Soluble CD22 as a tumor marker for hairy cell leukemia.

abstract：:The white-spotting (Ws) locus of rats represents a 12-base deletion of the c-kit receptor tyrosine kinase. Homozygous Ws/Ws rats are deficient in melanocytes, mast cells, and erythrocytes. Although mice possessing two mutant alleles at the c-kit (W) locus, such as mice of W/Wv genotype, show severe anemia even in adul...

journal_title：Blood

authors： Morimoto M,Kasugai T,Tei H,Jippo-Kanemoto T,Kanakura Y,Kitamura Y

更新日期：1993-12-01 00:00:00

abstract：:Intensive leukapheresis has been used as the initial treatment of chronic granulocytic leukemia (CGL) in six patients. The number of leukaphereses ranged from 3 in 7 days to 13 in 39 days (mean, 8 in 22 days). The procedures were well tolerated, and in all patients there was improvement in hematologic values, in most ...

journal_title：Blood

authors： Lowenthal RM,Buskard NA,Goldman JM,Spiers AS,Bergier N,Graubner M,Galton DA

更新日期：1975-12-01 00:00:00

abstract：:Folylpolyglutamate synthetase (FPGS) is responsible for the metabolism of natural folates and a broad range of folate antagonists to polyglutamate derivatives. Recent studies indicated increased accumulation of methotrexate (MTX) polyglutamates (MTX-PG) in blast cells as a predictor of favorable treatment outcome in c...

journal_title：Blood

authors： Barredo JC,Synold TW,Laver J,Relling MV,Pui CH,Priest DG,Evans WE

更新日期：1994-07-15 00:00:00

abstract：:The evolutionarily conserved immune system of the zebrafish (Danio rerio), in combination with its genetic tractability, position it as an excellent model system in which to elucidate the origin and function of vertebrate immune cells. We recently reported the existence of antigen-presenting mononuclear phagocytes in ...

journal_title：Blood

authors： Wittamer V,Bertrand JY,Gutschow PW,Traver D

更新日期：2011-06-30 00:00:00

abstract：:In patients with chronic myeloid leukemia, BCR-ABL mutations contribute to resistance to tyrosine kinase inhibitor therapy. We examined the occurrence of treatment-emergent mutations and their impact on response in patients from the ENESTnd phase 3 trial. At the 3-year data cutoff, mutations were detected in approxima...

journal_title：Blood

authors： Hochhaus A,Saglio G,Larson RA,Kim DW,Etienne G,Rosti G,De Souza C,Kurokawa M,Kalaycio ME,Hoenekopp A,Fan X,Shou Y,Kantarjian HM,Hughes TP

更新日期：2013-05-02 00:00:00

abstract：:Bleeding problems are associated with defects in platelet alpha-granules, yet little is known about how these granules are formed and released. Mutations affecting VPS33B, a novel Sec1/Munc18 protein, have recently been linked to arthrogryposis, renal dysfunction, and cholestasis (ARC) syndrome. We have characterized ...

journal_title：Blood

authors： Lo B,Li L,Gissen P,Christensen H,McKiernan PJ,Ye C,Abdelhaleem M,Hayes JA,Williams MD,Chitayat D,Kahr WH

更新日期：2005-12-15 00:00:00

abstract：:Using a recently described serum-free culture system of purified human CD34+ progenitor cells, we show here a critical cooperation of flt3 ligand (FL) with transforming growth factor-beta1 (TGF-beta1) in the induction of in vitro dendritic cell/Langerhans cell (DC/LC) development. The addition of FL to serum-free cult...

journal_title：Blood

authors： Strobl H,Bello-Fernandez C,Riedl E,Pickl WF,Majdic O,Lyman SD,Knapp W

更新日期：1997-08-15 00:00:00

abstract：:Optimal conditions necessary for the cytochemical demonstration of megakaryocyte (Mk) and platelet acid phosphatase (AP) were determined. Methanol, a constituent of fixatives commonly used in AP cytochemistry, was found to inhibit MkAP, and the degree of inhibition varied with Mk maturity. Immature Mk contained predom...

journal_title：Blood

authors： Markovic OS,Shulman NR

更新日期：1977-11-01 00:00:00

abstract：:The initiation of primary hemostasis is mediated by interaction of the platelet glycoprotein Ib (GPIb) surface receptor and its arterial subendothelial von Willebrand factor (vWF) ligand. The intracellular signaling immediately following GPIb receptor occupancy connecting the adhesive event to platelet activation and ...

journal_title：Blood

authors： Calverley DC,Kavanagh TJ,Roth GJ

更新日期：1998-02-15 00:00:00

abstract：:Seventy-five patients with resistant acute leukemia or lymphoma received high-dose cyclophosphamide and etoposide to explore the activity of this combination in resistant hematologic malignancies, and to determine the maximum doses of these drugs that can be combined without bone marrow transplantation. Etoposide was ...

journal_title：Blood

authors： Brown RA,Herzig RH,Wolff SN,Frei-Lahr D,Pineiro L,Bolwell BJ,Lowder JN,Harden EA,Hande KR,Herzig GP

