Rare RHCE phenotypes in black individuals of Afro-Caribbean origin: identification and transfusion safety.

abstract：:Signaling through the receptor tyrosine kinase kit controls proliferation and differentiation of hematopoietic precursor cells and mast cells. Somatic point mutations of the receptor that constitutively activate kit signaling are associated with mastocytosis and various hematopoietic malignancies. We generated a Cre/l...

journal_title：Blood

authors： Gerbaulet A,Wickenhauser C,Scholten J,Peschke K,Drube S,Horny HP,Kamradt T,Naumann R,Müller W,Krieg T,Waskow C,Hartmann K,Roers A

更新日期：2011-02-10 00:00:00

abstract：:Myeloperoxidase (MPO) is a lysosomal enzyme present in the azurophilic granules of human neutrophils and monocytes and is important for optimal oxygen-dependent killing of microorganisms. The native molecule is a heterodimer composed of a pair of heavy-light protomers, each containing a 59-kDa and 13.5-kDa subunit. Th...

journal_title：Blood

authors： Nauseef WM

更新日期：1987-10-01 00:00:00

abstract：:Autologous stem cell transplantation (ASCT) is considered the gold standard in the frontline therapy of younger patients with multiple myeloma because it results in higher complete remission (CR) rates and longer event-free survival than conventional chemotherapy. The greatest benefit from ASCT is obtained in patients...

journal_title：Blood

authors： Bladé J,Rosiñol L,Cibeira MT,Rovira M,Carreras E

更新日期：2010-05-06 00:00:00

abstract：:Recent evidence suggests chronic myeloid leukemia (CML) stem cells are insensitive to kinase inhibitors and responsible for minimal residual disease in treated patients. We investigated whether CML stem cells, in a transgenic mouse model of CML-like disease or derived from patients, are dependent on Bcr-Abl. In the tr...

journal_title：Blood

authors： Hamilton A,Helgason GV,Schemionek M,Zhang B,Myssina S,Allan EK,Nicolini FE,Müller-Tidow C,Bhatia R,Brunton VG,Koschmieder S,Holyoake TL

更新日期：2012-02-09 00:00:00

abstract：:Setdb1, also known as Eset, is a methyltransferase that catalyzes trimethylation of H3K9 (H3K9me3) and plays an essential role in the silencing of endogenous retroviral elements (ERVs) in the developing embryo and embryonic stem cells (ESCs). Its role in somatic stem cells, however, remains unclear because of the earl...

journal_title：Blood

authors： Koide S,Oshima M,Takubo K,Yamazaki S,Nitta E,Saraya A,Aoyama K,Kato Y,Miyagi S,Nakajima-Takagi Y,Chiba T,Matsui H,Arai F,Suzuki Y,Kimura H,Nakauchi H,Suda T,Shinkai Y,Iwama A

更新日期：2016-08-04 00:00:00

abstract：:Vascular cell adhesion molecule-1 (VCAM-1) and endothelial-leukocyte adhesion molecule-1 (ELAM-1) are adhesive proteins induced on endothelium by cytokines. We examined the contribution of these adhesive proteins to human peripheral blood monocyte adherence to endothelium using transfected Chinese hamster ovary (CHO) ...

journal_title：Blood

authors： Carlos T,Kovach N,Schwartz B,Rosa M,Newman B,Wayner E,Benjamin C,Osborn L,Lobb R,Harlan J

更新日期：1991-05-15 00:00:00

abstract：:Expression of the myeloperoxidase (MPO) gene is tightly regulated in a tissue- and development-specific manner. Accumulation of MPO messenger RNA (mRNA) occurs only at the late myeloblastic and promyelocytic stages of myeloid differentiation and is negligible at other stages of myeloid development and in other tissues...

