Heterogeneous prognostic impact of derivative chromosome 9 deletions in chronic myelogenous leukemia.

abstract：:Subclones homozygous for JAK2V617F are more common in polycythemia vera (PV) than essential thrombocythemia (ET), but their prevalence and significance remain unclear. The JAK2 mutation status of 6495 BFU-E, grown in low erythropoietin conditions, was determined in 77 patients with PV or ET. Homozygous-mutant colonies...

journal_title：Blood

authors： Godfrey AL,Chen E,Pagano F,Ortmann CA,Silber Y,Bellosillo B,Guglielmelli P,Harrison CN,Reilly JT,Stegelmann F,Bijou F,Lippert E,McMullin MF,Boiron JM,Döhner K,Vannucchi AM,Besses C,Campbell PJ,Green AR

更新日期：2012-09-27 00:00:00

abstract：:Human neutrophils possess a very short half-life because they constitutively undergo apoptosis. Cytokines, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), and other agents can rescue neutrophils from apoptosis but the molecular mechanisms involved in this rescue are undefined. Here, we show by Weste...

journal_title：Blood

authors： Moulding DA,Quayle JA,Hart CA,Edwards SW

更新日期：1998-10-01 00:00:00

abstract：:The extent and rapidity with which T cells are regenerated from graft-derived precursor cells directly influences the incidence of infection and the T-cell-based graft-versus-tumor effect. Measurement of T-cell receptor excision circles (TRECs) in peripheral blood is a means of quantifying recent thymic T-cell product...

journal_title：Blood

authors： Chen X,Barfield R,Benaim E,Leung W,Knowles J,Lawrence D,Otto M,Shurtleff SA,Neale GA,Behm FG,Turner V,Handgretinger R

更新日期：2005-01-15 00:00:00

abstract：:Current dosing algorithms do not account for genetic and environmental factors for warfarin dose determinations. This study investigated the contribution of age, CYP2C9 and VKORC1 genotype, and body size to warfarin-dose requirements. Studied were 297 patients with stable anticoagulation with a target international no...

journal_title：Blood

authors： Sconce EA,Khan TI,Wynne HA,Avery P,Monkhouse L,King BP,Wood P,Kesteven P,Daly AK,Kamali F

更新日期：2005-10-01 00:00:00

abstract：:The D816V mutation of c-kit has been detected in patients with mastocytosis. This mutation leads to constitutive tyrosine kinase activation of Kit. Because stem cell factor (SCF), the ligand for Kit (CD117(+)), is a chemoattractant for CD117(+) cells and one feature of mastocytosis is an abnormal collection of mast ce...

journal_title：Blood

authors： Taylor ML,Dastych J,Sehgal D,Sundstrom M,Nilsson G,Akin C,Mage RG,Metcalfe DD

更新日期：2001-08-15 00:00:00

abstract：:CD4(+), CD56(+) DC2 malignancies constitute a novel disease entity, which has recently been shown to arise from a transformed lymphoid-related plasmacytoid dendritic cell (DC2). Diagnosis is primarily based on a particular immunophenotype with tumor cells expressing CD4 and CD56 antigens in the absence of common lymph...

journal_title：Blood

authors： Leroux D,Mugneret F,Callanan M,Radford-Weiss I,Dastugue N,Feuillard J,Le Mée F,Plessis G,Talmant P,Gachard N,Uettwiller F,Pages MP,Mozziconacci MJ,Eclache V,Sibille C,Avet-Loiseau H,Lafage-Pochitaloff M

更新日期：2002-06-01 00:00:00

abstract：:beta and gamma T cell receptor (TCR) gene configuration was studied in 12 patients with large granular lymphocyte T cell leukemia (LGL-leukemia). Both genes were found rearranged in ten cases. In the remaining two patients TCR beta was found in germline configuration. In one of them rearrangement of T cell-rearranging...

