The human Kell blood group gene maps to chromosome 7q33 and its expression is restricted to erythroid cells.

abstract：:To elucidate the role of retinoic acid (RA) in anti-CD40 + interleukin-4 (IL-4)-mediated B-cell activation, the effect of 10(-12) to 10(-6) mol/L RA was studied in anti-CD40 (1 microgram/mL) + IL-4 (5 ng/mL)-mediated proliferation and Ig synthesis by human peripheral blood mononuclear cells (PBMC) and B cells in healt...

journal_title：Blood

authors： Worm M,Krah JM,Manz RA,Henz BM

更新日期：1998-09-01 00:00:00

abstract：:Characterization of lymphocytes including B cells during early versus chronic HIV infection is important for understanding the impact of chronic viremia on immune cell function. In this setting, we investigated B cells before and after reduction of HIV plasma viremia by antiretroviral therapy (ART). At baseline, perip...

journal_title：Blood

authors： Moir S,Buckner CM,Ho J,Wang W,Chen J,Waldner AJ,Posada JG,Kardava L,O'Shea MA,Kottilil S,Chun TW,Proschan MA,Fauci AS

更新日期：2010-12-16 00:00:00

abstract：:Transplantation-associated thrombotic microangiopathy (TA-TMA) is a challenging diagnosis after hematopoietic stem cell transplantation. Although endothelial injury represents the final common pathway of disease, the exact pathophysiology of TA-TMA remains unclear. Potential causes include infections, chemotherapy, ra...

journal_title：Blood

authors： Laskin BL,Goebel J,Davies SM,Jodele S

更新日期：2011-08-11 00:00:00

abstract：:Interleukin 21 (IL-21) is a newly described cytokine with homology to IL-4 and IL-15. They belong to a cytokine family that uses the common gamma chain for signaling but also have their private high-affinity receptors. Since it is well known that IL-4 modulates differentiation and activation of dendritic cells (DCs), ...

journal_title：Blood

authors： Brandt K,Bulfone-Paus S,Foster DC,Rückert R

更新日期：2003-12-01 00:00:00

abstract：:It is difficult to imagine a greater challenge to the transplantation of haploidentical cells than thalassemia. ...

journal_title：Blood

authors： Woolfrey A

更新日期：2010-02-11 00:00:00

abstract：:We have investigated the hormonal responsiveness of K562 cells using a serum-substituted in vitro clonogenic assay. Dexamethasone inhibited colony formation by the K562 cells, and the inhibitory effect could be reversed by progesterone (10(-6) M). Fluoxymesterone caused a prominent enhancement of K562 colony growth, w...

journal_title：Blood

authors： Gauwerky C,Golde DW

更新日期：1980-11-01 00:00:00

abstract：:We examined the prevalence and prognostic relevance of bone marrow reticulin fibrosis in 526 patients with World Health Organization-defined polycythemia vera evaluated at the time of initial diagnosis. Seventy-four patients (14%) displayed mostly grade 1 reticulin fibrosis, with only 2 cases showing higher-grade fibr...

journal_title：Blood

authors： Barbui T,Thiele J,Passamonti F,Rumi E,Boveri E,Randi ML,Bertozzi I,Marino F,Vannucchi AM,Pieri L,Rotunno G,Gisslinger H,Gisslinger B,Müllauer L,Finazzi G,Carobbio A,Gianatti A,Ruggeri M,Nichele I,D'Amore E,Rambald

更新日期：2012-03-08 00:00:00

abstract：:We conducted a prospective randomized trial to evaluate the ability of the interleukin-3/granulocyte-macrophage colony-stimulating factor (GM-CSF) fusion protein, PIXY321, to ameliorate cumulative thrombocytopenia after multiple cycles of 5-fluorouracil, leucovorin, doxorubicin, cyclophosphamide (FLAC) chemotherapy co...

journal_title：Blood

authors： O'Shaughnessy JA,Tolcher A,Riseberg D,Venzon D,Zujewski J,Noone M,Gossard M,Danforth D,Jacobson J,Chang V,Goldspiel B,Keegan P,Giusti R,Cowan KH

更新日期：1996-03-15 00:00:00

abstract：:The epidemic form of the hemolytic uremic syndrome (HUS), beginning with an acute gastroenteritis, has been associated with a verocytotoxin-producing Escherichia coli infection. The endothelial cell is believed to play an important role in the pathogenesis of HUS. Endothelial cell damage by verocytotoxin-1 (VT-1) in v...

journal_title：Blood

authors： van de Kar NC,Monnens LA,Karmali MA,van Hinsbergh VW

更新日期：1992-12-01 00:00:00

abstract：:Patients after allogeneic stem-cell transplantation (alloSCT) have an increased risk for invasive aspergillosis (IA). Here, recipients of an allograft with IA (n=81) or without IA (n=58) were screened for 84 single nucleotide polymorphisms in 18 immune relevant genes. We found 3 markers in chemokine (C-X-C motif) liga...

journal_title：Blood

authors： Mezger M,Steffens M,Beyer M,Manger C,Eberle J,Toliat MR,Wienker TF,Ljungman P,Hebart H,Dornbusch HJ,Einsele H,Loeffler J

