Abstract:
:A longstanding endeavor to define the genetic lesions that drive myeloid malignances has stimulated a period of remarkable discovery. Enabled by technological advances that have sharply decreased the cost of DNA sequencing, the full compendium of common, recurrent somatic mutations in the coding genome of myeloid malignancies is nearly complete. As the focus of genetic discovery shifts to the noncoding genome, renewed attention is being applied to the clinical and biological implications of recent genomic advances. Although the potential for this newfound knowledge to influence the care of patients has not yet been realized, broad genetic surveys of patient samples are now being used to improve the accuracy of disease diagnosis, define a molecular taxonomy of myeloid malignancies, refine prognostic and predictive models, and identify novel therapeutic strategies. Here, we will review recent advances in the genetics of myeloid malignancies and discuss their potential impact on clinical practice.
journal_name
Bloodjournal_title
Bloodauthors
Lindsley RC,Ebert BLdoi
10.1182/blood-2013-06-460295subject
Has Abstractpub_date
2013-11-28 00:00:00pages
3741-8issue
23eissn
0006-4971issn
1528-0020pii
blood-2013-06-460295journal_volume
122pub_type
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