Modification of hemoglobin by ninhydrin.

abstract：:The relationship between neutrophil function and the neutrophil antigen, Kx, as well as the linkage of the gene, Xk, with Xg was examined in a kindred with X-linked chronic granulomatous disease. Four of the eight male siblings had chronic granulomatous disease by clinical history and tests of neutrophil function, and...

journal_title：Blood

authors： Densen P,Wilkinson-Kroovand S,Mandell GL,Sullivan G,Oyen R,Marsh WL

更新日期：1981-07-01 00:00:00

abstract：:This phase 2 study evaluated the efficacy and safety of the oral farnesyltransferase inhibitor tipifarnib in adults with refractory or relapsed acute myeloid leukemia (AML). Patients (n=252) received tipifarnib 600 mg twice a day for 21 days in 28-day cycles. Median age was 62 years; 99 (39%) patients were 65 years or...

journal_title：Blood

authors： Harousseau JL,Lancet JE,Reiffers J,Lowenberg B,Thomas X,Huguet F,Fenaux P,Zhang S,Rackoff W,De Porre P,Stone R,Farnesyltransferase Inhibition Global Human Trials (FIGHT) Acute Myeloid Leukemia Study Group.

更新日期：2007-06-15 00:00:00

abstract：:Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is widely used in healthy donors for collection of peripheral blood progenitor cells (PBPCs) for allogeneic transplantation and granulocytes for transfusion. The spectrum of its biologic and molecular activities in healthy individuals is coming into sha...

journal_title：Blood

authors： Anderlini P,Champlin RE

更新日期：2008-02-15 00:00:00

abstract：:In this issue of Blood, Allinne et al propose the nucleolin-dependent activation of the translocated CCND1 allele in mantle cell lymphoma (MCL) because of its relocalization to a transcriptionally favorable area in the perinucleolar region. ...

journal_title：Blood

authors： Beà S

更新日期：2014-03-27 00:00:00

abstract：:BB-10010 is a variant of the human form of macrophage inflammatory protein-1alpha (MIP-1alpha), which has been shown in mice to block the entry of hematopoietic stem cells into S-phase and to increase their self-renewal capacity during recovery from cytotoxic damage. Its use may constitute a novel approach for protect...

journal_title：Blood

authors： Clemons MJ,Marshall E,Dürig J,Watanabe K,Howell A,Miles D,Earl H,Kiernan J,Griffiths A,Towlson K,DeTakats P,Testa NG,Dougal M,Hunter MG,Wood LM,Czaplewski LG,Millar A,Dexter TM,Lord BI

更新日期：1998-09-01 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the most effective tumor immunotherapy available. Although allo-HSCT provides beneficial graft-versus-tumor effects, acute GVHD (aGVHD) is the primary source of morbidity and mortality after HSCT. Diagnosis of aGVHD is typically based on clinical sympto...

journal_title：Blood

authors： Paczesny S

更新日期：2013-01-24 00:00:00

abstract：:During the course of multiple myeloma (MM), new monoclonal proteins of an isotype distinct from the original clone, referred to as secondary monoclonal gammopathy of undetermined significance (MGUS), have been described. We report on the frequency, characteristics, and outcome of secondary MGUS. Of the 1942 patients w...

journal_title：Blood

authors： Wadhera RK,Kyle RA,Larson DR,Dispenzieri A,Kumar S,Lazarus HM,Rajkumar SV

更新日期：2011-09-15 00:00:00

abstract：:We have identified and cloned a novel human cytokine with homology to cytokines of the interleukin-17 (IL-17) family, which we have termed human IL-17E (hIL-17E). With the identification of several IL-17 family members, it is critical to understand the in vivo function of these molecules. We have generated transgenic ...

journal_title：Blood

authors： Kim MR,Manoukian R,Yeh R,Silbiger SM,Danilenko DM,Scully S,Sun J,DeRose ML,Stolina M,Chang D,Van GY,Clarkin K,Nguyen HQ,Yu YB,Jing S,Senaldi G,Elliott G,Medlock ES

更新日期：2002-10-01 00:00:00

abstract：:An inhibitor of procoagulant and fibrinolytic enzymes was derived from cabbage seeds by a procedure using acetone precipitation, ion-exchange chromatography, and gel filtration. The cabbage seed inhibitor was a 10-Kd monomeric protein with intrachain disulfide bonds. This preparation prevented clot formation in whole ...

journal_title：Blood

authors： Carter TH,Everson BA,Ratnoff OD

更新日期：1990-01-01 00:00:00

abstract：:Recently, the contractile protein alpha-actinin was identified in normal human platelets by its antigenic cross-reaction with a monospecific antibody to purified muscle alpha-actinin. In this study, we extend that preliminary identification of platelet alpha-actinin. Amino acid analysis, one-dimensional peptide maps, ...

