An allelic association implicates myeloperoxidase in the etiology of acute promyelocytic leukemia.

abstract：:Overactivated complement is a high-risk feature in hematopoietic stem cell transplant (HSCT) recipients with transplant-associated thrombotic microangiopathy (TA-TMA), and untreated patients have dismal outcomes. We present our experience with 64 pediatric HSCT recipients who had high-risk TA-TMA (hrTA-TMA) and multio...

journal_title：Blood

authors： Jodele S,Dandoy CE,Lane A,Laskin BL,Teusink-Cross A,Myers KC,Wallace G,Nelson A,Bleesing J,Chima RS,Hirsch R,Ryan TD,Benoit S,Mizuno K,Warren M,Davies SM

更新日期：2020-03-26 00:00:00

abstract：:The transcription of insulin-like growth factor 2 (IGF-2) is affected by genomic imprinting, a multistep process through which the parental origin of a gene influences its transcription. The maternal copy of IGF-2 is silenced in most human tissues, but in the choroid plexus and the adult liver both alleles of IGF-2 ar...

journal_title：Blood

authors： Morison IM,Eccles MR,Reeve AE

更新日期：2000-11-01 00:00:00

abstract：:Productive T-cell immunity requires both the activation and the migration of specific T cells to the antigenic tissue. The costimulatory molecule CD28 plays an essential role in the initiation of T-cell-mediated immunity. We investigated the possibility that CD28 may also regulate migration of primed T cells to target...

journal_title：Blood

authors： Mirenda V,Jarmin SJ,David R,Dyson J,Scott D,Gu Y,Lechler RI,Okkenhaug K,Marelli-Berg FM

更新日期：2007-04-01 00:00:00

abstract：:We have identified and cloned a novel human cytokine with homology to cytokines of the interleukin-17 (IL-17) family, which we have termed human IL-17E (hIL-17E). With the identification of several IL-17 family members, it is critical to understand the in vivo function of these molecules. We have generated transgenic ...

journal_title：Blood

authors： Kim MR,Manoukian R,Yeh R,Silbiger SM,Danilenko DM,Scully S,Sun J,DeRose ML,Stolina M,Chang D,Van GY,Clarkin K,Nguyen HQ,Yu YB,Jing S,Senaldi G,Elliott G,Medlock ES

更新日期：2002-10-01 00:00:00

abstract：:The presence of lysosomal enzymes in human platelets is well documented; the identity of the "lysosome," however, has been the subject of some disagreement. In order to determine the time of appearance and subcellular localization of two lysosomal enzymes in megakaryocytes (MK) and platelets, we examined normal human ...

journal_title：Blood

authors： Bentfeld-Barker ME,Bainton DF

更新日期：1982-03-01 00:00:00

abstract：:Little is known about the role of active immunization in suppressing undesirable immune responses. Because CD8alpha(+) dendritic cells (DCs) suppress certain immune responses, we tested the hypothesis that immunization of donors with host-derived CD8alpha(+) DCs will reduce host-specific donor T-cell responses. BALB/c...

journal_title：Blood

authors： Toubai T,Malter C,Tawara I,Liu C,Nieves E,Lowler KP,Sun Y,Reddy P

更新日期：2010-01-21 00:00:00

abstract：:In cases of T-cell acute lymphoblastic leukemia (T-ALL), the basic helix-loop-helix (bHLH) oncogene SCL/tal undergoes frequent rearrangements activating ectopic expression. Despite the compelling epidemiological association of SCL/tal expression with T-ALL, no specific transforming function has been attributable to th...

journal_title：Blood

authors： Goldfarb AN,Lewandowska K

更新日期：1995-01-15 00:00:00

abstract：:Heparin-induced thrombocytopenia/thrombosis (HIT/T) is a common complication of heparin therapy that is caused by antibodies to platelet factor 4 (PF4) complexed with heparin. The immune response is polyclonal and polyspecific, ie, more than one neoepitope on PF4 is recognized by HIT/T antibodies. One such epitope has...

journal_title：Blood

authors： Li ZQ,Liu W,Park KS,Sachais BS,Arepally GM,Cines DB,Poncz M

更新日期：2002-02-15 00:00:00

abstract：:We have identified a small molecular weight compound, SCH 14988, which specifically stimulates in vitro granulocyte-colony stimulating factor (G-CSF) production from activated human peripheral blood mononuclear cells and monocytes but not other cytokines or CSFs with hematoregulatory activity. In vivo administration o...

journal_title：Blood

authors： Fine JS,Cai XY,Justice L,Gommoll CP Jr,Hamilton LD,Waters TA,Narula SK,Bober LA,Grace MJ

更新日期：1997-07-15 00:00:00

abstract：:The role of subendothelial fibronectin in platelet interaction with subendothelium was studied. Human umbilical artery subendothelium was exposed to flowing blood containing 111In-labeled platelets in an annular perfusion chamber. Platelet adhesion was determined from the 111In radioactivity on the vessel wall. When p...

