B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406.

abstract：:Immunoglobulin class switching from IgM to IgG in response to peptides is generally T cell-dependent and vaccination in T cell-deficient individuals is inefficient. We show that a vaccine consisting of a dense array of peptides on liposomes induced peptide-specific IgG responses totally independent of T-cell help. Ind...

journal_title：Blood

authors： Pihlgren M,Silva AB,Madani R,Giriens V,Waeckerle-Men Y,Fettelschoss A,Hickman DT,López-Deber MP,Ndao DM,Vukicevic M,Buccarello AL,Gafner V,Chuard N,Reis P,Piorkowska K,Pfeifer A,Kündig TM,Muhs A,Johansen P

更新日期：2013-01-03 00:00:00

abstract：:In this issue of Blood, Kasirer-Friede and colleagues show that the adhesion and degranulation promoter protein (ADAP) promotes αIIbβ3 activation by presenting the cytoplasmic proteins talin and kindlin to the β3 cytoplasmic tail. ...

journal_title：Blood

authors： Bennett JS

更新日期：2014-05-15 00:00:00

abstract：:Primary graft rejection after marrow transplantation occurs more frequently in patients receiving HLA-haploidentical compared with HLA-identical sibling transplants. Both human and experimental animal data suggest that the cells responsible for this phenomenon are either host natural killer (NK) cells, T cells, or bot...

journal_title：Blood

authors： Sandmaier BM,Storb R,Bennett KL,Appelbaum FR,Santos EB

更新日期：1998-05-01 00:00:00

abstract：:We previously reported the inhibitory action of interleukin-6 (IL-6) on B lymphopoiesis with SHIP(-/-) mice and showed that IL-6 biases lineage commitment toward myeloid cell fates in vitro and in vivo. Because elevated IL-6 is a feature of chronic inflammatory diseases, we applied an animal model of systemic lupus er...

journal_title：Blood

authors： Maeda K,Malykhin A,Teague-Weber BN,Sun XH,Farris AD,Coggeshall KM

更新日期：2009-05-07 00:00:00

abstract：:Two distinct classes of granulocyte progenitor cells present in normal mouse bone marrow are expressed sequentially in the vivo plasma clot diffusion chamber culture system. By several criteria, progenitor cells giving rise to granulocyte colonies on day 4 of culture (CFU-D4) are different from those giving rise to co...

journal_title：Blood

authors： Steinberg HN,Page PL,Robinson SH

更新日期：1982-04-01 00:00:00

abstract：:Because interleukin-10 (IL-10) is a potent differentiation factor of human B cells into mature plasma cells, we investigated its effect on human malignant plasma cells. IL-10 did not induce any differentiation and increase in Ig synthesis in four human IL-6-dependent malignant plasma cell lines. However, it stimulated...

journal_title：Blood

authors： Lu ZY,Zhang XG,Rodriguez C,Wijdenes J,Gu ZJ,Morel-Fournier B,Harousseau JL,Bataille R,Rossi JF,Klein B

更新日期：1995-05-01 00:00:00

abstract：:CD8+ Foxp3+ T cells (Tregs) are a potent regulatory population whose functional and ontological similarities to CD4+ Fox3+ T cells have not been well delineated. Using an experimental model of graft-versus-host disease (GVHD), we observed that CD8+ Tregs were significantly less potent than CD4+ Tregs for the suppressi...

journal_title：Blood

authors： Agle K,Vincent BG,Piper C,Belle L,Zhou V,Shlomchik W,Serody JS,Drobyski WR

更新日期：2018-07-26 00:00:00

abstract：:Whereas the chimeric type I anti-CD20 Ab rituximab has improved outcomes for patients with B-cell malignancies significantly, many patients with non-Hodgkin lymphoma (NHL) remain incurable. Obinutuzumab (GA101) is a glycoengineered, humanized anti-CD20 type II Ab that has demonstrated superior activity against type I ...

journal_title：Blood

authors： Salles G,Morschhauser F,Lamy T,Milpied N,Thieblemont C,Tilly H,Bieska G,Asikanius E,Carlile D,Birkett J,Pisa P,Cartron G

