A critical role for TNFalpha in the selective attachment of mononuclear leukocytes to angiotensin-II-stimulated arterioles.

abstract：:Beginning in 1985, patients in British Columbia with Hodgkin lymphoma (HL) that was not controlled by conventional chemotherapy routinely underwent high-dose chemotherapy and autologous stem cell transplantation (HD-ASCT). Long-term complications of HD-ASCT have become apparent as more patients survive without recurre...

journal_title：Blood

authors： Lavoie JC,Connors JM,Phillips GL,Reece DE,Barnett MJ,Forrest DL,Gascoyne RD,Hogge DE,Nantel SH,Shepherd JD,Smith CA,Song KW,Sutherland HJ,Toze CL,Voss NJ,Nevill TJ

更新日期：2005-08-15 00:00:00

abstract：:In this study, the question of whether glycoprotein Ib (GPIb) mediates both high and moderate affinity pathways of alpha-thrombin-induced platelet activation was examined. Flow cytometric studies, using a panel of monoclonal antibodies (MoAbs), showed that Serratia marcescens protease treatment removed greater than 97...

journal_title：Blood

authors： Yamamoto N,Greco NJ,Barnard MR,Tanoue K,Yamazaki H,Jamieson GA,Michelson AD

更新日期：1991-04-15 00:00:00

abstract：:The American Board of Internal Medicine (ABIM) has called on directors of hematology training programs to establish systems to evaluate, document, and substantiate those components of overall clinical competence considered essential for certification in the subspecialty. Many of these can be assessed only by repeated ...

journal_title：Blood

authors： Schrier SL,Benson JA Jr

更新日期：1988-10-01 00:00:00

abstract：:The model of erythroleukemia caused by Spi-1/PU.1 transgenesis in mice is a multistage disease. A preleukemic step is characterized by an acute proliferation of proerythroblasts due to the arrest of differentiation provoked by Spi-1/PU.1. Later on, a blastic crisis occurs associated with somatic oncogenic mutations in...

journal_title：Blood

authors： Monni R,Haddaoui L,Naba A,Gallais I,Arpin M,Mayeux P,Moreau-Gachelin F

更新日期：2008-03-15 00:00:00

abstract：:Although small deletions, splice site abnormalities, missense, and nonsense mutations have been identified in patients with factor VII deficiency, there have been no reports of mutations in the factor VII promoter. We investigated a girl with factor VII levels that were less than 1% of normal in association with a sev...

journal_title：Blood

authors： Arbini AA,Pollak ES,Bayleran JK,High KA,Bauer KA

更新日期：1997-01-01 00:00:00

abstract：:Identification of prognostic factors for patients with relapsed/refractory Hodgkin lymphoma (HL) is essential for optimizing therapy with risk-adapted approaches. In our phase 2 study of positron emission tomography (PET)-adapted salvage therapy with brentuximab vedotin (BV) and augmented ifosfamide, carboplatin, and ...

journal_title：Blood

authors： Moskowitz AJ,Schöder H,Gavane S,Thoren KL,Fleisher M,Yahalom J,McCall SJ,Cadzin BR,Fox SY,Gerecitano J,Grewal R,Hamlin PA,Horwitz SM,Kumar A,Matasar M,Ni A,Noy A,Palomba ML,Perales MA,Portlock CS,Sauter C,Straus

更新日期：2017-11-16 00:00:00

abstract：:Neutrophils from healthy elderly donors generate significantly less diacylglycerol (DAG) and inositol triphosphate (IP3) than neutrophils from young donors, following stimulation by the chemotactic peptide, formyl-methionyl-leucylphenylalanine (FMLP). The defect in signal transduction occurred at a point proximal to t...

journal_title：Blood

authors： Lipschitz DA,Udupa KB,Indelicato SR,Das M

更新日期：1991-09-01 00:00:00

abstract：:Megakaryoblastic leukemia 1 (MKL1), identified as part of the t(1;22) translocation specific to acute megakaryoblastic leukemia, is highly expressed in differentiated muscle cells and promotes muscle differentiation by activating serum response factor (SRF). Here we show that Mkl1 expression is up-regulated during mur...

journal_title：Blood

authors： Cheng EC,Luo Q,Bruscia EM,Renda MJ,Troy JA,Massaro SA,Tuck D,Schulz V,Mane SM,Berliner N,Sun Y,Morris SW,Qiu C,Krause DS

更新日期：2009-03-19 00:00:00

abstract：:We have investigated the interaction of fibroblast growth factor (FGF) with megakaryocytopoiesis. Acidic FGF (aFGF) stimulated the proliferation of murine megakaryocytes and human erythroleukemia (HEL) cells in a concentration-dependent manner. The concentrations of aFGF required to elicit half-maximum and maximum eff...

journal_title：Blood

authors： Bikfalvi A,Han ZC,Fuhrmann G

更新日期：1992-10-15 00:00:00

abstract：:In diffuse large B-cell lymphoma (DLBCL), the number of circulating monocytes and neutrophils represents an independent prognostic factor. These cell subsets include monocytic and granulocytic myeloid-derived suppressor cells (M- and G-MDSCs) defined by their ability to suppress T-cell responses. MDSCs are a heterogen...

