson T,Pasi KJ,Rangarajan S,Symington E,Giermasz A,Pierce GF,Kim B,Zoog SJ,Vettermann C

更新日期：2020-11-26 00:00:00

abstract：:The aim of this study was to investigate whether interleukin (IL)-6 induces the production of IL-1 and tumor necrosis factor (TNF) antagonists. Serial plasma samples were obtained from cancer patients participating in phase I and II trials of recombinant IL-6 administered as a 120-hour continuous intravenous (IV) infu...

journal_title：Blood

authors： Tilg H,Trehu E,Atkins MB,Dinarello CA,Mier JW

更新日期：1994-01-01 00:00:00

abstract：:Src homology 2 domain-containing phosphatase 2 (Shp2), encoded by Ptpn11, is a member of the nonreceptor protein-tyrosine phosphatase family, and functions in cell survival, proliferation, migration, and differentiation in many tissues. Here we report that loss of Ptpn11 in murine hematopoietic cells leads to bone mar...

journal_title：Blood

authors： Chan G,Cheung LS,Yang W,Milyavsky M,Sanders AD,Gu S,Hong WX,Liu AX,Wang X,Barbara M,Sharma T,Gavin J,Kutok JL,Iscove NN,Shannon KM,Dick JE,Neel BG,Braun BS

更新日期：2011-04-21 00:00:00

abstract：:Plasmodium falciparum-infected erythrocytes (IRBC) roll on the adhesion molecule P-selectin in vitro under flow conditions that approximate the shear stress in capillary and postcapillary venules in which cytoadherence occurs in vivo. The pathological significance of this adhesive interaction is currently unknown. In ...

journal_title：Blood

authors： Ho M,Schollaardt T,Niu X,Looareesuwan S,Patel KD,Kubes P

更新日期：1998-06-15 00:00:00

abstract：:It has previously been shown that monolayer cultures derived adherent cells (MDAC), apparently consisting of fibroblasts, macrophages, epithelioid cells, and fat cells, can support long-term stem cell proliferation in vitro. In the present study, the hematopoietic support capability of murine MDAC monolayers was confi...

journal_title：Blood

authors： Bentley SA,Foidart JM

更新日期：1980-12-01 00:00:00

abstract：:The PI3K/AKT signaling is activated in various hematologic malignancies. We evaluated the effect of a novel, pan-AKT kinase inhibitor, GSK690693, on the proliferation of 112 cell lines representing different hematologic neoplasia. Fifty-five percent of all cell lines tested were sensitive to AKT inhibitor (EC(50)<1 mi...

journal_title：Blood

authors： Levy DS,Kahana JA,Kumar R

更新日期：2009-02-19 00:00:00

abstract：:Advances in immune assessment, including the development of T-cell receptor excision circle (TREC) assays of thymopoiesis, cytokine-flow cytometry assays of T-cell function, and higher-order phenotyping of T-cell maturation subsets have improved our understanding of T-cell homeostasis. Limited data exist using these m...

journal_title：Blood

authors： Komanduri KV,St John LS,de Lima M,McMannis J,Rosinski S,McNiece I,Bryan SG,Kaur I,Martin S,Wieder ED,Worth L,Cooper LJ,Petropoulos D,Molldrem JJ,Champlin RE,Shpall EJ

更新日期：2007-12-15 00:00:00

abstract：:Hematopoietic stem cell transplantation (HSCT) is a highly successful treatment for severe congenital immunodeficiencies. However, some studies have suggested that children may experience cognitive difficulties after HSCT. This large-scale study assessed cognitive and behavioral function for the cohort of children tre...

journal_title：Blood

authors： Titman P,Pink E,Skucek E,O'Hanlon K,Cole TJ,Gaspar J,Xu-Bayford J,Jones A,Thrasher AJ,Davies EG,Veys PA,Gaspar HB

更新日期：2008-11-01 00:00:00

abstract：:Subclones homozygous for JAK2V617F are more common in polycythemia vera (PV) than essential thrombocythemia (ET), but their prevalence and significance remain unclear. The JAK2 mutation status of 6495 BFU-E, grown in low erythropoietin conditions, was determined in 77 patients with PV or ET. Homozygous-mutant colonies...

journal_title：Blood

authors： Godfrey AL,Chen E,Pagano F,Ortmann CA,Silber Y,Bellosillo B,Guglielmelli P,Harrison CN,Reilly JT,Stegelmann F,Bijou F,Lippert E,McMullin MF,Boiron JM,Döhner K,Vannucchi AM,Besses C,Campbell PJ,Green AR

更新日期：2012-09-27 00:00:00

abstract：:An effective response to extreme hematopoietic stress requires an extreme elevation in hematopoiesis and preservation of hematopoietic stem cells (HSCs). These diametrically opposed processes are likely to be regulated by genes that mediate cellular adaptation to physiologic stress. Herein, we show that heme oxygenase...

journal_title：Blood

authors： Cao YA,Wagers AJ,Karsunky H,Zhao H,Reeves R,Wong RJ,Stevenson DK,Weissman IL,Contag CH

更新日期：2008-12-01 00:00:00

abstract：:Activated platelets release their granule content in a concentrated fashion at sites of injury. We examined whether ectopically expressed factor VIII in developing megakaryocytes would be stored in alpha-granules and whether its release from circulating platelets would effectively ameliorate bleeding in a factor VIIIn...

journal_title：Blood

authors： Yarovoi HV,Kufrin D,Eslin DE,Thornton MA,Haberichter SL,Shi Q,Zhu H,Camire R,Fakharzadeh SS,Kowalska MA,Wilcox DA,Sachais BS,Montgomery RR,Poncz M

更新日期：2003-12-01 00:00:00

abstract：:Platelet von Willebrand factor (vWF) has been suggested to play an important role in the hemostatic process. Clinical and experimental data indicate that bleeding time (BT) and platelet-vessel wall interaction cannot be normalized unless the defect of platelet vWF is also corrected. We have examined the effect of norm...

journal_title：Blood

authors： Castillo R,Monteagudo J,Escolar G,Ordinas A,Magallón M,Martín Villar J

更新日期：1991-05-01 00:00:00

abstract：:A recent clinical trial for adrenoleukodystrophy (ALD) showed the efficacy and safety of lentiviral vector (LV) gene transfer in hematopoietic stem progenitor cells. However, several common insertion sites (CIS) were found in patients' cells, suggesting that LV integrations conferred a selective advantage. We performe...

journal_title：Blood

authors： Biffi A,Bartolomae CC,Cesana D,Cartier N,Aubourg P,Ranzani M,Cesani M,Benedicenti F,Plati T,Rubagotti E,Merella S,Capotondo A,Sgualdino J,Zanetti G,von Kalle C,Schmidt M,Naldini L,Montini E

更新日期：2011-05-19 00:00:00

abstract：:Daratumumab targets CD38-expressing myeloma cells through a variety of immune-mediated mechanisms (complement-dependent cytotoxicity, antibody-dependent cell-mediated cytotoxicity, and antibody-dependent cellular phagocytosis) and direct apoptosis with crosslinking. These mechanisms may also target nonplasma cells tha...

journal_title：Blood

authors： Krejcik J,Casneuf T,Nijhof IS,Verbist B,Bald J,Plesner T,Syed K,Liu K,van de Donk NW,Weiss BM,Ahmadi T,Lokhorst HM,Mutis T,Sasser AK

更新日期：2016-07-21 00:00:00