Cytogenetic and histologic correlations in malignant lymphoma.

abstract：:The transcription repressor BCL-6 is known to play critical roles in B-cell lymphomagenesis, germinal center formation, and balanced Th1/Th2 differentiation. In macrophages, although BCL-6 has also been shown to regulate the expression of several chemokine genes, its function in other aspects of macrophage biology has...

journal_title：Blood

authors： Yu RY,Wang X,Pixley FJ,Yu JJ,Dent AL,Broxmeyer HE,Stanley ER,Ye BH

更新日期：2005-02-15 00:00:00

abstract：:The survival of patients with Waldenstrom macroglobulinemia (WM) varies enormously. The development of prognostic models in WM has been fraught by limited follow-up in current studies. Here, we update the outcome of a prospective WM trial with a median follow-up of 10 years for live patients. Of the 59 previously untr...

journal_title：Blood

authors： Dhodapkar MV,Hoering A,Gertz MA,Rivkin S,Szymonifka J,Crowley J,Barlogie B

更新日期：2009-01-22 00:00:00

abstract：:Myeloperoxidase (MPO) catalyzes a reaction between chloride and hydrogen peroxide to generate hypochlorous acid and other reactive compounds that have been linked to DNA damage. The MPO gene is expressed at high levels in normal myeloid precursors and in acute myeloid leukemias (AMLs) which are clonal derivatives of m...

journal_title：Blood

authors： Reynolds WF,Chang E,Douer D,Ball ED,Kanda V

更新日期：1997-10-01 00:00:00

abstract：:Escherichia coli were labeled with 59Fe and then either treated with myeloperoxidase, H2O2, and chloride or opsonized and mixed with human neutrophils. The myeloperoxidase system at pH 7.4 caused release of most of the bacterial 59Fe. A similar result has been obtained by Rosen and Klebanoff (J Biol Chem 257:13731, 19...

journal_title：Blood

authors： Molloy AL,Winterbourn CC

更新日期：1990-02-15 00:00:00

abstract：:Anemia and neutropenia often develop in cats that are infected with the feline immunodeficiency virus (FIV), a lentivirus biologically similar to the human immunodeficiency virus (HIV). To assess the role of FIV in the pathogenesis of these abnormalities, marrow culture studies were performed on nine asymptomatic, hem...

journal_title：Blood

authors： Linenberger ML,Shelton GH,Persik MT,Abkowitz JL

更新日期：1991-10-15 00:00:00

abstract：:Delivery of biologically active peptides into human polymorphonuclear neutrophils (PMNs) has implications for studying cellular functions and may be therapeutically relevant. The transcription factor nuclear factor-kappaB (NF-kappaB) regulates the expression of multiple genes controlling inflammation, proliferation, a...

journal_title：Blood

authors： Choi M,Rolle S,Wellner M,Cardoso MC,Scheidereit C,Luft FC,Kettritz R

更新日期：2003-09-15 00:00:00

abstract：:Oncostatin M (OSM) and leukemia inhibitory factor (LIF) are members of the interleukin-6 (IL-6) subfamily of cytokines that use a common signal transducer gp130. Human OSM (hOSM) and LIF share a functional high-affinity receptor that is composed of gp130 and LIF receptor beta subunit (LIFRbeta). A second high-affinity...

journal_title：Blood

authors： Ichihara M,Hara T,Kim H,Murate T,Miyajima A

更新日期：1997-07-01 00:00:00

abstract：:The median age of chronic myeloid leukemia (CML) patients is ~60 years, and age is still considered an important prognostic factor, included in Sokal and EURO risk scores. However, few data are available about the long-term outcome of older patients treated with imatinib (IM) frontline. We analyzed the relationship be...

journal_title：Blood

authors： Gugliotta G,Castagnetti F,Palandri F,Breccia M,Intermesoli T,Capucci A,Martino B,Pregno P,Rupoli S,Ferrero D,Gherlinzoni F,Montefusco E,Bocchia M,Tiribelli M,Pierri I,Grifoni F,Marzocchi G,Amabile M,Testoni N,Martin