journal_title：Blood

authors： Lübbert M,Miller CW,Koeffler HP

更新日期：1991-07-15 00:00:00

abstract：:Primary effusion lymphoma (PEL) is an aggressive subtype of non-Hodgkin lymphoma characterized by short survival with current therapies, emphasizing the urgent need to develop new therapeutic approaches. Brentuximab vedotin (SGN-35) is an anti-CD30 monoclonal antibody (cAC10) conjugated by a protease-cleavable linker ...

journal_title：Blood

authors： Bhatt S,Ashlock BM,Natkunam Y,Sujoy V,Chapman JR,Ramos JC,Mesri EA,Lossos IS

更新日期：2013-08-15 00:00:00

abstract：:Between February 1996 and December 2004, the German Leukemia Study Initiative registered 1766 consecutive patients for the acute myeloid leukemia (AML) 96 study, all of whom were diagnosed by central cytomorphology according to the French-American-British (FAB) and the new World Health Organization (WHO) classificatio...

journal_title：Blood

authors： Wandt H,Schäkel U,Kroschinsky F,Prange-Krex G,Mohr B,Thiede C,Pascheberg U,Soucek S,Schaich M,Ehninger G

更新日期：2008-02-15 00:00:00

abstract：:CD10/neutral endopeptidase 24.11 (NEP) regulates peptidemediated proliferation of lymphoid progenitors and certain epithelial cells and is itself regulated by cellular proliferation. To further characterize mechanisms by which cell-surface signaling might regulate CD10/NEP expression, we determined whether CD10/NEP wa...

journal_title：Blood

authors： Ganju RK,Shpektor RG,Brenner DG,Shipp MA

更新日期：1996-12-01 00:00:00

abstract：:A human malignant melanoma cell line (M3Dau) was observed by electron microscopy to interact directly with human platelets and induced platelet aggregation. Fab fragments of a monoclonal antibody MoAb (LYP18), directed against the platelet glycoprotein (GP) IIb-IIIa complex, inhibited platelet-melanoma interactions an...

journal_title：Blood

authors： Boukerche H,Berthier-Vergnes O,Tabone E,Doré JF,Leung LL,McGregor JL

更新日期：1989-08-01 00:00:00

abstract：:Steroid-resistant or steroid-refractory acute graft-versus-host disease (SR-aGVHD) poses one of the most vexing challenges faced by providers who care for patients after allogeneic hematopoietic cell transplantation. For the past 4 decades, research in the field has been driven by the premise that persistent graft-ver...

journal_title：Blood

authors： Martin PJ

更新日期：2020-05-07 00:00:00

abstract：:Type I interferon (IFNalpha/beta) plays a complex role in HIV-1 infection and has been proposed alternately to have roles in either disease protection or progression. Although IFNalpha/beta plays crucial roles in regulating monocytes and dendritic cells, responsiveness of these cells to IFNalpha/beta in HIV-1 infectio...

journal_title：Blood

authors： Hardy GA,Sieg SF,Rodriguez B,Jiang W,Asaad R,Lederman MM,Harding CV

更新日期：2009-05-28 00:00:00

abstract：:Recent studies have shown a discrepancy between the level of tissue factor (TF) expression and the level of TF procoagulant activity on the apical and basolateral surface domains of polarized epithelial cells. The present investigation was performed to elucidate possible reasons for the discordant expression of TF and...

journal_title：Blood

authors： Hansen CB,van Deurs B,Petersen LC,Rao LV

更新日期：1999-09-01 00:00:00

abstract：:Cryopreservation of hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) is crucial for cord blood (CB) banking and transplantation. We evaluated recovery of functional HPC cryopreserved as mononuclear or unseparated cells for up to 23.5 years compared with prefreeze values of the same CB units. H...

journal_title：Blood

authors： Broxmeyer HE,Lee MR,Hangoc G,Cooper S,Prasain N,Kim YJ,Mallett C,Ye Z,Witting S,Cornetta K,Cheng L,Yoder MC

