Unraveling hemophilic arthropathy.


:In this issue of Blood, Acharya and colleagues provide evidence for the role of angiogenesis in the pathophysiology of hemophilic joint disease. Is this the linchpin that unravels this important clinical condition or merely a cog in a not so stepwise process?






Abshire T




Has Abstract


2011-02-24 00:00:00
















  • Targeting BCL-2 in B-cell lymphomas.

    abstract::The B-cell leukemia/lymphoma-2 (BCL-2) family of proteins governs the intrinsic pathway of mitochondrial apoptosis. Dysregulation of BCL-2 has long been known to be a crucial part of the pathophysiology of B-cell lymphomas; however, several early attempts to target this pathway therapeutically were unsuccessful becaus...


    pub_type: 杂志文章,评审


    authors: Davids MS

    更新日期:2017-08-31 00:00:00

  • GATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndrome.

    abstract::Children with constitutional trisomy 21 (Down syndrome) have an approximately 500-fold increased risk of developing acute megakaryoblastic leukemia (AMKL), a form of acute myeloid leukemia. Unique to newborn infants with Down syndrome is a transient leukemia (TL), also referred to as transient myeloproliferative syndr...


    pub_type: 杂志文章


    authors: Hitzler JK,Cheung J,Li Y,Scherer SW,Zipursky A

    更新日期:2003-06-01 00:00:00

  • Phosphorylation of protein 4.1 in Plasmodium falciparum-infected human red blood cells.

    abstract::The composition of the erythrocyte plasma membrane is extensively modified during the intracellular growth of the malaria parasite Plasmodium falciparum. It has been previously shown that an 80-kD phosphoprotein is associated with the plasma membrane of human red blood cells (RBCs) infected with trophozoite/schizont s...


    pub_type: 杂志文章


    authors: Chishti AH,Maalouf GJ,Marfatia S,Palek J,Wang W,Fisher D,Liu SC

    更新日期:1994-06-01 00:00:00

  • CD30 targeting with brentuximab vedotin: a novel therapeutic approach to primary effusion lymphoma.

    abstract::Primary effusion lymphoma (PEL) is an aggressive subtype of non-Hodgkin lymphoma characterized by short survival with current therapies, emphasizing the urgent need to develop new therapeutic approaches. Brentuximab vedotin (SGN-35) is an anti-CD30 monoclonal antibody (cAC10) conjugated by a protease-cleavable linker ...


    pub_type: 杂志文章


    authors: Bhatt S,Ashlock BM,Natkunam Y,Sujoy V,Chapman JR,Ramos JC,Mesri EA,Lossos IS

    更新日期:2013-08-15 00:00:00

  • Isolation and functional characterization of human erythroblasts at distinct stages: implications for understanding of normal and disordered erythropoiesis in vivo.

    abstract::Terminal erythroid differentiation starts from morphologically recognizable proerythroblasts that proliferate and differentiate to generate red cells. Although this process has been extensively studied in mice, its characterization in humans is limited. By examining the dynamic changes of expression of membrane protei...


    pub_type: 杂志文章


    authors: Hu J,Liu J,Xue F,Halverson G,Reid M,Guo A,Chen L,Raza A,Galili N,Jaffray J,Lane J,Chasis JA,Taylor N,Mohandas N,An X

    更新日期:2013-04-18 00:00:00

  • An endogenous glycosylphosphatidylinositol-specific phospholipase D releases basic fibroblast growth factor-heparan sulfate proteoglycan complexes from human bone marrow cultures.

    abstract::Basic fibroblast growth factor (bFGF) is a hematopoietic cytokine that stimulates stromal and stem cell growth. It binds to a glycosylphosphatidylinositol (GPI)-anchored heparan sulfate proteoglycan on human bone marrow (BM) stromal cells. The bFGF-proteoglycan complex is biologically active and is released by additio...


    pub_type: 杂志文章


    authors: Brunner G,Metz CN,Nguyen H,Gabrilove J,Patel SR,Davitz MA,Rifkin DB,Wilson EL

    更新日期:1994-04-15 00:00:00

  • Quinine-dependent, platelet-reactive monoclonals mimic antibodies found in patients with quinine-induced immune thrombocytopenia.

    abstract::Drug-induced immune thrombocytopenia (DITP) is caused by drug-dependent antibodies (DDAbs) that are nonreactive in themselves but bind tightly to specific platelet membrane glycoproteins (GP) when soluble drug is present at pharmacologic concentrations. This reaction takes place without covalent linkage of drug to the...


    pub_type: 杂志文章


    authors: Bougie DW,Birenbaum J,Rasmussen M,Poncz M,Aster RH

    更新日期:2009-01-29 00:00:00

  • Synergistic effect of sphingosine 1-phosphate on thrombin-induced tissue factor expression in endothelial cells.