journal_title：Blood

authors： Langer BG,Gonnella PA,Nachmias VT

更新日期：1984-03-01 00:00:00

abstract：:Thrombin Metz and normal thrombin, resulting from activation of the respective prothrombins by factor Xa in the presence of calcium, phospholipid, and factor Va, were purified by chromatography on sulfopropyl Sephadex. By physicochemical criteria, thrombin Metz is identical to normal thrombin. Its functional propertie...

journal_title：Blood

authors： Rabiet MJ,Jandrot-Perrus M,Boissel JP,Elion J,Josso F

更新日期：1984-04-01 00:00:00

abstract：:Neutrophils from healthy elderly donors generate significantly less diacylglycerol (DAG) and inositol triphosphate (IP3) than neutrophils from young donors, following stimulation by the chemotactic peptide, formyl-methionyl-leucylphenylalanine (FMLP). The defect in signal transduction occurred at a point proximal to t...

journal_title：Blood

authors： Lipschitz DA,Udupa KB,Indelicato SR,Das M

更新日期：1991-09-01 00:00:00

abstract：:We demonstrated that Flk-1(+) cells derived from mouse embryonic stem (ES) cells can differentiate into both endothelial cells (ECs) and mural cells (MCs) to suffice as vascular progenitor cells (VPCs). In the present study, we investigated the importance of the stage of ES cell differentiation on effective participat...

journal_title：Blood

authors： Yurugi-Kobayashi T,Itoh H,Yamashita J,Yamahara K,Hirai H,Kobayashi T,Ogawa M,Nishikawa S,Nishikawa S,Nakao K

更新日期：2003-04-01 00:00:00

abstract：:The use of recombinant adeno-associated virus (rAAV) vectors provides a new strategy to investigate the role of specific regulatory elements and trans-acting factors in globin gene expression. We linked hypersensitivity site 2 (HS2) from the locus control region (LCR) to a A gamma-globin gene (A gamma*) mutationally m...

journal_title：Blood

authors： Miller JL,Walsh CE,Ney PA,Samulski RJ,Nienhuis AW

更新日期：1993-09-15 00:00:00

abstract：:The past 40 years have witnessed major advances in defining the cytogenetic aberrations, mutational landscape, epigenetic profiles, and expression changes underlying hematological malignancies. Although it has become apparent that acute myeloid leukemia (AML) is highly heterogeneous at the molecular level, the standar...

journal_title：Blood

authors： Grimwade D,Freeman SD

更新日期：2014-11-27 00:00:00

abstract：:Using flow cytometric techniques, we determined the pretreatment distribution of DNA content in propidium iodide-stained leukemic blasts from 205 children with "standard-risk" acute lymphoblastic leukemia (ALL). Risk assignment was based on an initial WBC count less than 100 X 10(9)/L, no thymic mass, no meningeal leu...

journal_title：Blood

authors： Look AT,Roberson PK,Williams DL,Rivera G,Bowman WP,Pui CH,Ochs J,Abromowitch M,Kalwinsky D,Dahl GV

更新日期：1985-05-01 00:00:00

abstract：:An in vitro system has been developed that mimics the passage of erythrocytes from the bone marrow to the circulation. Bone marrow egress and its proper regulation are vital physiologic processes. However, because of the inaccessibility of the marrow, it is difficult to evaluate the various factors important in contro...

journal_title：Blood

authors： Waugh RE,Sassi M

更新日期：1986-07-01 00:00:00

abstract：:The cellular immune defect in untreated Hodgkin's disease (HD) has long been recognized. This defect appears to be responsible for at least some of the morbidity and ultimately the mortality associated with the disease. In recent years, many studies have shown that the T cell component of the immune response is the ap...

journal_title：Blood

authors： Ford RJ,Tsao J,Kouttab NM,Sahasrabuddhe CG,Mehta SR

更新日期：1984-08-01 00:00:00

abstract：:The expression of Lewis fucosyltransferase (FT) mRNA was examined in gastric mucosa from two Lewis-positive [Le(+)] and two Lewis-negative [Le(-)] individuals. Northern blot analysis demonstrated that levels of mRNA were similar in both Le(+) and Le(-) gastric mucosa. We isolated the protein-coding region of the Lewis...

journal_title：Blood

authors： Koda Y,Kimura H,Mekada E

更新日期：1993-11-01 00:00:00

abstract：:It has been shown that histamine induces early changes on endothelial cells (EC), such as a transient expression of P-selectin and secretion and/or surface expression of early mediators (eg, prostacyclin [PG1(2)], platelet-activating factor [PAF], and leukotriene B4 [LTB4]). However, delayed effects of histamine on EC...

journal_title：Blood

authors： Jeannin P,Delneste Y,Gosset P,Molet S,Lassalle P,Hamid Q,Tsicopoulos A,Tonnel AB

更新日期：1994-10-01 00:00:00

abstract：:Polycythemia vera (PV) is a clonal myeloproliferative disorder characterized by excessive erythrocyte production. Most patients with PV harbor an activating JAK2 mutation, but the molecular links between this mutation and erythrocyte overproduction are unknown. The interaction between death receptors and their ligands...

journal_title：Blood

authors： Zeuner A,Pedini F,Signore M,Ruscio G,Messina C,Tafuri A,Girelli G,Peschle C,De Maria R

