Suppressor of cytokine signaling 1 attenuates IL-15 receptor signaling in CD8+ thymocytes.

abstract：:To evaluate the relationship between myeloperoxidase (MPO) gene expression and specific lineages of hematopoietic differentiation, we analyzed expression of the MPO gene in a variety of normal and leukemic human cells. As a first step, we synthesized several oligonucleotide probes and isolated cDNA clones for the MPO ...

journal_title：Blood

authors： Zaki SR,Austin GE,Swan D,Srinivasan A,Ragab AH,Chan WC

更新日期：1989-11-01 00:00:00

abstract：:Mutations within exon 3 of the beta-globin gene are relatively uncommon, and many of these mutations produce a dominant thalassemia-like phenotype. We describe a novel thalassemic hemoglobinopathy caused by a single nucleotide substitution (CTG-->CCG) at codon 114 resulting in a leucine to proline substitution and des...

journal_title：Blood

authors： de Castro CM,Devlin B,Fleenor DE,Lee ME,Kaufman RE

更新日期：1994-02-15 00:00:00

abstract：:Human cord blood progenitor-derived erythroblasts have recently been shown to respond to erythropoietin (Epo) or granulocyte-macrophage colony-stimulating factor (GM-CSF) with a transient increase in intracellular free calcium concentration [Cac]. However, the importance of [Cac] changes in mediating cell proliferatio...

journal_title：Blood

authors： Miller BA,Cheung JY,Tillotson DL,Hope SM,Scaduto RC Jr

更新日期：1989-04-01 00:00:00

abstract：:The Kell blood group is one of the major antigenic systems in human red blood cells. To determine the location of the Kell gene on human chromosomes, panels containing genomic DNA of human-hamster somatic cell hybrids were hybridized with radiolabeled cDNA probe specific for the Kell locus. Only the samples containing...

journal_title：Blood

authors： Lee S,Zambas ED,Marsh WL,Redman CM

更新日期：1993-05-15 00:00:00

abstract：:Leukemia-cell expression of ZAP-70, CD38, or unmutated immunoglobulin heavy chain variable region genes (U-IGHV) each is associated with aggressive disease in patients with chronic lymphocytic leukemia (CLL). To assess the relative strength of each marker, we defined thresholds for designating a case as positive for C...

journal_title：Blood

authors： Rassenti LZ,Jain S,Keating MJ,Wierda WG,Grever MR,Byrd JC,Kay NE,Brown JR,Gribben JG,Neuberg DS,He F,Greaves AW,Rai KR,Kipps TJ

更新日期：2008-09-01 00:00:00

abstract：:The combined blockade of the IL-6R/STAT3 and the MAPK signaling pathways has been shown to inhibit bone marrow microenvironment (BMM)-mediated survival of multiple myeloma (MM) cells. Here, we identify the molecular chaperones heat shock proteins (Hsp) 90alpha and beta as target genes of both pathways. The siRNA-media...

journal_title：Blood

authors： Chatterjee M,Jain S,Stühmer T,Andrulis M,Ungethüm U,Kuban RJ,Lorentz H,Bommert K,Topp M,Krämer D,Müller-Hermelink HK,Einsele H,Greiner A,Bargou RC

更新日期：2007-01-15 00:00:00

abstract：:Pneumonia induced by Gram-negative bacteria is a common and serious disease associated with high morbidity and mortality. Elimination of bacterial pathogens relies on the recruitment and functions of neutrophils. The adhesion molecule L-selectin has recently been implicated in integrin activation in neutrophils (insid...

journal_title：Blood

authors： Cappenberg A,Margraf A,Thomas K,Bardel B,McCreedy DA,Van Marck V,Mellmann A,Lowell CA,Zarbock A

更新日期：2019-10-24 00:00:00

abstract：:Src homology 2 domain-containing phosphatase 2 (Shp2), encoded by Ptpn11, is a member of the nonreceptor protein-tyrosine phosphatase family, and functions in cell survival, proliferation, migration, and differentiation in many tissues. Here we report that loss of Ptpn11 in murine hematopoietic cells leads to bone mar...

journal_title：Blood

authors： Chan G,Cheung LS,Yang W,Milyavsky M,Sanders AD,Gu S,Hong WX,Liu AX,Wang X,Barbara M,Sharma T,Gavin J,Kutok JL,Iscove NN,Shannon KM,Dick JE,Neel BG,Braun BS

更新日期：2011-04-21 00:00:00

abstract：:Cytomegalovirus (CMV) has been a major cause of morbidity and mortality after allogeneic stem cell transplantation (SCT). The importance of the recipient's serologic status is paramount. However, the importance of the donor's serologic status in CMV-seropositive recipients is controversial. We analyzed the influence o...

journal_title：Blood

authors： Ljungman P,Brand R,Einsele H,Frassoni F,Niederwieser D,Cordonnier C

更新日期：2003-12-15 00:00:00

abstract：:Outgrowth, long-term self-renewal, and terminal maturation of human erythroid progenitors derived from umbilical cord blood in serum-free medium can be modulated by steroid hormones. Homogeneous erythroid cultures, as characterized by flow cytometry and dependence on a specific mixture of physiologic proliferation fac...