    abstract::Sphingosine 1-phosphate (S1P), a bioactive lipid, is produced and stored in platelets and is released from activated platelets during blood coagulation activation. Thrombin, which is also generated during blood coagulation, has been shown to induce tissue factor (TF), the initiator of blood coagulation, in endothelial...


    pub_type: 杂志文章


    authors: Takeya H,Gabazza EC,Aoki S,Ueno H,Suzuki K

    更新日期:2003-09-01 00:00:00

  • BCL-6 negatively regulates macrophage proliferation by suppressing autocrine IL-6 production.

    abstract::The transcription repressor BCL-6 is known to play critical roles in B-cell lymphomagenesis, germinal center formation, and balanced Th1/Th2 differentiation. In macrophages, although BCL-6 has also been shown to regulate the expression of several chemokine genes, its function in other aspects of macrophage biology has...


    pub_type: 杂志文章


    authors: Yu RY,Wang X,Pixley FJ,Yu JJ,Dent AL,Broxmeyer HE,Stanley ER,Ye BH

    更新日期:2005-02-15 00:00:00

  • Glycol-split nonanticoagulant heparins are inhibitors of hepcidin expression in vitro and in vivo.

    abstract::Hepcidin controls systemic iron availability, and its excess contributes to the anemia of chronic diseases, the most prevalent anemia in hospitalized patients. We previously reported that heparins are efficient hepcidin inhibitors both in vitro and in vivo, but their anticoagulant activity limits therapeutic use. We s...


    pub_type: 杂志文章


    authors: Poli M,Asperti M,Naggi A,Campostrini N,Girelli D,Corbella M,Benzi M,Besson-Fournier C,Coppin H,Maccarinelli F,Finazzi D,Arosio P

    更新日期:2014-03-06 00:00:00

  • Janus kinase inhibition by ruxolitinib extends dasatinib- and dexamethasone-induced remissions in a mouse model of Ph+ ALL.

    abstract::Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) is initiated and driven by the oncogenic fusion protein BCR-ABL, a constitutively active tyrosine kinase. Despite major advances in the treatment of this highly aggressive disease with potent inhibitors of the BCR-ABL kinase such as dasatinib, pat...


    pub_type: 杂志文章


    authors: Appelmann I,Rillahan CD,de Stanchina E,Carbonetti G,Chen C,Lowe SW,Sherr CJ

    更新日期:2015-02-26 00:00:00

  • Fetal liver myelopoiesis occurs through distinct, prospectively isolatable progenitor subsets.

    abstract::Hematopoietic fate maps in the developing mouse embryo remain imprecise. Definitive, adult-type hematopoiesis first appears in the fetal liver, then progresses to the spleen and bone marrow. Clonogenic common lymphoid progenitors and clonogenic common myeloid progenitors (CMPs) in adult mouse bone marrow that give ris...


    pub_type: 杂志文章


    authors: Traver D,Miyamoto T,Christensen J,Iwasaki-Arai J,Akashi K,Weissman IL

    更新日期:2001-08-01 00:00:00

  • T cell receptor (alpha, beta, gamma) gene rearrangements and expression in normal and leukemic large granular lymphocytes/natural killer cells.

    abstract::The large granular lymphocyte (LGL) population, which effects a natural killer (NK) function, consists of cells whose lineage derivation has not been clearly established on the basis of phenotypic and functional properties. To clarify the relationship of LGL/NK cells to T cells we studied patterns of rearrangement and...


    pub_type: 杂志文章


    authors: Pelicci PG,Allavena P,Subar M,Rambaldi A,Pirelli A,Di Bello M,Barbui T,Knowles DM 2nd,Dalla-Favera R,Mantovani A

    更新日期:1987-11-01 00:00:00

  • It takes a village.

    abstract::In this issue of Blood, Bhatia et al demonstrate the critical importance of an adherence to oral chemotherapy regimens in attaining cure for children with acute lymphoblastic leukemia (ALL) and identify race-specific determinants of adherence. ...


    pub_type: 评论,杂志文章


    authors: Winick N

    更新日期:2014-10-09 00:00:00

  • Murine myeloid cells transformed by myb require fibroblast-derived or autocrine growth factors in addition to granulocyte-macrophage colony-stimulating factor for proliferation.

    abstract::Murine myeloid cells can be transformed in vitro by infection with recombinant retroviruses carrying activated myb genes. While these myb-transformed hematopoietic cells (MTHCs) can proliferate continuously in culture, they exhibit several characteristics of progenitor cells of the granulocyte-macrophage (GM) lineage,...


    pub_type: 杂志文章


    authors: Macmillan EM,Gonda TJ

    更新日期:1994-01-01 00:00:00

  • p53 and N-ras mutations in two new leukemia cell lines established from a patient with multilineage CD7-positive acute leukemia.

