CD3/CD28-costimulated T1 and T2 subsets: differential in vivo allosensitization generates distinct GVT and GVHD effects.

abstract：:The Strecker degradation reaction was evaluated as a means of modifying hemoglobin in vitro, utilizing ninhydrin as a model compound. Ninhydrin led to modification of hemoglobin (when incubated with hemoglobin or red cells) at physiologic temperature and pH. Isoelectric focusing documented the formation of new hemoglo...

journal_title：Blood

authors： Kokkini G,Stevens VJ,Peterson CM,Cerami A

更新日期：1980-10-01 00:00:00

abstract：:In common variable immunodeficiency (CVID) defects in early stages of B-cell development, bone marrow (BM) plasma cells and T lymphocytes have not been studied systematically. Here we report the first morphologic and flow cytometric study of B- and T-cell populations in CVID BM biopsies and aspirates. Whereas the hema...

journal_title：Blood

authors： Ochtrop ML,Goldacker S,May AM,Rizzi M,Draeger R,Hauschke D,Stehfest C,Warnatz K,Goebel H,Technau-Ihling K,Werner M,Salzer U,Eibel H,Schlesier M,Peter HH

更新日期：2011-07-14 00:00:00

abstract：:In this issue of Blood, Khorana and colleagues report a simple and practical model for the prediction of symptomatic venous thrombosis after the initiation of chemotherapy in cancer outpatients. ...

journal_title：Blood

authors： Doggen CJ

更新日期：2008-05-15 00:00:00

abstract：:Proteolytic events at the cell surface are essential in the regulation of signal transduction pathways. During the past years, the family of type II transmembrane serine proteases (TTSPs) has acquired an increasing relevance because of their privileged localization at the cell surface, although our current understandi...

journal_title：Blood

authors： Folgueras AR,de Lara FM,Pendás AM,Garabaya C,Rodríguez F,Astudillo A,Bernal T,Cabanillas R,López-Otín C,Velasco G

更新日期：2008-09-15 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are widespread in adult organisms and may be involved in tissue maintenance and repair as well as in the regulation of hematopoiesis and immunologic responses. Thus, it is important to discover the factors controlling MSC renewal and differentiation. Here we report that adult MSCs express...

journal_title：Blood

authors： Pevsner-Fischer M,Morad V,Cohen-Sfady M,Rousso-Noori L,Zanin-Zhorov A,Cohen S,Cohen IR,Zipori D

更新日期：2007-02-15 00:00:00

abstract：:Reconstitution of cellular immunity by 3 months after hematopoietic stem cell transplantation (HSCT) is a critical determinant of the long-term success of the transplantation. We analyzed the factors affecting recovery of cytomegalovirus (CMV)-specific CD4+ and CD8+ function at 3 months after HSCT by univariate and mu...

journal_title：Blood

authors： Hakki M,Riddell SR,Storek J,Carter RA,Stevens-Ayers T,Sudour P,White K,Corey L,Boeckh M

更新日期：2003-10-15 00:00:00

abstract：:A study of the Bernard-Soulier syndrome in two unrelated families using different polyclonal antibodies in a sensitive immunoblot assay showed residual amounts of platelet membrane glycoprotein (GP) lb in the eight homozygotes, as well as the near-absence of GPlb beta and GPIX. The eight heterozygotes studied showed a...

journal_title：Blood

authors： Drouin J,McGregor JL,Parmentier S,Izaguirre CA,Clemetson KJ

更新日期：1988-09-01 00:00:00

abstract：:The initiation and progression of diffuse large B-cell lymphoma (DLBCL) is governed by genetic and epigenetic aberrations. As the most abundant eukaryotic message RNA modification, N6-methyladenosine (m6A) is known to influence various fundamental bioprocesses by regulating target gene; however, the function of m6A mo...

journal_title：Blood

authors： Han H,Fan G,Song S,Jiang Y,Qian C,Zhang W,Su Q,Xue X,Zhuang W,Li B

更新日期：2020-09-23 00:00:00

abstract：:Omenn syndrome (OS) is a severe immunodeficiency associated with erythroderma, lymphoproliferation, elevated IgE, and hyperactive oligoclonal T cells. A restricted T-cell repertoire caused by defective thymic T-cell development and selection, lymphopenia with homeostatic proliferation, and lack of regulatory T cells a...

journal_title：Blood

authors： Fuchs S,Rensing-Ehl A,Pannicke U,Lorenz MR,Fisch P,Jeelall Y,Rohr J,Speckmann C,Vraetz T,Farmand S,Schmitt-Graeff A,Krüger M,Strahm B,Henneke P,Enders A,Horikawa K,Goodnow C,Schwarz K,Ehl S

更新日期：2015-10-01 00:00:00

abstract：:Cyclic adenosine monophosphate (cAMP) is an important modulator of platelet responses to agonists. Cyclic nucleotide phosphodiesterase (PDE) controls intracellular cAMP concentrations by hydrolyzing it to AMP. The major PDE activity in platelets is PDE3A (cyclic guanosine monophosphate [cGMP]-inhibited PDE). To obtain...

