Genetic correction of p67phox deficient chronic granulomatous disease using peripheral blood progenitor cells as a target for retrovirus mediated gene transfer.

abstract：:Granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3) control the proliferation of human acute myeloid leukemia (AML) cells in vitro. Previously, we have shown that receptors for GM-CSF and IL-3 are often coexpressed on AML cells. Here we present experiments with purified AML blasts, norma...

journal_title：Blood

authors： Budel LM,Elbaz O,Hoogerbrugge H,Delwel R,Mahmoud LA,Löwenberg B,Touw IP

更新日期：1990-04-01 00:00:00

abstract：:The original activated partial thromboplastin time-based assay for activated protein C (APC)-resistant factor Va (FVa) requires carefully prepared fresh plasma and cannot be used in patients receiving warfarin or in patients with antiphospholipid antibodies. A new test is described here that circumvents these limitati...

journal_title：Blood

authors： Le DT,Griffin JH,Greengard JS,Mujumdar V,Rapaport SI

更新日期：1995-04-01 00:00:00

abstract：:Throughout its history, chronic myeloid leukemia (CML) has set precedents for cancer research and therapy. These range from the identification of the first specific chromosomal abnormality associated with cancer to the development of imatinib as a specific, targeted therapy for the disease. The successful development ...

journal_title：Blood

authors： Druker BJ

更新日期：2008-12-15 00:00:00

abstract：:The mi locus of mice encodes a member of the basic-helix-loop-helix-leucine zipper (bHLH-Zip) protein family of transcription factors (hereafter called MITF). Cultured mast cells of mi/mi genotype (mi/mi CMCs) did not normally respond to stem cell factor (SCF), a ligand for the c-kit receptor tyrosine kinase. The poor...

journal_title：Blood

authors： Tsujimura T,Morii E,Nozaki M,Hashimoto K,Moriyama Y,Takebayashi K,Kondo T,Kanakura Y,Kitamura Y

更新日期：1996-08-15 00:00:00

abstract：:Juvenile chronic myelogenous leukemia (JCML), a myeloproliferative disorder of childhood, is distinct from adult-type chronic myelogenous leukemia (CML) and bears resemblance to chronic myelomonocytic leukemia (CMMoL). Since mutations in the N-ras gene have been found at high frequencies in CMMoL, but only rarely in C...

journal_title：Blood

authors： Miyauchi J,Asada M,Sasaki M,Tsunematsu Y,Kojima S,Mizutani S

更新日期：1994-04-15 00:00:00

abstract：:A new unstable hemoglobin with high oxygen affinity, Hb Toyoake: beta 142 (H20) Ala replaced by Pro, was found in Japanese male with a normal blood hemoglobin level, shortened red cell survival, and increased plasma erythropoietin. Hemoglobin studies showed heat and isopropanol instability, and an increased tendency t...

journal_title：Blood

authors： Hirano M,Ohba Y,Imai K,Ino T,Morishita Y,Matsui T,Shimizu S,Sumi H,Yamamoto K,Miyaji T

更新日期：1981-04-01 00:00:00

abstract：:A new human leukemia cell line, KT-1, was established from a patient in the blastic crisis phase of chronic myelogenous leukemia (CML). This cell line had a positive reaction for intracytoplasmic myeloperoxidase and two Philadelphia chromosomes (Ph1) [t(9;22)(q34;q11)] and lacked normal copies of chromosomes 9 and 22....

journal_title：Blood

authors： Yanagisawa K,Yamauchi H,Kaneko M,Kohno H,Hasegawa H,Fujita S

更新日期：1998-01-15 00:00:00

abstract：:Microarray gene expression profiling studies have demonstrated immune response gene signatures that appear predictive of outcome in follicular lymphoma (FL). However, measurement of these marker genes in routine practice remains difficult. We have therefore investigated the immune response in FL using real-time polyme...

