Abstract:
:De novo presentation of acute myeloid leukemia (AML) expressing the Philadelphia (Ph) chromosomal abnormality is rare and is associated with a dismal prognosis. To date, reported cases of Ph(+) AML have expressed either the e13a2 or e14a2 BCR-ABL fusion transcripts. We report a unique case of de novo AML expressing the e6a2 fusion transcript and describe disease sensitivity to both imatinib before allogeneic stem-cell transplantation and dasatinib for AML relapse after allogeneic stem-cell transplantation. Furthermore, we report that sustained molecular remission has been achieved despite withdrawal of tyrosine kinase inhibitor (TKI) therapy.
journal_name
Bloodjournal_title
Bloodauthors
Ritchie DS,McBean M,Westerman DA,Kovalenko S,Seymour JF,Dobrovic Adoi
10.1182/blood-2007-08-107508subject
Has Abstractpub_date
2008-03-01 00:00:00pages
2896-8issue
5eissn
0006-4971issn
1528-0020pii
blood-2007-08-107508journal_volume
111pub_type
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