更新日期：1990-08-01 00:00:00

abstract：:Recent studies on the immunoglobulin variable heavy chain (IgV(H)) genes have revealed that B-cell chronic lymphocytic leukemia (B-CLL) consists of at least 2 clinical entities with either somatically mutated or unmutated V(H) genes. We have analyzed the V(H) gene mutation status and V(H) gene usage in 119 B-CLL cases...

journal_title：Blood

authors： Tobin G,Thunberg U,Johnson A,Thörn I,Söderberg O,Hultdin M,Botling J,Enblad G,Sällström J,Sundström C,Roos G,Rosenquist R

更新日期：2002-03-15 00:00:00

abstract：:Endothelial cell receptors for tissue plasminogen activator (t-PA) have been demonstrated recently, and we have sought to identify a region of the t-PA molecule involved in its interaction with these receptors on human umbilical vein endothelial cells. Of three monoclonal antibodies against various regions of t-PA, on...

journal_title：Blood

authors： Beebe DP,Miles LA,Plow EF

更新日期：1989-11-01 00:00:00

abstract：:GVHD and tumor relapse are fundamental problems in allogeneic HSCT. Recent research has linked neovascularization to GVHD, tumor growth, and graft-versus-tumor (GVT) activity. Damage of the endothelium by the conditioning regimen provides the initiation stimulus for recruitment of donor-derived endothelial cells and t...

journal_title：Blood

authors： Penack O,Socié G,van den Brink MR

更新日期：2011-04-21 00:00:00

abstract：:In common variable immunodeficiency (CVID) defects in early stages of B-cell development, bone marrow (BM) plasma cells and T lymphocytes have not been studied systematically. Here we report the first morphologic and flow cytometric study of B- and T-cell populations in CVID BM biopsies and aspirates. Whereas the hema...

journal_title：Blood

authors： Ochtrop ML,Goldacker S,May AM,Rizzi M,Draeger R,Hauschke D,Stehfest C,Warnatz K,Goebel H,Technau-Ihling K,Werner M,Salzer U,Eibel H,Schlesier M,Peter HH

更新日期：2011-07-14 00:00:00

abstract：:Lentiviral vectors are attractive for hematopoietic stem cell (HSC) gene therapy because they do not require mitosis for nuclear entry, they efficiently transduce hematopoietic repopulating cells, and self-inactivating (SIN) designs can be produced at high titer. Experiments to evaluate HIV-derived lentiviral vectors ...

journal_title：Blood

authors： Trobridge GD,Beard BC,Gooch C,Wohlfahrt M,Olsen P,Fletcher J,Malik P,Kiem HP

更新日期：2008-06-15 00:00:00

abstract：:Currently availabel staging systems for non-Hodgkin lymphomas are not useful for clinical staging classification of most primary cutaneous lymphomas. The tumor, node, metastases (TNM) system used for mycosis fungoides (MF) and Sézary syndrome (SS) is not appropriate for other primary cutaneous lymphomas. A usable, uni...

journal_title：Blood

authors： Kim YH,Willemze R,Pimpinelli N,Whittaker S,Olsen EA,Ranki A,Dummer R,Hoppe RT,ISCL and the EORTC.

更新日期：2007-07-15 00:00:00

abstract：:We report the results of unrelated cord blood transplantation (CBT) for 18 adult patients with de novo acute myeloid leukemia (AML). The median age was 43 years, the median weight was 55.2 kg, and the median number of cryopreserved nucleated cells was 2.51 x 107/kg. Seventeen patients had myeloid reconstitution and th...

journal_title：Blood

authors： Ooi J,Iseki T,Takahashi S,Tomonari A,Takasugi K,Shimohakamada Y,Yamada T,Ishii K,Ohno N,Nagamura F,Uchimaru K,Tojo A,Asano S

更新日期：2004-01-15 00:00:00

abstract：:Cancer patients are at increased risk of deep vein thrombosis and pulmonary embolism. The incidence among different groups of cancer patients varies considerably depending on clinical factors, the most important being tumor entity and stage. Biomarkers have been specifically investigated for their capacity of predicti...

journal_title：Blood

authors： Pabinger I,Thaler J,Ay C

更新日期：2013-09-19 00:00:00

abstract：:Graft-versus-host disease (GVHD), a life-threatening complication after allogeneic hematopoietic stem cell transplantation, is caused by alloreactive donor T cells that trigger host tissue damage. The inflammatory environment inside recipients is critical for GVHD pathogenesis, but the underpinning mechanisms remain e...

journal_title：Blood

authors： Zhao F,Zhang Y,Wang H,Jin M,He S,Shi Y,Guo Y,Zhang Y

更新日期：2011-02-03 00:00:00

abstract：:The multimeric size and the function of circulating von Willebrand factor are modulated via its proteolytic cleavage by the plasma metalloproteinase, ADAMTS13. It is unclear how ADAMTS13 activity is regulated within the vascular system. In the absence of a regulatory mechanism, ADAMTS13 activity might compromise plate...