更新日期：2011-05-26 00:00:00

abstract：:IL-12 exerts several regulatory effects on natural killer (NK) cells by activating IL-12 signaling. IL-12 signaling is tightly auto-regulated to control its onset and termination, with prolonged IL-12 treatment resulting in IL-12 hyporesponsiveness. However, the mechanisms underlying IL-12 auto-regulation are still un...

journal_title：Blood

authors： Huang Y,Lei Y,Zhang H,Hou L,Zhang M,Dayton AI

更新日期：2011-12-22 00:00:00

abstract：:The presence of circulating tumor idiotype interferes with the in vivo effectiveness of anti-idiotype antibodies. We developed two assays that permit identification of patients with high levels of serum idiotype without the need for first producing an anti-idiotype antibody. A cell suspension made from the tumor was c...

journal_title：Blood

authors： Miller RA,Lowder JN,Gralow J,Meeker T,Levy R

更新日期：1987-04-01 00:00:00

abstract：:One of the functions of HLA class I alleles is interaction with natural killer (NK) cells. Receptors termed killer immunoglobulin-like receptors (KIRs) on NK cells recognize groups of HLA class I alleles, and interaction between receptor and class I allele inhibits reactivity of the NK cell. Failure to recognize the a...

journal_title：Blood

authors： Davies SM,Ruggieri L,DeFor T,Wagner JE,Weisdorf DJ,Miller JS,Velardi A,Blazar BR

更新日期：2002-11-15 00:00:00

abstract：:Interleukin (IL)-23 is a proinflammatory cytokine belonging to the IL-12 superfamily. The antitumor activity of IL-23 is controversial, and it is unknown whether or not the cytokine can act directly on tumor cells. The aim of this study was to investigate the potential direct antitumor activity of IL-23 in pediatric B...

journal_title：Blood

authors： Cocco C,Canale S,Frasson C,Di Carlo E,Ognio E,Ribatti D,Prigione I,Basso G,Airoldi I

更新日期：2010-11-11 00:00:00

abstract：:Pharmacologic infusion of activated protein C (APC) improves survival in severe sepsis, and platelet factor 4 (PF4) accelerates APC generation in a primate thrombin-infusion model. We now tested whether endogenous platelet PF4 content affects APC generation. Mice completely deficient in PF4 (mPF4(-/-)) had impaired AP...

journal_title：Blood

authors： Kowalska MA,Mahmud SA,Lambert MP,Poncz M,Slungaard A

更新日期：2007-09-15 00:00:00

abstract：:Recent findings that hemoglobin S gelation and sickling are pH-dependent and also influence oxygen affinity suggested that the red cells containing this hemoglobin variant might show an abnormal Bohr effect. We therefore studied the effects of pH variation on the in vitro oxygen affinity of whole blood from persons wi...

journal_title：Blood

authors： Ueda Y,Nagel RL,Bookchin RM

更新日期：1979-03-01 00:00:00

abstract：:Heparin-induced thrombocytopenia (HIT) is caused by platelet-activating IgG antibodies that recognize platelet factor 4 (PF4) bound to heparin. Immunogenicity of heparins differs in that unfractionated heparin (UFH) induces more anti-PF4/heparin antibodies than low-molecular-weight heparin (LMWH) and UFH also causes m...

journal_title：Blood

authors： Warkentin TE,Cook RJ,Marder VJ,Sheppard JA,Moore JC,Eriksson BI,Greinacher A,Kelton JG

更新日期：2005-12-01 00:00:00

abstract：:In this issue of Blood, Rollin et al demonstrate that heparin-induced thrombocytopenia and thrombosis (HIT) patients homozygous for arginine (R) at position 131 in the immunoglobulin (Ig)G receptor FcγRIIA have a significantly higher incidence of thrombosis, and show that plasma IgG may play a key role in modulating t...

