Gamma (immune) interferon production by leukocytes from a patient with a TG cell proliferative disease.

abstract：:Age-associated clonal hematopoiesis caused by acquired mutations in myeloid cancer-associated genes is highly prevalent in the normal population. Its etiology, biological impact on hematopoiesis, and oncogenic risk is poorly defined at this time. To gain insight into this phenomenon, we analyzed a cohort of 2530 relat...

journal_title：Blood

authors： Buscarlet M,Provost S,Zada YF,Barhdadi A,Bourgoin V,Lépine G,Mollica L,Szuber N,Dubé MP,Busque L

更新日期：2017-08-10 00:00:00

abstract：:Because of their potent immunoregulatory capacity, dendritic cells (DCs) have been exploited as therapeutic tools to boost immune responses against tumors or pathogens, or dampen autoimmune or allergic responses. Murine bone marrow-derived DCs (BM-DCs) are the closest known equivalent of the blood monocyte-derived DCs...

journal_title：Blood

authors： Creusot RJ,Yaghoubi SS,Chang P,Chia J,Contag CH,Gambhir SS,Fathman CG

更新日期：2009-06-25 00:00:00

abstract：:The underlying pathways that lead to relapse in childhood acute lymphoblastic leukemia (ALL) are unknown. To comprehensively characterize the molecular evolution of relapsed childhood B-precursor ALL, we used human 500K single-nucleotide polymorphism arrays to identify somatic copy number alterations (CNAs) in 20 diag...

journal_title：Blood

authors： Yang JJ,Bhojwani D,Yang W,Cai X,Stocco G,Crews K,Wang J,Morrison D,Devidas M,Hunger SP,Willman CL,Raetz EA,Pui CH,Evans WE,Relling MV,Carroll WL

更新日期：2008-11-15 00:00:00

abstract：:CD4(+)CD25(+)FOXP3(+) regulatory T cells (CD4(+) Treg cells) are thought to differentiate in the thymus and immigrate from the thymus to the periphery. Treg cells can regulate both acquired and innate immunity through multiple modes of suppression. The cross-talk between Treg cells and targeted cells, such as antigen-...

journal_title：Blood

authors： Wei S,Kryczek I,Zou W

更新日期：2006-07-15 00:00:00

abstract：:Burkitt lymphoma (BL) is classified into 3 clinical subsets: endemic, sporadic, and immunodeficiency-associated BL. So far, possible differences in their gene expression profiles (GEPs) have not been investigated. We studied GEPs of BL subtypes, other B-cell lymphomas, and B lymphocytes; first, we found that BL is a u...

journal_title：Blood

authors： Piccaluga PP,De Falco G,Kustagi M,Gazzola A,Agostinelli C,Tripodo C,Leucci E,Onnis A,Astolfi A,Sapienza MR,Bellan C,Lazzi S,Tumwine L,Mawanda M,Ogwang M,Calbi V,Formica S,Califano A,Pileri SA,Leoncini L

更新日期：2011-03-31 00:00:00

abstract：:Children with Philadelphia chromosome (Ph+) acute lymphoblastic leukemia (ALL) have a poorer prognosis than do most pediatric patients with ALL. Because of this poor prognosis and the presence of the Ph chromosome, we have asked whether or not Ph + ALL involves a multipotential stem cell. We cultured hematopoietic pro...

journal_title：Blood

authors： Tachibana N,Raimondi SC,Lauer SJ,Sartain P,Dow LW

更新日期：1987-11-01 00:00:00

abstract：:Microscopic intracellular detection of Epstein-Barr virus (EBV) messenger RNA in Reed-Sternberg cells of Hodgkin's disease (HD) was possible by in situ hybridization, in tissue sections prepared by a method termed modified acetone methyl benzoate xylene (ModAMeX). The ModAMeX method was initially developed for simulta...

journal_title：Blood

authors： Brousset P,Chittal S,Schlaifer D,Icart J,Payen C,Rigal-Huguet F,Voigt JJ,Delsol G

