Donating used CARs.

abstract：:We examined the expression of messenger RNA (mRNA) of the human inducible nitric oxide synthase (hiNOS) gene in a panel of human T-cell lines. Reverse transcriptase-polymerase chain reaction showed that human T-cell leukemia virus type-I (HTLV-I)-infected T-cell lines (MT-1, SLB-1, and C5/MJ) expressed mRNA for the hi...

journal_title：Blood

authors： Mori N,Nunokawa Y,Yamada Y,Ikeda S,Tomonaga M,Yamamoto N

更新日期：1999-10-15 00:00:00

abstract：:Some patients lose chimerism following nonmyeloablative hematopoietic cell transplantation (HCT), yet, surprisingly, enjoy sustained tumor remissions. We hypothesized that host-versus-graft (HVG) alloresponses might induce antitumor effects against recipient tumors. We explored this question in mice by administering r...

journal_title：Blood

authors： Rubio MT,Kim YM,Sachs T,Mapara M,Zhao G,Sykes M

更新日期：2003-09-15 00:00:00

abstract：:A number of studies have recently demonstrated that super-enhancers, which are large cluster of enhancers typically marked by a high level of acetylation of histone H3 lysine 27 and mediator bindings, are frequently associated with genes that control and define cell identity during normal development. Super-enhancers ...

journal_title：Blood

authors： Wong RWJ,Ngoc PCT,Leong WZ,Yam AWY,Zhang T,Asamitsu K,Iida S,Okamoto T,Ueda R,Gray NS,Ishida T,Sanda T

更新日期：2017-11-23 00:00:00

abstract：:A hybridoma-derived monoclonal antibody, produced by immunization with the Burkitt's tumor-derived B-lymphoblastoid cell line, B35M, was previously shown to detect a 68,000 dalton surface membrane protein, BL2, on the surface of peripheral blood B cells, which is absent from thymocytes, T cells, and granulocytes. In t...

journal_title：Blood

authors： Knowles DM 2nd,Tolidjian B,Marboe CC,Halper JP,Azzo W,Wang CY

更新日期：1983-07-01 00:00:00

abstract：:The cellular immune defect in untreated Hodgkin's disease (HD) has long been recognized. This defect appears to be responsible for at least some of the morbidity and ultimately the mortality associated with the disease. In recent years, many studies have shown that the T cell component of the immune response is the ap...

journal_title：Blood

authors： Ford RJ,Tsao J,Kouttab NM,Sahasrabuddhe CG,Mehta SR

更新日期：1984-08-01 00:00:00

abstract：:Acquired hemophilia is a rare bleeding disorder characterized by the spontaneous occurrence of inhibitory antibodies against endogenous factor VIII (FVIII). IgG from some patients with acquired hemophilia hydrolyze FVIII. Because of the complex etiology of the disease, no clinical parameter, including the presence of ...

journal_title：Blood

authors： Wootla B,Christophe OD,Mahendra A,Dimitrov JD,Repessé Y,Ollivier V,Friboulet A,Borel-Derlon A,Levesque H,Borg JY,Andre S,Bayry J,Calvez T,Kaveri SV,Lacroix-Desmazes S

更新日期：2011-02-17 00:00:00

abstract：:To assess the relationship between venous thrombosis and plasma glucosylceramide (GlcCer) or phosphatidylethanolamine (PE), plasma levels of GlcCer and PE were determined for 70 venous thrombosis patients referred for evaluation and 70 healthy blood donors. The mean GlcCer level, but not the PE level, was lower in pat...

journal_title：Blood

authors： Deguchi H,Fernández JA,Pabinger I,Heit JA,Griffin JH

更新日期：2001-04-01 00:00:00

abstract：:SOCS1-/- mice die prematurely of increased interferon-gamma (IFNgamma) signaling with severe thymic atrophy and accelerated maturation of T cells. However, it was unclear whether the thymic defects were caused by SOCS1 deficiency or by increased IFNgamma signaling. Using SOCS1-/- IFNgamma-/- mice, we show in this stud...