journal_title：Blood

authors： Foroni L,Matutes E,Foldi J,Morilla R,Rabbitts T,Luzzatto L,Catovsky D

更新日期：1988-02-01 00:00:00

abstract：:Chromosomal translocations involving band 3q27 are the recently described nonrandom cytogenetic abnormalities in B-cell malignancies. We have previously cloned the breakpoint region of 3q27, designated as the BCL5 locus, from the B-cell line carrying the t(3;22). The cDNA for the BCL5 gene was cloned from the human li...

journal_title：Blood

authors： Miki T,Kawamata N,Hirosawa S,Aoki N

更新日期：1994-01-01 00:00:00

abstract：:A significant proportion of hemophilia A patients receiving transfusions of factor VIII (FVIII) develop a specific antibody response towards FVIII. These antibodies are usually detected by assays in which they inhibit the function of the molecule, such as the Bethesda clotting test. We have prepared anti-FVIII antibod...

journal_title：Blood

authors： Gilles JG,Arnout J,Vermylen J,Saint-Remy JM

更新日期：1993-10-15 00:00:00

abstract：:Human bone marrow (BM) cells contain low levels of the DNA repair protein, O6-alkylguanine-DNA alkyltransferase, which may explain their susceptibility to nitrosourea-induced cytotoxicity and the development of secondary leukemia after nitrosourea treatment. Isolated CD34+ myeloid progenitors were also found to have l...

journal_title：Blood

authors： Gerson SL,Phillips W,Kastan M,Dumenco LL,Donovan C

更新日期：1996-09-01 00:00:00

abstract：:The present study sought to determine the impact of the route of administration of an adeno-associated virus (AAV) vector encoding human factor IX (hFIX) on the induction of an immune response against the vector and its xenogenic transgene product, hFIX. Increasing doses of AAV-hFIX were administered by different rout...

journal_title：Blood

authors： Ge Y,Powell S,Van Roey M,McArthur JG

更新日期：2001-06-15 00:00:00

abstract：:We developed a risk score to predict event-free survival (EFS) after allogeneic hematopoietic cell transplantation for sickle cell disease. The study population (n = 1425) was randomly split into training (n = 1070) and validation (n = 355) cohorts. Risk factors were identified and validated via Cox regression models....

journal_title：Blood

authors： Brazauskas R,Scigliuolo GM,Wang HL,Cappelli B,Ruggeri A,Fitzhugh CD,Hankins JS,Kanter J,Meerpohl JJ,Panepinto JA,Rondelli D,Shenoy S,Walters MC,Wagner JE,Tisdale JF,Gluckman E,Eapen M

更新日期：2020-07-30 00:00:00

abstract：:Monocyte and macrophage Fc gamma receptors are important components in the recognition of IgG-coated cells and IgG-containing immune complexes. Two proteins have been identified on human peripheral blood monocytes that can function as Fc gamma receptors, Fc gamma RI (70 Kd) and Fc gamma RII (40 Kd). We studied the rol...

journal_title：Blood

authors： Gomez F,Chien P,King M,McDermott P,Levinson AI,Rossman MD,Schreiber AD

更新日期：1989-08-15 00:00:00

abstract：:The influence of interferon (IFN) on cellular proliferation, blast transformation, and differentiation was studied in lymph node cells from 17 patients with B-cell lymphomas, one patient with T-cell lymphoma, and eight patients with enlarged, non-malignant lymph nodes. The effects of IFN on lymph node cells were compa...

journal_title：Blood

authors： Ostlund L,Biberfeld P,Robèrt KH,Christensson B,Einhorn S

更新日期：1989-06-01 00:00:00

abstract：:Depressed cellular immune function and increased susceptibility to infection characterize familial erythrophagocytic lymphohistiocytosis (FEL), a usually fatal autosomal recessive disease. One component of the immunodeficiency is plasma-mediated inhibition of lymphocyte proliferation. We have tested whether repeated p...