journal_title：Blood

authors： Leberbauer C,Boulmé F,Unfried G,Huber J,Beug H,Müllner EW

更新日期：2005-01-01 00:00:00

abstract：:From ten patients with advanced malignant disease involving the bone marrow, autologous hematopoietic stem cells were collected from the peripheral blood during eight four-hour pheresis procedures and cryopreserved. No manipulations to increase the number of stem cells circulating in the blood were used during the col...

journal_title：Blood

authors： Kessinger A,Armitage JO,Landmark JD,Smith DM,Weisenburger DD

更新日期：1988-03-01 00:00:00

abstract：:Latency enables human cytomegalovirus (HCMV) to persist in the hematopoietic cells of infected individuals indefinitely and prevents clearance of the pathogen. Despite its critical importance to the viral infectious cycle, viral mechanisms that contribute to latency have not been identified. We compared the ability of...

journal_title：Blood

authors： Goodrum F,Reeves M,Sinclair J,High K,Shenk T

更新日期：2007-08-01 00:00:00

abstract：:The extended (E) isoform unique to Fibrinogen420 (Fib420) is distinguished from the conventional chain of Fibrinogen340 by the presence of an additional 236-residue carboxyl terminus globular domain (EC). A recombinant form of EC (rEC), having a predicted mass of 27,653 Daltons, was expressed in yeast (Pichia pastoris...

journal_title：Blood

authors： Applegate D,Haraga L,Hertzberg KM,Steben LS,Zhang JZ,Redman CM,Grieninger G

更新日期：1998-11-15 00:00:00

abstract：:NKG2D is an activation receptor that allows natural killer (NK) cells to detect diseased host cells. The engagement of NKG2D with corresponding ligand results in surface modulation of the receptor and reduced function upon subsequent receptor engagement. However, it is not clear whether in addition to modulation the N...

journal_title：Blood

authors： Coudert JD,Zimmer J,Tomasello E,Cebecauer M,Colonna M,Vivier E,Held W

更新日期：2005-09-01 00:00:00

abstract：:Hermansky-Pudlak syndrome (HPS) is an inherited hemorrhagic disease affecting the related subcellular organelles platelet dense granules, lysosomes, and melanosomes. The mouse genes for HPS, pale ear and pearl, orthologous to the human HPS1 and HPS2 (ADTB3A) genes, encode a novel protein of unknown function and the be...

journal_title：Blood

authors： Feng L,Novak EK,Hartnell LM,Bonifacino JS,Collinson LM,Swank RT

更新日期：2002-03-01 00:00:00

abstract：:Forty-nine patients with primary myelodysplastic syndromes (MDS) were subclassified according to French-American-British (FAB) Cooperative Group criteria. Eight patients had acquired idiopathic sideroblastic anemia (AISA), ten had chronic myelomonocytic leukemia (CMMoL), 14 had refractory anemia (RA), nine had refract...

journal_title：Blood

authors： Jacobs RH,Cornbleet MA,Vardiman JW,Larson RA,Le Beau MM,Rowley JD

更新日期：1986-06-01 00:00:00

abstract：:The selectins are lectin-like cell surface glycoproteins that have been implicated in playing a crucial role in the initiation of leukocyte adhesion to endothelial cells (ECs) during inflammation. Binding of selectins under conditions of flow mediates leukocyte rolling, which in vivo is almost exclusively observed in ...

journal_title：Blood

authors： Olofsson AM,Arfors KE,Ramezani L,Wolitzky BA,Butcher EC,von Andrian UH

更新日期：1994-10-15 00:00:00

abstract：:In this report, we show that the Src family nonreceptor protein tyrosine kinase (PTK) Lyn associates with aggregated IgA Fc receptor (Fc alpha R) in the monocytic cell line THP-1. Receptor aggregation and subsequent immunoprecipitation of receptor complexes with huIgA adsorbed to nitrocellulose particles shows that Ly...

journal_title：Blood

authors： Gulle H,Samstag A,Eibl MM,Wolf HM

更新日期：1998-01-15 00:00:00

abstract：:Approximately 30% to 40% of patients with acute leukemia receiving repeated pooled random-donor platelet transfusions develop anti-HLA alloantibodies. Over time, however, serum anti-HLA concentrations decrease in approximately 50% of these patients, despite continued exposure to platelet and/or red blood cell transfus...

journal_title：Blood

authors： Atlas E,Freedman J,Blanchette V,Kazatchkine MD,Semple JW

更新日期：1993-01-15 00:00:00

abstract：:Monitoring unfractionated heparin (UFH) is crucial to prevent over- or under-anticoagulation. However, the optimal parameters for monitoring UFH in children are not well established. The study objectives were to investigate (1) the relationship between UFH dose and its anticoagulant effect as assessed by anti-Xa, acti...

journal_title：Blood

authors： Hanslik A,Kitzmüller E,Tran US,Thom K,Karapetian H,Prutsch N,Voitl J,Michel-Behnke I,Newall F,Male C

