Hemoglobin stimulates mononuclear leukocytes to release interleukin-8 and tumor necrosis factor alpha.

abstract：:In the 2005-01 trial, we have demonstrated that bortezomib-dexamethasone as induction therapy before autologous stem cell transplantation was superior to vincristine-adriamycin-dexamethasone. We conducted a post-hoc analysis to assess the prognostic impact of initial characteristics as well as response to therapy in p...

journal_title：Blood

authors： Moreau P,Attal M,Pégourié B,Planche L,Hulin C,Facon T,Stoppa AM,Fuzibet JG,Grosbois B,Doyen C,Ketterer N,Sebban C,Kolb B,Chaleteix C,Dib M,Voillat L,Fontan J,Garderet L,Jaubert J,Mathiot C,Esseltine D,Avet-Loise

更新日期：2011-03-17 00:00:00

abstract：:To investigate genetic variants that affect iron concentrations in persons not affected by overt genetic disorders of iron metabolism, a genome-wide association study was conducted in the InCHIANTI Study (N = 1206) and the Baltimore Longitudinal Study of Aging (N = 713). The top 2 single-nucleotide polymorphisms were ...

journal_title：Blood

authors： Tanaka T,Roy CN,Yao W,Matteini A,Semba RD,Arking D,Walston JD,Fried LP,Singleton A,Guralnik J,Abecasis GR,Bandinelli S,Longo DL,Ferrucci L

更新日期：2010-01-07 00:00:00

abstract：:Bone marrow suppression is an adverse effect associated with many antibiotics, especially when administered for prolonged treatment courses. Recent advances in our understanding of steady-state hematopoiesis have allowed us to explore the effects of antibiotics on hematopoietic progenitors in detail using a murine mod...

journal_title：Blood

authors： Josefsdottir KS,Baldridge MT,Kadmon CS,King KY

更新日期：2017-02-09 00:00:00

abstract：:CCR5 is a receptor for several beta chemokines and the entry coreceptor used by macrophage-tropic (R5) strains of HIV-1. In addition to supporting viral entry, CCR5 ligation by the HIV-1 envelope glycoprotein 120 (gp120) can activate intracellular signals in macrophages and trigger inflammatory mediator release. Using...

journal_title：Blood

authors： Tomkowicz B,Lee C,Ravyn V,Cheung R,Ptasznik A,Collman RG

更新日期：2006-08-15 00:00:00

abstract：:Although hepatitis C virus (HCV) mainly affects hepatocytes, infection is widespread and involves immunologically privileged sites. Whether lymphoid cells represent further targets of early HCV infection, or whether other cells in the hematopoietic microenvironment may serve as a potential virus reservoir, is still un...

journal_title：Blood

authors： Sansonno D,Lotesoriere C,Cornacchiulo V,Fanelli M,Gatti P,Iodice G,Racanelli V,Dammacco F

更新日期：1998-11-01 00:00:00

abstract：:We examined the prevalence and prognostic relevance of bone marrow reticulin fibrosis in 526 patients with World Health Organization-defined polycythemia vera evaluated at the time of initial diagnosis. Seventy-four patients (14%) displayed mostly grade 1 reticulin fibrosis, with only 2 cases showing higher-grade fibr...

journal_title：Blood

authors： Barbui T,Thiele J,Passamonti F,Rumi E,Boveri E,Randi ML,Bertozzi I,Marino F,Vannucchi AM,Pieri L,Rotunno G,Gisslinger H,Gisslinger B,Müllauer L,Finazzi G,Carobbio A,Gianatti A,Ruggeri M,Nichele I,D'Amore E,Rambald

更新日期：2012-03-08 00:00:00

abstract：:Bone marrow (BM) cells from a child with an immature (CD3-) acute T lymphoblastic leukemia (T-ALL) bearing no chromosomal abnormalities failed to grow in long-term culture in the presence or absence of recombinant human (rh) growth factors but could be engrafted in severe combined immunodeficient (SCID) mice and induc...