    abstract::Two new myeloid cell lines (K051 and K052) were established from a patient with multilineage CD7-positive acute leukemia. The K051 and K052 were established from the patient's bone marrow cells at diagnosis and at relapse, respectively. The K051 cell expressed myeloid-associated antigens (CD13 and CD33), a platelet-as...


    pub_type: 杂志文章


    authors: Abo J,Inokuchi K,Dan K,Nomura T

    更新日期:1993-11-01 00:00:00

  • Detection of the carrier state for classic hemophilia using an enzyme-linked immunosorbent assay (ELISA).

    abstract::A high proportion of carriers of classic hemophilia can be identified in the laboratory because, in comparison to normal women, the concentration of antigens related to antihemophilic factor (AHF, factor VIII) that are detected in their plasma by heterologous antiserum (factor VIIIR:Ag) is relatively higher than the t...


    pub_type: 杂志文章


    authors: Fishman DJ,Jones PK,Menitove JE,Ratnoff OD,Everson B

    更新日期:1982-06-01 00:00:00

  • Concordant but not discordant bone marrow involvement in diffuse large B-cell lymphoma predicts a poor clinical outcome independent of the International Prognostic Index.

    abstract::In diffuse large B-cell lymphoma (DLBCL), previous studies have suggested that, while concordant bone marrow (BM) involvement confers a poor prognosis, discordant BM involvement does not. Whether this correlation is independent of the non-Hodgkin lymphoma International Prognostic Index (IPI) was previously unknown. We...


    pub_type: 杂志文章


    authors: Chung R,Lai R,Wei P,Lee J,Hanson J,Belch AR,Turner AR,Reiman T

    更新日期:2007-08-15 00:00:00

  • A ligand-receptor signaling threshold model of stem cell differentiation control: a biologically conserved mechanism applicable to hematopoiesis.

    abstract::A major limitation to the widespread use of hematopoietic stem cells (HSC) is the relatively crude level of our knowledge of how to maintain these cells in vitro without loss of the long-term multilineage growth and differentiation properties required for their clinical utility. An experimental and theoretical framewo...


    pub_type: 杂志文章,评审


    authors: Zandstra PW,Lauffenburger DA,Eaves CJ

    更新日期:2000-08-15 00:00:00

  • Mig, the monokine induced by interferon-gamma, promotes tumor necrosis in vivo.

    abstract::Mig, the monokine induced by interferon-gamma, is a CXC chemokine active as a chemoattractant for activated T cells. Mig is related functionally to interferon-inducible protein 10 (IP-10), with which it shares a receptor, CXCR3. Previously, IP-10 was found to have antitumor activity in vivo. In the present study, muri...


    pub_type: 杂志文章


    authors: Sgadari C,Farber JM,Angiolillo AL,Liao F,Teruya-Feldstein J,Burd PR,Yao L,Gupta G,Kanegane C,Tosato G

    更新日期:1997-04-15 00:00:00

  • Sialylated O-glycans and L-selectin sequentially mediate myeloid cell rolling in vivo.

    abstract::Leukocyte rolling precedes firm adhesion and emigration in inflammatory cell recruitment. Both P-selectin, an endothelial lectin that binds to sialylated O-glycans containing sialyl-Lewisx (sLex) on the granulocyte surface, and leukocyte L-selectin have been shown to mediate leukocyte rolling in vivo. Here, we investi...


    pub_type: 杂志文章


    authors: Ley K,Zakrzewicz A,Hanski C,Stoolman LM,Kansas GS

    更新日期:1995-06-15 00:00:00

  • Primitive quiescent leukemic cells from patients with chronic myeloid leukemia spontaneously initiate factor-independent growth in vitro in association with up-regulation of expression of interleukin-3.

    abstract::It was previously shown that patients with chronic myeloid leukemia (CML) have a rare but consistently detectable population of quiescent (G0) leukemic (Philadelphia chromosome-positive and BCR-ABL-positive [BCR-ABL+]) CD34+ cells. In the study described here, most such cells expressed a primitive phenotype (CD38-, CD...


    pub_type: 杂志文章


    authors: Holyoake TL,Jiang X,Jorgensen HG,Graham S,Alcorn MJ,Laird C,Eaves AC,Eaves CJ

    更新日期:2001-02-01 00:00:00

  • In vitro production of granulocyte-macrophage colony-stimulating factor in aplastic anemia: possible mechanisms of action of antithymocyte globulin.

    abstract::Various abnormalities of lymphokine production have been described in patients with aplastic anemia. To determine if abnormal production of hematopoietic growth factors could contribute to the process of aplastic anemia we studied the in vitro production of human granulocyte-macrophage colony-stimulating factor (GM-CS...


    pub_type: 杂志文章


    authors: Nimer SD,Golde DW,Kwan K,Lee K,Clark S,Champlin R

    更新日期:1991-07-01 00:00:00

  • ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes.

