Platelet-melanoma cell interaction is mediated by the glycoprotein IIb-IIIa complex.

Abstract:

:A human malignant melanoma cell line (M3Dau) was observed by electron microscopy to interact directly with human platelets and induced platelet aggregation. Fab fragments of a monoclonal antibody MoAb (LYP18), directed against the platelet glycoprotein (GP) IIb-IIIa complex, inhibited platelet-melanoma interactions and platelet-platelet aggregation. M3Dau melanoma cells bind LYP 18 and synthesize IIb-IIIa-like GPs. When the melanoma cells were preincubated with LYP 18, tumor-platelet interaction did not occur, suggesting that the interaction may be mediated by the IIb-IIIa-like GPs present on the melanoma cell surface. Glanzmann's thrombasthenic platelets, lacking GPIIb and IIIa, did not interact with melanoma cells, indicating that the platelet GPIIb-IIIa complex is also necessary for the platelet-melanoma cell interaction. This work demonstrates the importance of the IIb-IIIa-like GPs, present on M3Dau melanoma cells, in mediating tumor-platelet interactions.

journal_name

Blood

journal_title

Blood

authors

Boukerche H,Berthier-Vergnes O,Tabone E,Doré JF,Leung LL,McGregor JL

subject

Has Abstract

pub_date

1989-08-01 00:00:00

pages

658-63

issue

2

eissn

0006-4971

issn

1528-0020

journal_volume

74

pub_type

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