更新日期：2006-05-01 00:00:00

abstract：:Tumor necrosis factor (TNF)-related activation-induced cytokine (TRANCE) induces osteoclast formation from monocyte/macrophage lineage cells via various transcription factors, including the Mi transcription factor (Mitf). Here, we show that inhibitors of differentiation/DNA binding (Ids), helix-loop-helix (HLH) transc...

journal_title：Blood

authors： Lee J,Kim K,Kim JH,Jin HM,Choi HK,Lee SH,Kook H,Kim KK,Yokota Y,Lee SY,Choi Y,Kim N

更新日期：2006-04-01 00:00:00

abstract：:An attractive hypothesis is that in utero exposure of hematopoietic cells to oncogenic agents can induce molecular changes leading to overt acute lymphoblastic leukemia (ALL) in infants and perhaps older children as well. Although supported by studies of identical infant twins with concordant leukemia, and of nontwine...

journal_title：Blood

authors： Yagi T,Hibi S,Tabata Y,Kuriyama K,Teramura T,Hashida T,Shimizu Y,Takimoto T,Todo S,Sawada T,Imashuku S

更新日期：2000-07-01 00:00:00

abstract：:Targeted disruption of the Friend leukemia integration 1 (Fli-1) proto-oncogene results in severe dysmegakaryopoiesis and embryonic lethality. We used morula-stage aggregation as a strategy to further clarify the hematopoietic defects of the Fli-1 gene-targeted mice. Analyses of lineage expression of Fli-1(+/-) and Fl...

journal_title：Blood

authors： Masuya M,Moussa O,Abe T,Deguchi T,Higuchi T,Ebihara Y,Spyropoulos DD,Watson DK,Ogawa M

更新日期：2005-01-01 00:00:00

abstract：:Pediatric-type follicular lymphoma (PTFL) is a B-cell lymphoma with distinctive clinicopathological features. Recently, recurrent genetic alterations of potential importance for its pathogenesis that disrupt pathways associated with the germinal center reaction (TNFRSF14, IRF8), immune escape (TNFRSF14), and anti-apop...

journal_title：Blood

authors： Schmidt J,Ramis-Zaldivar JE,Nadeu F,Gonzalez-Farre B,Navarro A,Egan C,Montes-Mojarro IA,Marafioti T,Cabeçadas J,van der Walt J,Dojcinov S,Rosenwald A,Ott G,Bonzheim I,Fend F,Campo E,Jaffe ES,Salaverria I,Quintanilla-M

更新日期：2017-07-20 00:00:00

abstract：:Eleven of twenty-four patients with severe aplastic anemia given marrow grafts from HLA-identical siblings between October 1970 and March 1973 are alive with normal marrow function and continued evidence of engraftment 3-5 yr later. Ten have been leading normal lives with no immunosuppressive or other drug therapy sin...

journal_title：Blood

authors： Storb R,Thomas ED,Buckner CD,Clift RA,Fefer A,Fernando LP,Giblett ER,Johnson FL,Neiman PE

更新日期：1976-10-01 00:00:00

abstract：:Myofibroblasts are fibrosis-driving cells and are well characterized in solid organ fibrosis, but their role and cellular origin in bone marrow fibrosis remains obscure. Recent work has demonstrated that Gli1+ and LepR+ mesenchymal stromal cells (MSCs) are progenitors of fibrosis-causing myofibroblasts in the bone mar...

journal_title：Blood

authors： Kramann R,Schneider RK

更新日期：2018-05-10 00:00:00

abstract：:Infection by human immunodeficiency virus type 1 (HIV-1) results in a progressive depletion of CD4+ T lymphocytes, leading to fatal immunodeficiency. The mechanisms causing the marked loss of CD4+ T lymphocytes are incompletely understood. However, several lines of evidence indicate that direct cytopathology mediated ...

journal_title：Blood

authors： Cantin R,Fortin JF,Lamontagne G,Tremblay M

更新日期：1997-08-01 00:00:00

abstract：:Kinetic studies have been carried out to investigate the functional heterogeneity previously observed in populations of human marrow or peripheral blood cells separated by velocity sedimentation. The results obtained confirm the earlier results, in that slowly-sedimenting cells were found to stimulate both colony form...

journal_title：Blood

authors： Niho Y,Till JE,McCulloch EA

更新日期：1975-06-01 00:00:00

abstract：:The adoptive transfer of donor T cells that recognize recipient minor histocompatibility antigens (mHAgs) is a potential strategy for preventing or treating leukemic relapse after allogeneic hematopoietic cell transplantation (HCT). A total of 7 patients with recurrent leukemia after major histocompatibility complex (...

journal_title：Blood

authors： Warren EH,Fujii N,Akatsuka Y,Chaney CN,Mito JK,Loeb KR,Gooley TA,Brown ML,Koo KK,Rosinski KV,Ogawa S,Matsubara A,Appelbaum FR,Riddell SR

更新日期：2010-05-13 00:00:00