更新日期：1991-04-15 00:00:00

abstract：:Incubation of human mononuclear leukocytes (MNL) with human stroma-free hemolysate (SFH), purified adult hemoglobin Ao (HbAo), and oxidized HbAo (METHb) caused MNL to release compounds into the supernate that mediated neutrophil (polymorphonuclear leukocytes, PMN) chemotaxis and PMN adherence to human umbilical vein e...

journal_title：Blood

authors： McFaul SJ,Bowman PD,Villa VM,Gutierrez-Ibanez MJ,Johnson M,Smith D

更新日期：1994-11-01 00:00:00

abstract：:Stem cell proliferation induced by potent cytokines usually leads to a loss of primitive potential through differentiation. In this study, the ability of cytokines and murine MS5 stromal cells to independently regulate the proliferation and long-term culture-initiating cell (LTC-IC) activity of primitive CD34(+)CD38(l...

journal_title：Blood

authors： Bennaceur-Griscelli A,Pondarré C,Schiavon V,Vainchenker W,Coulombel L

更新日期：2001-01-15 00:00:00

abstract：:Glanzmann thrombasthenia (GT) is a rare bleeding disorder resulting from mutations in either glycoprotein (GP) IIb or GPIIIa genes. The disease is relatively frequent in highly inbred populations such as Iraqi Jews. The molecular basis of GT in 6 unrelated Iraqi-Jewish patients was previously identified as an 11-bp de...

journal_title：Blood

authors： Rosenberg N,Yatuv R,Orion Y,Zivelin A,Dardik R,Peretz H,Seligsohn U

更新日期：1997-05-15 00:00:00

abstract：:An abnormality of platelet aggregation has been detected in six family members with mild bleeding tendencies. In citrated platelet-rich plasma, primary aggregation induced by ADP or epinephrine and agglutination in response to ristocetin were present but second wave aggregation and aggregation in response to collagen ...

journal_title：Blood

authors： Ingerman CM,Smith JB,Shapiro S,Sedar A,Silver MJ

更新日期：1978-08-01 00:00:00

abstract：:The ultrastructure of the lymphocytes from three children with severe combined immunodeficiency disease (SCID) is described. Parallel tubular arrays (PTA) were found in a large percentage of circulating lymphocytes (53%, 41%, and 13%) in three SCID patients when compared to age-matched controls. The size of these incl...

journal_title：Blood

authors： Payne CM,Jones JF,Sieber OF Jr,Fulginiti VA

更新日期：1977-07-01 00:00:00

abstract：:Rh(o)(D) immune globulin intravenous (anti-D IGIV) was licensed by the United States Food and Drug Administration (FDA) in March 1995 to treat patients with immune thrombocytopenic purpura (ITP). Anti-D IGIV induces extravascular hemolysis, an expected adverse reaction that is consistent with the presumed mechanism of...

journal_title：Blood

authors： Gaines AR

更新日期：2000-04-15 00:00:00

abstract：:Antiphospholipid antibodies including anticardiolipin antibodies, lupus anticoagulants, and anti-beta(2) glycoprotein-1-specific antibodies may identify patients at elevated risk of first or recurrent venous or arterial thromboembolism. Traditionally, published case series supplemented by anecdotal experience have for...

journal_title：Blood

authors： Garcia DA,Khamashta MA,Crowther MA

更新日期：2007-11-01 00:00:00

abstract：:The abnormal adherence of red blood cells (RBC to the blood vessel wall is believed to contribute to the vascular occlusion observed in patients with sickle call anemia. The cell adhesion receptors GPIV (CD36) and integrin alpha 4 beta 1 (CD49d/CD29) were previously identified on circulating sickle reticulocytes, and ...

