CD44 is a RAS/STAT5-regulated invasion receptor that triggers disease expansion in advanced mastocytosis.

abstract：:Previous analyses of the roles of alpha4 integrins in hematopoiesis by other groups have led to conflicting evidence. alpha4 integrin mutant cells developing in [alpha4 integrin(-/-): wt] chimeric mice are not capable of completing lymphomyeloid differentiation, whereas conditional inactivation of alpha4 integrin in a...

journal_title：Blood

authors： Gribi R,Hook L,Ure J,Medvinsky A

更新日期：2006-07-15 00:00:00

abstract：:It has previously been shown that human granulocyte-macrophage colony-stimulating factor (GM-CSF) can be fused to a truncated diphtheria toxin (DT) to produce a recombinant fusion toxin that kills GM-CSF receptor-bearing cells. We now report that DT388-GM-CSF induces apoptosis and inhibition of colony formation in sem...

journal_title：Blood

authors： Frankel AE,Hall PD,Burbage C,Vesely J,Willingham M,Bhalla K,Kreitman RJ

更新日期：1997-11-01 00:00:00

abstract：:Transfusion-associated graft-versus-host disease can be prevented by treating cellular blood products with gamma irradiation. A wide range of gamma irradiation dose levels has been used in routine practice. We used limiting dilution analysis, which measures clonable T cells, to assess the influence of 500 to 3,000 cGy...

journal_title：Blood

authors： Pelszynski MM,Moroff G,Luban NL,Taylor BJ,Quinones RR

更新日期：1994-03-15 00:00:00

abstract：:We have investigated the interaction of fibroblast growth factor (FGF) with megakaryocytopoiesis. Acidic FGF (aFGF) stimulated the proliferation of murine megakaryocytes and human erythroleukemia (HEL) cells in a concentration-dependent manner. The concentrations of aFGF required to elicit half-maximum and maximum eff...

journal_title：Blood

authors： Bikfalvi A,Han ZC,Fuhrmann G

更新日期：1992-10-15 00:00:00

abstract：:Seven of 21 patients with sickle cell anemia developed neurologic complications 5 to 243 days (median, 33 days) after allogeneic marrow transplantation. Among these 7 patients, indications for transplantation included either a past history of stroke (4 patients) or recurrent severe vaso-occlusive events (3 patients). ...

journal_title：Blood

authors： Walters MC,Sullivan KM,Bernaudin F,Souillet G,Vannier JP,Johnson FL,Lenarsky C,Powars D,Bunin N,Ohene-Frempong K

更新日期：1995-02-15 00:00:00

abstract：:Allelic loss at nonrandom chromosomal sites is thought to mark the position of tumor suppressor genes involved in the pathogenesis and progression of human malignancies. Solid tumors in particular have been found to harbor multiple genetic changes resulting in loss of function mutations. Tumor suppressor genes have al...

journal_title：Blood

authors： Bullrich F,Veronese ML,Kitada S,Jurlander J,Caligiuri MA,Reed JC,Croce CM

更新日期：1996-10-15 00:00:00

abstract：:Keratinocyte growth factor (KGF) is important in tissue repair and wound healing and its administration can abrogate chemical- and radiation-induced tissue damage in rodents. We investigated KGF as a therapeutic agent for the prevention of graft-versus-host disease (GVHD)-induced tissue damage, morbidity, and mortalit...

journal_title：Blood

authors： Panoskaltsis-Mortari A,Lacey DL,Vallera DA,Blazar BR

更新日期：1998-11-15 00:00:00

abstract：:Aggregation of high-affinity receptors for immunoglobulin E (Fc epsilon RI) on the surface of mast cells results in degranulation, a response that is potentiated by binding of stem cell factor (SCF) to its receptor Kit. We observed that one of the major initial signaling events associated with Fc epsilon RI-mediated a...

journal_title：Blood

authors： Tkaczyk C,Horejsi V,Iwaki S,Draber P,Samelson LE,Satterthwaite AB,Nahm DH,Metcalfe DD,Gilfillan AM