更新日期：2011-05-05 00:00:00

abstract：:Interleukin-12 (IL-12) is a cytokine that plays a central role in the control of cell-mediated immunity. We have previously shown that transforming growth factor-beta1 (TGF-beta) inhibitory effects on human primary allogeneic cytotoxicity and proliferative responses interfere with IL-12 pathway. The present study was ...

journal_title：Blood

authors： Pardoux C,Ma X,Gobert S,Pellegrini S,Mayeux P,Gay F,Trinchieri G,Chouaib S

更新日期：1999-03-01 00:00:00

abstract：:Protein disulfide isomerase (PDI) derived from intravascular cells is required for thrombus formation. However, it remains unclear whether platelet PDI contributes to the process. Using platelet-specific PDI-deficient mice, we demonstrate that PDI-null platelets have defects in aggregation and adenosine triphosphate s...

journal_title：Blood

authors： Kim K,Hahm E,Li J,Holbrook LM,Sasikumar P,Stanley RG,Ushio-Fukai M,Gibbins JM,Cho J

更新日期：2013-08-08 00:00:00

abstract：:Dendritic cells (DC) are the main stimulators of primary T-cell responses and, thus, probably play a role in the immune reactions after stem cell transplantation. Very little is known about DC in cord blood (CB) and about their potential involvement in the low incidence and severity of acute graft-versus-host disease ...

journal_title：Blood

authors： Sorg RV,Kögler G,Wernet P

更新日期：1999-04-01 00:00:00

abstract：:We show the molecular and functional characterization of a novel population of lineage-negative CD34-negative (Lin(-)CD34(-)) hematopoietic stem cells from chronic myelogenous leukemia (CML) patients at diagnosis. Molecular karyotyping and quantitative analysis of BCR-ABL transcript demonstrated that approximately one...

journal_title：Blood

authors： Lemoli RM,Salvestrini V,Bianchi E,Bertolini F,Fogli M,Amabile M,Tafuri A,Salati S,Zini R,Testoni N,Rabascio C,Rossi L,Martin-Padura I,Castagnetti F,Marighetti P,Martinelli G,Baccarani M,Ferrari S,Manfredini R

更新日期：2009-12-10 00:00:00

abstract：:Follicular lymphoma (FL) is the second most common non-Hodgkin lymphoma in the Western world. FL cell-intrinsic and cell-extrinsic factors influence FL biology and clinical outcome. To further our understanding of the genetic basis of FL, we performed whole-exome sequencing of 23 highly purified FL cases and 1 transfo...

journal_title：Blood

authors： Yildiz M,Li H,Bernard D,Amin NA,Ouillette P,Jones S,Saiya-Cork K,Parkin B,Jacobi K,Shedden K,Wang S,Chang AE,Kaminski MS,Malek SN

更新日期：2015-01-22 00:00:00

abstract：:Members of the B7 family have been shown to be important for regulating immune responses by providing either positive or negative costimulatory signals. The function of B7-H3 has been controversial. We show that B7-H3 is upregulated in graft-versus-host disease (GVHD) target organs, including the colon, liver, and lun...

journal_title：Blood

authors： Veenstra RG,Flynn R,Kreymborg K,McDonald-Hyman C,Saha A,Taylor PA,Osborn MJ,Panoskaltsis-Mortari A,Schmitt-Graeff A,Lieberknecht E,Murphy WJ,Serody JS,Munn DH,Freeman GJ,Allison JP,Mak TW,van den Brink M,Zeiser R,Blaz

更新日期：2015-05-21 00:00:00

abstract：:Many lineage-specific developmental regulator genes are transcriptionally primed in embryonic stem (ES) cells; RNA Pol(II) is bound at their promoters but is prevented from productive elongation by the activity of polycomb repressive complexes (PRC) 1 and 2. This epigenetically poised state is thought to enable ES cel...

journal_title：Blood

authors： Mazzarella L,Jørgensen HF,Soza-Ried J,Terry AV,Pearson S,Lacaud G,Kouskoff V,Merkenschlager M,Fisher AG

