Unraveling hemophilic arthropathy.

abstract：:Basic fibroblast growth factor or fibroblast growth factor-2 (FGF) has been shown to affect myeloid cell proliferation and hypothesized to stimulate primitive hematopoietic cells. We sought to evaluate the effect of FGF on hematopoietic stem cells and to determine if FGF mediated its effects on progenitor cells direct...

journal_title：Blood

authors： Berardi AC,Wang A,Abraham J,Scadden DT

更新日期：1995-09-15 00:00:00

abstract：:Dendritic cells (DCs) represent a small and heterogeneous fraction of the hematopoietic system, specialized in antigen capture, processing, and presentation. The different DC subsets act as sentinels throughout the body and perform a key role in the induction of immunogenic as well as tolerogenic immune responses. Bec...

journal_title：Blood

authors： van de Laar L,Coffer PJ,Woltman AM

更新日期：2012-04-12 00:00:00

abstract：:Telomere erosion may be counteracted by telomerase. Here we explored telomere length (TL) and telomerase activity (TA) in primary cutaneous T-cell lymphoma (CTCL) by using quantitative polymerase chain reaction and interphase quantitative fluorescence in situ hybridization assays. Samples from patients with Sézary syn...

journal_title：Blood

authors： Chevret E,Andrique L,Prochazkova-Carlotti M,Ferrer J,Cappellen D,Laharanne E,Idrissi Y,Boettiger A,Sahraoui W,Ruiz F,Pham-Ledard A,Vergier B,Belloc F,Dubus P,Beylot-Barry M,Merlio JP

更新日期：2014-03-20 00:00:00

abstract：:Although bispecific antibodies directed against malignant lymphoma have been shown to be effective in vitro and in vivo, extended clinical trials so far have been hampered by the fact that conventional approaches to produce these antibodies suffer from low yields, ill-defined byproducts, or laborious purification proc...

journal_title：Blood

authors： Löffler A,Kufer P,Lutterbüse R,Zettl F,Daniel PT,Schwenkenbecher JM,Riethmüller G,Dörken B,Bargou RC

更新日期：2000-03-15 00:00:00

abstract：:Activating mutations of the Fms-like tyrosine kinase 3 (FLT3) receptor are the most common genetic alteration in acute myeloid leukemia (AML). Two distinct groups of FLT3 mutations are found: internal tandem duplications (ITDs) of the juxtamembrane region and point mutations within the tyrosine kinase domain (TKD). Re...

journal_title：Blood

authors： Grundler R,Miething C,Thiede C,Peschel C,Duyster J

更新日期：2005-06-15 00:00:00

abstract：:Five novel monoclonal antibodies (mAbs; p0p 1-5) were used to characterize the structural and functional properties and the in vivo expression of the murine GPIb-IX complex (von Willebrand factor receptor). The molecular weights of the subunits are similar to the human homologs: GPIbalpha (150 kd), GPIbbeta (25 kd), a...

journal_title：Blood

authors： Bergmeier W,Rackebrandt K,Schröder W,Zirngibl H,Nieswandt B

更新日期：2000-02-01 00:00:00

abstract：:Natural killer (NK) cells can alter the outcome of hematopoietic cell transplantation (HCT) if donor alloreactivity targets the recipient. Since most NK cells express inhibitory killer-immunoglobulin receptors (KIRs), we hypothesized that the susceptibility of recipient cells to donor NK cell-mediated lysis is genetic...

journal_title：Blood

authors： Miller JS,Cooley S,Parham P,Farag SS,Verneris MR,McQueen KL,Guethlein LA,Trachtenberg EA,Haagenson M,Horowitz MM,Klein JP,Weisdorf DJ

更新日期：2007-06-01 00:00:00

abstract：:The effects of protein deprivation on erythropoietin (Ep) production were studied. The posthypoxia plasma Ep levels of rats fed a protein-free diet for only 1 day prior to being exposed to 0.5 atmosphere for 7 hr were significantly lower than those of comparably hypoxic rats maintained on a normal diet. The postthypox...

journal_title：Blood

authors： Anagnostou A,Schade S,Ashkinaz M,Barone J,Fried W

更新日期：1977-12-01 00:00:00

abstract：:Interleukin-6 (IL-6) is a growth factor with diverse biologic activity. Originally described as a T-cell product that enhances immunoglobulin (Ig) secretion in antigen-stimulated B cells, it also affects the growth of T cells, plasmacytomas, hybridomas, and hematopoietic stem cells. We report the expression and secret...

journal_title：Blood

authors： Yee C,Biondi A,Wang XH,Iscove NN,de Sousa J,Aarden LA,Wong GG,Clark SC,Messner HA,Minden MD

更新日期：1989-08-01 00:00:00

abstract：:Sickle red cell (SS RBC) adhesion is believed to contribute to the process of vaso-occlusion in sickle cell disease (SCD). We previously found that the LW RBC adhesion receptor can be activated by epinephrine to mediate SS RBC adhesion to endothelial alphavbeta3 integrin. To determine the contribution of LW activation...

