Prognostic implications of morphology and karyotype in primary myelodysplastic syndromes.

Abstract:

:Forty-nine patients with primary myelodysplastic syndromes (MDS) were subclassified according to French-American-British (FAB) Cooperative Group criteria. Eight patients had acquired idiopathic sideroblastic anemia (AISA), ten had chronic myelomonocytic leukemia (CMMoL), 14 had refractory anemia (RA), nine had refractory anemia with excess blasts (RAEB), and five had refractory anemia with excess blasts in transformation (RAEB-T); three patients could not be subclassified. The actuarial median survival for patients with AISA or with RA had not been reached at 60 months of follow-up. The median survival times for patients with CMMoL, RAEB, and RAEB-T were 25, 21, and 16 months, respectively. The percentages of patients with each subtype who developed ANLL were none in AISA, 20% in CMMoL, 7% in RA, 56% in RAEB, and 40% in RAEB-T. Patients with CMMoL had a poor prognosis independent of transformation to acute nonlymphocytic leukemia (ANLL), whereas patients with RAEB and RAEB-T had a high incidence of transformation and short survival times. Clonal chromosomal abnormalities were present in bone marrow cells from 19 patients at the time of diagnosis, and two others developed an abnormal karyotype at the time of leukemic transformation. The most frequent abnormalities, including initial and evolutionary changes, were trisomy 8 (9 patients), deletion of 5q (4 patients), and deletion of 20q (4 patients). The median survival times were 32 months for patients with an abnormal karyotype, and 48 months for those with a normal karyotype (P = 0.2). Specific chromosomal abnormalities were not associated with particular histologic subtypes; however, a high percentage of patients with RAEB and RAEB-T had an abnormal clone (89% and 80%, respectively). The percentages of patients with clonal abnormalities were 13% for AISA, 20% for CMMoL, and 29% for RA. The MDS transformed to ANLL in 42% of patients with an abnormal karyotype, compared to 10% of those with an initially normal karyotype (P less than .01). Among patients with RA, RAEB, and RAEB-T, the risk of leukemic transformation was confined to those with an abnormal karyotype (P less than .01). Thus, in the present study, morphology and karyotype combined were the best indicators of outcome in patients with MDS.

journal_name

Blood

journal_title

Blood

authors

Jacobs RH,Cornbleet MA,Vardiman JW,Larson RA,Le Beau MM,Rowley JD

subject

Has Abstract

pub_date

1986-06-01 00:00:00

pages

1765-72

issue

6

eissn

0006-4971

issn

1528-0020

journal_volume

67

pub_type

杂志文章

相关文献

BLOOD文献大全
  • Erythropoietin alone induces erythroid burst formation by human embryonic but not adult BFU-E in unicellular serum-free culture.

    abstract::Erythroid progenitors (BFU-E) from adult human peripheral blood generate erythroid bursts in semisolid culture supplemented with at least two growth factors, ie, erythropoietin (Ep) and interleukin-3 (IL-3) or granulocyte-macrophage colony-stimulating factor (GM-CSF). We have analyzed the hematopoietin(s) requirement ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Valtieri M,Gabbianelli M,Pelosi E,Bassano E,Petti S,Russo G,Testa U,Peschle C

    更新日期:1989-07-01 00:00:00

  • Allogeneic peripheral blood progenitor cell transplantation in a murine model: evidence for an improved graft-versus-leukemia effect.

    abstract::Peripheral blood progenitor cells (PBPCs) are increasingly being used to replace bone marrow cells (BMCs) as a source of hematopoietic stem cells also in the field of allogeneic transplantation. Whereas it is well known that PBPC grafts and BM differ significantly in progenitor cell content and lymphocyte dose, the cl...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Glass B,Uharek L,Zeis M,Dreger P,Löffler H,Steinmann J,Schmitz N

    更新日期:1997-08-15 00:00:00

  • Incidence of the myelodysplastic syndromes using a novel claims-based algorithm: high number of uncaptured cases by cancer registries.

    abstract::The myelodysplastic syndromes (MDSs) are hematologically diverse hematopoietic stem cell malignancies primarily affecting older individuals. The incidence of MDS in the United States is estimated at 3.3 per 100 000; however, evidence suggests underreporting of MDS to centralized cancer registries. Contrary to clinical...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2011-02-337964

    authors: Cogle CR,Craig BM,Rollison DE,List AF

    更新日期:2011-06-30 00:00:00

  • Prothrombin activation in blood coagulation: the erythrocyte contribution to thrombin generation.