journal_title：Blood

authors： Crawley JT,Lam JK,Rance JB,Mollica LR,O'Donnell JS,Lane DA

更新日期：2005-02-01 00:00:00

abstract：:Two sisters in whom a diagnosis of Fanconi's anemia was made at ages 12 and 18 subsequently developed acute nonlymphocytic leukemia (ANLL). A third sibling had previously died at age 11 of apparent sepsis. Both sisters had cytogenetic studies that showed increased chromosomal breakage and a 46,XX karyotype, but subseq...

journal_title：Blood

authors： Stivrins TJ,Davis RB,Sanger W,Fritz J,Purtilo DT

更新日期：1984-07-01 00:00:00

abstract：:Adoptive transfer of T cells genetically modified to express chimeric antigen receptors (CARs) targeting CD19 has produced impressive results in treating patients with B-cell malignancies. Although these CAR-modified T cells target the same antigen, the designs of CARs vary as well as several key aspects of the clinic...

journal_title：Blood

authors： Park JH,Geyer MB,Brentjens RJ

更新日期：2016-06-30 00:00:00

abstract：:Antibody-induced antigenic modulation (AIAM) of CD10 and CD19 was studied on NALM-6, RAJI, and JOK-1 cell lines using fluorescence microscopy (FM), flow cytometry (FCM), and immunoelectron microscopy (IEM). Cross-linking with monoclonal antibodies (MoAbs) induced rapid redistribution of CD10 and CD19 on the cell surfa...

journal_title：Blood

authors： Pulczynski S,Boesen AM,Jensen OM

更新日期：1993-03-15 00:00:00

abstract：:Circulating lymphocytes leave the blood by binding to specialized high endothelial cells lining postcapillary venules in lymphoid organs or sites of chronic inflammations, migrating through the vessel wall into the surrounding tissue. The capacity of lymphocytes to recognize and bind to high endothelial venules (HEVs)...

journal_title：Blood

authors： Jalkanen ST,Butcher EC

更新日期：1985-09-01 00:00:00

abstract：:The reported outcome of hematopoietic stem cell transplantation (HSCT) from HLA-mismatched family members has been inconsistent. The object of this study was to evaluate the true impact of HLA-mismatch by using recent data from a homogenous population, excluding HSCT procedures that used graft manipulations, and by co...

journal_title：Blood

authors： Kanda Y,Chiba S,Hirai H,Sakamaki H,Iseki T,Kodera Y,Karasuno T,Okamoto S,Hirabayashi N,Iwato K,Maruta A,Fujimori Y,Furukawa T,Mineishi S,Matsuo K,Hamajima N,Imamura M

更新日期：2003-08-15 00:00:00

abstract：:The technique described in the preceding paper was applied to 12 abnormal sera selected for their increase in one or more B12-binding proteins. Even in the presence of large amounts of R-type binder, the ammonium sulfate technique gave a reliable separation of R binding proteins from TC II. Measurement of the TC II in...

journal_title：Blood

authors： Begley JA,Hall CA

更新日期：1975-02-01 00:00:00

abstract：:Reduced levels of somatic hypermutation (SHM) have recently been described in IgG-switched immunoglobulin genes in a minority of patients with common variable immunodeficiency (CVID), demonstrating a disruption of the normal linkage between isotype switch and SHM. To see if, irrespective of isotype, there is a tendenc...

journal_title：Blood

authors： Andersen P,Permin H,Andersen V,Schejbel L,Garred P,Svejgaard A,Barington T

更新日期：2005-01-15 00:00:00

abstract：:CD10/neutral endopeptidase 24.11 (NEP) regulates peptidemediated proliferation of lymphoid progenitors and certain epithelial cells and is itself regulated by cellular proliferation. To further characterize mechanisms by which cell-surface signaling might regulate CD10/NEP expression, we determined whether CD10/NEP wa...

journal_title：Blood

authors： Ganju RK,Shpektor RG,Brenner DG,Shipp MA

更新日期：1996-12-01 00:00:00

abstract：:Large granular lymphocyte (LGL) leukemia results from clonal expansion of CD3+ cytotoxic T lymphocytes or CD3- natural killer (NK) cells. Chronic antigen stimulation is postulated to promote long-term survival of LGL leukemia cells through constitutive activation of multiple survival pathways, resulting in global dysr...

journal_title：Blood

authors： Yang J,LeBlanc FR,Dighe SA,Hamele CE,Olson TL,Feith DJ,Loughran TP Jr

更新日期：2018-06-21 00:00:00

abstract：:Twenty four samples of DNA from 23 unrelated individuals were analyzed for the presence of a novel restriction fragment length polymorphism (RFLP) involving the proto-oncogene ETS-1 at an Xba I site. Four samples from unrelated individuals lacked an Xba I site, giving rise to a longer restriction fragment detectable b...

journal_title：Blood

authors： Savage PD,Hanson CA,Kersey JH

更新日期：1987-07-01 00:00:00