更新日期：2015-10-29 00:00:00

abstract：:Regulatory T (Treg) cells contribute to immune evasion by malignancies. To investigate their importance in non-Hodgkin lymphoma (NHL), we enumerated Treg cells in peripheral blood mononuclear cells (PBMCs) and involved tissues from 30 patients. CD25(+)FoxP3(+)CD127(low)CD4(+) Treg cells were increased markedly in PBMC...

journal_title：Blood

authors： Mittal S,Marshall NA,Duncan L,Culligan DJ,Barker RN,Vickers MA

更新日期：2008-06-01 00:00:00

abstract：:We investigated the functions of adiponectin, an adipocyte-specific secretory protein and a new member of the family of soluble defense collagens, in hematopoiesis and immune responses. Adiponectin suppressed colony formation from colony-forming units (CFU)-granulocyte-macrophage, CFU-macrophage, and CFU-granulocyte, ...

journal_title：Blood

authors： Yokota T,Oritani K,Takahashi I,Ishikawa J,Matsuyama A,Ouchi N,Kihara S,Funahashi T,Tenner AJ,Tomiyama Y,Matsuzawa Y

更新日期：2000-09-01 00:00:00

abstract：:Development of acute graft-versus-host disease (aGVHD) predisposes to chronic GVHD with autoimmune manifestations. A characteristic of experimental aGVHD is the de novo generation of autoreactive T cells. Central tolerance is dependent on the intrathymic expression of tissue-restricted peripheral self-antigens (TRA), ...

journal_title：Blood

authors： Dertschnig S,Nusspaumer G,Ivanek R,Hauri-Hohl MM,Holländer GA,Krenger W

更新日期：2013-08-01 00:00:00

abstract：:MicroRNAs (miRNAs) have emerged as important regulators of the immune system. However, despite this prominence, our understanding of the function of miRNAs in the early hematopoietic stages is incomplete. In this study, we found that miR-139-5p negatively regulated the proliferation of hematopoietic stem cells and pro...

journal_title：Blood

authors： Choi J,Kim YK,Park K,Nah J,Yoon SS,Kim DW,Kim VN,Seong RH

更新日期：2016-10-27 00:00:00

abstract：:Dosing of enzyme replacement therapy (ERT) for Gaucher disease type 1 is still a subject of debate and varies from 15 to 130 U/kg/mo, making a huge economic difference of 70,000 US dollars to 380,000 US dollars(euro55,000-300,000) per patient per year. To investigate whether this difference in dosing ultimately transl...

journal_title：Blood

authors： de Fost M,Hollak CE,Groener JE,Aerts JM,Maas M,Poll LW,Wiersma MG,Häussinger D,Brett S,Brill N,vom Dahl S

更新日期：2006-08-01 00:00:00

abstract：:The causes of anemia and immunosuppression, major outcomes of malaria, are not well established. This study was undertaken to investigate whether erythropoietin (EP) production is adequate and whether the hemopoietic stem cells (CFU-S) were affected during the course of infection. Groups of female Balb/c mice infected...

journal_title：Blood

authors： Silverman PH,Schooley JC,Mahlmann LJ

更新日期：1987-02-01 00:00:00

abstract：:Autoimmune lymphoproliferative syndrome (ALPS) is characterized by childhood onset of lymphadenopathy, hepatosplenomegaly, autoimmune cytopenias, elevated numbers of double-negative T (DNT) cells, and increased risk of lymphoma. Most cases of ALPS are associated with germline mutations of the FAS gene (type Ia), where...

journal_title：Blood

authors： Dowdell KC,Niemela JE,Price S,Davis J,Hornung RL,Oliveira JB,Puck JM,Jaffe ES,Pittaluga S,Cohen JI,Fleisher TA,Rao VK

更新日期：2010-06-24 00:00:00

abstract：:Factor XIII is the fibrin-stabilizing factor that covalently cross-links fibrin monomers to form a highly organized, stable fibrin clot. The plasma form of factor XIII is a heterodimer, a2b2, consisting of two a-chains and two b-chains; the intracellular form, such as in platelets and placenta, is a dimer, a2, consist...

journal_title：Blood

authors： Weisberg LJ,Shiu DT,Conkling PR,Shuman MA

更新日期：1987-08-01 00:00:00

abstract：:Hydroxyl radical generation was demonstrated during heme-catalyzed decomposition of 15-hydroperoxy arachidonic acid. The hydroperoxide-mediated inactivation of prostacyclin synthetase seems to be related to the generation of this highly reactive species. A relationship between hydroperoxides and the hydroxyl radical m...

journal_title：Blood

authors： Weiss SJ,Turk J,Needleman P

更新日期：1979-06-01 00:00:00

abstract：:Natural killer cells (NK) were studied to determine factors important in their expansion. Flourescence-activated cell sorter (FACS) purified CD56+/CD3- NK cells cultured alone for 18 days in rIL-2 containing medium (1,000 U/mL) showed enhanced cytotoxicity but only minimal expansion. NK expansion was increased (12.5 +...

journal_title：Blood

authors： Pierson BA,Gupta K,Hu WS,Miller JS

更新日期：1996-01-01 00:00:00