journal_title：Blood

authors： Zennadi R,Moeller BJ,Whalen EJ,Batchvarova M,Xu K,Shan S,Delahunty M,Dewhirst MW,Telen MJ

更新日期：2007-10-01 00:00:00

abstract：:Hepatitis C virus (HCV) is associated with the B-cell lymphoproliferative disorders mixed cryoglobulinemia (MC) and non-Hodgkin lymphoma. We have previously reported that HCV(+)MC(+) patients have clonal expansions of hypermutated, rheumatoid factor-bearing marginal zone-like IgM(+)CD27(+) peripheral B cells using the...

journal_title：Blood

authors： Charles ED,Brunetti C,Marukian S,Ritola KD,Talal AH,Marks K,Jacobson IM,Rice CM,Dustin LB

更新日期：2011-05-19 00:00:00

abstract：:Epithin/PRSS14, a type II transmembrane serine protease, is involved in normal epithelial development and tumor progression. Here we report, as an interacting substrate of epithin, a receptor tyrosine kinase Tie2 that is well known for important roles in the vessel stability. Epithin interacts with and degrades the Ti...

journal_title：Blood

authors： Kim C,Lee HS,Lee D,Lee SD,Cho EG,Yang SJ,Kim SB,Park D,Kim MG

更新日期：2011-01-27 00:00:00

abstract：:Mutations in the kinase domain (KD) of BCR-ABL are the most prevalent mechanism of acquired imatinib resistance in patients with chronic myeloid leukemia (CML). Here we examine predisposing factors underlying acquisition of KD mutations, evidence for acquisition of mutations before and during therapy, and whether the ...

journal_title：Blood

authors： O'Hare T,Eide CA,Deininger MW

更新日期：2007-10-01 00:00:00

abstract：:Chimeric antigen receptor (CAR) T cells have emerged as a novel form of treatment of patients with B-cell malignancies. In particular, anti-CD19 CAR T-cell therapy has effected impressive clinical responses in B-cell acute lymphoblastic leukemia and diffuse large B-cell lymphoma. However, not all patients respond, and...

journal_title：Blood

authors： Scarfò I,Ormhøj M,Frigault MJ,Castano AP,Lorrey S,Bouffard AA,van Scoyk A,Rodig SJ,Shay AJ,Aster JC,Preffer FI,Weinstock DM,Maus MV

更新日期：2018-10-04 00:00:00

abstract：:We describe a novel localization of C7 as a membrane-bound molecule on endothelial cells (ECs). Data obtained by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), Western blot analysis, Northern blot analysis, and mass spectrometry revealed that membrane-associated C7 (mC7) was indistinguishable fr...

journal_title：Blood

authors： Bossi F,Rizzi L,Bulla R,Debeus A,Tripodo C,Picotti P,Betto E,Macor P,Pucillo C,Würzner R,Tedesco F

更新日期：2009-04-09 00:00:00

abstract：:Myofibroblasts are fibrosis-driving cells and are well characterized in solid organ fibrosis, but their role and cellular origin in bone marrow fibrosis remains obscure. Recent work has demonstrated that Gli1+ and LepR+ mesenchymal stromal cells (MSCs) are progenitors of fibrosis-causing myofibroblasts in the bone mar...

journal_title：Blood

authors： Kramann R,Schneider RK

更新日期：2018-05-10 00:00:00

abstract：:To obtain insight into the mechanism(s) of posttransplantation humoral immunodeficiency, we evaluated factors affecting serum antibody levels against polio, tetanus, Haemophilus influenzae, and Streptococcus pneumoniae in 87 patients. Patients with hematologic malignancies were randomized to receive marrow versus bloo...

journal_title：Blood

authors： Storek J,Viganego F,Dawson MA,Herremans MM,Boeckh M,Flowers ME,Storer B,Bensinger WI,Witherspoon RP,Maloney DG

更新日期：2003-04-15 00:00:00

abstract：:In a previous multicenter phase III trial comparing peripheral blood stem cell transplantation (PBSCT) to bone marrow transplantation (BMT) from HLA-matched related donors, we found no statistically significant difference in the cumulative incidence of clinical extensive chronic graft-versus-host disease (GVHD) in the...

journal_title：Blood

authors： Flowers ME,Parker PM,Johnston LJ,Matos AV,Storer B,Bensinger WI,Storb R,Appelbaum FR,Forman SJ,Blume KG,Martin PJ

更新日期：2002-07-15 00:00:00

abstract：:Approximately 4% to 5% of all bone marrow (BM) cells and 8% to 9% of low density BM cells from FVB/N and BALB/c mice (Ly-6a haplotype) show high to intermediate expression of Ly-6E.1 antigen, recognized by the Sca-1 antibody. Functional properties of enriched cells expressing Ly-6E.1-allelic form of Sca-1 antigen were...

journal_title：Blood

authors： Jurecic R,Van NT,Belmont JW

更新日期：1993-11-01 00:00:00

abstract：:Two tumor necrosis factor receptors (TNFRs) with molecular weights of 55 kD (TNFR-p55) and 75 kD (TNFR-p75) have recently been identified and cloned. In previous studies, TNFR-p55 has been shown to exclusively mediate bidirectional effects of TNF-alpha on committed bone marrow granulocyte-macrophage progenitor cells, ...

