Total lymphoid irradiation and cyclophosphamide as preparation for bone marrow transplantation in severe aplastic anemia.

abstract：:Stem cell factor (SCF) is expressed as an integral membrane growth factor that may be differentially processed to produce predominantly soluble (S) (SCF(248)) or membrane-associated (MA) (SCF(220)) protein. A critical role for membrane presentation of SCF in the hematopoietic microenvironment (HM) has been suggested f...

journal_title：Blood

authors： Kapur R,Cooper R,Xiao X,Weiss MJ,Donovan P,Williams DA

更新日期：1999-09-15 00:00:00

abstract：:One of the most serious complications of successful treatments for Hodgkin's disease is an increased incidence of acute nonlymphocytic leukemia (ANLL) and other malignancies. A retrospective analysis carried out on 1032 consecutive patients with Hodgkin's disease admitted to our Institute between 1965 and 1978 and tre...

journal_title：Blood

authors： Valagussa P,Santoro A,Fossati Bellani F,Franchi F,Banfi A,Bonadonna G

更新日期：1982-03-01 00:00:00

abstract：:Monocytes regulate host defenses, inflammation, and tissue homeostasis. The transcription factor interferon regulatory factor-8 (IRF8) stimulates monocyte/macrophage differentiation, yet genome-wide understanding of the differentiation program initiated by IRF8 is lacking. By combining chromatin immunoprecipitation se...

journal_title：Blood

authors： Kurotaki D,Osato N,Nishiyama A,Yamamoto M,Ban T,Sato H,Nakabayashi J,Umehara M,Miyake N,Matsumoto N,Nakazawa M,Ozato K,Tamura T

更新日期：2013-03-07 00:00:00

abstract：:We report a patient with a disease characterized by proliferation of T cells with Fc receptors for IgG (TG). However, unlike lymphoid cells from normal individuals or from patients with other lymphoid malignancies, the patient's lymphocytes spontaneously produced gamma interferon (IFN-gamma) in vitro. The peripheral l...

journal_title：Blood

authors： Hooks JJ,Haynes BF,Detrick-Hooks B,Diehl LF,Gerrard TL,Fauci AS

更新日期：1982-01-01 00:00:00

abstract：:The pathogenesis of thrombotic thrombocytopenic purpura (TTP) is obscure. It is manifested classically by platelet thrombi and localized microvascular endothelial cell (EC) proliferation, in the absence of an inflammatory response. It is statistically associated with human retroviral disease, but pathological studies ...

journal_title：Blood

authors： Laurence J,Mitra D,Steiner M,Staiano-Coico L,Jaffe E

更新日期：1996-04-15 00:00:00

abstract：:The primitive hematopoietic stem/progenitor cells (HSPCs) during embryonic hematopoiesis are thought to be short-lived (SL) with limited self-renewal potential. The fate and consequence of these short-lived HSPCs, once reprogrammed into "long-lived" in a living animal body, remain unknown. Here we show that targeted e...

journal_title：Blood

authors： Zhou T,Wang L,Zhu KY,Dong M,Xu PF,Chen Y,Chen SJ,Chen Z,Deng M,Liu TX

更新日期：2011-10-06 00:00:00

abstract：:Mammalian beta-globin loci are composed of multiple orthologous genes whose expression is erythroid specific and developmentally regulated. The expression of these genes both from the endogenous locus and from transgenes is strongly influenced by a linked 15-kilobase region of clustered DNaseI hypersensitive sites (HS...

journal_title：Blood

authors： Bender MA,Mehaffey MG,Telling A,Hug B,Ley TJ,Groudine M,Fiering S

更新日期：2000-06-01 00:00:00

abstract：:Ten patients with idiopathic thrombocytopenic purpura (ITP) were studied before and following a rise in circulating platelets subsequent to infusions of intravenous gammaglobulin (400 mg/kg/day x 5 days). We quantitated the amount of circulating IgG capable of binding to normal donor platelets in vitro using an 125I-m...

