Abstract:
:The purpose of the present study was to evaluate the use of the variable regions of the T gamma rearranging gene of the second T cell receptor. Genomic DNA was extracted from leukemic cells of T and B precursor phenotypes and hybridized to probes that detect rearrangement of the V gamma regions. We present data showing that the V gamma use is nonrandom in acute lymphoblastic leukemias (ALLs). B precursor ALL rearranged the more 5' variable regions. The results obtained suggest that the T precursor leukemias more frequently rearrange the 3' V gamma regions. Two leukemias that expressed the gamma protein rearranged V gamma 8 and V gamma 9.
journal_name
Bloodjournal_title
Bloodauthors
González-Sarmiento R,Greenberg JM,Kersey JHsubject
Has Abstractpub_date
1988-12-01 00:00:00pages
2038-41issue
6eissn
0006-4971issn
1528-0020journal_volume
72pub_type
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