journal_title：Blood

authors： Ilangumaran S,Ramanathan S,Ning T,La Rose J,Reinhart B,Poussier P,Rottapel R

更新日期：2003-12-01 00:00:00

abstract：:Cell suspensions of normal rat marrow mixed with rat acute myelogenous leukemic cells were prepared and incubated in vitro with graded doses of 4-hydroperoxycyclophosphamide (4HC). The cell suspensions were injected into rats prepared with a lethal dose of total body irradiation. Animals injected with these cells surv...

journal_title：Blood

authors： Sharkis SJ,Santos GW,Colvin M

更新日期：1980-03-01 00:00:00

abstract：:BRCA1 is critical for maintenance of genomic stability and interacts directly with several proteins that regulate hematopoietic stem cell function and are part of the Fanconi anemia (FA) double-strand break DNA repair pathway. The effects of complete BRCA1 deficiency on bone marrow (BM) function are unknown. To test t...

journal_title：Blood

authors： Vasanthakumar A,Arnovitz S,Marquez R,Lepore J,Rafidi G,Asom A,Weatherly M,Davis EM,Neistadt B,Duszynski R,Vardiman JW,Le Beau MM,Godley LA,Churpek JE

更新日期：2016-01-21 00:00:00

abstract：:Immune reconstitution of autologous hematopoietic stem-cell transplant recipients with the progeny of mature T cells in the graft leads to profound changes in the emerging functional T-cell repertoire. In the steady state, the host is frequently tolerant to tumor antigens, reflecting dominant suppression of naive and ...

journal_title：Blood

authors： Mirmonsef P,Tan G,Zhou G,Morino T,Noonan K,Borrello I,Levitsky HI

更新日期：2008-02-15 00:00:00

abstract：:Two patients with progressive hairy cell leukemia following splenectomy were treated with low-dose daily chlorambucil. Both had an objective hematologic response as determined by a return to normal hematocrit and platelet count. This was also reflected in the mononuclear cell fraction by the normalization of cholester...

journal_title：Blood

authors： Krigel R,Liebes LF,Pelle E,Silber R

更新日期：1982-07-01 00:00:00

abstract：:To elucidate the role of thrombocytosis, alone or in combination with standard (age, previous cardiovascular events) and novel (leukocytosis, JAK2(V617F) mutational status) risk factors, in the cardiovascular events of essential thrombocythemia (ET), we analyzed a cohort of 1063 patients. We found that a platelet coun...

journal_title：Blood

authors： Carobbio A,Finazzi G,Antonioli E,Guglielmelli P,Vannucchi AM,Delaini F,Guerini V,Ruggeri M,Rodeghiero F,Rambaldi A,Barbui T

更新日期：2008-10-15 00:00:00

abstract：:The influence of interferon (IFN) on cellular proliferation, blast transformation, and differentiation was studied in lymph node cells from 17 patients with B-cell lymphomas, one patient with T-cell lymphoma, and eight patients with enlarged, non-malignant lymph nodes. The effects of IFN on lymph node cells were compa...

journal_title：Blood

authors： Ostlund L,Biberfeld P,Robèrt KH,Christensson B,Einhorn S

更新日期：1989-06-01 00:00:00

abstract：:Immune thrombocytopenia (ITP) is an acquired bleeding disorder characterized by antibody-mediated platelet destruction. Different mechanisms have been suggested to explain accelerated platelet clearance and impaired thrombopoiesis, but the pathophysiology of ITP has yet to be fully delineated. In this study, we tested...