    abstract::Anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma (ALCL) is a CD30-positive T-cell non-Hodgkin lymphoma that morphologically resembles ALK-positive ALCL but lacks chromosomal rearrangements of the ALK gene. The genetic and clinical heterogeneity of ALK-negative ALCL has not been delineated. We p...


    pub_type: 杂志文章


    authors: Parrilla Castellar ER,Jaffe ES,Said JW,Swerdlow SH,Ketterling RP,Knudson RA,Sidhu JS,Hsi ED,Karikehalli S,Jiang L,Vasmatzis G,Gibson SE,Ondrejka S,Nicolae A,Grogg KL,Allmer C,Ristow KM,Wilson WH,Macon WR,Law ME,Ce

    更新日期:2014-08-28 00:00:00

  • Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target.

    abstract::The importance of glutamine (Gln) metabolism in multiple myeloma (MM) cells and its potential role as a therapeutic target are still unknown, although it has been reported that human myeloma cell lines (HMCLs) are highly sensitive to Gln depletion. In this study, we found that both HMCLs and primary bone marrow (BM) C...


    pub_type: 杂志文章


    authors: Bolzoni M,Chiu M,Accardi F,Vescovini R,Airoldi I,Storti P,Todoerti K,Agnelli L,Missale G,Andreoli R,Bianchi MG,Allegri M,Barilli A,Nicolini F,Cavalli A,Costa F,Marchica V,Toscani D,Mancini C,Martella E,Dall'Asta V

    更新日期:2016-08-04 00:00:00

  • LXR as a novel antithrombotic target.

    abstract::Liver X receptors (LXRs) are transcription factors involved in the regulation of cholesterol homeostasis. LXR ligands have athero-protective properties independent of their effects on cholesterol metabolism. Platelets are involved in the initiation of atherosclerosis and despite being anucleate express nuclear recepto...


    pub_type: 杂志文章


    authors: Spyridon M,Moraes LA,Jones CI,Sage T,Sasikumar P,Bucci G,Gibbins JM

    更新日期:2011-05-26 00:00:00

  • Treatment of adult acute lymphoblastic leukemia with intensive cyclical chemotherapy: a follow-up report.

    abstract::We treated 109 patients with adult acute lymphoblastic leukemia (ALL) diagnosed by histochemical and immunologic techniques. Patients were excluded only for age greater than 50 years and Burkitt's leukemia. Treatment included a four-drug remission induction phase followed by alternating cycles of noncrossresistant che...


    pub_type: 临床试验,杂志文章


    authors: Linker CA,Levitt LJ,O'Donnell M,Forman SJ,Ries CA

    更新日期:1991-12-01 00:00:00

  • Felic (CIP4b), a novel binding partner with the Src kinase Lyn and Cdc42, localizes to the phagocytic cup.

    abstract::Through its Src homology 3 (SH3) and SH2 domains, the Src kinase Lyn interacts with a small number of phosphoproteins, such as Shc, Cbl, and Vav, which regulate cell cycle and the cytoskeleton. Using Lyn's Unique, SH3, and SH2 domains as bait in a yeast 2-hybrid screen, we isolated a novel gene product with features o...


    pub_type: 杂志文章


    authors: Dombrosky-Ferlan P,Grishin A,Botelho RJ,Sampson M,Wang L,Rudert WA,Grinstein S,Corey SJ

    更新日期:2003-04-01 00:00:00

  • Selective binding of the factor VIII/von Willebrand factor protein to human platelets.

    abstract::The factor VIII/von Willebrand factor protein was radiolabeled after modification by galactose oxidase and reduction with tritiated potassium borohydride. This mild efficient method for labeling resulted in retention of over 90% of the biologic activities of the factor VIII/von Willebrand factor protein. Binding of th...


    pub_type: 杂志文章


    authors: Morisato DK,Gralnick HR

    更新日期:1980-01-01 00:00:00

  • Inherited genetic susceptibility to monoclonal gammopathy of unknown significance.

    abstract::Monoclonal gammopathy of undetermined significance (MGUS) is present in ∼2% of individuals age >50 years. The increased risk of multiple myeloma (MM) in relatives of individuals with MGUS is consistent with MGUS being a marker of inherited genetic susceptibility to MM. Common single-nucleotide polymorphisms (SNPs) at ...


    pub_type: 杂志文章


    authors: Weinhold N,Johnson DC,Rawstron AC,Försti A,Doughty C,Vijayakrishnan J,Broderick P,Dahir NB,Begum DB,Hosking FJ,Yong K,Walker BA,Hoffmann P,Mühleisen TW,Langer C,Dörner E,Jöckel KH,Eisele L,Nöthen MM,Hose D,Davies

    更新日期:2014-04-17 00:00:00