更新日期：2012-05-31 00:00:00

abstract：:The presence of circulating tumor idiotype interferes with the in vivo effectiveness of anti-idiotype antibodies. We developed two assays that permit identification of patients with high levels of serum idiotype without the need for first producing an anti-idiotype antibody. A cell suspension made from the tumor was c...

journal_title：Blood

authors： Miller RA,Lowder JN,Gralow J,Meeker T,Levy R

更新日期：1987-04-01 00:00:00

abstract：:We report here 7 new mutations in the ADAMTS13 gene responsible for Upshaw-Schulman syndrome (USS), a catastrophic phenotype of congenital thrombotic thrombocytopenic purpura, by analyzing 5 Japanese families. There were 3 mutations that occurred at exon-intron boundaries: 414+1G>A at intron 4, 686+1G>A at intron 6, a...

journal_title：Blood

authors： Matsumoto M,Kokame K,Soejima K,Miura M,Hayashi S,Fujii Y,Iwai A,Ito E,Tsuji Y,Takeda-Shitaka M,Iwadate M,Umeyama H,Yagi H,Ishizashi H,Banno F,Nakagaki T,Miyata T,Fujimura Y

更新日期：2004-02-15 00:00:00

abstract：:This report discusses a case of T cell chronic lymphocytic leukemia (T-CLL) in an elderly white man whose lymphocytes expressed a post-thymic phenotype except for the coexpression of T4 and T8 on 80% to 95% of the cells. Because of the uncommon phenotype, in vitro functional assays were performed that showed decreased...

journal_title：Blood

authors： Simpkins H,Kiprov DD,Davis JL 3rd,Morand P,Puri S,Grahn EP

更新日期：1985-01-01 00:00:00

abstract：:Bleeding problems are associated with defects in platelet alpha-granules, yet little is known about how these granules are formed and released. Mutations affecting VPS33B, a novel Sec1/Munc18 protein, have recently been linked to arthrogryposis, renal dysfunction, and cholestasis (ARC) syndrome. We have characterized ...

journal_title：Blood

authors： Lo B,Li L,Gissen P,Christensen H,McKiernan PJ,Ye C,Abdelhaleem M,Hayes JA,Williams MD,Chitayat D,Kahr WH

更新日期：2005-12-15 00:00:00

abstract：:The role of thrombophilia testing in predicting catheter-related deep vein thrombosis (DVT) after an incident (ie, first) catheter-related DVT in children remains unclear. The present study investigated the association between thrombophilia and recurrent catheter-related DVT. Children with thrombophilia testing, perfo...

journal_title：Blood

authors： Avila ML,Amiri N,Stanojevic S,Vu TT,Barron K,Krol P,Yue N,Williams S,Brandão LR

更新日期：2018-06-14 00:00:00

abstract：:Natural killer (NK) cells have held great promise for the immunotherapy of cancer for more than 3 decades. However, to date only modest clinical success has been achieved manipulating the NK cell compartment in patients with malignant disease. Progress in the field of NK cell receptors has revolutionized our concept o...

journal_title：Blood

authors： Farag SS,Fehniger TA,Ruggeri L,Velardi A,Caligiuri MA

更新日期：2002-09-15 00:00:00

abstract：:Understanding leukemia heterogeneity is critical for the development of curative treatments as the failure to eliminate therapy-persistent leukemic stem cells (LSCs) may result in disease relapse. Here we have combined high-throughput immunophenotypic screens with large-scale single-cell gene expression analysis to de...

journal_title：Blood

authors： Warfvinge R,Geironson L,Sommarin MNE,Lang S,Karlsson C,Roschupkina T,Stenke L,Stentoft J,Olsson-Strömberg U,Hjorth-Hansen H,Mustjoki S,Soneji S,Richter J,Karlsson G

更新日期：2017-04-27 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha), a cytokine possessing pleiotropic biological activities, is produced by leukemic lymphocytes in patients with chronic lymphocytic leukemia (CLL) and acts as an autocrine and paracrine growth factor in this disease. In this study, TNF-alpha levels were determined in 150 patients...