journal_title：Blood

authors： Morodomi Y,Kanaji S,Won E,Ruggeri ZM,Kanaji T

更新日期：2020-06-18 00:00:00

abstract：:Although receptor activator of nuclear factor (NF)-kappaB ligand (RANKL) signaling has been shown to prolong the survival of mature dendritic cells (DCs), the association of RANKL pathway with Fas-mediated apoptosis is obscure. Here, we found that bone marrow-derived DCs (BMDCs) from the Fas-deficient strain MRL/lpr m...

journal_title：Blood

authors： Izawa T,Ishimaru N,Moriyama K,Kohashi M,Arakaki R,Hayashi Y

更新日期：2007-07-01 00:00:00

abstract：:Seventy-one patients with hematologic malignancies received bone marrow from a histocompatible sibling (n = 48) or a partially matched relative (n = 23) that had been depleted of CD5+ T cells with either an anti-CD5 mooclonal antibody (MoAb) plus complement (anti-Leu1 + C) or an anti-CD5 MoAb conjugated to ricin A cha...

journal_title：Blood

authors： Antin JH,Bierer BE,Smith BR,Ferrara J,Guinan EC,Sieff C,Golan DE,Macklis RM,Tarbell NJ,Lynch E

更新日期：1991-10-15 00:00:00

abstract：:Transforming growth factor-alpha (TGF-alpha) exerts several effects on target cells, such as neovascularization promotion and mitogenic signalling. Using immunoelectron microscopy, we show that monocytes and neutrophils, store TGF-alpha in cytoplasmic granules. In monocytes, TGF-alpha did not colocalize with component...

journal_title：Blood

authors： Calafat J,Janssen H,Ståhle-Bäckdahl M,Zuurbier AE,Knol EF,Egesten A

更新日期：1997-08-01 00:00:00

abstract：:Nitric oxide is a short-lived reactive mediator that inhibits bone marrow (BM) cell proliferation induced by granulocyte-macrophage colony-stimulating factor (GM-CSF). The present studies show that nitric oxide also inhibits macrophage colony-stimulating factor (M-CSF)-induced growth of mouse BM cells, an effect that ...

journal_title：Blood

authors： Punjabi CJ,Laskin JD,Hwang SM,MacEachern L,Laskin DL

更新日期：1994-06-01 00:00:00

abstract：:We have identified and cloned a novel human cytokine with homology to cytokines of the interleukin-17 (IL-17) family, which we have termed human IL-17E (hIL-17E). With the identification of several IL-17 family members, it is critical to understand the in vivo function of these molecules. We have generated transgenic ...

journal_title：Blood

authors： Kim MR,Manoukian R,Yeh R,Silbiger SM,Danilenko DM,Scully S,Sun J,DeRose ML,Stolina M,Chang D,Van GY,Clarkin K,Nguyen HQ,Yu YB,Jing S,Senaldi G,Elliott G,Medlock ES

更新日期：2002-10-01 00:00:00

abstract：:Sickle cell trait (SCT) is unique among the carrier states that are identified during newborn screening. Unlike other heterozygous states for rare recessive diseases, SCT is exceedingly prevalent throughout regions of the world, making sickle cell disease one of the most common monogenetic diseases worldwide. Because ...

journal_title：Blood

authors： Pecker LH,Naik RP

更新日期：2018-11-29 00:00:00

abstract：:Marrow cells of myeloid lineage from 115 patients with myelodysplastic syndrome (MDS) were characterized by multidimensional flow cytometry and compared with findings in 104 patients with various disorders and 25 healthy donors. Based on phenotypic and scatter characteristics, a flow cytometric scoring system (FCSS) w...

journal_title：Blood

authors： Wells DA,Benesch M,Loken MR,Vallejo C,Myerson D,Leisenring WM,Deeg HJ

更新日期：2003-07-01 00:00:00

abstract：:Whole saliva samples collected from available people at risk in Boston for infection with human T-lymphotropic virus type III (HTLV-III/LAV), from late 1984 through early 1985, were analyzed for the presence of antibodies to viral proteins. Fourteen of 20 (70%) acquired immunodeficiency syndrome (AIDS) patients and 14...