更新日期：2008-01-15 00:00:00

abstract：:We have recently shown that interleukin-9 (IL-9) strongly stimulates the proliferation of mouse thymic lymphomas in vitro. Here we report that this factor is also one of the most potent inhibitors of apoptosis induced by dexamethasone (DEX) in such cell lines, even if they do not depend on exogenous factors for growth...

journal_title：Blood

authors： Renauld JC,Vink A,Louahed J,Van Snick J

更新日期：1995-03-01 00:00:00

abstract：:Human K562 erythroleukemia cells were transfected with human band 3 (anion exchanger 1 [AE1]) cDNA, using the pBabe retroviral vector. Stable K562 clones expressing band 3 were isolated by flow cytometry, and surface expression was quantified by immunoblotting. The function of band 3 expressed at the cell surface was ...

journal_title：Blood

authors： Beckmann R,Smythe JS,Anstee DJ,Tanner MJ

更新日期：1998-12-01 00:00:00

abstract：:The monoclonal antibody STRO-1 identifies clonogenic bone marrow stromal cell progenitors (fibroblast colony-forming units [CFU-F]) in adult human bone marrow. These STRO-1+ CFU-F have previously been shown to give rise to cells with the phenotype of fibroblasts, adipocytes, and smooth muscle cells. In this study, the...

journal_title：Blood

authors： Gronthos S,Graves SE,Ohta S,Simmons PJ

更新日期：1994-12-15 00:00:00

abstract：:The Hermes receptor CD44 is a multifunctional adhesion molecule that plays an essential role in the homing and invasion of neoplastic stem cells in various myeloid malignancies. Although mast cells (MCs) reportedly express CD44, little is known about the regulation and function of this receptor in neoplastic cells in ...

journal_title：Blood

authors： Mueller N,Wicklein D,Eisenwort G,Jawhar M,Berger D,Stefanzl G,Greiner G,Boehm A,Kornauth C,Muellauer L,Sehner S,Hoermann G,Sperr WR,Staber PB,Jaeger U,Zuber J,Arock M,Schumacher U,Reiter A,Valent P

更新日期：2018-11-01 00:00:00

abstract：:Although virtually all pediatric patients with acute myeloid leukemia (AML) achieve a complete remission after initial induction therapy, 30%-40% of patients will encounter a relapse and have a dismal prognosis. To prevent relapses, personalized treatment strategies are currently being developed, which target specific...

journal_title：Blood

authors： Bachas C,Schuurhuis GJ,Hollink IH,Kwidama ZJ,Goemans BF,Zwaan CM,van den Heuvel-Eibrink MM,de Bont ES,Reinhardt D,Creutzig U,de Haas V,Assaraf YG,Kaspers GJ,Cloos J

更新日期：2010-10-14 00:00:00

abstract：:Measurement of plasma levels of two secreted platelet proteins (beta-thromboglobulin and platelet factor 4) has been suggested as a means for detecting increased platelet activation in vivo. A crucial question in the measurement is the distinction between in vivo and in vitro secretion of the proteins. One approach to...

journal_title：Blood

authors： Kaplan KL,Owen J

更新日期：1981-02-01 00:00:00

abstract：:Pretreatment of endothelial cells with cytokines enhances the adherence of leukocytes, a process that is mediated by surface proteins expressed on both cell types. A three-dimensional model system for the simultaneous determination of leukocyte adherence and migration was used to study the contribution of CD11/CD18, e...

journal_title：Blood

authors： Hakkert BC,Kuijpers TW,Leeuwenberg JF,van Mourik JA,Roos D

更新日期：1991-11-15 00:00:00

abstract：:The purpose of the present study was to evaluate the use of the variable regions of the T gamma rearranging gene of the second T cell receptor. Genomic DNA was extracted from leukemic cells of T and B precursor phenotypes and hybridized to probes that detect rearrangement of the V gamma regions. We present data showin...

journal_title：Blood

authors： González-Sarmiento R,Greenberg JM,Kersey JH

更新日期：1988-12-01 00:00:00

abstract：:We hypothesized that a granulocyte macrophage colony-stimulating factor (GMCSF) and interleukin 15 (IL-15) fusokine (GIFT15) would possess greater immune-stimulatory properties than their combined use. Unexpectedly, tumor cells engineered to secrete GIFT15 protein led to suppression of natural killer (NK) and NKT-cell...

journal_title：Blood

authors： Rafei M,Wu JH,Annabi B,Lejeune L,François M,Galipeau J

更新日期：2007-03-01 00:00:00

abstract：:The animal assay of potential new iron-chelating agents is at present dependent on cumbersome and imprecise iron balance studies in hypertransfused rodents. We report the development of a radioisotope assay in intact rats based on the transient labeling by ferritin 59Fe of the main source of chelatable iron within hep...

journal_title：Blood

authors： Pippard MJ,Johnson DK,Finch CA

更新日期：1981-10-01 00:00:00

abstract：:Control of intensity and duration of erythropoietin (Epo) signaling is necessary to tightly regulate red blood cell production. We have recently shown that the ubiquitin/proteasome system plays a major role in the control of Epo-R signaling. Indeed, after Epo stimulation, Epo-R is ubiquitinated and its intracellular p...

