Abstract:
:MicroRNAs (miRNAs) have emerged as important regulators of the immune system. However, despite this prominence, our understanding of the function of miRNAs in the early hematopoietic stages is incomplete. In this study, we found that miR-139-5p negatively regulated the proliferation of hematopoietic stem cells and progenitor cells and that downregulation of miR-139-5p expression was associated with hematopoietic malignancy, such as chronic myeloid leukemia (CML). Knockdown of miR-139-5p resulted in myeloid-biased differentiation with expansion of myeloid progenitor cells. In contrast, miR-139-5p expression inhibited the proliferation of hematopoietic progenitors and resulted in the remission of a CML-like disease that is induced by breakpoint cluster region-Abelson (BCR-ABL) transformation. We also found that Brg1 is a functional target of miR-139-5p and that Brg1 is involved in BCR-ABL-induced leukemogenesis. Thus, our results identify miR-139-5p as a key regulator of cellular proliferation during early hematopoiesis and suggest that it is a potent antileukemic molecule.
journal_name
Bloodjournal_title
Bloodauthors
Choi J,Kim YK,Park K,Nah J,Yoon SS,Kim DW,Kim VN,Seong RHdoi
10.1182/blood-2016-02-702464subject
Has Abstractpub_date
2016-10-27 00:00:00pages
2117-2129issue
17eissn
0006-4971issn
1528-0020pii
blood-2016-02-702464journal_volume
128pub_type
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