journal_title：Blood

authors： Archibald DW,Zon L,Groopman JE,McLane MF,Essex M

更新日期：1986-03-01 00:00:00

abstract：:Neutrophil dysfunction consequent to influenza A virus infection has been described in vivo and in vitro and may contribute to the serious bacterial sequelae which occur in influenza-infected hosts. On the premise that such dysfunction may represent a form of "deactivation," we sought to characterize neutrophil activa...

journal_title：Blood

authors： Hartshorn KL,Collamer M,White MR,Schwartz JH,Tauber AI

更新日期：1990-01-01 00:00:00

abstract：:The International Peripheral T-Cell Lymphoma Project is a collaborative effort designed to gain better understanding of peripheral T-cell and natural killer (NK)/T-cell lymphomas (PTCLs). A total of 22 institutions in North America, Europe, and Asia submitted clinical and pathologic information on PTCLs diagnosed and ...

journal_title：Blood

authors： Savage KJ,Harris NL,Vose JM,Ullrich F,Jaffe ES,Connors JM,Rimsza L,Pileri SA,Chhanabhai M,Gascoyne RD,Armitage JO,Weisenburger DD,International Peripheral T-Cell Lymphoma Project.

更新日期：2008-06-15 00:00:00

abstract：:A new combination of total lymphoid irradiation and cyclophosphamide was used prior to bone marrow transplantation in an attempt to achieve decreased rejection rates and graft-versus-host disease. Nine previously transfused patients with severe aplastic anemia received marrow from an HLA-identical, MLC-compatible sibl...

journal_title：Blood

authors： Ramsay NK,Kim T,Nesbit ME,Krivit W,Coccia PF,Levitt SH,Woods WG,Kersey JH

更新日期：1980-02-01 00:00:00

abstract：:In this issue of Blood, White et al provide compelling evidence that the intrinsic apoptotic caspase cascade, while required for megakaryocyte and platelet death under pathophysiologic conditions, is dispensable for normal platelet formation and function. ...

journal_title：Blood

authors： Cantor AB

更新日期：2012-05-03 00:00:00

abstract：:Acute bleeding after bone marrow transplantation (BMT) was investigated in 1,402 patients receiving transplants at Johns Hopkins Hospital between January 1, 1986 and June 30, 1995. Bleeding categorization was based on daily scores of intensity used by the blood transfusion service. Moderate and severe episodes were an...

journal_title：Blood

authors： Nevo S,Swan V,Enger C,Wojno KJ,Bitton R,Shabooti M,Fuller AK,Jones RJ,Braine HG,Vogelsang GB

更新日期：1998-02-15 00:00:00

abstract：:Variations within proteasome β (PSMB) genes, which encode the β subunits of the 20S proteasome, may affect proteasome function, assembly, and/or binding of proteasome inhibitors. To investigate the potential association between PSMB gene variants and treatment-emergent resistance to bortezomib and/or long-term outcome...

journal_title：Blood

authors： Lichter DI,Danaee H,Pickard MD,Tayber O,Sintchak M,Shi H,Richardson PG,Cavenagh J,Bladé J,Façon T,Niesvizky R,Alsina M,Dalton W,Sonneveld P,Lonial S,van de Velde H,Ricci D,Esseltine DL,Trepicchio WL,Mulligan G,And

更新日期：2012-11-29 00:00:00

abstract：:Isolated splenic hairy cells from three untreated patients were cultured in presence of recombinant human interferon alpha-2C (IFN alpha). Ultrastructural cytochemistry and immunophenotype analysis with a large panel of monoclonal antibodies were performed to study cellular modification induced by IFN alpha. Hairy cel...

journal_title：Blood

authors： Baldini L,Cortelezzi A,Polli N,Neri A,Nobili L,Maiolo AT,Lambertenghi-Deliliers G,Polli EE

更新日期：1986-02-01 00:00:00