A genome-wide association analysis of serum iron concentrations.

abstract：:One of the most serious complications of successful treatments for Hodgkin's disease is an increased incidence of acute nonlymphocytic leukemia (ANLL) and other malignancies. A retrospective analysis carried out on 1032 consecutive patients with Hodgkin's disease admitted to our Institute between 1965 and 1978 and tre...

journal_title：Blood

authors： Valagussa P,Santoro A,Fossati Bellani F,Franchi F,Banfi A,Bonadonna G

更新日期：1982-03-01 00:00:00

abstract：:To migrate efficiently through the interstitium, dendritic cells (DCs) constantly adapt their shape to the given structure of the extracellular matrix and follow the path of least resistance. It is known that this amoeboid migration of DCs requires Cdc42, yet the upstream regulators critical for localization and activ...

journal_title：Blood

authors： Harada Y,Tanaka Y,Terasawa M,Pieczyk M,Habiro K,Katakai T,Hanawa-Suetsugu K,Kukimoto-Niino M,Nishizaki T,Shirouzu M,Duan X,Uruno T,Nishikimi A,Sanematsu F,Yokoyama S,Stein JV,Kinashi T,Fukui Y

更新日期：2012-05-10 00:00:00

abstract：:Complement plays a key role in host defense, but its dysregulation can cause autologous tissue injury. Complement activation is normally controlled by regulatory proteins, including factor H (FH) in plasma and membrane cofactor protein (MCP) on the cell surface. Mutations in FH and MCP are linked to atypical hemolytic...

journal_title：Blood

authors： Ueda Y,Mohammed I,Song D,Gullipalli D,Zhou L,Sato S,Wang Y,Gupta S,Cheng Z,Wang H,Bao J,Mao Y,Brass L,Zheng XL,Miwa T,Palmer M,Dunaief J,Song WC

更新日期：2017-03-02 00:00:00

abstract：:Clonal expansion of activated T cells is controlled by homeostatic mechanisms leading to cell death of a large proportion of the cells. The CD3/TcR pathway induces cell death, mostly when triggered in the absence of costimulatory signal. The unique T cell-specific chemokine of the C class, lymphotactin (Lptn), has rec...

journal_title：Blood

authors： Cerdan C,Devilard E,Xerri L,Olive D

更新日期：2001-04-15 00:00:00

abstract：:The finding that the risk of relapse in hematologic malignancy decreases after allogeneic hematopoietic stem cell transplantation (HSCT) has lead to the concept of a graft-versus-leukemia (GVL) effect. However, this beneficial effect is considered to be frequently offset by graft-versus-host disease (GVHD). Thus, impr...

journal_title：Blood

authors： Kawase T,Matsuo K,Kashiwase K,Inoko H,Saji H,Ogawa S,Kato S,Sasazuki T,Kodera Y,Morishima Y,Japan Marrow Donor Program.

更新日期：2009-03-19 00:00:00

abstract：:The white-spotting (Ws) locus of rats represents a 12-base deletion of the c-kit receptor tyrosine kinase. Homozygous Ws/Ws rats are deficient in melanocytes, mast cells, and erythrocytes. Although mice possessing two mutant alleles at the c-kit (W) locus, such as mice of W/Wv genotype, show severe anemia even in adul...

journal_title：Blood

authors： Morimoto M,Kasugai T,Tei H,Jippo-Kanemoto T,Kanakura Y,Kitamura Y

更新日期：1993-12-01 00:00:00

abstract：:Catabolism of free heme by heme oxygenase-1 (HO-1) generates carbon monoxide, biliverdin, and free iron (Fe). These end-products are responsible for much of the biologic activity of HO-1, including anti-inflammatory, antiapo-ptotic, antiproliferative, and antioxidant effects. We have identified an additional cytoprote...

journal_title：Blood

authors： Kinderlerer AR,Pombo Gregoire I,Hamdulay SS,Ali F,Steinberg R,Silva G,Ali N,Wang B,Haskard DO,Soares MP,Mason JC