journal_title：Blood

authors： Houdijk WP,Sixma JJ

更新日期：1985-03-01 00:00:00

abstract：:We previously reported the characterization of human osteoclast-associated receptor (hOSCAR), a novel Fc receptor gamma-chain (FcRgamma)-associated receptor expressed by myeloid cells. Here we show that ligation of hOSCAR by specific antibodies promotes dendritic cell (DC) survival by an extracellular signal-regulated...

journal_title：Blood

authors： Merck E,de Saint-Vis B,Scuiller M,Gaillard C,Caux C,Trinchieri G,Bates EE

更新日期：2005-05-01 00:00:00

abstract：:The production and deployment of phagocytes are central functions of the hematopoietic system. In the 1950s, radioisotopic studies demonstrated the high production rate and short lifespan of neutrophils and allowed researchers to follow the monocytes as they moved from the marrow through the blood to become tissue mac...

journal_title：Blood

authors： Dale DC,Boxer L,Liles WC

更新日期：2008-08-15 00:00:00

abstract：:Regulatory T cells (Tregs) down-regulate immunity and are associated with chronic viral infections, suggesting that their inhibition might be used to treat life-threatening diseases. Using the FrCasE mouse retroviral model, we have recently shown that short mAb-based immunotherapies can induce life-long protective imm...

journal_title：Blood

authors： Nasser R,Pelegrin M,Plays M,Gros L,Piechaczyk M

更新日期：2013-02-14 00:00:00

abstract：:Mice lacking all 3 Vav proteins fail to produce significant numbers of recirculating follicular or marginal zone B cells. Those B cells that do mature have shortened lifespans. The constitutive nuclear factor-kappaB (NF-kappaB) activity of resting naive B cells required Vav function and expression of cellular reticulo...

journal_title：Blood

authors： Vigorito E,Gambardella L,Colucci F,McAdam S,Turner M

更新日期：2005-10-01 00:00:00

abstract：:Red cell concentrates (RCC) are stored for 35 to 42 days in plastic containers manufactured with the liquid plasticizer di(2-ethylhexyl)phthalate (DEHP). DEHP leaches from the polyvinylchloride (PVC) plastic bag, then binds to and stabilizes the RC membrane. This study was undertaken to determine the deformability of ...

journal_title：Blood

authors： Labow RS,Card RT,Rock G

更新日期：1987-07-01 00:00:00

abstract：:The effect of granulocyte-macrophage colony stimulatory factors (GM-CSF), acidic isoferritins, and E-type prostaglandins on the detection of the cycle status of human granulocyte-macrophage progenitor cells (CFU-GM) was investigated. Bone marrow cells were pulse-treated with control medium or high specific activity tr...

journal_title：Blood

authors： Broxmeyer HE

更新日期：1982-10-01 00:00:00

abstract：:The EEN (extra eleven nineteen) gene, located on chromosome 19p13, was cloned as a fusion with MLL from a patient with acute myeloid leukemia (AML) with translocation t(11;19)(q23;p13). In this study, we characterized the genomic structure of the EEN gene, including its 5' regulatory region and transcription start sit...

journal_title：Blood

authors： Ma LH,Liu H,Xiong H,Chen B,Zhang XW,Wang YY,Le HY,Huang QH,Zhang QH,Li BL,Chen Z,Chen SJ

更新日期：2007-01-15 00:00:00

abstract：:Annexin V has phospholipid-binding capacity and plays a potent antithrombotic role. Recently, a C to T transition has been described in the Kozak region of this gene, affecting the nucleotide preceding the initiation ATG codon. We have developed a simple method to detect this genetic change, showing by analysis of 580...

journal_title：Blood

authors： González-Conejero R,Corral J,Roldán V,Martínez C,Marín F,Rivera J,Iniesta JA,Lozano ML,Marco P,Vicente V

更新日期：2002-09-15 00:00:00

abstract：:In vitro models of granulopoiesis involving the inducible expression of either CCAAT enhancer binding protein alpha (C/EBP alpha) or C/EBP epsilon in myeloid cells have been shown to lead to the induction of a granulocytic maturation program accompanied by the expression of myeloid-specific genes. Since members of the...

journal_title：Blood

authors： Khanna-Gupta A,Zibello T,Sun H,Gaines P,Berliner N

更新日期：2003-05-01 00:00:00

abstract：:Concurrent activation of the T-cell receptor (TCR) and complement regulator CD46 on human CD4+ T lymphocytes induces Tr1-like regulatory T cells that suppress through IL-10 secretion bystander T-cell proliferation. Here we show that, despite their IL-10 production, CD46-induced T-regulatory T cells (Tregs) do not supp...

journal_title：Blood

authors： Barchet W,Price JD,Cella M,Colonna M,MacMillan SK,Cobb JP,Thompson PA,Murphy KM,Atkinson JP,Kemper C