journal_title：Blood

authors： Byers RJ,Sakhinia E,Joseph P,Glennie C,Hoyland JA,Menasce LP,Radford JA,Illidge T

更新日期：2008-05-01 00:00:00

abstract：:In The Netherlands from July 1988 to October 1991, children (0 to 16 years of age) with de novo acute lymphoblastic leukemia (ALL) were treated according to protocol ALL-7 of the Dutch Childhood Leukemia Study Group (DCLSG). In this protocol, chemotherapy and treatment stratification were identical to the ALL-BFM-86 p...

journal_title：Blood

authors： Kamps WA,Bökkerink JP,Hählen K,Hermans J,Riehm H,Gadner H,Schrappe M,Slater R,van den Berg-de Ruiter E,Smets LA,de Vaan GA,Weening RS,van Weerden JF,van Wering ER,den der Does-van den Berg A

更新日期：1999-08-15 00:00:00

abstract：:Recombinant gibbon interleukin-3 (IL-3) is a multilineage hematopoietic colony-stimulating factor (CSF) that recently was cloned and found to be highly homologous with human IL-3. Gibbon IL-3, as well as human granulocyte-CSF (G-CSF) and human granulocyte-macrophage CSF (GM-CSF), stimulated normal human bone marrow ce...

journal_title：Blood

authors： Paquette RL,Zhou JY,Yang YC,Clark SC,Koeffler HP

更新日期：1988-06-01 00:00:00

abstract：:T-cell prolymphocytic leukemia (T-PLL) is a rare form of mature leukemia that occurs both in adults as a sporadic disease and in younger patients suffering an hereditary condition, ataxia telangiectasia (AT). The ATM gene, located in the 11q22-23 chromosomal region, is consistently mutated in AT patients. The strong p...

journal_title：Blood

authors： Stoppa-Lyonnet D,Soulier J,Laugé A,Dastot H,Garand R,Sigaux F,Stern MH

更新日期：1998-05-15 00:00:00

abstract：:Chronic myeloid leukemia (CML) is a malignant disorder of the hematopoietic stem cell. It has been shown that normal stem cells coexist with malignant stem cells in the bone marrow of patients with chronic-phase CML. To characterize the primitive hematopoietic progenitor cells within CML marrow, CD34+DR- and CD34+DR+ ...

journal_title：Blood

authors： Leemhuis T,Leibowitz D,Cox G,Silver R,Srour EF,Tricot G,Hoffman R

更新日期：1993-02-01 00:00:00

abstract：:An unusual group of human B-cell tumors with cellular features of chronic lymphocytic leukemia or lymphoplasmacytoid leukemia, together with high levels of a monoclonal IgG serum protein, has been investigated. Analysis of tumor-derived VH genes of neoplastic B lymphocytes was used to determine the clonal relationship...

journal_title：Blood

authors： Sahota SS,Garand R,Bataille R,Smith AJ,Stevenson FK

更新日期：1998-01-01 00:00:00

abstract：:Intracranial hemorrhage is the third most frequent cause of cerebrovascular disease, but few genetic risk factors have been associated with its development. Recently, it has been reported that some polymorphisms that affect clotting factors increase the risk for thrombosis. However, reports have analyzed the effect of...

journal_title：Blood

authors： Corral J,Iniesta JA,González-Conejero R,Villalón M,Vicente V

更新日期：2001-05-15 00:00:00

abstract：:We investigated the intracellular site of pro-von Willebrand factor (pro-vWF) cleavage and multimerization, as well as the fate of the propolypeptide (von Willebrand antigen II) after cleavage. Analysis of subcellular fractions of endothelial cells metabolically labeled with sulfate showed that both cleavage and coval...

journal_title：Blood

authors： Vischer UM,Wagner DD

更新日期：1994-06-15 00:00:00

abstract：:Little is known about the behavior of hematopoietic stem cells (HSCs) in primates because direct observations and competitive-repopulation assays are not feasible. Therefore, we used 2 different and independent experimental strategies, the tracking of transgene expression after retroviral-mediated gene transfer (N = 1...