更新日期：2011-01-06 00:00:00

abstract：:Naive T cells continuously recirculate between secondary lymphoid tissue via the blood and lymphatic systems, a process that maximizes the chances of an encounter between a T cell and its cognate antigen. This recirculation depends on signals from chemokine receptors, integrins, and the sphingosine-1-phosphate recepto...

journal_title：Blood

authors： Faroudi M,Hons M,Zachacz A,Dumont C,Lyck R,Stein JV,Tybulewicz VL

更新日期：2010-12-16 00:00:00

abstract：:Haploinsufficiency of ribosomal proteins (RPs) has been proposed to be the common basis for the anemia observed in Diamond-Blackfan anemia (DBA) and myelodysplastic syndrome with loss of chromosome 5q [del(5q) MDS]. We have modeled DBA and del(5q) MDS in zebrafish using antisense morpholinos to rps19 and rps14, respec...

journal_title：Blood

authors： Payne EM,Virgilio M,Narla A,Sun H,Levine M,Paw BH,Berliner N,Look AT,Ebert BL,Khanna-Gupta A

更新日期：2012-09-13 00:00:00

abstract：:Human natural killer (NK) cells express Toll-like receptor 9 (TLR9) transcript and, upon exposure to microbial CpG oligodeoxynucleotide (ODN), release cytokines and kill target cells. Here we show that NK cell treatment with CpG ODN results in down-modulation of KIR3DL2 inhibitory receptor from the cell surface and in...

journal_title：Blood

authors： Sivori S,Falco M,Carlomagno S,Romeo E,Soldani C,Bensussan A,Viola A,Moretta L,Moretta A

更新日期：2010-09-09 00:00:00

abstract：:The granulocyte-macrophage colony-stimulating factor (GM-CSF)/interleukin (IL)-3/IL-5 receptor family regulates the production and function of myeloid cells. These cytokines signal through receptor complexes that consist of unique ligand-binding alpha-chains and common signaling beta-chains. IL-5 is distinct from IL-3...

journal_title：Blood

authors： Beekman JM,Verhagen LP,Geijsen N,Coffer PJ

更新日期：2009-10-29 00:00:00

abstract：:In B cells, expression of CIITA and resulting major histocompatibility complex II (MHCII) is mediated exclusively by promoter III (CIITA-PIII) activation. Recent studies have established that CIITA-PIII also participates in the expression of CIITA in activated human T cells, dendritic cells, and monocytes. In this stu...

journal_title：Blood

authors： van der Stoep N,Quinten E,Marcondes Rezende M,van den Elsen PJ

更新日期：2004-11-01 00:00:00

abstract：:The molecular basis for the recently described hereditary hyperferritinemia-cataract syndrome is the presence of a mutation in the iron-responsive element (IRE) of the L ferritin gene, located on chromosome 19q13.3-13.4. Two mutations have been reported so far, altering adjacent nucleotides in the IRE loop, in a regio...

journal_title：Blood

authors： Martin ME,Fargion S,Brissot P,Pellat B,Beaumont C

更新日期：1998-01-01 00:00:00

abstract：:Dendritic cells (DCs) represent a family of ontogenically distinct leukocytes involved in immune response regulation. The ability of DCs to stimulate T-cell immunity has led to their use as vectors for immunotherapy vaccines. However, it is unclear whether and to what degree in vitro-generated DCs are representative o...

journal_title：Blood

authors： Maraskovsky E,Daro E,Roux E,Teepe M,Maliszewski CR,Hoek J,Caron D,Lebsack ME,McKenna HJ

更新日期：2000-08-01 00:00:00

abstract：:Venous thromboembolism (VTE) is rare in healthy children, but is an increasing problem in children with underlying medical conditions. Pediatric VTE encompasses a highly heterogenous population, with variation in age, thrombosis location, and underlying medical comorbidities. Evidence from pediatric clinical trials to...

journal_title：Blood

authors： Witmer C,Raffini L

更新日期：2020-01-30 00:00:00