journal_title：Blood

authors： Cesano A,O'Connor R,Nowell PC,Lange B,Clark SC,Santoli D

更新日期：1993-05-15 00:00:00

abstract：:Ferroportin (FPN) mediates iron export from cells; FPN mutations are associated with the iron overloading disorder hemochromatosis. Previously, we found that the A77D, V162del, and G490D mutations inhibited FPN activity, but that other disease-associated FPN variants retained full iron export capability. The peptide h...

journal_title：Blood

authors： Drakesmith H,Schimanski LM,Ormerod E,Merryweather-Clarke AT,Viprakasit V,Edwards JP,Sweetland E,Bastin JM,Cowley D,Chinthammitr Y,Robson KJ,Townsend AR

更新日期：2005-08-01 00:00:00

abstract：:Cell cycle checkpoints ensure orderly progression of events during cell division. A microtubule damage (MTD)-induced checkpoint has been described in G(1) phase of the cell cycle (G(1)MTC) for which little is known. The present study shows that the G(1)MTC is intact in activated T lymphocytes from mice with the p21(wa...

journal_title：Blood

authors： Mantel CR,Braun SE,Lee Y,Kim YJ,Broxmeyer HE

更新日期：2001-03-01 00:00:00

abstract：:Serum cobalamin (vitamin B12) and unsaturated B12 binding capacity (UBBC) have been measured in 24 cases of hypereosinophilia: 16 were cases of hypereosinophilic syndrome (HES) and 8 of secondary eosinophilia. The two groups were similar with respect to absolute eosinophil counts. Serum cobalamin and UBBC were found t...

journal_title：Blood

authors： Zittoun J,Farcet JP,Marquet J,Sultan C,Zittoun R

更新日期：1984-04-01 00:00:00

abstract：:Kaposi sarcoma-associated herpesvirus (KSHV)-related multicentric Castleman disease (MCD) is potentially lethal. Growing evidence indicates that, as in Epstein-Barr virus-driven lymphoproliferative disorders after transplantation, KSHV DNA burden in peripheral blood mononuclear cells (PBMCs) may represent the most acc...

journal_title：Blood

authors： Corbellino M,Bestetti G,Scalamogna C,Calattini S,Galazzi M,Meroni L,Manganaro D,Fasan M,Moroni M,Galli M,Parravicini C

更新日期：2001-12-01 00:00:00

abstract：:The thrombolytic efficacy of recombinant unglycosylated full length single chain urokinase-type plasminogen activator (rscu-PA, saruplase), applied either as single intravenous bolus or as a continuous infusion over 60 minutes, was studied in 5 randomized blinded groups of 5 dogs with combined copper coil induced coro...

journal_title：Blood

authors： Rapold HJ,Wu ZM,Stassen T,Van de Werf F,Collen D

更新日期：1990-10-15 00:00:00

abstract：:Whereas the final differentiation of conventional dendritic cells (CDCs) from committed precursors occurs locally in secondary lymphoid or peripheral tissues, plasmacytoid dendritic cells (PDCs) are thought to fully develop in the bone marrow from common DC progenitors before migrating to the periphery. In our study, ...

journal_title：Blood

authors： Schlitzer A,Loschko J,Mair K,Vogelmann R,Henkel L,Einwächter H,Schiemann M,Niess JH,Reindl W,Krug A

更新日期：2011-06-16 00:00:00

abstract：:The calcium ionophore A23187 promotes histamine synthesis in murine bone marrow cells by increasing the expression of mRNA encoding histidine decarboxylase (HDC), the histamine-forming enzyme. The cells responsible for this biological activity copurify with hematopoietic progenitors in terms of density, light scatter ...

journal_title：Blood

authors： Dy M,Arnould A,Lemoine FM,Machavoine F,Ziltener H,Schneider E

更新日期：1996-04-15 00:00:00

abstract：:De novo presentation of acute myeloid leukemia (AML) expressing the Philadelphia (Ph) chromosomal abnormality is rare and is associated with a dismal prognosis. To date, reported cases of Ph(+) AML have expressed either the e13a2 or e14a2 BCR-ABL fusion transcripts. We report a unique case of de novo AML expressing th...