更新日期：2009-02-12 00:00:00

abstract：:Two patients developed thrombocytopenia associated with an in vitro platelet to leukocyte adherence phenomenon (PLAP). In one patient, whole serum, intact plasma, and the IgG fraction of the serum could induce the PLAP of normal platelets in normal whole blood or buffy coat preparations. Passage of serum over a Sephar...

journal_title：Blood

authors： Greipp PR,Gralnick HR

更新日期：1976-03-01 00:00:00

abstract：:In a series of 153 children with T-cell malignancies enrolled in 2 consecutive European Organization for Research and Treatment of Cancer (EORTC) trials, we assessed the HOX11L2 expression and/or the presence of a t(5;14)(q35;q32). Additionally, in 138 of these patients, HOX11 expression and SIL-TAL rearrangement were...

journal_title：Blood

authors： Cavé H,Suciu S,Preudhomme C,Poppe B,Robert A,Uyttebroeck A,Malet M,Boutard P,Benoit Y,Mauvieux L,Lutz P,Méchinaud F,Grardel N,Mazingue F,Dupont M,Margueritte G,Pages MP,Bertrand Y,Plouvier E,Brunie G,Bastard C,P

更新日期：2004-01-15 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are multipotent progenitor cells that have emerged as a promising tool for clinical application. Further clinical interest has been raised by the observation that MSCs are immunoprivileged and, more important, display immunosuppressive capacities. These properties may be of therapeutic va...

journal_title：Blood

authors： Nauta AJ,Westerhuis G,Kruisselbrink AB,Lurvink EG,Willemze R,Fibbe WE

更新日期：2006-09-15 00:00:00

abstract：:Development of inhibitory antibodies is a serious complication of treatment with repeated factor IX infusions in a minority of patients with hemophilia B. Such antibodies detected in 8 patients have been characterized. Typing studies revealed that patients' immune response toward factor IX is highly heterogeneous and ...

journal_title：Blood

authors： Christophe OD,Lenting PJ,Cherel G,Boon-Spijker M,Lavergne JM,Boertjes R,Briquel ME,de Goede-Bolder A,Goudemand J,Gaillard S,d'Oiron R,Meyer D,Mertens K

更新日期：2001-09-01 00:00:00

abstract：:Several transgenic murine models for sickle cell anemia have been developed that closely reproduce the biochemical and physiological disorders in the human disease. A comprehensive characterization is described of hematologic parameters of mature red blood cells, reticulocytes, and red cell precursors in the bone marr...

journal_title：Blood

authors： de Jong K,Emerson RK,Butler J,Bastacky J,Mohandas N,Kuypers FA

更新日期：2001-09-01 00:00:00

abstract：:We have investigated the structure of the Ig heavy (IGH) chain locus in 309 cases of acute leukemia. Seventy-one cases of B-cell precursor (BCP) acute lymphoblastic leukemia (ALL) were analyzed: in six cases deletion of joining (JH) segments in the presence of cytogenetically normal chromosome 14 was observed. Similar...

journal_title：Blood

authors： Dyer MJ,Heward JM,Zani VJ,Buccheri V,Catovsky D

更新日期：1993-08-01 00:00:00

abstract：:Somatic mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) were recently demonstrated in acute myeloid leukemia (AML), but their prevalence and prognostic impact remain to be explored in large extensively characterized AML series, and also in various other hematologic malignancies. Here, we demonstrate in 8...

journal_title：Blood

authors： Abbas S,Lugthart S,Kavelaars FG,Schelen A,Koenders JE,Zeilemaker A,van Putten WJ,Rijneveld AW,Löwenberg B,Valk PJ

更新日期：2010-09-23 00:00:00

abstract：:In animal models, tissue stem cells were proposed to exhibit an unexpected level of plasticity, although issues on cell fusions have lead to some controversies. Only transplantation experiments using genetically distinct recipients and donors can unequivocally show these changes in cell fate. We have analyzed oral squ...