    abstract::Prothrombin activation can proceed through the intermediates meizothrombin or prethrombin-2. To assess the contributions that these 2 intermediates make to prothrombin activation in tissue factor (Tf)-activated blood, immunoassays were developed that measure the meizothrombin antithrombin (mTAT) and α-thrombin antithr...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2012-05-427856

    authors: Whelihan MF,Zachary V,Orfeo T,Mann KG

    更新日期:2012-11-01 00:00:00

  • Developmental differences in megakaryocytopoiesis are associated with up-regulated TPO signaling through mTOR and elevated GATA-1 levels in neonatal megakaryocytes.

    abstract::Multiple observations support the existence of developmental differences in megakaryocytopoiesis. We have previously shown that neonatal megakaryocyte (MK) progenitors are hyperproliferative and give rise to MKs smaller and of lower ploidy than adult MKs. Based on these characteristics, neonatal MKs have been consider...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2010-07-293092

    authors: Liu ZJ,Italiano J Jr,Ferrer-Marin F,Gutti R,Bailey M,Poterjoy B,Rimsza L,Sola-Visner M

    更新日期:2011-04-14 00:00:00

  • Platelet size in man.

    abstract::The shape and parameters of platelet size distributions were studied in 50 normal persons and 97 patients in order to test the proposed thesis that platelet size heterogeneity results mainly from aging in the circulation. This thesis was contradicted (1) by size distributions of age-homogeneous, newly-born cell popula...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Paulus JM

    更新日期:1975-09-01 00:00:00

  • Nbeal2 interacts with Dock7, Sec16a, and Vac14.

    abstract::Mutations in NBEAL2, the gene encoding the scaffolding protein Nbeal2, are causal of gray platelet syndrome (GPS), a rare recessive bleeding disorder characterized by platelets lacking α-granules and progressive marrow fibrosis. We present here the interactome of Nbeal2 with additional validation by reverse immunoprec...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2017-08-800359

    authors: Mayer L,Jasztal M,Pardo M,Aguera de Haro S,Collins J,Bariana TK,Smethurst PA,Grassi L,Petersen R,Nurden P,Favier R,Yu L,Meacham S,Astle WJ,Choudhary J,Yue WW,Ouwehand WH,Guerrero JA

    更新日期:2018-03-01 00:00:00

  • Bleomycin in older early-stage favorable Hodgkin lymphoma patients: analysis of the German Hodgkin Study Group (GHSG) HD10 and HD13 trials.

    abstract::Doxorubicin, bleomycin, vinblastine sulfate, and dacarbazine (ABVD) is associated with severe toxicity in older patients, particularly from bleomycin-induced lung toxicity (BLT). Therefore, using bleomycin has been questioned in older Hodgkin lymphoma (HL) patients, especially in early-stage HL. We therefore analyzed ...

    journal_title:Blood

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1182/blood-2015-11-681064

    authors: Böll B,Goergen H,Behringer K,Bröckelmann PJ,Hitz F,Kerkhoff A,Greil R,von Tresckow B,Eichenauer DA,Bürkle C,Borchmann S,Fuchs M,Diehl V,Engert A,Borchmann P

    更新日期:2016-05-05 00:00:00

  • Molecular determinants of clinical expression of hereditary elliptocytosis and pyropoikilocytosis.

    abstract::The clinical severity of common hereditary elliptocytosis (HE) is highly variable, ranging from an asymptomatic carrier state to a severe hemolytic anemia. To elucidate the molecular basis of this variable clinical expression, we evaluated 56 subjects from 24 HE kindred, who carry alpha spectrin mutants characterized ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Coetzer T,Lawler J,Prchal JT,Palek J

    更新日期:1987-09-01 00:00:00

  • Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF.

    abstract::Fibrinogen, coagulation factor VII (FVII), and factor VIII (FVIII) and its carrier von Willebrand factor (vWF) play key roles in hemostasis. Previously identified common variants explain only a small fraction of the trait heritabilities, and additional variations may be explained by associations with rarer variants wi...

    journal_title:Blood

    pub_type: 杂志文章,meta分析

    doi:10.1182/blood-2015-02-624551

    authors: Huffman JE,de Vries PS,Morrison AC,Sabater-Lleal M,Kacprowski T,Auer PL,Brody JA,Chasman DI,Chen MH,Guo X,Lin LA,Marioni RE,Müller-Nurasyid M,Yanek LR,Pankratz N,Grove ML,de Maat MP,Cushman M,Wiggins KL,Qi L,Sennb