journal_title：Blood

authors： Ladisch S,Ho W,Matheson D,Pilkington R,Hartman G

更新日期：1982-10-01 00:00:00

abstract：:To explore the use of stem/progenitor cells from peripheral blood (PB) for allogeneic transplantation, we have studied the mobilization of progenitor cells in normal donors by growth factors. Normal subjects were administered either granulocyte-macrophage colony-stimulating factor (GM-CSF) at 10 micrograms/kg/d, or G-...

journal_title：Blood

authors： Lane TA,Law P,Maruyama M,Young D,Burgess J,Mullen M,Mealiffe M,Terstappen LW,Hardwick A,Moubayed M

更新日期：1995-01-01 00:00:00

abstract：:We investigated the functions of adiponectin, an adipocyte-specific secretory protein and a new member of the family of soluble defense collagens, in hematopoiesis and immune responses. Adiponectin suppressed colony formation from colony-forming units (CFU)-granulocyte-macrophage, CFU-macrophage, and CFU-granulocyte, ...

journal_title：Blood

authors： Yokota T,Oritani K,Takahashi I,Ishikawa J,Matsuyama A,Ouchi N,Kihara S,Funahashi T,Tenner AJ,Tomiyama Y,Matsuzawa Y

更新日期：2000-09-01 00:00:00

abstract：:Recent studies of retroviral-mediated gene transfer have shown that retroviral integrations themselves may trigger nonmalignant clonal expansion of hematopoietic stem cells (HSCs) in transplant recipients. These observations suggested that previous conclusions of HSC dynamics based on gamma-retroviral gene marking sho...

journal_title：Blood

authors： Gonzalez-Murillo A,Lozano ML,Montini E,Bueren JA,Guenechea G

更新日期：2008-10-15 00:00:00

abstract：:Chromosome 11q deletions are frequently observed in chronic lymphocytic leukemia (CLL) in association with progressive disease and a poor prognosis. A minimal region of deletion has been assigned to 11q22-q23. Trinucleotide repeats have been associated with anticipation in disease, and evidence of anticipation has bee...

journal_title：Blood

authors： Auer RL,Jones C,Mullenbach RA,Syndercombe-Court D,Milligan DW,Fegan CD,Cotter FE

更新日期：2001-01-15 00:00:00

abstract：:The capacity to convert exogenous leukotriene A4 to lipoxins (LXs) was investigated in platelet suspensions from patients with myeloproliferative disorders (MPD) (n = 22) and healthy control subjects (n = 14). Platelets isolated from the controls produced mainly LXA4, but also 6(S)-LXA4 and the all-trans isomers of li...

journal_title：Blood

authors： Stenke L,Edenius C,Samuelsson J,Lindgren JA

更新日期：1991-12-01 00:00:00

abstract：:The human leukocyte integrin subunit CD11b is expressed predominantly on myelomonocytic cells. To identify CD11b promoter sequences important for myelomonocytic gene expression and to assess the utility of the CD11b promoter for expressing heterologous genes in vivo, we generated transgenic mice with a human CD4 repor...

journal_title：Blood

authors： Back A,East K,Hickstein D

更新日期：1995-02-15 00:00:00

abstract：:Glanzmann thrombasthenia (GT) is the most common inherited disorder of platelets. Most of the molecular defects previously identified in GT have been caused by point (or other small) mutations in the genes for glycoprotein (GP) IIb or GPIIIa. We have used single-strand conformation polymorphism (SSCP) analysis to rapi...

journal_title：Blood

authors： Jin Y,Dietz HC,Nurden A,Bray PF

更新日期：1993-10-15 00:00:00

abstract：:In 2017, 4 drugs received US Food and Drug Administration marketing approval for acute myeloid leukemia (AML) treatment: targeted therapies for mutant FLT3 and IDH2, a liposomal cytarabine-daunorubicin formulation for therapy-related AML and AML with myelodysplasia-related changes, and resurgence of an antibody-drug c...

journal_title：Blood

authors： Wei AH,Tiong IS

更新日期：2017-12-07 00:00:00

abstract：:The status of the T cell receptor beta and gamma genes in natural killer (NK) cells was investigated in two patients with a marked expansion of CD2+, CD3- NK cells. Both genes were found to be in the germline state. The T alpha and complete T beta gene transcripts were not detected, but a 1.0-kilobase T beta gene tran...