更新日期：2004-07-01 00:00:00

abstract：:Angiotensin II (Ang-II) exerts inflammatory activity and is involved in different cardiovascular disorders. This study has evaluated the involvement of tumor necrosis factor alpha (TNFalpha) in the leukocyte accumulation elicited by Ang-II. Ang-II (1 nM intraperitoneally in rats) induced TNFalpha release at 1 hour fol...

journal_title：Blood

authors： Mateo T,Naim Abu Nabah Y,Losada M,Estellés R,Company C,Bedrina B,Cerdá-Nicolás JM,Poole S,Jose PJ,Cortijo J,Morcillo EJ,Sanz MJ

更新日期：2007-09-15 00:00:00

abstract：:The duration of immunodeficiency following marrow transplantation is not known. Questionnaires were used to study the infection rates in 72 patients surviving 20 to 30 years after marrow grafting. Furthermore, in 33 of the 72 patients and in 16 donors (siblings who originally donated the marrow) leukocyte subsets were...

journal_title：Blood

authors： Storek J,Joseph A,Espino G,Dawson MA,Douek DC,Sullivan KM,Flowers ME,Martin P,Mathioudakis G,Nash RA,Storb R,Appelbaum FR,Maloney DG

更新日期：2001-12-15 00:00:00

abstract：:We describe the identification, experimental transmission, and pathogenesis of a naturally occurring powerfully immunosuppressive isolate of feline leukemia virus (designated here as FeLV-FAIDS) which induces fatal acquired immunodeficiency syndrome (AIDS) in 100% (25 of 25) of persistently viremic experimentally infe...

journal_title：Blood

authors： Hoover EA,Mullins JI,Quackenbush SL,Gasper PW

更新日期：1987-12-01 00:00:00

abstract：:The genes for the hemopoietic growth factors, GM colony-stimulating factor (CSF) and G-CSF have been cloned, and recombinant material is available for both. We tested these recombinant factors for their effects on the blast cells of acute myeloblastic leukemia (AML). Culture methods are available that support both col...

journal_title：Blood

authors： Kelleher C,Miyauchi J,Wong G,Clark S,Minden MD,McCulloch EA

更新日期：1987-05-01 00:00:00

abstract：:The CD14-dependent and -independent dendritic cell (DC) pathways are instituted simultaneously when CD34(+) progenitor cells are treated with granulocyte-macrophage colony-stimulating factor (GM-CSF)/tumor necrosis factor (TNF) +/- stem cell factor (SCF) (GTS). If TNF activity is neutralized within 48 hours of cytokin...

journal_title：Blood

authors： Santiago-Schwarz F,McCarthy M,Tucci J,Carsons SE

更新日期：1998-08-01 00:00:00

abstract：:The chemokines platelet factor 4 (PF4) and RANTES (regulated on activation normal T cell expressed and secreted) are secreted by activated platelets and influence multiple cell types and biologic processes. For instance, PF4 inhibits progenitor cell proliferation and angiogenesis, while platelet-derived RANTES is invo...

journal_title：Blood

authors： von Hundelshausen P,Koenen RR,Sack M,Mause SF,Adriaens W,Proudfoot AE,Hackeng TM,Weber C

更新日期：2005-02-01 00:00:00

abstract：:Plasma fibronectin (Fn) induces phagocytosis of C3b-opsonized sheep erythrocytes (EC3b) by human peripheral blood monocytes. However, Fn does not induce erythrophagocytosis of EC3b by human polymorphonuclear leukocytes (PMN), unless the PMN have been exposed to C5a or N-formyl-methionyl-leucyl-phenylalanine. Because o...

journal_title：Blood

authors： Pommier CG,O'Shea J,Chused T,Takahashi T,Ochoa M,Nutman TB,Bianco C,Brown EJ

更新日期：1984-10-01 00:00:00

abstract：:The introduction of agents targeted at specific molecular events is changing the treatment paradigms in a number of malignancies. Historically, we have relied entirely on DNA-interactive, cytotoxic drugs for treating patients with leukemia. Increased understanding of the leukemic cell biology and pathogenesis, and the...

