Evidence for a multipotential stem cell disease in some childhood Philadelphia chromosome-positive acute lymphoblastic leukemia.

abstract：:Human ADAMTS13 is a multidomain protein with metalloprotease (M), disintegrin-like (D), thrombospondin-1 (T), Cys-rich (C), and spacer (S) domains, followed by 7 additional T domains and 2 CUB (complement components C1r and C1s, sea urchin protein Uegf, and bone morphogenetic protein-1) domains. ADAMTS13 inhibits the ...

journal_title：Blood

authors： Zhu J,Muia J,Gupta G,Westfield LA,Vanhoorelbeke K,Tolia NH,Sadler JE

更新日期：2019-04-25 00:00:00

abstract：:The number of cells transplanted and their capacity to induce graft-versus-host reactivity (GvHR) are two factors that are suspected to influence the engraftment of allogeneic bone marrow. We have investigated their impact on graft rejection rates in busulfan-treated LEW rats. In a series of experiments, we varied (1)...

journal_title：Blood

authors： Uharek L,Gassmann W,Glass B,Steinmann J,Loeffler H,Mueller-Ruchholtz W

更新日期：1992-03-15 00:00:00

abstract：:To identify molecularly defined subgroups in multiple myeloma, gene expression profiling was performed on purified CD138(+) plasma cells of 320 newly diagnosed myeloma patients included in the Dutch-Belgian/German HOVON-65/GMMG-HD4 trial. Hierarchical clustering identified 10 subgroups; 6 corresponded to clusters desc...

journal_title：Blood

authors： Broyl A,Hose D,Lokhorst H,de Knegt Y,Peeters J,Jauch A,Bertsch U,Buijs A,Stevens-Kroef M,Beverloo HB,Vellenga E,Zweegman S,Kersten MJ,van der Holt B,el Jarari L,Mulligan G,Goldschmidt H,van Duin M,Sonneveld P

更新日期：2010-10-07 00:00:00

abstract：:The mouse Pim-1 gene encodes two cytoplasmic serine-threonine-specific protein kinases. The gene has been found to be activated (overexpressed) by retroviral insertion in hematopoietic tumors in mice. Transgenic mice that overexpress Pim-1 (E mu-Pim-1) have a low incidence of spontaneous T-cell lymphomas and an increa...

journal_title：Blood

authors： Domen J,van der Lugt NM,Laird PW,Saris CJ,Clarke AR,Hooper ML,Berns A

更新日期：1993-09-01 00:00:00

abstract：:T-cell dysfunction after human hematopoietic stem-cell transplantation (HSCT) is generally attributed to intrinsic T-cell defects. Here we show that the characteristic impaired proliferative responses to polyclonal stimulation of post-HSCT peripheral blood mononuclear cells (PB-MCs) were markedly (4-fold) improved by ...

journal_title：Blood

authors： Hainz U,Obexer P,Winkler C,Sedlmayr P,Takikawa O,Greinix H,Lawitschka A,Pötschger U,Fuchs D,Ladisch S,Heitger A

更新日期：2005-05-15 00:00:00

abstract：:We used a panel of reagents, polyclonal and monoclonal antibodies, and lectins to define the expression of the ABH- and Lewis-related specificities on platelets and lymphocytes. We also determined the expression of the alpha 2- and alpha 3-L-fucosyltransferases necessary for their biosynthesis. The antigens that could...

journal_title：Blood

authors： Mollicone R,Caillard T,Le Pendu J,François A,Sansonetti N,Villarroya H,Oriol R

更新日期：1988-04-01 00:00:00

abstract：:There is still controversy concerning the nature of the stem cells from bone marrow that colonize the thymus during embryogenesis and continually throughout life. To identify the bone marrow stem cells that home to and populate the thymus, we screened murine bone marrow cells for the presence of a population of surfac...

journal_title：Blood

authors： Antica M,Wu L,Shortman K,Scollay R

更新日期：1994-07-01 00:00:00

abstract：:The purpose of this study was to characterize the stimulus that activates the 5-lipoxygenase pathway in human peripheral monocytes (PM) during the process of contact activation. Incubation of PM, but not of polymorphonuclear leukocytes (PMN), in contact-activated, recalcified plasma induced a time-dependent release of...

