Abstract:
:Clinical trials have been started with the aim of inducing tumor immunity by blocking the immunosuppressive action of indoleamine-2,3-dioxygenase (IDO) with the IDO2-inhibitor dextro-1-methyl-tryptophan (D-1MT). Here we show that human dendritic cells (DCs) express both IDO-1 and IDO-2, but that only IDO1 mediates tryptophan catabolism; furthermore, its activity is blocked by levo-1MT, whereas D-1MT is inefficient. Consequently, in humans any possible antitumor effects of D-1MT cannot be attributed to abrogation of IDO activity in DCs as described in this study.
journal_name
Bloodjournal_title
Bloodauthors
Lob S,Konigsrainer A,Schafer R,Rammensee HG,Opelz G,Terness Pdoi
10.1182/blood-2007-10-116111subject
Has Abstractpub_date
2008-02-15 00:00:00pages
2152-4issue
4eissn
0006-4971issn
1528-0020pii
blood-2007-10-116111journal_volume
111pub_type
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