journal_title：Blood

authors： Azzaoui I,Uhel F,Rossille D,Pangault C,Dulong J,Le Priol J,Lamy T,Houot R,Le Gouill S,Cartron G,Godmer P,Bouabdallah K,Milpied N,Damaj G,Tarte K,Fest T,Roussel M

更新日期：2016-08-25 00:00:00

abstract：:In this issue of Blood, Bartel and colleagues report the independent predictive value of the PET/CT and of the FDG suppression before transplantation in newly diagnosed myeloma patients who were treated using the TT3 regimen. ...

journal_title：Blood

authors： Dimopoulos MA,Moulopoulos LA,Terpos E

更新日期：2009-09-03 00:00:00

abstract：:In this issue of Blood, Hong et al advocate for use of additional US Food and Drug Administration (FDA)–approved safety measures for transfusion. Most patients transfused with contaminated platelets do not show immediate clinical signs. Active surveillance suggests patient risk 10- to 40-fold higher than passive hemov...

journal_title：Blood

authors： Benjamin RJ

更新日期：2016-01-28 00:00:00

abstract：:Patients who are chronically infected with hepatitis C virus (HCV) often develop mixed cryoglobulinemia (MC), a B-cell proliferative disorder with polyclonal activation and autoantibody production. We investigated if MC is associated with a deficit of CD4(+)CD25(+) immunoregulatory T (Treg) cells, which have been show...

journal_title：Blood

authors： Boyer O,Saadoun D,Abriol J,Dodille M,Piette JC,Cacoub P,Klatzmann D

更新日期：2004-05-01 00:00:00

abstract：:The MLL gene located at 11q23 is frequently disrupted by chromosomal translocation in a wide spectrum of newly diagnosed acute leukemias. Recently, it has become apparent that the MLL gene is very frequently disrupted by chromosomal translocations in patients with secondary leukemias associated with chemotherapeutic r...

journal_title：Blood

authors： Aplan PD,Chervinsky DS,Stanulla M,Burhans WC

更新日期：1996-04-01 00:00:00

abstract：:Hermansky-Pudlak syndrome (HPS) is an inherited hemorrhagic disease affecting the related subcellular organelles platelet dense granules, lysosomes, and melanosomes. The mouse genes for HPS, pale ear and pearl, orthologous to the human HPS1 and HPS2 (ADTB3A) genes, encode a novel protein of unknown function and the be...

journal_title：Blood

authors： Feng L,Novak EK,Hartnell LM,Bonifacino JS,Collinson LM,Swank RT

更新日期：2002-03-01 00:00:00

abstract：:The number of cells transplanted and their capacity to induce graft-versus-host reactivity (GvHR) are two factors that are suspected to influence the engraftment of allogeneic bone marrow. We have investigated their impact on graft rejection rates in busulfan-treated LEW rats. In a series of experiments, we varied (1)...

journal_title：Blood

authors： Uharek L,Gassmann W,Glass B,Steinmann J,Loeffler H,Mueller-Ruchholtz W

更新日期：1992-03-15 00:00:00

abstract：:The zinc finger transcription factor GATA-2 is highly expressed in immature hematopoietic cells and declines with blood cell maturation. To investigate its role in normal adult hematopoiesis, a bicistronic retroviral vector encoding GATA-2 and the green fluorescent protein (GFP) was used to maintain the high levels of...

journal_title：Blood

authors： Persons DA,Allay JA,Allay ER,Ashmun RA,Orlic D,Jane SM,Cunningham JM,Nienhuis AW

更新日期：1999-01-15 00:00:00

abstract：:Rh(o)(D) immune globulin intravenous (anti-D IGIV) was licensed by the United States Food and Drug Administration (FDA) in March 1995 to treat patients with immune thrombocytopenic purpura (ITP). Anti-D IGIV induces extravascular hemolysis, an expected adverse reaction that is consistent with the presumed mechanism of...

journal_title：Blood

authors： Gaines AR

更新日期：2000-04-15 00:00:00

abstract：:A longstanding endeavor to define the genetic lesions that drive myeloid malignances has stimulated a period of remarkable discovery. Enabled by technological advances that have sharply decreased the cost of DNA sequencing, the full compendium of common, recurrent somatic mutations in the coding genome of myeloid mali...

journal_title：Blood

authors： Lindsley RC,Ebert BL

更新日期：2013-11-28 00:00:00

abstract：:We report here the results of polymerase chain reaction (PCR) for bcr-abl transcript and clinical details derived from 64 chronic myelogenous leukemia (CML) patients after allogeneic bone marrow transplantation (BMT). A total of 139 samples (2 to 220 weeks after BMT) were analyzed and bcr-abl transcript was detected i...

journal_title：Blood

authors： Miyamura K,Tahara T,Tanimoto M,Morishita Y,Kawashima K,Morishima Y,Saito H,Tsuzuki S,Takeyama K,Kodera Y