journal_title：Blood

authors： Janin A,Murata H,Leboeuf C,Cayuela JM,Gluckman E,Legrès L,Desveaux A,Varna M,Ratajczak P,Soulier J,de Thé H,Bertheau P,Socié G

更新日期：2009-02-19 00:00:00

abstract：:As the principal component of the membrane skeleton, spectrin confers integrity and flexibility to red cell membranes. Although this network involves many interactions, the most common hemolytic anemia mutations that disrupt erythrocyte morphology affect the spectrin tetramerization domains. Although much is known cli...

journal_title：Blood

authors： Ipsaro JJ,Harper SL,Messick TE,Marmorstein R,Mondragón A,Speicher DW

更新日期：2010-06-10 00:00:00

abstract：:The presence of a serum factor in chronic renal failure (CRF) which inhibits erythropoietin-stimulated erythropoiesis was studied, using a technique in which dog marrow cells were stimulated to produce heme in the presence of human serum. In the total series comparing 27 normal sera with 52 CRF sera, less heme was syn...

journal_title：Blood

authors： Wallner SF,Kurnick JE,Ward HP,Vautrin R,Alfrey AC

更新日期：1976-04-01 00:00:00

abstract：:Hypoxia-inducible factor-1α (HIF1α), a master transcriptional regulator of the cellular and systemic hypoxia response, is essential for the maintenance of self-renewal capacity of normal HSCs. It is still unknown whether HIF1α has a role in survival regulation of leukemia stem cells (LSCs) in chronic myeloid leukemia ...

journal_title：Blood

authors： Zhang H,Li H,Xi HS,Li S

更新日期：2012-03-15 00:00:00

abstract：:Plasmin exposure modulates platelet aggregation responses, but a direct effect of plasmin on the platelet fibrinogen receptor, glycoprotein IIb/IIIa (GPIIb/IIIa), has never been conclusively shown in a plasma milieu. To examine this issue, we incubated platelets in platelet-rich plasma with plasmin and measured the ef...

journal_title：Blood

authors： Pasche B,Ouimet H,Francis S,Loscalzo J

更新日期：1994-01-15 00:00:00

abstract：:Professional antigen-presenting cells (APCs) are sentinel cells of the immune system that present antigen to T lymphocytes and mediate an appropriate immune response. It is therefore surprising that knowledge of the professional APCs in human lymph nodes is limited. Using 3-color immunohistochemistry, we have identifi...

journal_title：Blood

authors： Angel CE,Chen CJ,Horlacher OC,Winkler S,John T,Browning J,MacGregor D,Cebon J,Dunbar PR

更新日期：2009-02-05 00:00:00

abstract：:We investigated whether the stem cell that reconstitutes total erythropoiesis of a WBB6F1-W/Wv mouse differentiates into lymphoid lineage. The electrophoretic pattern of hemoglobin was used as a marker of the reconstitution; 3-phosphoglycerate kinase (PGK), an X chromosome-linked enzyme was used as a tool for estimati...

journal_title：Blood

authors： Nakano T,Waki N,Asai H,Kitamura Y

更新日期：1989-04-01 00:00:00

abstract：:Whereas the final differentiation of conventional dendritic cells (CDCs) from committed precursors occurs locally in secondary lymphoid or peripheral tissues, plasmacytoid dendritic cells (PDCs) are thought to fully develop in the bone marrow from common DC progenitors before migrating to the periphery. In our study, ...

journal_title：Blood

authors： Schlitzer A,Loschko J,Mair K,Vogelmann R,Henkel L,Einwächter H,Schiemann M,Niess JH,Reindl W,Krug A