journal_title：Blood

authors： Padmanabhan A

更新日期：2015-04-09 00:00:00

abstract：:Natural killer (NK) cells have been originally defined by their "naturally occurring" effector function. However, only a fraction of human NK cells is reactive toward a panel of prototypical tumor cell targets in vitro, both for the production of interferon-gamma (IFN-gamma) and for their cytotoxic response. In patien...

journal_title：Blood

authors： Guia S,Cognet C,de Beaucoudrey L,Tessmer MS,Jouanguy E,Berger C,Filipe-Santos O,Feinberg J,Camcioglu Y,Levy J,Al Jumaah S,Al-Hajjar S,Stephan JL,Fieschi C,Abel L,Brossay L,Casanova JL,Vivier E

更新日期：2008-05-15 00:00:00

abstract：:Classical 5q- syndrome is an acquired macrocytic anemia of the elderly. Similar to Diamond Blackfan anemia (DBA), an inherited red cell aplasia, the bone marrow is characterized by a paucity of erythroid precursors. RPS14 deletions in combination with other deletions in the region have been implicated as causative of ...

journal_title：Blood

authors： Vlachos A,Farrar JE,Atsidaftos E,Muir E,Narla A,Markello TC,Singh SA,Landowski M,Gazda HT,Blanc L,Liu JM,Ellis SR,Arceci RJ,Ebert BL,Bodine DM,Lipton JM

更新日期：2013-10-03 00:00:00

abstract：:Chronic granulomatous disease (CGD) can result from any of four single gene defects involving the components of the superoxide (O-2) generating phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. We show that transduction of peripheral blood CD34+ hematopoietic progenitors from a p67phox deficient C...

journal_title：Blood

authors： Weil WM,Linton GF,Whiting-Theobald N,Vowells SJ,Rafferty SP,Li F,Malech HL

更新日期：1997-03-01 00:00:00

abstract：:A prominent feature of sickle cell anemia is the presence of dehydrated red blood cells (RBCs) in circulation. Loss of potassium (K(+)), chloride (Cl(-)), and water from RBCs is thought to contribute to the production of these dehydrated cells. One main route of K(+) loss in the RBC is the Gardos channel, a calcium (C...

journal_title：Blood

authors： Stocker JW,De Franceschi L,McNaughton-Smith GA,Corrocher R,Beuzard Y,Brugnara C

更新日期：2003-03-15 00:00:00

abstract：:Fetal/neonatal immune responses generally are considered to be immature and weaker than that of adults. We have studied the cord-blood T cells of newborns congenitally infected with Trypanosoma cruzi, the protozoan agent of Chagas disease. Our data demonstrate a predominant activation of CD8 T cells expressing activat...

journal_title：Blood

authors： Hermann E,Truyens C,Alonso-Vega C,Even J,Rodriguez P,Berthe A,Gonzalez-Merino E,Torrico F,Carlier Y

更新日期：2002-09-15 00:00:00

abstract：:Cyclin dependent kinase (CDK) inhibitors, such as flavopiridol, demonstrate significant single-agent activity in chronic lymphocytic leukemia (CLL), but the mechanism of action in these nonproliferating cells is unclear. Here we demonstrate that CLL cells undergo autophagy after treatment with therapeutic agents, incl...

journal_title：Blood

authors： Mahoney E,Lucas DM,Gupta SV,Wagner AJ,Herman SE,Smith LL,Yeh YY,Andritsos L,Jones JA,Flynn JM,Blum KA,Zhang X,Lehman A,Kong H,Gurcan M,Grever MR,Johnson AJ,Byrd JC

更新日期：2012-08-09 00:00:00

abstract：:Truncation of asparaginase treatment due to asparaginase related toxicities or silent inactivation (SI) is common and may increase relapse risk in acute lymphoblastic leukemia (ALL). We investigated relapse risk following suboptimal asparaginase exposure among 1401 children aged 1-17 years, diagnosed with ALL between ...