journal_title：Blood

authors： Shepherd BE,Kiem HP,Lansdorp PM,Dunbar CE,Aubert G,LaRochelle A,Seggewiss R,Guttorp P,Abkowitz JL

更新日期：2007-09-15 00:00:00

abstract：:CD8+ Foxp3+ T cells (Tregs) are a potent regulatory population whose functional and ontological similarities to CD4+ Fox3+ T cells have not been well delineated. Using an experimental model of graft-versus-host disease (GVHD), we observed that CD8+ Tregs were significantly less potent than CD4+ Tregs for the suppressi...

journal_title：Blood

authors： Agle K,Vincent BG,Piper C,Belle L,Zhou V,Shlomchik W,Serody JS,Drobyski WR

更新日期：2018-07-26 00:00:00

abstract：:Many surface receptors and signaling molecules are thought to associate with unique membrane microdomains termed lipid rafts. We examined the involvement of lipid rafts in the activation of leukocyte function-associated antigen-1 (LFA-1). Depletion or sequestration of cholesterol with methyl-beta-cyclodextrin (MCD) or...

journal_title：Blood

authors： Marwali MR,Rey-Ladino J,Dreolini L,Shaw D,Takei F

更新日期：2003-07-01 00:00:00

abstract：:To program pluripotent cells into blood, a knowledge of the locations of precursors during their journey through the embryo and the signals they experience would be informative. The anterior (a) and posterior (p) ventral blood islands (VBIs) in Xenopus are derived from opposite sides of the pregastrula embryo. The aVB...

journal_title：Blood

authors： Walmsley M,Cleaver D,Patient R

更新日期：2008-02-01 00:00:00

abstract：:During an 8-year period, 3,638 children from institutions of the Pediatric Oncology Group (POG) were diagnosed with acute lymphoblastic leukemia (ALL). Fifty-seven patients had Philadelphia chromosome-positive (Ph1) ALL. Blast cells obtained at diagnosis from 13 of these 57 cases (23%) were also found to have partial ...

journal_title：Blood

authors： Russo C,Carroll A,Kohler S,Borowitz M,Amylon M,Homans A,Kedar A,Shuster J,Land V,Crist W

更新日期：1991-03-01 00:00:00

abstract：:Highly purified natural killer (NK) cell suspensions were tested for their capacity to release colony-stimulating activity (CSA) in vitro. NK cell suspensions comprised primarily CD16+ cells and were devoid of CD3+ T cells, CD15+ monocytes, and of B cells. CSA was detected in the NK cell supernatants and sustained the...

journal_title：Blood

authors： Pistoia V,Zupo S,Corcione A,Roncella S,Matera L,Ghio R,Ferrarini M

更新日期：1989-07-01 00:00:00

abstract：:The Augustine-negative alias At(a-) blood type, which seems to be restricted to people of African ancestry, was identified half a century ago but remains one of the last blood types with no known genetic basis. Here we report that a nonsynonymous single nucleotide polymorphism in SLC29A1 (rs45458701) is responsible fo...

journal_title：Blood

authors： Daniels G,Ballif BA,Helias V,Saison C,Grimsley S,Mannessier L,Hustinx H,Lee E,Cartron JP,Peyrard T,Arnaud L

更新日期：2015-06-04 00:00:00

abstract：:We studied the impact of driver mutations of JAK2, CALR, (calreticulin gene) or MPL on clinical course, leukemic transformation, and survival of patients with primary myelofibrosis (PMF). Of the 617 subjects studied, 399 (64.7%) carried JAK2 (V617F), 140 (22.7%) had a CALR exon 9 indel, 25 (4.0%) carried an MPL (W515)...