更新日期：2011-06-16 00:00:00

abstract：:Myelodysplastic and leukemic stem cell clones that evolve in children and adults with Fanconi anemia universally bear complex cytogenetic abnormalities. The abnormalities are generally recurring deletions or chromosomal loss and involve precisely the same chromosomes with the same frequency as has been described in ma...

journal_title：Blood

authors： Lensch MW,Tischkowitz M,Christianson TA,Reifsteck CA,Speckhart SA,Jakobs PM,O'Dwyer ME,Olson SB,Le Beau MM,Hodgson SV,Mathew CG,Larson RA,Bagby GC Jr

更新日期：2003-07-01 00:00:00

abstract：:Platelets from patients with Montreal platelet syndrome (MPS) consistently display a defect in the mechanisms that regulate platelet size during shape change and undergo spontaneous aggregation and stir-induced microaggregate formation. We now provide data that the surface glycoprotein composition of MPS platelets is ...

journal_title：Blood

authors： Okita JR,Frojmovic MM,Kristopeit S,Wong T,Kunicki TJ

更新日期：1989-08-01 00:00:00

abstract：:Fanconi anemia (FA) is the most frequent inherited cause of bone marrow failure (BMF). Most FA patients experience hematopoietic stem cell attrition and cytopenia during childhood, which along with intrinsic chromosomal instability, favor clonal evolution and the frequent emergence in their teens or young adulthood of...

journal_title：Blood

authors： Peffault de Latour R,Soulier J

更新日期：2016-06-16 00:00:00

abstract：:The prognostic significance of c-kit receptor expression on leukemic blast cells was determined in 122 children with acute myeloid leukemia (AML) entered onto Childrens Cancer Group protocol 213. Clinical and laboratory characteristics as well as outcome were analyzed according to the percentage of blast cells express...

journal_title：Blood

authors： Smith FO,Broudy VC,Zsebo KM,Lampkin BC,Buckley CV,Buckley JD,Opie T,Woods WG,Hammond GD,Bernstein ID

更新日期：1994-08-01 00:00:00

abstract：:The detection of a monoclonal immunoglobulin in serum or urine usually raises concerns about the size of the underlying B-cell-derived clone and possible systemic effects caused by its expansion. However, a small clone can synthesize a very toxic protein, producing devastating systemic damage and protean clinical pres...

journal_title：Blood

authors： Merlini G,Stone MJ

更新日期：2006-10-15 00:00:00

abstract：:Thrombohemorrhagic complications are a major cause of morbidity and mortality in patients with essential thrombocythemia (ET) and polycythemia vera (PV). The pathogenesis of these complications is not completely clarified. Several studies have described abnormalities of red blood cells and platelets in these patients....

journal_title：Blood

authors： Falanga A,Marchetti M,Evangelista V,Vignoli A,Licini M,Balicco M,Manarini S,Finazzi G,Cerletti C,Barbui T

更新日期：2000-12-15 00:00:00

abstract：:Anaplastic large cell lymphoma (ALCL) is a highly proliferative neoplasm that frequently carries the t(2;5)(p23;q35) and aberrantly expresses nucleophosmin-anaplastic lymphoma kinase (NPM-ALK). Previously, NPM-ALK had been shown to activate the phosphatidylinositol 3 kinase (PI3K)/Akt pathway. As the cyclin-dependent ...

journal_title：Blood

authors： Rassidakis GZ,Feretzaki M,Atwell C,Grammatikakis I,Lin Q,Lai R,Claret FX,Medeiros LJ,Amin HM

更新日期：2005-01-15 00:00:00

abstract：:Chromosomal translocations involving band 3q27 are the recently described nonrandom cytogenetic abnormalities in B-cell malignancies. We have previously cloned the breakpoint region of 3q27, designated as the BCL5 locus, from the B-cell line carrying the t(3;22). The cDNA for the BCL5 gene was cloned from the human li...

journal_title：Blood

authors： Miki T,Kawamata N,Hirosawa S,Aoki N

更新日期：1994-01-01 00:00:00