journal_title：Blood

authors： Cheung PP,Xu H,McLaughlin MM,Ghazaleh FA,Livi GP,Colman RW

更新日期：1996-08-15 00:00:00

abstract：:Adhesive interactions between circulating sickle red blood cells (RBCs), leukocytes, and endothelial cells are major pathophysiologic events in sickle cell disease (SCD). To develop new therapeutics that efficiently inhibit adhesive interactions, we generated an anti-P-selectin aptamer and examined its effects on cell...

journal_title：Blood

authors： Gutsaeva DR,Parkerson JB,Yerigenahally SD,Kurz JC,Schaub RG,Ikuta T,Head CA

更新日期：2011-01-13 00:00:00

abstract：:Two families of Epstein-Barr virus (EBV), type A and type B, have been defined on the basis of sequence divergence in the EBNA-2 gene. Type A EBV immortalizes B cells more efficiently in vitro and infects immunocompetent individuals more commonly than type B EBV. However, increased rates of infection by type B EBV are...

journal_title：Blood

authors： Frank D,Cesarman E,Liu YF,Michler RE,Knowles DM

更新日期：1995-03-01 00:00:00

abstract：:We have previously demonstrated that young adult DBA/2 (DBA) mice have more stem cells than C57BL/6 (B6) mice, as measured in a cobblestone area-forming cell (CAFC) assay using unfractionated marrow. To study the nature of this difference, we have now compared the proliferative fate of single, highly enriched Sca-1(+)...

journal_title：Blood

authors： de Haan G,Szilvassy SJ,Meyerrose TE,Dontje B,Grimes B,Van Zant G

更新日期：2000-08-15 00:00:00

abstract：:Erythroid progenitor cells isolated from patients with polycythemia vera (PV) proliferate and differentiate in methylcellulose in the absence of exogenous erythropoietin (EPO). To investigate the potential role of the erythropoietin receptor (EPO-R) in the pathogenesis of PV, we cultured bone marrow-derived or periphe...

journal_title：Blood

authors： Fisher MJ,Prchal JF,Prchal JT,D'Andrea AD

更新日期：1994-09-15 00:00:00

abstract：:Lymphocytes bound at endothelial cell junctions extravasate within minutes. Lymphocyte-endothelial cell binding is mediated by receptors such as vascular cell adhesion molecule 1 (VCAM-1). VCAM-1 activates endothelial cell nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in minutes, and this activity is req...

journal_title：Blood

authors： Deem TL,Cook-Mills JM

更新日期：2004-10-15 00:00:00

abstract：:Human alpha2-antiplasmin (alpha2AP), also known as alpha2-plasmin inhibitor, is the major inhibitor of the proteolytic enzyme plasmin that digests fibrin. There are 2 N-terminal forms of alpha2AP that circulate in human plasma: a 464-residue protein with Met as the N-terminus, Met-alpha2AP, and a 452-residue version w...

journal_title：Blood

authors： Lee KN,Jackson KW,Christiansen VJ,Chung KH,McKee PA

更新日期：2004-05-15 00:00:00

abstract：:We have previously shown that G-CSF-deficient (G-CSF(-/-)) mice are markedly protected from collagen-induced arthritis (CIA), which is the major murine model of rheumatoid arthritis, and now investigate the mechanisms by which G-CSF can promote inflammatory disease. Serum G-CSF levels were significantly elevated durin...

journal_title：Blood

authors： Eyles JL,Hickey MJ,Norman MU,Croker BA,Roberts AW,Drake SF,James WG,Metcalf D,Campbell IK,Wicks IP

更新日期：2008-12-15 00:00:00

abstract：:We have investigated the clonality of Ph1-negative hemopoietic progenitor cells appearing in long-term marrow cultures established with cells from a mosaic Turner syndrome patient (46,XX/45,X) with Ph1-positive chronic myeloid leukemia (CML). The Ph1-positive clone had been shown previously to have arisen from a cell ...

journal_title：Blood

authors： Dubé ID,Arlin ZA,Kalousek DK,Eaves CJ,Eaves AC

更新日期：1984-12-01 00:00:00

abstract：:Expression of the von Willebrand factor (vWF) gene is restricted to the endothelial and megakaryocyte lineages. Within the endothelium, expression of vWF varies between different vascular beds. We have previously shown that the human vWF promoter spanning a region between -2182 (relative to the start site of transcrip...

journal_title：Blood

authors： Guan J,Guillot PV,Aird WC

更新日期：1999-11-15 00:00:00

abstract：:A longstanding endeavor to define the genetic lesions that drive myeloid malignances has stimulated a period of remarkable discovery. Enabled by technological advances that have sharply decreased the cost of DNA sequencing, the full compendium of common, recurrent somatic mutations in the coding genome of myeloid mali...