journal_title：Blood

authors： Joneckis CC,Shock DD,Cunningham ML,Orringer EP,Parise LV

更新日期：1996-06-01 00:00:00

abstract：:The molecular backgrounds of variants encountered in Afro-Caribbean black individuals and associated with the production of clinically significant antibodies against high-incidence antigens (anti-RH18, anti-RH34) and against Rhe epitopes were determined. We showed that RH:-18 phenotypes are produced by 3 distinct RHCE...

journal_title：Blood

authors： Noizat-Pirenne F,Lee K,Pennec PY,Simon P,Kazup P,Bachir D,Rouzaud AM,Roussel M,Juszczak G,Ménanteau C,Rouger P,Kotb R,Cartron JP,Ansart-Pirenne H

更新日期：2002-12-01 00:00:00

abstract：:Twenty four samples of DNA from 23 unrelated individuals were analyzed for the presence of a novel restriction fragment length polymorphism (RFLP) involving the proto-oncogene ETS-1 at an Xba I site. Four samples from unrelated individuals lacked an Xba I site, giving rise to a longer restriction fragment detectable b...

journal_title：Blood

authors： Savage PD,Hanson CA,Kersey JH

更新日期：1987-07-01 00:00:00

abstract：:Glucose is a major source of energy for living organisms, and its transport in vertebrates is a universally conserved property. Of all cell lineages, human erythrocytes express the highest level of the Glut1 glucose transporter with more than 200,000 molecules per cell. However, we recently reported that erythrocyte G...

journal_title：Blood

authors： Montel-Hagen A,Blanc L,Boyer-Clavel M,Jacquet C,Vidal M,Sitbon M,Taylor N

更新日期：2008-12-01 00:00:00

abstract：:Recent analyses of circulating blood B cells in myeloma have generated controversy concerning the exact levels of these cells and whether they may represent circulating clonal tumor B cells. Previous reports suggested that CD19+ B cells are markedly increased in myeloma patients and that this population shares clonoty...

journal_title：Blood

authors： Kay NE,Leong T,Kyle RA,Greipp P,Billadeau D,Van Ness B,Bone N,Oken MM

更新日期：1997-07-01 00:00:00

abstract：:Mice injected chronically with antiplatelet serum develop an increase in the number of megakaryocytic progenitor cells compared to animals given normal rabbit serum. To examine the specificity of this response, progenitor cells giving rise to megakaryocyte, granulocyte-macrophage, erythroid, and mixed-cell colonies we...

journal_title：Blood

authors： Burstein SA,Erb SK,Adamson JW,Harker LA

更新日期：1982-04-01 00:00:00

abstract：:Recently, we have demonstrated that human platelets carry preformed CD40 ligand (CD154) molecules, which rapidly appear on the platelet surface following stimulation by thrombin. Once on the surface, platelet CD154 induces an inflammatory reaction of CD40-bearing endothelial cells. This study shows that strong platele...

journal_title：Blood

authors： Henn V,Steinbach S,Büchner K,Presek P,Kroczek RA

更新日期：2001-08-15 00:00:00

abstract：:Mitochondrial DNA (mtDNA) biosynthesis requires replication factors and adequate nucleotide pools from the mitochondria and cytoplasm. We performed gene expression profiling analysis of 542 human acute myeloid leukemia (AML) samples and identified 55% with upregulated mtDNA biosynthesis pathway expression compared wit...

journal_title：Blood

authors： Liyanage SU,Hurren R,Voisin V,Bridon G,Wang X,Xu C,MacLean N,Siriwardena TP,Gronda M,Yehudai D,Sriskanthadevan S,Avizonis D,Shamas-Din A,Minden MD,Bader GD,Laposa R,Schimmer AD

更新日期：2017-05-11 00:00:00

abstract：:Chronic myeloid leukemia (CML) is a malignant disorder of the hematopoietic stem cell. It has been shown that normal stem cells coexist with malignant stem cells in the bone marrow of patients with chronic-phase CML. To characterize the primitive hematopoietic progenitor cells within CML marrow, CD34+DR- and CD34+DR+ ...