journal_title：Blood

authors： Chan WC,Dahl C,Waldmann T,Link S,Mawle A,Nicholson J,Bach FH,Bongiovanni K,McCue PA,Winton EF

更新日期：1988-01-01 00:00:00

abstract：:We examined the prevalence and prognostic relevance of bone marrow reticulin fibrosis in 526 patients with World Health Organization-defined polycythemia vera evaluated at the time of initial diagnosis. Seventy-four patients (14%) displayed mostly grade 1 reticulin fibrosis, with only 2 cases showing higher-grade fibr...

journal_title：Blood

authors： Barbui T,Thiele J,Passamonti F,Rumi E,Boveri E,Randi ML,Bertozzi I,Marino F,Vannucchi AM,Pieri L,Rotunno G,Gisslinger H,Gisslinger B,Müllauer L,Finazzi G,Carobbio A,Gianatti A,Ruggeri M,Nichele I,D'Amore E,Rambald

更新日期：2012-03-08 00:00:00

abstract：:Hematopoietic stem cell transplantation (HSCT) is a highly successful treatment for severe congenital immunodeficiencies. However, some studies have suggested that children may experience cognitive difficulties after HSCT. This large-scale study assessed cognitive and behavioral function for the cohort of children tre...

journal_title：Blood

authors： Titman P,Pink E,Skucek E,O'Hanlon K,Cole TJ,Gaspar J,Xu-Bayford J,Jones A,Thrasher AJ,Davies EG,Veys PA,Gaspar HB

更新日期：2008-11-01 00:00:00

abstract：:There is emerging evidence that neutrophil extracellular traps (NETs) play important roles in inflammatory processes. Here we report that neutrophils have to be simultaneously activated by integrin-mediated outside-in- and G-protein-coupled receptor (GPCR) signaling to induce NET formation in acute lung injury (ALI), ...

journal_title：Blood

authors： Rossaint J,Herter JM,Van Aken H,Napirei M,Döring Y,Weber C,Soehnlein O,Zarbock A

更新日期：2014-04-17 00:00:00

abstract：:The exact mechanisms underlying the role of oxidative stress in the pathogenesis and the prothrombotic or proinflammatory status of antiphospholipid syndrome (APS) remain unknown. Here, we investigate the role of oxidative stress and mitochondrial dysfunction in the proatherothrombotic status of APS patients induced b...

journal_title：Blood

authors： Perez-Sanchez C,Ruiz-Limon P,Aguirre MA,Bertolaccini ML,Khamashta MA,Rodriguez-Ariza A,Segui P,Collantes-Estevez E,Barbarroja N,Khraiwesh H,Gonzalez-Reyes JA,Villalba JM,Velasco F,Cuadrado MJ,Lopez-Pedrera C

更新日期：2012-06-14 00:00:00

abstract：:Signaling through the receptor tyrosine kinase kit controls proliferation and differentiation of hematopoietic precursor cells and mast cells. Somatic point mutations of the receptor that constitutively activate kit signaling are associated with mastocytosis and various hematopoietic malignancies. We generated a Cre/l...

journal_title：Blood

authors： Gerbaulet A,Wickenhauser C,Scholten J,Peschke K,Drube S,Horny HP,Kamradt T,Naumann R,Müller W,Krieg T,Waskow C,Hartmann K,Roers A

更新日期：2011-02-10 00:00:00

abstract：:Autologous membrane-bound IgG was isolated from a subpopulation of human red blood cells (RBC) with specific density greater than 1.110, by affinity chromatography of purified RBC membrane glycoprotein preparations using immobilized wheat germ agglutinin and immobilized anti-human immunoglobulin (Ig) as immunoabsorben...

journal_title：Blood

authors： Alderman EM,Fudenberg HH,Lovins RE

更新日期：1981-08-01 00:00:00