journal_title：Blood

authors： Weide I,Römisch J,Simmet T

更新日期：1994-04-01 00:00:00

abstract：:Fanconi anemia (FA) is an autosomal recessive disease characterized by congenital anomalies, aplastic anemia, and a susceptibility to leukemia. There are at least 8 complementation groups (A through H). Extensive analyses of the FA group C gene FANCC in Western countries revealed that 10% to 15% of FA patients have mu...

journal_title：Blood

authors： Futaki M,Yamashita T,Yagasaki H,Toda T,Yabe M,Kato S,Asano S,Nakahata T

更新日期：2000-02-15 00:00:00

abstract：:A key event in the successful induction of adaptive immune responses is the antigen-specific activation of T cells by dendritic cells (DCs). Although LFA-1 (lymphocyte function-associated antigen 1) on T cells is considered to be important for antigen-specific T-cell activation, the role for LFA-1 on DCs remains elusi...

journal_title：Blood

authors： Balkow S,Heinz S,Schmidbauer P,Kolanus W,Holzmann B,Grabbe S,Laschinger M

更新日期：2010-09-16 00:00:00

abstract：:Recurrent mutations in isocitrate dehydrogenase 2 (IDH2) occur in ∼12% of patients with acute myeloid leukemia (AML). Mutated IDH2 proteins neomorphically synthesize 2-hydroxyglutarate resulting in DNA and histone hypermethylation, which leads to blocked cellular differentiation. Enasidenib (AG-221/CC-90007) is a firs...

journal_title：Blood

authors： Stein EM,DiNardo CD,Pollyea DA,Fathi AT,Roboz GJ,Altman JK,Stone RM,DeAngelo DJ,Levine RL,Flinn IW,Kantarjian HM,Collins R,Patel MR,Frankel AE,Stein A,Sekeres MA,Swords RT,Medeiros BC,Willekens C,Vyas P,Tosolini A

更新日期：2017-08-10 00:00:00

abstract：:Because a pediatric-inspired Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) protocol yielded a markedly improved outcome in adults with Philadelphia chromosome-negative ALL, we aimed to reassess the role of allogeneic stem cell transplantation (SCT) in patients treated in the GRAALL-2003 and GRAALL-...

journal_title：Blood

authors： Dhédin N,Huynh A,Maury S,Tabrizi R,Beldjord K,Asnafi V,Thomas X,Chevallier P,Nguyen S,Coiteux V,Bourhis JH,Hichri Y,Escoffre-Barbe M,Reman O,Graux C,Chalandon Y,Blaise D,Schanz U,Lhéritier V,Cahn JY,Dombret H,If

更新日期：2015-04-16 00:00:00

abstract：:In this article, we present evidence that sialic acid-containing surface components play a role in the regulation of erythropoiesis. A 1-hr exposure of mouse bone marrow cells to high concentrations of neuraminidase reduced erythroid colony formation. Coculture of 10(6) untreated thymocytes with neuraminidase-treated ...

journal_title：Blood

authors： LaRussa VF,Sieber F,Sensenbrenner LL,Sharkis SJ

更新日期：1984-04-01 00:00:00

abstract：:The high iron demand associated with enhanced erythropoiesis during high-altitude hypoxia leads to skeletal muscle iron mobilization and decrease in myoglobin protein levels. To investigate the effect of enhanced erythropoiesis on systemic and muscle iron metabolism under nonhypoxic conditions, 8 healthy volunteers we...

journal_title：Blood

authors： Robach P,Recalcati S,Girelli D,Gelfi C,Aachmann-Andersen NJ,Thomsen JJ,Norgaard AM,Alberghini A,Campostrini N,Castagna A,Viganò A,Santambrogio P,Kempf T,Wollert KC,Moutereau S,Lundby C,Cairo G

更新日期：2009-06-25 00:00:00

abstract：:Seventy-one patients with acute myeloid leukemia (AML), most of them (63/71) considered ineligible for conventional allogeneic hematopoietic stem cell transplantation (HSCT), were enrolled into a phase 2 study on reduced-intensity myeloablative conditioning with fractionated 8-Gy total body irradiation (TBI) and fluda...

journal_title：Blood

authors： Stelljes M,Bornhauser M,Kroger M,Beyer J,Sauerland MC,Heinecke A,Berning B,Scheffold C,Silling G,Buchner T,Neubauer A,Fauser AA,Ehninger G,Berdel WE,Kienast J,Cooperative German Transplant Study Group.