    更新日期:2015-09-10 00:00:00

  • Single nucleotide polymorphisms and outcome risk in unrelated mismatched hematopoietic stem cell transplantation: an exploration study.

    abstract::Genetic risk factors contribute to adverse outcome of hematopoietic stem cell transplantation (HSCT). Mismatching of the HLA complex most strongly determines outcomes, whereas non-HLA genetic polymorphisms are also having an impact. Although the majority of HSCTs are mismatched, only few studies have investigated the ...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2012-01-406785

    authors: Harkensee C,Oka A,Onizuka M,Middleton PG,Inoko H,Hirayasu K,Kashiwase K,Yabe T,Nakaoka H,Gennery AR,Ando K,Morishima Y,Japan Marrow Donor Program.

    更新日期:2012-06-28 00:00:00

  • Follicular helper T-cell-related lymphomas.

    abstract::In this issue of Blood, Wang et al describe the occurrence and pathogenetic relevance of IDH2R172 mutations in angioimmunoblastic T-cell lymphoma (AITL). ...

    journal_title:Blood

    pub_type: 评论,杂志文章

    doi:10.1182/blood-2015-08-665075

    authors: Pileri SA

    更新日期:2015-10-08 00:00:00

  • Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function.

    abstract::Pathologic blood clotting is a leading cause of morbidity and mortality in the developed world, underlying deep vein thrombosis, myocardial infarction, and stroke. Genetic predisposition to thrombosis is still poorly understood, and we hypothesize that there are many additional risk alleles and modifying factors remai...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2014-03-561027

    authors: Liu Y,Kretz CA,Maeder ML,Richter CE,Tsao P,Vo AH,Huarng MC,Rode T,Hu Z,Mehra R,Olson ST,Joung JK,Shavit JA

    更新日期:2014-07-03 00:00:00

  • Enhanced immune activity of cytotoxic T-lymphocyte epitope analogs derived from positional scanning synthetic combinatorial libraries.

    abstract::The pp65(495-503) cytotoxic T-lymphocyte (CTL) epitope from cytomegalovirus (CMV) is universally recognized among CMV+ individuals who express an allele of the human leukocyte antigen A (HLA-A*0201). The relative binding affinity of the epitope to HLA-A*0201 is moderate, and its increased activity might prove benefici...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood.v97.6.1776

    authors: La Rosa C,Krishnan R,Markel S,Schneck JP,Houghten R,Pinilla C,Diamond DJ

    更新日期:2001-03-15 00:00:00

  • Molecular mechanism of transforming growth factor beta-mediated cell-cycle modulation in primary human CD34(+) progenitors.

    abstract::The mechanisms by which transforming growth factor beta (TGF-beta) exerts a negative effect on cell-cycle entry in primary human hematopoietic stem/progenitor cells were examined at the molecular and cellular levels. After treatment of primary human CD34+ progenitors with TGF-beta there was a decrease in the levels of...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood.v99.2.499

    authors: Dao MA,Hwa J,Nolta JA

    更新日期:2002-01-15 00:00:00

  • Cross talk between neutrophils and the microbiota.

    abstract::The microbiota has emerged as an important regulator of the host immunity by the induction, functional modulation, or suppression of local and systemic immune responses. In return, the host immune system restricts translocation and fine tunes the composition and distribution of the microbiota to maintain a beneficial ...

    journal_title:Blood

    pub_type: 杂志文章,评审

    doi:10.1182/blood-2018-11-844555

    authors: Zhang D,Frenette PS

    更新日期:2019-05-16 00:00:00

  • Mast cell number in the skin of heterozygotes reflects the molecular nature of c-kit mutation.

    abstract::The W locus of mice encodes the c-kit receptor tyrosine kinase. Heterozygous WJic/+ and Wn/+ mice and homozygous Wf/Wf mice were similar in appearance; all of them have large depigmented areas lacking any well-defined pattern. The WJic, Wn, and Wf mutant alleles were characterized and their molecular nature was correl...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Tsujimura T,Koshimizu U,Katoh H,Isozaki K,Kanakura Y,Tono T,Adachi S,Kasugai T,Tei H,Nishimune Y

    更新日期:1993-05-15 00:00:00

  • Sustained phenotypic correction of canine hemophilia A using an adeno-associated viral vector.