journal_title：Blood

authors： Ritchie DS,McBean M,Westerman DA,Kovalenko S,Seymour JF,Dobrovic A

更新日期：2008-03-01 00:00:00

abstract：:In this issue of Blood, Whyte et al describe how under flow conditions, phosphatidylserine-expressing platelets modulate the lysis of whole blood clots by providing direct and indirect binding sites for plasminogen. ...

journal_title：Blood

authors： Kim PY

更新日期：2015-04-16 00:00:00

abstract：:A specially designed rotational viscometer was used to investigate the effects of the antiplatelet agent PGI2 in combination with theophylline on the response of human platelets subjected to shear stress. Samples of citrated platelet-rich plasma (PRP) were exposed to shear stress in the viscometer for a period of 5 mi...

journal_title：Blood

authors： Hardwick RA,Hellums JD,Peterson DM,Moake JL,Olson JD

更新日期：1981-10-01 00:00:00

abstract：:Mutations in HFE lead to hereditary hemochromatosis (HH) because of inappropriately high iron uptake from the diet resulting from decreased hepatic expression of the iron-regulatory hormone hepcidin. -thalassemia is a congenital anemia caused by partial or complete loss of -globin synthesis causing ineffective erythro...

journal_title：Blood

authors： Schmidt PJ,Toudjarska I,Sendamarai AK,Racie T,Milstein S,Bettencourt BR,Hettinger J,Bumcrot D,Fleming MD

更新日期：2013-02-14 00:00:00

abstract：:Reduced levels of somatic hypermutation (SHM) have recently been described in IgG-switched immunoglobulin genes in a minority of patients with common variable immunodeficiency (CVID), demonstrating a disruption of the normal linkage between isotype switch and SHM. To see if, irrespective of isotype, there is a tendenc...

journal_title：Blood

authors： Andersen P,Permin H,Andersen V,Schejbel L,Garred P,Svejgaard A,Barington T

更新日期：2005-01-15 00:00:00

abstract：:HGAL is a newly identified germinal center (GC)-specific gene whose expression by the tumor cells correlates with a favorable prognosis in patients with diffuse large B-cell and classical Hodgkin lymphomas. The function of HGAL is unknown. Previous studies demonstrated that HGAL is dispensable for GC formation, immuno...

journal_title：Blood

authors： Lu X,Chen J,Malumbres R,Cubedo Gil E,Helfman DM,Lossos IS

更新日期：2007-12-15 00:00:00

abstract：:Studying human antigen-specific memory B cells has been challenging because of low frequencies in peripheral blood, slow proliferation, and lack of antibody secretion. Therefore, most studies have relied on conversion of memory B cells into antibody-secreting cells by in vitro culture. To facilitate direct ex vivo iso...

journal_title：Blood

authors： Franz B,May KF Jr,Dranoff G,Wucherpfennig K

更新日期：2011-07-14 00:00:00

abstract：:In this issue of Blood, Acharya and colleagues provide evidence for the role of angiogenesis in the pathophysiology of hemophilic joint disease. Is this the linchpin that unravels this important clinical condition or merely a cog in a not so stepwise process? ...

journal_title：Blood

authors： Abshire T

更新日期：2011-02-24 00:00:00

abstract：:The ability to transfer new genetic material into human hematopoietic cells provides the foundation for characterizing the organization and developmental program of human hematopoietic stem cells. It also provides a valuable model in which to test gene transfer and long-term expression in human hematopoietic cells as ...

journal_title：Blood

authors： Dick JE,Kamel-Reid S,Murdoch B,Doedens M

更新日期：1991-08-01 00:00:00

abstract：:Wnt signaling is involved in numerous aspects of vertebrate development and homeostasis, including the formation and function of blood cells. Here, we show that canonical and noncanonical Wnt signaling pathways are present and functional in megakaryocytes (MKs), with several Wnt effectors displaying MK-restricted expr...