journal_title：Blood

authors： Meyer L,Deau B,Forejtníková H,Duménil D,Margottin-Goguet F,Lacombe C,Mayeux P,Verdier F

更新日期：2007-06-15 00:00:00

abstract：:The treatment of multiple myeloma is considered a continuously evolving paradigm as a result of the growing availability of new and highly effective drugs, including first- and second-generation proteasome inhibitors, immunomodulatory agents, and monoclonal antibodies. Clinical trials advocate long-term rather than sh...

journal_title：Blood

authors： Delforge M,Ludwig H

更新日期：2017-04-27 00:00:00

abstract：:Monocytes/macrophages exert a series of important functions in vivo. To facilitate detailed investigation of their functional capacity and the mechanism leading to their differentiation, several cell lines have been established from primary material. We present here a new human monoblastic cell line, designated UG3. U...

journal_title：Blood

authors： Ikeda T,Sasaki K,Ikeda K,Yamaoka G,Kawanishi K,Kawachi Y,Uchida T,Takahara J,Irino S

更新日期：1998-06-15 00:00:00

abstract：:RUNX1 is crucial for the regulation of megakaryocyte specification, maturation, and thrombopoiesis. Runx1 possesses 2 promoters: the distal P1 and proximal P2 promoters. The major protein isoforms generated by P1 and P2 are RUNX1C and RUNX1B, respectively, which differ solely in their N-terminal amino acid sequences. ...

journal_title：Blood

authors： Draper JE,Sroczynska P,Leong HS,Fadlullah MZH,Miller C,Kouskoff V,Lacaud G

更新日期：2017-07-20 00:00:00

abstract：:The replating capability of human umbilical cord blood (CB) multipotential (CFU-GEMM) progenitors was assessed in vitro as an estimate of self-renewal using erythropoietin (Epo), steel factor (SLF), and either fetal bovine serum (FBS) or CB plasma. This study found a much higher replating efficiency for CB CFU-GEMM th...

journal_title：Blood

authors： Carow CE,Hangoc G,Broxmeyer HE

更新日期：1993-02-15 00:00:00

abstract：:CD10 and MUM1 are representative B cell differentiation markers. Follicular lymphoma (FL) is usually positive for CD10 and negative for MUM1. In this study, however, we compared 22 FLs with peculiar phenotype CD10-MUM1+ with 119 typical CD10+MUM1- FLs. All CD10-MUM1+ FL patients exhibited follicular structure with fol...

journal_title：Blood

authors： Karube K,Guo Y,Suzumiya J,Sugita Y,Nomura Y,Yamamoto K,Shimizu K,Yoshida S,Komatani H,Takeshita M,Kikuchi M,Nakamura N,Takasu O,Arakawa F,Tagawa H,Seto M,Ohshima K

更新日期：2007-04-01 00:00:00

abstract：:Congenital dyserythropoietic anemias (CDAs) are a heterogeneous group of inherited anemias that affect the normal differentiation-proliferation pathways of the erythroid lineage. They belong to the wide group of ineffective erythropoiesis conditions that mainly result in monolinear cytopenia. CDAs are classified into ...

journal_title：Blood

authors： Iolascon A,Andolfo I,Russo R

更新日期：2020-09-10 00:00:00

abstract：:Induction of red blood cell (RBC) fetal hemoglobin (HbF; α2γ2) ameliorates the pathophysiology of sickle cell disease (SCD) by reducing the concentration of sickle hemoglobin (HbS; α2βS2) to inhibit its polymerization. Hydroxyurea (HU), the only US Food and Drug Administration (FDA)-approved drug for SCD, acts in part...

journal_title：Blood

authors： Zhang Y,Paikari A,Sumazin P,Ginter Summarell CC,Crosby JR,Boerwinkle E,Weiss MJ,Sheehan VA

更新日期：2018-07-19 00:00:00

abstract：:Ferroportin (FPN) mediates iron export from cells; FPN mutations are associated with the iron overloading disorder hemochromatosis. Previously, we found that the A77D, V162del, and G490D mutations inhibited FPN activity, but that other disease-associated FPN variants retained full iron export capability. The peptide h...

journal_title：Blood

authors： Drakesmith H,Schimanski LM,Ormerod E,Merryweather-Clarke AT,Viprakasit V,Edwards JP,Sweetland E,Bastin JM,Cowley D,Chinthammitr Y,Robson KJ,Townsend AR

更新日期：2005-08-01 00:00:00

abstract：:To investigate the role of peritoneal mesothelial cells in regulating hematopoiesis, as well as inflammation, healing, and tissue regeneration processes, long-term cultures of peritoneal mesothelial cells from human endocavitarian fluids were established. The purity of the cell population was assessed by morphologic a...

journal_title：Blood

authors： Lanfrancone L,Boraschi D,Ghiara P,Falini B,Grignani F,Peri G,Mantovani A,Pelicci PG

更新日期：1992-12-01 00:00:00