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Imatinib mesylate therapy in newly diagnosed patients with Philadelphia chromosome-positive chronic myelogenous leukemia: high incidence of early complete and major cytogenetic responses.

Abstract：

:Fifty patients with Philadelphia chromosome-positive (Ph(+)) chronic myelogenous leukemia (CML) in early chronic phase received imatinib mesylate, 400 mg orally daily. After a median follow-up of 9 months, 49 patients (98%) achieved a complete hematologic response and 45 patients (90%) achieved a major cytogenetic response, complete in 36 patients (72%). Compared with similar patients who received interferon-alpha with or without hydroxyurea or other interferon-alpha combination regimens, those receiving imatinib mesylate had higher incidences of complete and major (Ph < 35%) cytogenetic responses at 3 months (34% and 74% versus 1%-4% and 9%-24%, respectively), 6 months (52% and 80% versus 3%-7% and 11%-28%, respectively), and 9 months (60% and 77% versus 5%-11% and 14%-30%, respectively; P <.001). Competitive quantitative polymerase chain reaction (QPCR) studies at 9 months showed a median QPCR value (ratio of BCR-ABL/ABL transcripts x 100) of 0.59% overall and of 0.24% (range, 0.001%-29.5%) for complete cytogenetic response.

journal_name

Blood

journal_title

Blood

authors

Kantarjian HM,Cortes JE,O'Brien S,Giles F,Garcia-Manero G,Faderl S,Thomas D,Jeha S,Rios MB,Letvak L,Bochinski K,Arlinghaus R,Talpaz M

doi

10.1182/blood-2002-02-0545

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

97-100

issue

1

eissn

0006-4971

issn

1528-0020

pii

2002-02-0545

journal_volume

101

pub_type

临床试验,杂志文章

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