journal_title：Blood

authors： Gottschalk Højfeldt S,Grell K,Abrahamsson J,Lund B,Vettenranta K,Jonsson OG,Frandsen TL,Wolthers BO,Marquart HVH,Vaitkeviciene G,Lepik K,Heyman M,Schmiegelow K,Albertsen BK

更新日期：2020-11-04 00:00:00

abstract：:In vitro studies suggest that Ras activation is necessary for erythroid cell development. However, genetic inactivation of the Ras isoforms H-Ras, N-Ras, and K-Ras in mice reportedly did not affect adult or fetal erythropoiesis, though K-Ras(-/-) embryos were anemic. Given these discrepancies, we performed a more deta...

journal_title：Blood

authors： Khalaf WF,White H,Wenning MJ,Orazi A,Kapur R,Ingram DA

更新日期：2005-05-01 00:00:00

abstract：:Naive T cells continuously recirculate between secondary lymphoid tissue via the blood and lymphatic systems, a process that maximizes the chances of an encounter between a T cell and its cognate antigen. This recirculation depends on signals from chemokine receptors, integrins, and the sphingosine-1-phosphate recepto...

journal_title：Blood

authors： Faroudi M,Hons M,Zachacz A,Dumont C,Lyck R,Stein JV,Tybulewicz VL

更新日期：2010-12-16 00:00:00

abstract：:Forkhead box P3 (FOXP3) is constitutively expressed by CD4(+)CD25(hi) regulatory T cells (nTregs). Mutations of FOXP3 cause a severe autoimmune syndrome known as immune dysregulation polyendocrinopathy enteropathy X-linked, in which nTregs are absent or dysfunctional. Whether FOXP3 is essential for both differentiatio...

journal_title：Blood

authors： Di Nunzio S,Cecconi M,Passerini L,McMurchy AN,Baron U,Turbachova I,Vignola S,Valencic E,Tommasini A,Junker A,Cazzola G,Olek S,Levings MK,Perroni L,Roncarolo MG,Bacchetta R

更新日期：2009-11-05 00:00:00

abstract：:We conducted a double-blind, randomized multicenter trial to determine whether the addition of mycophenolate mofetil (MMF) improves the efficacy of initial systemic treatment of chronic graft-versus-host disease (GVHD). The primary endpoint was resolution of chronic GVHD and withdrawal of all systemic treatment within...

journal_title：Blood

authors： Martin PJ,Storer BE,Rowley SD,Flowers ME,Lee SJ,Carpenter PA,Wingard JR,Shaughnessy PJ,DeVetten MP,Jagasia M,Fay JW,van Besien K,Gupta V,Kitko C,Johnston LJ,Maziarz RT,Arora M,Jacobson PA,Weisdorf D

更新日期：2009-05-21 00:00:00

abstract：:Over the past decade, extracellular nucleotides (such as ATP and UTP) have emerged as key immunomodulators. This family of molecules, already known for its key metabolic functions, has been the focus of intense investigation that has unambiguously shown its crucial role as mediators of cell-to-cell communication. More...

journal_title：Blood

authors： Rossi L,Salvestrini V,Ferrari D,Di Virgilio F,Lemoli RM

更新日期：2012-09-20 00:00:00

abstract：:The effects of alpha 2-antiplasmin and fibrin on the activation of plasminogen by recombinant staphylokinase (STAR) were studied in an effort to elucidate further the molecular basis of the fibrin-specificity of this fibrinolytic agent. In purified systems consisting of 1.5 mumol/L intact or low-M(r) plasminogen and 3...

journal_title：Blood

authors： Silence K,Collen D,Lijnen HR

更新日期：1993-08-15 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) is a rare histiocytic neoplasm associated with somatic mutations in the genes involved in the RAF/MEK/extracellular signal-regulated kinase (ERK) signaling pathway. Recently, oncogenic mutations in NRAS/KRAS, upstream regulators of the RAF/MEK/ERK pathway, have been reported in pulm...

journal_title：Blood

authors： Kamata T,Giblett S,Pritchard C

更新日期：2017-07-27 00:00:00