journal_title：Blood

authors： Ferrajoli A,Keating MJ,Manshouri T,Giles FJ,Dey A,Estrov Z,Koller CA,Kurzrock R,Thomas DA,Faderl S,Lerner S,O'Brien S,Albitar M

更新日期：2002-08-15 00:00:00

abstract：:Trial ALL-BFM 90 was designed to improve outcome in patients with childhood acute lymphoblastic leukemia (ALL) by using a reduced treatment regimen. Patients were stratified into a standard-risk group (SRG), a medium-risk group (MRG), both defined by adequate early treatment response; and a high-risk group (HRG), defi...

journal_title：Blood

authors： Schrappe M,Reiter A,Ludwig WD,Harbott J,Zimmermann M,Hiddemann W,Niemeyer C,Henze G,Feldges A,Zintl F,Kornhuber B,Ritter J,Welte K,Gadner H,Riehm H

更新日期：2000-06-01 00:00:00

abstract：:It has now been 3 years since the von Willebrand factor (VWF)-cleaving protease implicated in thrombocytopenic purpura (TTP) pathogenesis was identified as ADAMTS13 (a disintegrin-like and metalloprotease with thrombospondin type 1 motif 13). More than 50 ADAMTS13 mutations resulting in familial TTP have been reported...

journal_title：Blood

authors： Levy GG,Motto DG,Ginsburg D

更新日期：2005-07-01 00:00:00

abstract：:It has recently been shown that the Naka antigen, which is absent in 3% to 11% of Japanese blood donors, is expressed on platelet glycoprotein IV (GPIV; CD36) (Tomiyama et al, BLOOD, 75:684, 1990). In the present studies, flow cytometry was used to distinguish differences in the reactivity of Naka+ and Naka- platelets...

journal_title：Blood

authors： Yamamoto N,Ikeda H,Tandon NN,Herman J,Tomiyama Y,Mitani T,Sekiguchi S,Lipsky R,Kralisz U,Jamieson GA

更新日期：1990-11-01 00:00:00

abstract：:Hydroxyurea, interferon, and HLA-identical sibling bone marrow transplantation are common therapies for chronic myelogenous leukemia (CML) in chronic phase. Which is best is controversial. The purpose of this study was to compare survival of patients with CML receiving HLA-identical sibling transplants versus hydroxyu...

journal_title：Blood

authors： Gale RP,Hehlmann R,Zhang MJ,Hasford J,Goldman JM,Heimpel H,Hochhaus A,Klein JP,Kolb HJ,McGlave PB,Passweg JR,Rowlings PA,Sobocinski KA,Horowitz MM

更新日期：1998-03-01 00:00:00

abstract：:Chemokines as well as the signaling through the adhesion molecules intercellular adhesion molecule (ICAM)-3 and CD43 are able to induce in T lymphocytes their switching from a spherical to a polarized motile morphology, with the formation of a uropod at the rear of the cell. We investigated here the role of CD43 in th...

journal_title：Blood

authors： Serrador JM,Nieto M,Alonso-Lebrero JL,del Pozo MA,Calvo J,Furthmayr H,Schwartz-Albiez R,Lozano F,González-Amaro R,Sánchez-Mateos P,Sánchez-Madrid F

更新日期：1998-06-15 00:00:00

abstract：:The tetraspanin family member CD151 forms complexes with integrins and regulates cell adhesion and migration. While CD151 is highly expressed in megakaryocytes and to a lesser extent in platelets, its physiologic role in platelets is unclear. In this study, we investigate the physical and functional importance of CD15...

journal_title：Blood

authors： Lau LM,Wee JL,Wright MD,Moseley GW,Hogarth PM,Ashman LK,Jackson DE

更新日期：2004-10-15 00:00:00

abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor that stimulates the proliferation, maturation, and functional activity of myeloid cells in peripheral blood and bone marrow. Expression of GM-CSF is tightly regulated and is limited to cells stimulated directly (T cells, macroph...