journal_title：Blood

authors： Ravandi F

更新日期：2019-01-10 00:00:00

abstract：:We studied the relationship between the production of the 23-Kd interleukin-1 receptor antagonist (IL-1ra) and IL-1 beta in cultures of human peripheral blood mononuclear cells (PBMC) using a specific radioimmunoassay for IL-1ra that had a sensitivity of 166 +/- 11 pg/mL. PBMC cultured without human serum made little ...

journal_title：Blood

authors： Poutsiaka DD,Clark BD,Vannier E,Dinarello CA

更新日期：1991-09-01 00:00:00

abstract：:Intracranial hemorrhage is the third most frequent cause of cerebrovascular disease, but few genetic risk factors have been associated with its development. Recently, it has been reported that some polymorphisms that affect clotting factors increase the risk for thrombosis. However, reports have analyzed the effect of...

journal_title：Blood

authors： Corral J,Iniesta JA,González-Conejero R,Villalón M,Vicente V

更新日期：2001-05-15 00:00:00

abstract：:Autologous hematopoietic cell transplant (AHCT) for HIV-infected patients is largely limited to centers with HIV-specific expertise. The Blood and Marrow Transplant Clinical Trials Network 0803/AIDS Malignancy Consortium 071 trial is a multicenter phase 2 study of AHCT for patients with HIV-related lymphoma (HRL). Eli...

journal_title：Blood

authors： Alvarnas JC,Le Rademacher J,Wang Y,Little RF,Akpek G,Ayala E,Devine S,Baiocchi R,Lozanski G,Kaplan L,Noy A,Popat U,Hsu J,Morris LE Jr,Thompson J,Horowitz MM,Mendizabal A,Levine A,Krishnan A,Forman SJ,Navarro WH,

更新日期：2016-08-25 00:00:00

abstract：:The origin of low-grade mucosa-associated lymphoid tissue (MALT)-type B-cell lymphoma is still unclear. Using a novel two-step procedure, we have sequenced the Ig VH genes expressed by cells from four patients with gastric low-grade MALT-type lymphoma. The nucleotide sequences of the complementarity determining region...

journal_title：Blood

authors： Qin Y,Greiner A,Trunk MJ,Schmausser B,Ott MM,Müller-Hermelink HK

更新日期：1995-11-01 00:00:00

abstract：:Patients with a t(9;11) translocation (MLL-AF9) develop acute myeloid leukemia (AML), and while in mice the expression of this fusion oncogene also results in the development of myeloid leukemia, it is with long latency. To identify mutations that cooperate with Mll-AF9, we infected neonatal wild-type (WT) or Mll-AF9 ...

journal_title：Blood

authors： Bergerson RJ,Collier LS,Sarver AL,Been RA,Lugthart S,Diers MD,Zuber J,Rappaport AR,Nixon MJ,Silverstein KA,Fan D,Lamblin AF,Wolff L,Kersey JH,Delwel R,Lowe SW,O'Sullivan MG,Kogan SC,Adams DJ,Largaespada DA

更新日期：2012-05-10 00:00:00

abstract：:The treatment of mice with high doses of 5-fluorouracil (5-FU) results in an enrichment of primitive hematopoietic progenitors. Using this procedure, we obtained a new class of murine hematopoietic colonies that had very high secondary plating efficiencies in vitro and could differentiate into not only myeloid cells b...

journal_title：Blood

authors： Tsunoda J,Okada S,Suda J,Nagayoshi K,Nakauchi H,Hatake K,Miura Y,Suda T

更新日期：1991-07-15 00:00:00

abstract：:Recently, we have demonstrated that human platelets carry preformed CD40 ligand (CD154) molecules, which rapidly appear on the platelet surface following stimulation by thrombin. Once on the surface, platelet CD154 induces an inflammatory reaction of CD40-bearing endothelial cells. This study shows that strong platele...