    abstract::Gene therapy for hemophilia A requires efficient delivery of the factor VIII gene and sustained protein expression at circulating levels of at least 1% to 2% of normal. Adeno-associated viral type 2 (AAV2) vectors have a number of advantages over other viral vectors, including an excellent safety profile and persisten...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2003-01-0292

    authors: Scallan CD,Lillicrap D,Jiang H,Qian X,Patarroyo-White SL,Parker AE,Liu T,Vargas J,Nagy D,Powell SK,Wright JF,Turner PV,Tinlin SJ,Webster SE,McClelland A,Couto LB

    更新日期:2003-09-15 00:00:00

  • RNA-transfected CD40-activated B cells induce functional T-cell responses against viral and tumor antigen targets: implications for pediatric immunotherapy.

    abstract::Vaccination with antigen-presenting cells (APCs) engineered to mimic mechanisms of immune stimulation represents a promising approach for cancer immunotherapy. Dendritic cell vaccines have entered phase 3 testing in adult malignancies, but such vaccines in children have been limited. We demonstrate that CD40-activated...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2003-07-2379

    authors: Coughlin CM,Vance BA,Grupp SA,Vonderheide RH

    更新日期:2004-03-15 00:00:00

  • Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia.

    abstract::CRLF2 rearrangements, JAK1/2 point mutations, and JAK2 fusion genes have been identified in Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL), a recently described subtype of pediatric high-risk B-precursor ALL (B-ALL) which exhibits a gene expression profile similar to Ph-positive ALL and has a poo...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2012-03-415448

    authors: Maude SL,Tasian SK,Vincent T,Hall JW,Sheen C,Roberts KG,Seif AE,Barrett DM,Chen IM,Collins JR,Mullighan CG,Hunger SP,Harvey RC,Willman CL,Fridman JS,Loh ML,Grupp SA,Teachey DT

    更新日期:2012-10-25 00:00:00

  • Bcl-2 protein expression is the strongest independent prognostic factor of survival in primary cutaneous large B-cell lymphomas.

    abstract::Bcl-2 protein expression has been associated with poor prognosis in patients with noncutaneous diffuse large B-cell lymphomas. In primary cutaneous large B-cell lymphomas, the location on the leg, the round-cell morphology defined as the predominance of centroblasts and immunoblasts over large centrocytes, and multipl...

    journal_title:Blood

    pub_type: 杂志文章,多中心研究

    doi:10.1182/blood-2003-08-2726

    authors: Grange F,Petrella T,Beylot-Barry M,Joly P,D'Incan M,Delaunay M,Machet L,Avril MF,Dalac S,Bernard P,Carlotti A,Esteve E,Vergier B,Dechelotte P,Cassagnau E,Courville P,Saiag P,Laroche L,Bagot M,Wechsler J

    更新日期:2004-05-15 00:00:00

  • Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: remission induction, follow-up, and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patients.

    abstract::Fifty-eight acute promyelocytic leukemia (APL) patients (11 newly diagnosed and 47 relapsed) were studied for arsenic trioxide (As2O3) treatment. Clinical complete remission (CR) was obtained in 8 of 11 (72.7%) newly diagnosed cases. However, As2O3 treatment resulted in hepatic toxicity in 7 cases including 2 deaths, ...

    journal_title:Blood

    pub_type: 临床试验,杂志文章

    doi:

    authors: Niu C,Yan H,Yu T,Sun HP,Liu JX,Li XS,Wu W,Zhang FQ,Chen Y,Zhou L,Li JM,Zeng XY,Yang RR,Yuan MM,Ren MY,Gu FY,Cao Q,Gu BW,Su XY,Chen GQ,Xiong SM,Zhang TD,Waxman S,Wang ZY,Chen Z,Hu J,Shen ZX,Chen SJ

    更新日期:1999-11-15 00:00:00

  • Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire.

    abstract::The human peripheral B-cell compartment displays a large population of immunoglobulin M-positive, immunoglobulin D-positive CD27(+) (IgM(+)IgD(+)CD27(+)) "memory" B cells carrying a mutated immunoglobulin receptor. By means of phenotypic analysis, complementarity-determining region 3 (CDR3) spectratyping during a T-in...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2004-01-0346

    authors: Weller S,Braun MC,Tan BK,Rosenwald A,Cordier C,Conley ME,Plebani A,Kumararatne DS,Bonnet D,Tournilhac O,Tchernia G,Steiniger B,Staudt LM,Casanova JL,Reynaud CA,Weill JC