更新日期：2006-02-15 00:00:00

abstract：:A gamma-chain variant with a lower molecular weight than the normal gamma chain was detected in a new congenital abnormal fibrinogen with impaired polymerization of the fibrin monomer and with normal release of fibrinopeptides A and B in a 45-year-old male. Purified fibrinogen analyzed on SDS-polyacrylamide gel electr...

journal_title：Blood

authors： Yoshida N,Okuma M,Moroi M,Matsuda M

更新日期：1986-09-01 00:00:00

abstract：:SOCS1-/- mice die prematurely of increased interferon-gamma (IFNgamma) signaling with severe thymic atrophy and accelerated maturation of T cells. However, it was unclear whether the thymic defects were caused by SOCS1 deficiency or by increased IFNgamma signaling. Using SOCS1-/- IFNgamma-/- mice, we show in this stud...

journal_title：Blood

authors： Ilangumaran S,Ramanathan S,Ning T,La Rose J,Reinhart B,Poussier P,Rottapel R

更新日期：2003-12-01 00:00:00

abstract：:The pathogenesis of acute painful crisis in children with sickle cell disease is poorly understood; suggested risk factors include sickle cell type, severity of anemia, fetal hemoglobin concentration, and hypoxemia from upper airway obstruction. In a cohort study of 95 patients the relationship between clinical, labor...

journal_title：Blood

authors： Hargrave DR,Wade A,Evans JP,Hewes DK,Kirkham FJ

更新日期：2003-02-01 00:00:00

abstract：:The t(8;21)(q22;q22) is common in adult acute myeloid leukemia (AML). The RUNX1-ETO fusion protein that is expressed by this translocation is poorly leukemogenic and requires additional mutations for transformation. Loss of sex chromosome (LOS) is frequently observed in t(8;21) AML. In the present study, to evaluate w...

journal_title：Blood

authors： Matsuura S,Yan M,Lo MC,Ahn EY,Weng S,Dangoor D,Matin M,Higashi T,Feng GS,Zhang DE

更新日期：2012-03-29 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) is a rare histiocytic neoplasm associated with somatic mutations in the genes involved in the RAF/MEK/extracellular signal-regulated kinase (ERK) signaling pathway. Recently, oncogenic mutations in NRAS/KRAS, upstream regulators of the RAF/MEK/ERK pathway, have been reported in pulm...

journal_title：Blood

authors： Kamata T,Giblett S,Pritchard C

更新日期：2017-07-27 00:00:00

abstract：:Retention of lipoproteins within the vasculature is a central event in the pathogenesis of atherosclerosis. However, the signals that mediate this process are only partially understood. Prompted by putative links between inflammation and atherosclerosis, we previously reported that alpha-defensins released by neutroph...

journal_title：Blood

authors： Bdeir K,Cane W,Canziani G,Chaiken I,Weisel J,Koschinsky ML,Lawn RM,Bannerman PG,Sachais BS,Kuo A,Hancock MA,Tomaszewski J,Raghunath PN,Ganz T,Higazi AA,Cines DB

更新日期：1999-09-15 00:00:00

abstract：:The evolutionarily conserved immune system of the zebrafish (Danio rerio), in combination with its genetic tractability, position it as an excellent model system in which to elucidate the origin and function of vertebrate immune cells. We recently reported the existence of antigen-presenting mononuclear phagocytes in ...

journal_title：Blood

authors： Wittamer V,Bertrand JY,Gutschow PW,Traver D

更新日期：2011-06-30 00:00:00

abstract：:In previous studies, the prevalence of HLA-linked hemochromatosis, thought to be the most common genetic illness in whites, has been estimated by identifying homozygotes in the population. Because not all homozygotes express the disease phenotypically, the accuracy of these estimates is uncertain. We analyzed the dist...

journal_title：Blood

authors： McLaren CE,Gordeuk VR,Looker AC,Hasselblad V,Edwards CQ,Griffen LM,Kushner JP,Brittenham GM

更新日期：1995-09-01 00:00:00

abstract：:Oxidative stress has been implicated in the triggering of apoptosis in neutrophils. Because red blood cells (RBCs) are well known to scavenge oxidants including H2O2, we tested the hypothesis that RBCs inhibit apoptosis of neutrophils by reducing intracellular oxidative stress. Apoptosis of neutrophils was evaluated b...

journal_title：Blood

authors： Aoshiba K,Nakajima Y,Yasui S,Tamaoki J,Nagai A

更新日期：1999-06-01 00:00:00

abstract：:ADAMTS13 proteolytically regulates the platelet-tethering function of von Willebrand factor (VWF). ADAMTS13 function is dependent upon multiple exosites that specifically bind the unraveled VWF A2 domain and enable proteolysis. We carried out a comprehensive functional analysis of the ADAMTS13 cysteine-rich (Cys-rich)...

journal_title：Blood

authors： de Groot R,Lane DA,Crawley JT

更新日期：2015-03-19 00:00:00