journal_title：Blood

authors： Rusten LS,Jacobsen SE

更新日期：1995-02-15 00:00:00

abstract：:Although small deletions, splice site abnormalities, missense, and nonsense mutations have been identified in patients with factor VII deficiency, there have been no reports of mutations in the factor VII promoter. We investigated a girl with factor VII levels that were less than 1% of normal in association with a sev...

journal_title：Blood

authors： Arbini AA,Pollak ES,Bayleran JK,High KA,Bauer KA

更新日期：1997-01-01 00:00:00

abstract：:As a promising new class of anticancer drugs, camptothecins have advanced to the forefront of several areas of therapeutic and developmental chemotherapy. In the present study, we report that NSC606985, a rarely studied camptothecin analog, induces apoptosis in acute myeloid leukemia (AML) cells NB4 and U937 and inhib...

journal_title：Blood

authors： Song MG,Gao SM,Du KM,Xu M,Yu Y,Zhou YH,Wang Q,Chen Z,Zhu YS,Chen GQ

更新日期：2005-05-01 00:00:00

abstract：:Hemoglobin and ferritin iron content have been followed during differentiation in tissue cultures of murine erythroleukemia cells (MELC) using the techniques of Mössbauer spectroscopy and electron microscopy. In undifferentiated cells grown without DMSO, only iron stored in ferritin was detected. The amount of iron in...

journal_title：Blood

authors： Ofer S,Fibach E,Kessel M,Bauminger ER,Cohen SG,Eikelboom J,Rachmilewitz EA

更新日期：1981-08-01 00:00:00

abstract：:Ischemia/reperfusion (I/R) injury in the kidney is a major cause of acute kidney injury (AKI) in humans and is associated with significantly high mortality. To identify genes that modulate kidney injury and repair, we conducted genome-wide expression analysis in the rat kidneys after I/R and found that the mRNA levels...

journal_title：Blood

authors： Krishnamoorthy A,Ajay AK,Hoffmann D,Kim TM,Ramirez V,Campanholle G,Bobadilla NA,Waikar SS,Vaidya VS

更新日期：2011-08-18 00:00:00

abstract：:Mice deficient for the transcription factor, interferon consensus sequence binding protein (ICSBP), are immunodeficient and develop disease symptoms similar to human chronic myeloid leukemia (CML). To elucidate the hematopoietic disorder of ICSBP(-/-) mice, we investigated the growth, differentiation, and leukemogenic...

journal_title：Blood

authors： Scheller M,Foerster J,Heyworth CM,Waring JF,Löhler J,Gilmore GL,Shadduck RK,Dexter TM,Horak I

更新日期：1999-12-01 00:00:00

abstract：:As our technological capacities improve, genomic testing is increasingly integrating into patient care. The field of clinical hematology is no exception. Genomic testing carries great promise, but several ethical issues must be considered whenever such testing is performed. This review addresses these ethical consider...

journal_title：Blood

authors： Marron JM,Joffe S

更新日期：2017-07-27 00:00:00

abstract：:It has recently been shown that the ultralarge platelet-recruiting von Willebrand factor (VWF) strings formed immediately at exocytosis from endothelial cells may be anchored to the cell surface by interaction with the integral membrane protein P-selectin. This finding of a new binding partner for VWF immediately prom...

journal_title：Blood

authors： Michaux G,Pullen TJ,Haberichter SL,Cutler DF

更新日期：2006-05-15 00:00:00

abstract：:Systemic inflammation perturbs the bone marrow environment by evicting resident B cells and favoring granulopoiesis over lymphopoiesis. Despite these conditions, a subset of marrow B cell remains to become activated and produce potent acute immunoglobulin M (IgM) responses. This discrepancy is currently unresolved and...

journal_title：Blood

authors： Moreau JM,Berger A,Nelles ME,Mielnik M,Furlonger C,Cen SY,Besla R,Robbins CS,Paige CJ

更新日期：2015-09-03 00:00:00

abstract：:Human herpesvirus 8 (HHV-8) is the causative agent of Kaposi sarcoma (KS) and multicentric Castleman disease (MCD), a life-threatening, virally induced B-cell lymphoproliferative disorder. HHV-8 is a B-lymphotropic γ-herpesvirus closely related to the Epstein-Barr virus (EBV). Invariant natural killer T (iNKT) cells a...

journal_title：Blood

authors： Sbihi Z,Dossier A,Boutboul D,Galicier L,Parizot C,Emarre A,Hoareau B,Dupin N,Marcelin AG,Oudin A,Fieschi C,Agbalika F,Autran B,Oksenhendler E,Carcelain G

更新日期：2017-02-16 00:00:00

abstract：:Inhibition of complement-mediated granulocyte aggregation has recently been proposed as a mechanism of action of high-dose corticosteroids in shock states. Such inhibition may be effected through alteration of receptor function. Methylprednisolone inhibits binding of the synthetic chemotaxin f-methionine-leucine-pheny...

journal_title：Blood

authors： Skubitz KM,Hammerschmidt DE

更新日期：1986-10-01 00:00:00