    更新日期:2004-12-01 00:00:00

  • Deregulation of microRNA involved in hematopoiesis and the immune response in HTLV-I adult T-cell leukemia.

    abstract::Human T-cell leukemia virus type-I (HTLV-I) is the etiologic agent of adult T-cell leukemia (ATL), an aggressive lymphoproliferative disease. MicroRNAs (miRNAs) are differentially expressed during hematopoiesis and lineage commitment of hematopoietic stem cell progenitors (HSCPs). Here, we report aberrant expression o...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2008-11-189845

    authors: Bellon M,Lepelletier Y,Hermine O,Nicot C

    更新日期:2009-05-14 00:00:00

  • Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants. Killer immunoglobulin-like receptor.

    abstract::One of the functions of HLA class I alleles is interaction with natural killer (NK) cells. Receptors termed killer immunoglobulin-like receptors (KIRs) on NK cells recognize groups of HLA class I alleles, and interaction between receptor and class I allele inhibits reactivity of the NK cell. Failure to recognize the a...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2002-04-1197

    authors: Davies SM,Ruggieri L,DeFor T,Wagner JE,Weisdorf DJ,Miller JS,Velardi A,Blazar BR

    更新日期:2002-11-15 00:00:00

  • Plasma levels of beta-thromboglobulin and platelet factor 4 as indices of platelet activation in vivo.

    abstract::Measurement of plasma levels of two secreted platelet proteins (beta-thromboglobulin and platelet factor 4) has been suggested as a means for detecting increased platelet activation in vivo. A crucial question in the measurement is the distinction between in vivo and in vitro secretion of the proteins. One approach to...

    journal_title:Blood

    pub_type: 杂志文章,评审

    doi:

    authors: Kaplan KL,Owen J

    更新日期:1981-02-01 00:00:00

  • Colony-stimulating factor-1-induced oscillations in phosphatidylinositol-3 kinase/AKT are required for caspase activation in monocytes undergoing differentiation into macrophages.

    abstract::The differentiation of human peripheral blood monocytes into resident macrophages is driven by colony-stimulating factor-1 (CSF-1), which upon interaction with CSF-1 receptor (CSF-1R) induces within minutes the phosphorylation of its cytoplasmic tyrosine residues and the activation of multiple signaling complexes. Cas...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2009-03-208843

    authors: Jacquel A,Benikhlef N,Paggetti J,Lalaoui N,Guery L,Dufour EK,Ciudad M,Racoeur C,Micheau O,Delva L,Droin N,Solary E

    更新日期:2009-10-22 00:00:00

  • Role of arginine residues in the coagulant activity of high molecular weight kininogen.

    abstract::High molecular weight (HMW) kininogen, the cofactor for activation of the contact system of plasma proteolysis, transports and optimally positions prekallikrein and factor XI on a negatively charged surface, allowing those zymogens to be activated by surface-bound factor XIIa. HMW kininogen circulates in plasma as a p...

    journal_title:Blood

    pub_type: 杂志文章

    doi:

    authors: Chang JJ,Scott CF,Colman RW

    更新日期:1986-03-01 00:00:00

  • New transgenic evidence for a system of sympathetic axons able to express tissue plasminogen activator (t-PA) within arterial/arteriolar walls.

    abstract::Sympathetic axons embedded in a few arterioles and vasa vasora were recently shown to store tissue plasminogen activator (t-PA) in vesicles. But the extension of such t-PA axons to arteries and arterioles throughout the organism has not been verified. Confirmation of this anatomy would identify a second significant so...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2005-12-4884

    authors: Hao Z,Guo C,Jiang X,Krueger S,Pietri T,Dufour S,Cone RE,O'Rourke J

    更新日期:2006-07-01 00:00:00

  • Characteristics and outcomes of patients with chronic myeloid leukemia and T315I mutation following failure of imatinib mesylate therapy.

    abstract::Chronic myeloid leukemia (CML) with T315I mutation has been reported to have poor prognosis. We analyzed 27 patients with T315I, including 20 who developed T315I after imatinib failure (representing 11% of 186 patients with imatinib failure), and 7 of 23 who developed new mutations after second tyrosine kinase inhibit...

    journal_title:Blood

    pub_type: 杂志文章

    doi:10.1182/blood-2007-11-123950

    authors: Jabbour E,Kantarjian H,Jones D,Breeden M,Garcia-Manero G,O'Brien S,Ravandi F,Borthakur G,Cortes J

    更新日期:2008-07-01 00:00:00