journal_title：Blood

authors： Barbano G,Saleh MN,Mori PG,LoBuglio AF,Shaw DR

更新日期：1989-02-15 00:00:00

abstract：:Low molecular weight heparin (LMWH) is being tested as an experimental drug for improving pregnancy outcome in women with inherited thrombophilia and placenta-mediated pregnancy complications, such as recurrent pregnancy loss. The role of thrombotic processes in these disorders remains unproven, and the issue of antit...

journal_title：Blood

authors： An J,Waitara MS,Bordas M,Arumugam V,Hoffmann RG,Petrich BG,Sinha U,North PE,Sood R

更新日期：2013-03-14 00:00:00

abstract：:We compared 48-hour urinary iron excretion after a twice-daily subcutaneous bolus injection of deferoxamine and after 12 hours of subcutaneous continuous infusion of the drug in 27 patients with iron overload (mean age, 55.7 years). In most patients, the iron overload was due to multiple transfusions administered duri...

journal_title：Blood

authors： Franchini M,Gandini G,de Gironcoli M,Vassanelli A,Borgna-Pignatti C,Aprili G

更新日期：2000-05-01 00:00:00

abstract：:Thrombopoietin (TPO) is a hematopoietic growth factor that regulates megakaryocytopoiesis and platelet production through binding to its receptor, Mpl, encoded by the c-mpl proto-oncogene. Circulating levels of TPO are regulated by receptor-mediated uptake and degradation. To better understand this mode of TPO regulat...

journal_title：Blood

authors： Cohen-Solal K,Vitrat N,Titeux M,Vainchenker W,Wendling F

更新日期：1999-05-01 00:00:00

abstract：:Congenital blood disorders are common and yet clinically challenging globin disorders. Gene therapy continues to serve as a potential therapeutic method to treat these disorders. While tremendous advances have been made in vivo, gene delivery protocols and vector prototypes still require optimization. Alternative cis-...

journal_title：Blood

authors： Staplin WR,Knezetic JA

更新日期：2003-03-01 00:00:00

abstract：:The experience at a single institution in harvesting marrow for allogeneic transplantation on 1,270 occasions from 1,160 normal donors is presented in detail, together with an analysis of all the donor complications. Four donors were less than 2 years old, and the youngest was 6 1/2 months. No special difficulties wer...

journal_title：Blood

authors： Buckner CD,Clift RA,Sanders JE,Stewart P,Bensinger WI,Doney KC,Sullivan KM,Witherspoon RP,Deeg HJ,Appelbaum FR

更新日期：1984-09-01 00:00:00

abstract：:Patients with congenital T lymphocyte deficiency disorders received transplants with parental bone marrow depleted of mature T cells by the use of an anti-T cell monoclonal antibody (CT-2) and complement. Our results with 16 consecutive patients (20 transplants) showed rapid engraftment of donor cells; cytoreduction (...

journal_title：Blood

authors： Moen RC,Horowitz SD,Sondel PM,Borcherding WR,Trigg ME,Billing R,Hong R

更新日期：1987-09-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is an incurable adult disease of unknown etiology. Understanding the biology of CLL cells, particularly cell maturation and growth in vivo, has been impeded by lack of a reproducible adoptive transfer model. We report a simple, reproducible system in which primary CLL cells prolifera...

journal_title：Blood

authors： Bagnara D,Kaufman MS,Calissano C,Marsilio S,Patten PE,Simone R,Chum P,Yan XJ,Allen SL,Kolitz JE,Baskar S,Rader C,Mellstedt H,Rabbani H,Lee A,Gregersen PK,Rai KR,Chiorazzi N

更新日期：2011-05-19 00:00:00

abstract：:In this issue of Blood, Kochenderfer et al show that engineered CD19–chimeric antigen receptor (CAR) and donor-derived allogeneic T cells can safely treat CD19-positive B-cell malignancies, which have relapsed after allogeneic stem cell transplantation. ...