journal_title：Blood

authors： Rumi E,Pietra D,Pascutto C,Guglielmelli P,Martínez-Trillos A,Casetti I,Colomer D,Pieri L,Pratcorona M,Rotunno G,Sant'Antonio E,Bellini M,Cavalloni C,Mannarelli C,Milanesi C,Boveri E,Ferretti V,Astori C,Rosti V,Cerva

更新日期：2014-08-14 00:00:00

abstract：:The report of the so-called Berlin patient cured of HIV with hematopoietic stem cell transplantation and a few other studies raised tremendous hope, excitement, and curiosity in the field. The National Heart, Lung and Blood Institute of the National Institutes of Health convened a Working Group to address emerging hea...

journal_title：Blood

authors： Zou S,Glynn S,Kuritzkes D,Shah M,Cook N,Berliner N,NHLBI AIDS Blood Session Working Group.

更新日期：2013-10-31 00:00:00

abstract：:Human erythroid alpha-spectrin alleles responsible for hereditary elliptocytosis (alphaHE alleles) undergo increased incorporation into red blood cell membranes when the polymorphism alphaLELY (LELY: Low Expression LYon) occurs in trans. The alphaLELY polymorphism is characterized by a mutation in exon 40 at codon 185...

journal_title：Blood

authors： Wilmotte R,Harper SL,Ursitti JA,Maréchal J,Delaunay J,Speicher DW

更新日期：1997-11-15 00:00:00

abstract：:Aberrant regulation of endogenous survival pathways plays a major role in progression of chronic lymphocytic leukemia (CLL). Signaling via conjugation of surface receptors within the tumor environmental niche activates survival and proliferation pathways in CLL. Of these, the phosphoinositide 3-kinase (PI3K)/protein k...

journal_title：Blood

authors： Liu TM,Ling Y,Woyach JA,Beckwith K,Yeh YY,Hertlein E,Zhang X,Lehman A,Awan F,Jones JA,Andritsos LA,Maddocks K,MacMurray J,Salunke SB,Chen CS,Phelps MA,Byrd JC,Johnson AJ

更新日期：2015-01-08 00:00:00

abstract：:Two distinct classes of granulocyte progenitor cells present in normal mouse bone marrow are expressed sequentially in the vivo plasma clot diffusion chamber culture system. By several criteria, progenitor cells giving rise to granulocyte colonies on day 4 of culture (CFU-D4) are different from those giving rise to co...

journal_title：Blood

authors： Steinberg HN,Page PL,Robinson SH

更新日期：1982-04-01 00:00:00

abstract：:The effect of recombinant factor VIII (rFVIII) brand on inhibitor development was investigated in all 407 severe hemophilia A previously untreated patients born in the United Kingdom (UK) between 1 January 2000 and 31 December 2011. Eighty-eight (22%) had been in the RODIN study. Information was extracted from the Nat...

journal_title：Blood

authors： Collins PW,Palmer BP,Chalmers EA,Hart DP,Liesner R,Rangarajan S,Talks K,Williams M,Hay CR,UK Haemophilia Centre Doctors’ Organization.

更新日期：2014-11-27 00:00:00

abstract：:From ten patients with advanced malignant disease involving the bone marrow, autologous hematopoietic stem cells were collected from the peripheral blood during eight four-hour pheresis procedures and cryopreserved. No manipulations to increase the number of stem cells circulating in the blood were used during the col...

journal_title：Blood

authors： Kessinger A,Armitage JO,Landmark JD,Smith DM,Weisenburger DD

更新日期：1988-03-01 00:00:00

abstract：:Multipotent adult progenitor cells (MAPCs) are bone marrow-derived stem cells that have extensive in vitro expansion capacity and can differentiate in vivo and in vitro into tissue cells of all 3 germinal layers: ectoderm, mesoderm, and endoderm. The origin of MAPCs within bone marrow is unknown. MAPCs are believed to...

journal_title：Blood

authors： Reyes M,Li S,Foraker J,Kimura E,Chamberlain JS

更新日期：2005-11-15 00:00:00