journal_title：Blood

authors： Leemhuis T,Leibowitz D,Cox G,Silver R,Srour EF,Tricot G,Hoffman R

更新日期：1993-02-01 00:00:00

abstract：:Forkhead box P3 (FOXP3) is constitutively expressed by CD4(+)CD25(hi) regulatory T cells (nTregs). Mutations of FOXP3 cause a severe autoimmune syndrome known as immune dysregulation polyendocrinopathy enteropathy X-linked, in which nTregs are absent or dysfunctional. Whether FOXP3 is essential for both differentiatio...

journal_title：Blood

authors： Di Nunzio S,Cecconi M,Passerini L,McMurchy AN,Baron U,Turbachova I,Vignola S,Valencic E,Tommasini A,Junker A,Cazzola G,Olek S,Levings MK,Perroni L,Roncarolo MG,Bacchetta R

更新日期：2009-11-05 00:00:00

abstract：:Recently, our laboratory showed that platelets, like leukocytes, roll on activated endothelium expressing P-selectin, thus suggesting a role for P-selectin in hemostasis (Frenette et at, Proc Natl Acad Sci USA 92:7450, 1995). We report here that the P-selectin--deficient mice show a 40% prolongation of the bleeding ti...

journal_title：Blood

authors： Subramaniam M,Frenette PS,Saffaripour S,Johnson RC,Hynes RO,Wagner DD

更新日期：1996-02-15 00:00:00

abstract：:The regulatory function of recombinant human granulocyte-macrophage colony stimulating factor (rhGM-CSF) on granulocyte production in vivo was evaluated in an autologous bone marrow transplantation model using rhesus monkeys. Monkeys were exposed to 9.0 Gy total body irradiation and then transplanted with 5.0 x 10(7) ...

journal_title：Blood

authors： Monroy RL,Skelly RR,MacVittie TJ,Davis TA,Sauber JJ,Clark SC,Donahue RE

更新日期：1987-11-01 00:00:00

abstract：:Expression of the myeloperoxidase (MPO) gene is tightly regulated in a tissue- and development-specific manner. Accumulation of MPO messenger RNA (mRNA) occurs only at the late myeloblastic and promyelocytic stages of myeloid differentiation and is negligible at other stages of myeloid development and in other tissues...

journal_title：Blood

authors： Lübbert M,Miller CW,Koeffler HP

更新日期：1991-07-15 00:00:00

abstract：:Previous studies have shown that cytokine-dependent eosinophils undergo apoptosis, yet the mechanisms governing this phenomenon remain obscure. Fas antigen is a transmembrane glycoprotein belonging to the tumor necrosis factor receptor family. Cross-linking of Fas antigen in numerous cell types leads to apoptosis. In ...

journal_title：Blood

authors： Druilhe A,Cai Z,Hailé S,Chouaib S,Pretolani M

更新日期：1996-04-01 00:00:00

abstract：:Intestinal mucosal mast cells (IMMC) express granule neutral proteases that are regulated by T-cell-derived cytokines, including interleukin-3 (IL-3) and IL-9, and by stem cell factor (SCF). The IMMC-specific chymase, mouse mast cell protease-1 (mMCP-1), is released in substantial quantities into the blood stream duri...

journal_title：Blood

authors： Miller HR,Wright SH,Knight PA,Thornton EM

更新日期：1999-05-15 00:00:00

abstract：:The functional activities of the tumor suppressor promyelocytic leukemia protein (PML) are mostly associated with its nuclear location. In the present study, we discovered an unexpected role of PML in NLRP3 inflammasome activation. In PML-deficient macrophages, the production of IL-1β was strongly impaired. The expres...

journal_title：Blood

authors： Lo YH,Huang YW,Wu YH,Tsai CS,Lin YC,Mo ST,Kuo WC,Chuang YT,Jiang ST,Shih HM,Lai MZ

更新日期：2013-04-18 00:00:00