Abstract：
:Selective depletion of the alloreactive T cells causing graft-versus-host disease (GVHD) without loss of the graft-versus-leukemia (GVL) effect is the holy grail of hematopoietic cell transplantation (HCT). In this issue of Blood, He et al demonstrate that inhibition of histone methylation leads to selective apoptosis of the alloreactive effector cells. Moreover, they demonstrate that this inhibition of histone methylation remarkably stops ongoing GVHD.
journal_name
Bloodjournal_title
Bloodauthors
Chao Ndoi
10.1182/blood-2011-12-395905subject
Has Abstractpub_date
2012-02-02 00:00:00pages
1102-3issue
5eissn
0006-4971issn
1528-0020pii
119/5/1102journal_volume
119pub_type
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