Abstract:
:Two sisters in whom a diagnosis of Fanconi's anemia was made at ages 12 and 18 subsequently developed acute nonlymphocytic leukemia (ANLL). A third sibling had previously died at age 11 of apparent sepsis. Both sisters had cytogenetic studies that showed increased chromosomal breakage and a 46,XX karyotype, but subsequently developed ANLL after, or coincident with, the emergence of monosomy 7. These observations suggest that, in addition to myelodysplastic syndromes and defective neutrophil chemotaxis, monosomy 7 may be associated with the emergence of leukemia in this disorder.
journal_name
Bloodjournal_title
Bloodauthors
Stivrins TJ,Davis RB,Sanger W,Fritz J,Purtilo DTsubject
Has Abstractpub_date
1984-07-01 00:00:00pages
173-6issue
1eissn
0006-4971issn
1528-0020journal_volume
64pub_type
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