更新日期：2005-11-01 00:00:00

abstract：:Accumulating evidence has designated B cells as central players in the pathogenesis of immune diseases. In the late 1990s, anti-CD20 monoclonal antibodies were developed for the treatment of B-cell non-Hodgkin lymphomas, offering the opportunity to efficiently deplete the B-cell compartment for therapeutic immunointer...

journal_title：Blood

authors： Thaunat O,Morelon E,Defrance T

更新日期：2010-07-29 00:00:00

abstract：:Asparaginase is an enzyme used in the treatment of acute lymphoblastic leukemia and lymphoblastic lymphoma in children. It has minimal bone marrow toxicity. Its major side effects are anaphylaxis, pancreatitis, diabetes, coagulation abnormalities, and thrombosis, especially intracranial. It is derived from 2 different...

journal_title：Blood

authors： Duval M,Suciu S,Ferster A,Rialland X,Nelken B,Lutz P,Benoit Y,Robert A,Manel AM,Vilmer E,Otten J,Philippe N

更新日期：2002-04-15 00:00:00

abstract：:We studied the effects of interleukin-4 (IL-4) and IL-6 on the growth of leukemic blasts from 40 patients with acute myelogenous leukemia (AML). Patients were selected on the basis of negativity for a series of B-cell antigens including CD10 and CD19. Twenty-one cases were CD34-positive (CD34+) (greater than 15% of bl...

journal_title：Blood

authors： Akashi K,Harada M,Shibuya T,Eto T,Takamatsu Y,Teshima T,Niho Y

更新日期：1991-07-01 00:00:00

abstract：:High doses of recombinant factor VIIa are useful in managing bleeding in hemophiliacs with inhibitors. Whether this therapeutic effect of factor VIIa is dependent on tissue factor (TF) is a matter of debate. We examined the ability of freshly isolated human monocytes (which lack TF) to support the activation of coagul...

journal_title：Blood

authors： Hoffman M,Monroe DM,Roberts HR

更新日期：1994-01-01 00:00:00

abstract：:The transcription factor nuclear factor-kappaB (NF-kappaB) confers significant survival potential in a variety of tumors. Several established or novel anti-multiple myeloma (anti-MM) agents, such as dexamethasone, thalidomide, and proteasome inhibitors (PS-341), inhibit NF-kappaB activity as part of their diverse acti...

journal_title：Blood

authors： Mitsiades N,Mitsiades CS,Poulaki V,Chauhan D,Richardson PG,Hideshima T,Munshi N,Treon SP,Anderson KC

更新日期：2002-06-01 00:00:00

abstract：:B19 parvovirus is the etiologic agent of fifth disease and transient aplastic crisis. In natural infections, B19 antigen and DNA have been detected in sera early in the course of aplastic crisis and only rarely in fifth disease. We have found B19 DNA in circulating cells of infected patients by DNA dot blot with a vir...

journal_title：Blood

authors： Kurtzman GJ,Gascon P,Caras M,Cohen B,Young NS

更新日期：1988-05-01 00:00:00

abstract：:The non-Hodgkin's lymphoma (NHL) subset commonly referred to as large cell lymphoma (LCL) has historically been characterized by it's marked cytological, immunological, and clinical heterogeneity. One potential defining feature of these lymphomas, the t(2;5)(p23;q35), occurs in 25% to 30% of anaplastic LCLs and is als...

journal_title：Blood

authors： Mathew P,Sanger WG,Weisenburger DD,Valentine M,Valentine V,Pickering D,Higgins C,Hess M,Cui X,Srivastava DK,Morris SW