更新日期：1993-02-15 00:00:00

abstract：:Photochemical decontamination (PCD) of platelet concentrates, with adequate preservation of platelet function, has been shown using 8-methoxypsoralen (8-MOP) and long wavelength UV light (UVA). To further evaluate this technique, models for the inactivation of pathogenic human cell-associated viruses and integrated pr...

journal_title：Blood

authors： Lin L,Londe H,Hanson CV,Wiesehahn G,Isaacs S,Cimino G,Corash L

更新日期：1993-07-01 00:00:00

abstract：:To examine the possible receptor-ligand pairs mediating adhesion of activated and "unactivated" platelets to leukocytes and the kinetics of leukocyte-platelet binding, we developed a flow cytometric assay using isolated cell fractions to accurately measure heterotypic cell adhesion, including both total leukocyte-plat...

journal_title：Blood

authors： Rinder HM,Bonan JL,Rinder CS,Ault KA,Smith BR

更新日期：1991-10-01 00:00:00

abstract：:Efflux of Hoechst 33342 from normal hematopoietic cells identifies a "side population" (SP(+)) of negatively staining cells that, in the mouse, are largely CD34(-) and are enriched for primitive progenitors. To further characterize human SP(+) cells, blood or bone marrow from 16 patients with acute myeloid leukemia (A...

journal_title：Blood

authors： Feuring-Buske M,Hogge DE

更新日期：2001-06-15 00:00:00

abstract：:Recombinant human macrophage colony-stimulating factor (rhM-CSF) was given to cynomolgus monkeys by continuous intravenous infusion or subcutaneous injection, at a dose of 50 to 100 micrograms/kg/d in repetitive 14-day cycles. Starting within 24 to 48 hours of initiation of rhM-CSF, there was a progressive increase in...

journal_title：Blood

authors： Munn DH,Garnick MB,Cheung NK

更新日期：1990-05-15 00:00:00

abstract：:We show here that a human leukemic cell line, PER-117, bearing the markers of a T-cell precursor phenotype, can be induced to express receptors for interleukin-2 (IL-2). These IL-2 receptors could be demonstrated to mediate a physiologic response to the lymphokine for which the high-affinity form of the IL-2 receptor ...

journal_title：Blood

authors： Kees UR

更新日期：1988-11-01 00:00:00

abstract：:Telomere erosion may be counteracted by telomerase. Here we explored telomere length (TL) and telomerase activity (TA) in primary cutaneous T-cell lymphoma (CTCL) by using quantitative polymerase chain reaction and interphase quantitative fluorescence in situ hybridization assays. Samples from patients with Sézary syn...

journal_title：Blood

authors： Chevret E,Andrique L,Prochazkova-Carlotti M,Ferrer J,Cappellen D,Laharanne E,Idrissi Y,Boettiger A,Sahraoui W,Ruiz F,Pham-Ledard A,Vergier B,Belloc F,Dubus P,Beylot-Barry M,Merlio JP

更新日期：2014-03-20 00:00:00

abstract：:Omenn syndrome (OS) is a severe immunodeficiency associated with erythroderma, lymphoproliferation, elevated IgE, and hyperactive oligoclonal T cells. A restricted T-cell repertoire caused by defective thymic T-cell development and selection, lymphopenia with homeostatic proliferation, and lack of regulatory T cells a...

journal_title：Blood

authors： Fuchs S,Rensing-Ehl A,Pannicke U,Lorenz MR,Fisch P,Jeelall Y,Rohr J,Speckmann C,Vraetz T,Farmand S,Schmitt-Graeff A,Krüger M,Strahm B,Henneke P,Enders A,Horikawa K,Goodnow C,Schwarz K,Ehl S

更新日期：2015-10-01 00:00:00

abstract：:Cholesterol, in addition to providing rigidity to the fluid membrane, plays a critical role in receptor function, endocytosis, recycling, and signal transduction. In the present study, we examined the effect of membrane cholesterol on functional expression of tissue factor (TF), a cellular receptor for clotting factor...

journal_title：Blood

authors： Mandal SK,Iakhiaev A,Pendurthi UR,Rao LV

更新日期：2005-01-01 00:00:00

abstract：:c-Myc (Myc hereafter) is found to be deregulated and/or amplified in most acute myeloid leukemias (AMLs). Almost all AML cells are dependent upon Myc for their proliferation and survival. Thus, Myc has been proposed as a critical anti-AML target. Myc has Max-mediated transactivational and Myc-interacting zinc finger p...

journal_title：Blood

authors： Zhang L,Li J,Xu H,Shao X,Fu L,Hou Y,Hao C,Li W,Joshi K,Wei W,Xu Y,Zhang F,Dai S,Breslin P,Zhang J,Zhang J

更新日期：2020-04-02 00:00:00

abstract：:L-arginine (L-Arg) plays a central role in several biologic systems including the regulation of T-cell function. L-Arg depletion by myeloid-derived suppressor cells producing arginase I is seen in patients with cancer inducing T-cell anergy. We studied how L-Arg starvation could regulate T-cell-cycle progression. Stim...

journal_title：Blood

authors： Rodriguez PC,Quiceno DG,Ochoa AC

更新日期：2007-02-15 00:00:00