journal_title：Blood

authors： Lindsley RC,Ebert BL

更新日期：2013-11-28 00:00:00

abstract：:Human monocytes generate the procoagulant tissue factor (MTF) following exposure to a variety of immune stimuli in vitro. The generation of MTF is modified by T cells, lymphokines, and immunoregulatory lipoproteins, and recent studies have shown that MTF can be activated in an immune-specific manner following exposure...

journal_title：Blood

authors： Edwards RL,Perla D

更新日期：1984-09-01 00:00:00

abstract：:Efficient clearance of apoptotic cells seems to be a prerequisite to prevent the development of autoimmunity. Here we identify that macrophage colony-stimulating factor (M-CSF)-driven macrophages (Mø2s) are potent phagocytes that have the unique capacity to preferentially bind and ingest early apoptotic cells. This ma...

journal_title：Blood

authors： Xu W,Roos A,Schlagwein N,Woltman AM,Daha MR,van Kooten C

更新日期：2006-06-15 00:00:00

abstract：:Thrombophilia screening is controversial. In a retrospective family cohort, where probands had thrombosis and a thrombophilic defect, 2479 relatives were tested for thrombophilia. In antithrombin-, protein C-, and protein S-deficient relatives, annual incidences of venous thrombosis were 1.77% (95% CI, 1.14-2.60), 1.5...

journal_title：Blood

authors： Lijfering WM,Brouwer JL,Veeger NJ,Bank I,Coppens M,Middeldorp S,Hamulyák K,Prins MH,Büller HR,van der Meer J

更新日期：2009-05-21 00:00:00

abstract：:Between February 1996 and December 2004, the German Leukemia Study Initiative registered 1766 consecutive patients for the acute myeloid leukemia (AML) 96 study, all of whom were diagnosed by central cytomorphology according to the French-American-British (FAB) and the new World Health Organization (WHO) classificatio...

journal_title：Blood

authors： Wandt H,Schäkel U,Kroschinsky F,Prange-Krex G,Mohr B,Thiede C,Pascheberg U,Soucek S,Schaich M,Ehninger G

更新日期：2008-02-15 00:00:00

abstract：:Platelets contain and release several matrix metalloproteinases (MMPs). Among these, active MMP-2 enhances platelet aggregation by favoring the activation of phosphatidylinositol 3- kinase (PI3K) and contributes to arterial thrombosis. The platelet surface target of MMP-2 and the mechanism through which it primes plat...

journal_title：Blood

authors： Sebastiano M,Momi S,Falcinelli E,Bury L,Hoylaerts MF,Gresele P

更新日期：2017-02-16 00:00:00

abstract：:Natural killer T (NKT) cells are innate-like T cells that recognize specific microbial antigens and also display autoreactivity to self-antigens. The nature of NKT-cell autoreactive activation remains poorly understood. We show here that the mitogen-activated protein kinase (MAPK) pathway is operative during human NKT...

journal_title：Blood

authors： Wang X,Chen X,Rodenkirch L,Simonson W,Wernimont S,Ndonye RM,Veerapen N,Gibson D,Howell AR,Besra GS,Painter GF,Huttenlocher A,Gumperz JE

更新日期：2008-11-15 00:00:00

abstract：:Despite multiple disparate prognostic risk analysis systems for evaluating clinical outcome for patients with myelodysplastic syndrome (MDS), imprecision persists with such analyses. To attempt to improve on these systems, an International MDS Risk Analysis Workshop combined cytogenetic, morphological, and clinical da...

journal_title：Blood

authors： Greenberg P,Cox C,LeBeau MM,Fenaux P,Morel P,Sanz G,Sanz M,Vallespi T,Hamblin T,Oscier D,Ohyashiki K,Toyama K,Aul C,Mufti G,Bennett J

更新日期：1997-03-15 00:00:00

abstract：:The effect of HbA and HbF on both the aggregation and deaggregation of deoxy HbS and deoxy HbCHarlem in concentrated phosphate buffers was studied by a turbidimetric method. Although pure deoxy HbA is fully soluble in 2.4 M potassium phosphate buffer, the same concentration of deoxy HbAS was insoluble in the same buff...

journal_title：Blood

authors： Adachi K,Asakura T,Schwartz E

更新日期：1980-03-01 00:00:00

abstract：:Platelets are vital for hemostasis because they release their granule contents in response to vascular damage. Platelet exocytosis is mediated by soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs), whose interactions are governed by regulators, eg, Sec/Munc18 proteins. These proteins chape...

journal_title：Blood

authors： Al Hawas R,Ren Q,Ye S,Karim ZA,Filipovich AH,Whiteheart SW

更新日期：2012-09-20 00:00:00

abstract：:Human neutrophils possess a very short half-life because they constitutively undergo apoptosis. Cytokines, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), and other agents can rescue neutrophils from apoptosis but the molecular mechanisms involved in this rescue are undefined. Here, we show by Weste...

journal_title：Blood

authors： Moulding DA,Quayle JA,Hart CA,Edwards SW

更新日期：1998-10-01 00:00:00