更新日期：1997-03-01 00:00:00

abstract：:The MLL gene located at 11q23 is frequently disrupted by chromosomal translocation in a wide spectrum of newly diagnosed acute leukemias. Recently, it has become apparent that the MLL gene is very frequently disrupted by chromosomal translocations in patients with secondary leukemias associated with chemotherapeutic r...

journal_title：Blood

authors： Aplan PD,Chervinsky DS,Stanulla M,Burhans WC

更新日期：1996-04-01 00:00:00

abstract：:Rituximab therapy is associated with a long in vivo persistence, yet little is known about the effect of circulating rituximab on B-cell non-Hodgkin lymphoma (B-NHL) targeting by the other available anti-CD20 monoclonal antibodies (MoAbs) (131)iodine-tositumomab and (90)yttrium-ibritumomab tiuxetan. Therefore we asses...

journal_title：Blood

authors： Gopal AK,Press OW,Wilbur SM,Maloney DG,Pagel JM

更新日期：2008-08-01 00:00:00

abstract：:Malignant cells from 52 children with acute lymphocytic leukemia (ALL) were investigated for inactivation of the p15ink4B and p16ink4 genes and other genetic alterations on chromosome 9p21. Homozygous deletions of the p15ink4B and/or the p16ink4 genes were detected in 16 cases and a further 9 cases showed evidence of ...

journal_title：Blood

authors： Rasool O,Heyman M,Brandter LB,Liu Y,Grandér D,Söderhäll S,Einhorn S

更新日期：1995-06-15 00:00:00

abstract：:Deferoxamine (DF) has antimalarial activity that can be demonstrated in vitro and in vivo. This study is designed to examine the speed of onset and stage dependency of growth inhibition by DF and to determine whether its antimalarial activity is cytostatic or cytocidal. Growth inhibition was assessed by suppression of...

journal_title：Blood

authors： Whitehead S,Peto TE

更新日期：1990-09-15 00:00:00

abstract：:Although hepatitis C virus (HCV) mainly affects hepatocytes, infection is widespread and involves immunologically privileged sites. Whether lymphoid cells represent further targets of early HCV infection, or whether other cells in the hematopoietic microenvironment may serve as a potential virus reservoir, is still un...

journal_title：Blood

authors： Sansonno D,Lotesoriere C,Cornacchiulo V,Fanelli M,Gatti P,Iodice G,Racanelli V,Dammacco F

更新日期：1998-11-01 00:00:00

abstract：:In previous experimental animal studies it has been demonstrated that antibody depletion is not followed by increased antibody synthesis. To assess whether these results are conferrable to antibody-depleted humans, we measured free light chains (flcs) as markers of current antibody synthesis in 8 patients treated with...

journal_title：Blood

authors： Goldammer A,Derfler K,Herkner K,Bradwell AR,Hörl WH,Haas M

更新日期：2002-07-01 00:00:00

abstract：:Thrombopoietin (TPO) is a hematopoietic growth factor that regulates megakaryocytopoiesis and platelet production through binding to its receptor, Mpl, encoded by the c-mpl proto-oncogene. Circulating levels of TPO are regulated by receptor-mediated uptake and degradation. To better understand this mode of TPO regulat...

journal_title：Blood

authors： Cohen-Solal K,Vitrat N,Titeux M,Vainchenker W,Wendling F

更新日期：1999-05-01 00:00:00

abstract：:Aberrant activation of the Wnt pathway plays a pathogenetic role in various tumors and has been associated with adverse outcome in acute lymphoblastic leukemia (ALL). LEF1, a key mediator of Wnt signaling, has been linked to leukemic transformation, and recurrent mutations of LEF1 have been identified in pediatric T-A...

journal_title：Blood

authors： Kühnl A,Gökbuget N,Kaiser M,Schlee C,Stroux A,Burmeister T,Mochmann LH,Hoelzer D,Hofmann WK,Thiel E,Baldus CD

更新日期：2011-12-08 00:00:00