journal_title：Blood

authors： Henn V,Steinbach S,Büchner K,Presek P,Kroczek RA

更新日期：2001-08-15 00:00:00

abstract：:We conducted a genome-wide analysis of genes that are regulated by vascular endothelial growth factor (VEGF) in endothelial cells and identified DSCR1 to be most significantly induced. Consistent with an antagonistic function on calcineurin (CnA) signaling, expression of DSCR1 in endothelial cells blocked dephosphoryl...

journal_title：Blood

authors： Hesser BA,Liang XH,Camenisch G,Yang S,Lewin DA,Scheller R,Ferrara N,Gerber HP

更新日期：2004-07-01 00:00:00

abstract：:We conducted a double-blind, randomized multicenter trial to determine whether the addition of mycophenolate mofetil (MMF) improves the efficacy of initial systemic treatment of chronic graft-versus-host disease (GVHD). The primary endpoint was resolution of chronic GVHD and withdrawal of all systemic treatment within...

journal_title：Blood

authors： Martin PJ,Storer BE,Rowley SD,Flowers ME,Lee SJ,Carpenter PA,Wingard JR,Shaughnessy PJ,DeVetten MP,Jagasia M,Fay JW,van Besien K,Gupta V,Kitko C,Johnston LJ,Maziarz RT,Arora M,Jacobson PA,Weisdorf D

更新日期：2009-05-21 00:00:00

abstract：:Stem cell factor (SCF) binding to the c-kit receptor triggers homodimerization and intermolecular tyrosine phosphorylation of the c-kit receptor, thus initiating signal transduction. Receptor dimerization is a critical early step in this process. Prior biochemical studies of c-kit receptor dimerization have mainly use...

journal_title：Blood

authors： Broudy VC,Lin NL,Bühring HJ,Komatsu N,Kavanagh TJ

更新日期：1998-02-01 00:00:00

abstract：:The peripheral blood lymphocytes from 42 patients with multiple myeloma (MM) and 13 patients with monoclonal gammopathy of undetermined significance (MGUS) were studied by three-color immunofluorescence (IF) using antibodies directed to a broad range of B-cell markers (CD19, CD20, CD21, CD24), CALLA (CD10), PCA-1 (a p...

journal_title：Blood

authors： Jensen GS,Mant MJ,Belch AJ,Berenson JR,Ruether BA,Pilarski LM

更新日期：1991-08-01 00:00:00

abstract：:T-cell prolymphocytic leukemia (T-PLL) is a rare form of mature leukemia that occurs both in adults as a sporadic disease and in younger patients suffering an hereditary condition, ataxia telangiectasia (AT). The ATM gene, located in the 11q22-23 chromosomal region, is consistently mutated in AT patients. The strong p...

journal_title：Blood

authors： Stoppa-Lyonnet D,Soulier J,Laugé A,Dastot H,Garand R,Sigaux F,Stern MH

更新日期：1998-05-15 00:00:00

abstract：:Chromosomal abnormalities in acute leukemia have led to the discovery of many genes involved in normal hematopoiesis and in malignant transformation. We have identified the fusion partners in an inv(8)(p11q13) from a patient with acute mixed lineage leukemia. We show by fluorescence in situ hybridization (FISH) analys...

journal_title：Blood

authors： Liang J,Prouty L,Williams BJ,Dayton MA,Blanchard KL

更新日期：1998-09-15 00:00:00

abstract：:Natural killer (NK) cells can alter the outcome of hematopoietic cell transplantation (HCT) if donor alloreactivity targets the recipient. Since most NK cells express inhibitory killer-immunoglobulin receptors (KIRs), we hypothesized that the susceptibility of recipient cells to donor NK cell-mediated lysis is genetic...

journal_title：Blood

authors： Miller JS,Cooley S,Parham P,Farag SS,Verneris MR,McQueen KL,Guethlein LA,Trachtenberg EA,Haagenson M,Horowitz MM,Klein JP,Weisdorf DJ

更新日期：2007-06-01 00:00:00