journal_title：Blood

authors： Rapoport AP

更新日期：2013-12-12 00:00:00

abstract：:Dendritic cells (DCs) represent a family of ontogenically distinct leukocytes involved in immune response regulation. The ability of DCs to stimulate T-cell immunity has led to their use as vectors for immunotherapy vaccines. However, it is unclear whether and to what degree in vitro-generated DCs are representative o...

journal_title：Blood

authors： Maraskovsky E,Daro E,Roux E,Teepe M,Maliszewski CR,Hoek J,Caron D,Lebsack ME,McKenna HJ

更新日期：2000-08-01 00:00:00

abstract：:Cytotoxic T lymphocytes kill target cells via the polarized secretion of cytotoxic granules at the immune synapse. The lytic granules are initially recruited around the polarized microtubule-organizing center. In a dynein-dependent transport process, the granules move along microtubules toward the microtubule-organizi...

journal_title：Blood

authors： Kurowska M,Goudin N,Nehme NT,Court M,Garin J,Fischer A,de Saint Basile G,Ménasché G

更新日期：2012-04-26 00:00:00

abstract：:The present study focuses on a large family with an X-linked immunodeficiency in which there are variable clinical and laboratory phenotypes, including recurrent viral and bacterial infections, hypogammaglobulinemia, Epstein-Barr virus-driven lymphoproliferation, splenomegaly, colitis, and liver disease. Molecular and...

journal_title：Blood

authors： Rigaud S,Lopez-Granados E,Sibéril S,Gloire G,Lambert N,Lenoir C,Synaeve C,Stacey M,Fugger L,Stephan JL,Fischer A,Picard C,Durandy A,Chapel H,Latour S

更新日期：2011-07-14 00:00:00

abstract：:Following antigen acquisition and maturation, dendritic cells (DCs) disengage from the extracellular matrix, cross basement membranes, and travel to draining lymph nodes to activate T cells. CCR7 expression is necessary but not sufficient for the directional migration of DCs. Prostaglandin E2 (PGE2), present in inflam...

journal_title：Blood

authors： Yen JH,Khayrullina T,Ganea D

更新日期：2008-01-01 00:00:00

abstract：:An unmet need in cell engineering is the availability of a single transgene encoded, functionally inert, human polypeptide that can serve multiple purposes, including ex vivo cell selection, in vivo cell tracking, and as a target for in vivo cell ablation. Here we describe a truncated human EGFR polypeptide (huEGFRt) ...

journal_title：Blood

authors： Wang X,Chang WC,Wong CW,Colcher D,Sherman M,Ostberg JR,Forman SJ,Riddell SR,Jensen MC

更新日期：2011-08-04 00:00:00

abstract：:The effect of 5-fluorouracil (5-FU) pretreatment on human bone marrow (BM) progenitor/stem cells and recovery of hematopoiesis after autologous marrow transplant was studied. Twenty-one patients were treated with 5-FU (15 mg/kg to 45 mg/kg) intravenously (IV) for 1 to 3 days administered 6 to 22 days before BM harvest...

journal_title：Blood

authors： Stewart FM,Temeles D,Lowry P,Thraves T,Grosh WW,Quesenberry PJ

更新日期：1993-05-01 00:00:00

abstract：:Regulatory T (Treg) cells contribute to immune evasion by malignancies. To investigate their importance in non-Hodgkin lymphoma (NHL), we enumerated Treg cells in peripheral blood mononuclear cells (PBMCs) and involved tissues from 30 patients. CD25(+)FoxP3(+)CD127(low)CD4(+) Treg cells were increased markedly in PBMC...

journal_title：Blood

authors： Mittal S,Marshall NA,Duncan L,Culligan DJ,Barker RN,Vickers MA

更新日期：2008-06-01 00:00:00

abstract：:In sickle cell (SS) vaso-occlusion, the culminating event is blockage of blood vessels by sickled red blood cells (SS RBCs). As shown in animal models, SS RBC-induced vaso-occlusion is often partial, allowing for a residual flow, hence oxygen delivery to partially occluded vessels could reduce vaso-occlusion. The effi...