journal_title：Blood

authors： Fraser JK,Tran S,Nimer SD,Gasson JC

更新日期：1994-10-15 00:00:00

abstract：:A new type of A alpha Glu-11 to Gly substitution has been identified in a congenitally abnormal fibrinogen, fibrinogen Mitaka II, derived from a 14-year-old female suffering from easy bruising since childhood. Plasma of the patient and fibrinogen purified therefrom were found to clot slowly by thrombin but in a normal...

journal_title：Blood

authors： Niwa K,Yaginuma A,Nakanishi M,Wada Y,Sugo T,Asakura S,Watanabe N,Matsuda M

更新日期：1993-12-15 00:00:00

abstract：:We designed a phase 1-2 study to evaluate the safety and the efficacy of increasing doses of bendamustine (160 mg/m², 180 mg/m², and 200 mg/m² given on days -7 and -6) coupled with fixed doses of etoposide, cytarabine, and melphalan (BeEAM regimen) as the conditioning regimen to autologous stem cell transplantation fo...

journal_title：Blood

authors： Visani G,Malerba L,Stefani PM,Capria S,Galieni P,Gaudio F,Specchia G,Meloni G,Gherlinzoni F,Giardini C,Falcioni S,Cuberli F,Gobbi M,Sarina B,Santoro A,Ferrara F,Rocchi M,Ocio EM,Caballero MD,Isidori A

更新日期：2011-09-22 00:00:00

abstract：:Evidence has been provided recently that shows that high concentrations of cytokines can fulfill functions previously attributed to stromal cells, such as promote the survival of, and led to a net increase in human primitive progenitors initiating long-term cultures in vitro (LTC-IC) or engrafting NOD-SCID (nonobese d...

journal_title：Blood

authors： Bennaceur-Griscelli A,Tourino C,Izac B,Vainchenker W,Coulombel L

更新日期：1999-07-15 00:00:00

abstract：:One of the most serious complications of successful treatments for Hodgkin's disease is an increased incidence of acute nonlymphocytic leukemia (ANLL) and other malignancies. A retrospective analysis carried out on 1032 consecutive patients with Hodgkin's disease admitted to our Institute between 1965 and 1978 and tre...

journal_title：Blood

authors： Valagussa P,Santoro A,Fossati Bellani F,Franchi F,Banfi A,Bonadonna G

更新日期：1982-03-01 00:00:00

abstract：:Stat5 proteins are critical signaling molecules activated by many cytokines. Within the immune system, Stat5 plays important roles related to the development of thymocytes and proliferation of T cells. Stat5 has been implicated in malignant transformation, and moreover, the activated tyrosine phosphorylated form of St...

journal_title：Blood

authors： Bessette K,Lang ML,Fava RA,Grundy M,Heinen J,Horne L,Spolski R,Al-Shami A,Morse HC 3rd,Leonard WJ,Kelly JA

更新日期：2008-01-01 00:00:00

abstract：:Derivative chromosome 9 deletions are seen in 10% to 15% of patients with chronic myelogenous leukemia and have been associated with a poor prognosis; however, no studies have been performed in the context of a randomized clinical trial. We developed a DNA-based deletion screen and investigated 339 chronic phase patie...

journal_title：Blood

authors： Kreil S,Pfirrmann M,Haferlach C,Waghorn K,Chase A,Hehlmann R,Reiter A,Hochhaus A,Cross NC,German Chronic Myelogenous Leukemia (CML) Study Group.

更新日期：2007-08-15 00:00:00

abstract：:We here investigate the occurrence of fluoride intake-associated alterations in patients with hematologic disease on triazol antifungal medication. Clinical, laboratory, and radiology data of overall 43 patients with hematologic malignancies taking voriconazole (n = 20), posaconazole (n = 8), and itraconazole (n = 4),...

journal_title：Blood

authors： Gerber B,Guggenberger R,Fasler D,Nair G,Manz MG,Stussi G,Schanz U

更新日期：2012-09-20 00:00:00