journal_title：Blood

authors： Macaulay IC,Thon JN,Tijssen MR,Steele BM,MacDonald BT,Meade G,Burns P,Rendon A,Salunkhe V,Murphy RP,Bennett C,Watkins NA,He X,Fitzgerald DJ,Italiano JE Jr,Maguire PB

更新日期：2013-01-03 00:00:00

abstract：:Alkylureas are capable of inhibiting sickling in vitro and the gelation of solutions of hemoglobin S at concentrations between 0.05 and 0.1 M with increasing effectiveness that is directly proportional to the length of the alkyl chain (butyl greater than propyl greater than ethyl greater than methyl). 6The inhibitory ...

journal_title：Blood

authors： Elbaum D,Roth EF Jr,Neumann G,Jaffé ER,Bookchin RM,Nagel RL

更新日期：1976-08-01 00:00:00

abstract：:p38 MAP kinase in human platelets is activated by platelet agonists including thrombin, thromboxane A2 (TxA2), ADP, and others. However, both upstream mechanisms of p38 MAP kinase activation, and their downstream sequelae, are presently controversial and essentially unclear. Certain studies report sequential activatio...

journal_title：Blood

authors： Begonja AJ,Geiger J,Rukoyatkina N,Rauchfuss S,Gambaryan S,Walter U

更新日期：2007-01-15 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) is a myeloproliferative disorder characterized by lesions composed of pathological CD207(+) dendritic cells with an inflammatory infiltrate. BRAFV600E remains the only recurrent mutation reported in LCH. In order to evaluate the spectrum of somatic mutations in LCH, whole exome sequ...

journal_title：Blood

authors： Chakraborty R,Hampton OA,Shen X,Simko SJ,Shih A,Abhyankar H,Lim KP,Covington KR,Trevino L,Dewal N,Muzny DM,Doddapaneni H,Hu J,Wang L,Lupo PJ,Hicks MJ,Bonilla DL,Dwyer KC,Berres ML,Poulikakos PI,Merad M,McClain K

更新日期：2014-11-06 00:00:00

abstract：:Overexpression of BAALC is an adverse prognostic factor in adults with cytogenetically normal acute myeloid leukemia and T-cell acute lymphoblastic leukemia (ALL). Here, we analyzed the prognostic significance of BAALC in B-precursor ALL. BAALC MRNA expression was determined in 368 primary adult B-precursor ALL patien...

journal_title：Blood

authors： Kühnl A,Gökbuget N,Stroux A,Burmeister T,Neumann M,Heesch S,Haferlach T,Hoelzer D,Hofmann WK,Thiel E,Baldus CD

更新日期：2010-05-06 00:00:00

abstract：:Deletion of TP53 gene, under routine assessment by fluorescence in situ hybridization analysis, connects with the worst prognosis in chronic lymphocytic leukemia (CLL). The presence of isolated TP53 mutation (without deletion) is associated with reduced survival in CLL patients. It is unclear how these abnormalities a...

journal_title：Blood

authors： Malcikova J,Smardova J,Rocnova L,Tichy B,Kuglik P,Vranova V,Cejkova S,Svitakova M,Skuhrova Francova H,Brychtova Y,Doubek M,Brejcha M,Klabusay M,Mayer J,Pospisilova S,Trbusek M

更新日期：2009-12-17 00:00:00

abstract：:Recently, point mutations in the gene of the granulocyte colony-stimulating factor (G-CSF) receptor have been reported in two patients with severe congenital neutropenia who developed acute myeloid leukemia (AML). We investigated the frequency of these specific G-CSF receptor mutations in patients with congenital neut...

journal_title：Blood

authors： Tidow N,Pilz C,Teichmann B,Müller-Brechlin A,Germeshausen M,Kasper B,Rauprich P,Sykora KW,Welte K

更新日期：1997-04-01 00:00:00