journal_title：Blood

authors： Kaul DK,Liu X,Nagel RL

更新日期：2001-11-15 00:00:00

abstract：:Mast cells may be cultured from human peripheral blood in the presence of recombinant human stem cell factor (rhSCF). The characteristics of the cells in peripheral blood that give rise to mast cells are unknown. Because mast cell precursors in human marrow are CD34+, human peripheral blood mononuclear cells from pati...

journal_title：Blood

authors： Rottem M,Okada T,Goff JP,Metcalfe DD

更新日期：1994-10-15 00:00:00

abstract：:Natural killer T (NKT) cells are innate-like T cells that recognize specific microbial antigens and also display autoreactivity to self-antigens. The nature of NKT-cell autoreactive activation remains poorly understood. We show here that the mitogen-activated protein kinase (MAPK) pathway is operative during human NKT...

journal_title：Blood

authors： Wang X,Chen X,Rodenkirch L,Simonson W,Wernimont S,Ndonye RM,Veerapen N,Gibson D,Howell AR,Besra GS,Painter GF,Huttenlocher A,Gumperz JE

更新日期：2008-11-15 00:00:00

abstract：:The bone marrow plays a unique role within the immune system. We compared the phenotype and function of virus-specific CD8(+) T cells from matched samples of human peripheral blood and bone marrow. Analysis of virus-specific memory CD8(+) T cells showed widely divergent partition of antigen-specific populations betwee...

journal_title：Blood

authors： Palendira U,Chinn R,Raza W,Piper K,Pratt G,Machado L,Bell A,Khan N,Hislop AD,Steyn R,Rickinson AB,Buckley CD,Moss P

更新日期：2008-10-15 00:00:00

abstract：:CTLA-4 is an inhibitory molecule that down-regulates T-cell activation. Although polymorphisms at CTLA-4 have been correlated with autoimmune diseases their association with clinical outcome after allogeneic hematopoietic stem cell transplantation (allo-HSCT) has yet to be explored. A total of 5 CTLA-4 single-nucleoti...

journal_title：Blood

authors： Pérez-García A,De la Cámara R,Román-Gómez J,Jiménez-Velasco A,Encuentra M,Nieto JB,de la Rubia J,Urbano-Ispizúa A,Brunet S,Iriondo A,González M,Serrano D,Espigado I,Solano C,Ribera JM,Pujal JM,Hoyos M,Gallardo D,GVHD\

更新日期：2007-07-01 00:00:00

abstract：:Attempts to maintain or expand primitive hematopoietic stem cells in vitro without the concomitant loss of their differentiative and proliferative potential in vivo have largely been unsuccessful. To investigate this problem, we compared the ability of three cloned bone marrow (BM) stromal cell lines to support the gr...

journal_title：Blood

authors： Szilvassy SJ,Weller KP,Lin W,Sharma AK,Ho AS,Tsukamoto A,Hoffman R,Leiby KR,Gearing DP

更新日期：1996-06-01 00:00:00

abstract：:We examined the prevalence and prognostic relevance of bone marrow reticulin fibrosis in 526 patients with World Health Organization-defined polycythemia vera evaluated at the time of initial diagnosis. Seventy-four patients (14%) displayed mostly grade 1 reticulin fibrosis, with only 2 cases showing higher-grade fibr...

journal_title：Blood

authors： Barbui T,Thiele J,Passamonti F,Rumi E,Boveri E,Randi ML,Bertozzi I,Marino F,Vannucchi AM,Pieri L,Rotunno G,Gisslinger H,Gisslinger B,Müllauer L,Finazzi G,Carobbio A,Gianatti A,Ruggeri M,Nichele I,D'Amore E,Rambald

更新日期：2012-03-08 00:00:00