Abstract：
:Tumor necrosis factor (TNF)-related activation-induced cytokine (TRANCE) induces osteoclast formation from monocyte/macrophage lineage cells via various transcription factors, including the Mi transcription factor (Mitf). Here, we show that inhibitors of differentiation/DNA binding (Ids), helix-loop-helix (HLH) transcription factors, negatively regulate TRANCE-induced osteoclast differentiation. Expression levels of Id1, Id2, and Id3 genes are significantly reduced by TRANCE during osteoclastogenesis. Interestingly, overexpression of the 3 Id genes in bone marrow-derived monocyte/macrophage lineage cells (BMMs) inhibits the formation of tartrate-resistant acid phosphatase (TRAP)-positive multinuclear osteoclasts, but it does not alter the ability of BMMs to either phagocytose or differentiate into dendritic cells (DCs). Overexpression of Id2 in BMMs attenuates the gene induction of nuclear factor of activated T cells c1 (NFATc1) and osteoclast-associated receptor (OSCAR) during TRANCE-mediated osteoclastogenesis. Furthermore, Id proteins interact with Mitf, a basic HLH (bHLH) transcription factor, and inhibit its transactivation of OSCAR, which is a costimulatory receptor expressed by osteoclast precursors, by attenuating the DNA binding ability of Mitf to the E-box site of the OSCAR promoter. Taken together, our results reveal both a new facet of negative regulation, mediated by Id proteins, as well as the mechanism whereby TRANCE signaling overcomes it, allowing osteoclastogenesis to proceed.
journal_name
Bloodjournal_title
Bloodauthors
Lee J,Kim K,Kim JH,Jin HM,Choi HK,Lee SH,Kook H,Kim KK,Yokota Y,Lee SY,Choi Y,Kim Ndoi
10.1182/blood-2005-07-2798subject
Has Abstractpub_date
2006-04-01 00:00:00pages
2686-93issue
7eissn
0006-4971issn
1528-0020pii
2005-07-2798journal_volume
107pub_type
杂志文章相关文献
BLOOD文献大全abstract：:We investigated the clinical activity of the farnesyl transferase inhibitor R115777 in 22 patients with chronic myelogenous leukemia (CML) in chronic, accelerated, or blastic phase and in 8 patients with myelofibrosis (MF) and 10 patients with multiple myeloma (MM). R115777 was administered at 600 mg orally twice dail...
journal_title：Blood
pub_type： 临床试验,杂志文章
doi：10.1182/blood-2002-07-1973
更新日期：2003-03-01 00:00:00
abstract：:Signaling through the Notch pathway plays an essential role in inducing T-lineage commitment and promoting the maturation of immature thymocytes. Using an in vitro culture system, we show that 2 different classes of Notch ligands, Jagged1 or Delta1, transmit distinct signals to T-cell progenitors. OP9 stromal cells ex...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2004-08-3257
更新日期：2005-02-15 00:00:00
abstract：:Several primary murine and human B lymphomas and cell lines were found to constitutively express high levels of the activated form of c-jun N-terminal kinase (JNK), a member of the mitogen-activated protein (MAP) kinase family. Proliferation of murine B lymphomas CH31, CH12.Lx, BKS-2, and WEHI-231 and the human B lymp...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2004-10-3819
更新日期：2005-08-15 00:00:00
abstract：:The last 2 years have seen much excitement in the field of genetics with the identification of a formerly unappreciated level of "structural variation" within the normal human genome. Genetic structural variants include deletions, duplications, and inversions in addition to the recently discovered, copy number variant...
journal_title：Blood
pub_type： 杂志文章,评审
doi：10.1182/blood-2006-06-030858
更新日期：2007-02-15 00:00:00
abstract：:Using flow cytometric techniques, we determined the pretreatment distribution of DNA content in propidium iodide-stained leukemic blasts from 205 children with "standard-risk" acute lymphoblastic leukemia (ALL). Risk assignment was based on an initial WBC count less than 100 X 10(9)/L, no thymic mass, no meningeal leu...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1985-05-01 00:00:00
abstract：:Hereditary glutathione reductase (GR) deficiency was found in only 2 cases when testing more than 15 000 blood samples. We have investigated the blood cells of 2 patients (1a and 1b) in a previously described family suffering from favism and cataract and of a novel patient (2) presenting with severe neonatal jaundice....
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2006-08-042531
更新日期：2007-04-15 00:00:00
abstract：:Heme biosynthesis was examined in erythroid tissue of a 4-yr-old girl with severe sideroblastic anemia since infancy, as documented by the presence of intramitochondrial deposits of iron in erythroblasts. Free red cell protoporphyrin, urinary porphyrins, and activities of erythrocyte porphobilinogen synthase, uroporph...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:PRKAR1A (R1A)-retinoic acid receptor-alpha (R1A-RARalpha) is the sixth RARalpha-containing fusion protein in acute promyelocytic leukemia (APL). Using the murine bone-marrow retroviral transduction/transformation assay, we showed that R1A-RARalpha fusion protein could transform bone-marrow progenitor/stem cells. In ge...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2009-07-232652
更新日期：2010-01-21 00:00:00
abstract：:Endothelial progenitor cells are critically involved in essential biologic processes, such as vascular homeostasis, regeneration, and tumor angiogenesis. Endothelial colony-forming cells (ECFCs) are endothelial progenitor cells with robust proliferative potential. Their profound vessel-forming capacity makes them a pr...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2008-09-181362
更新日期：2009-06-25 00:00:00
abstract：:Peripheral eosinophilia is almost invariably observed during the course of interleukin-2 (IL-2) therapy and is frequently accompanied by the development of a capillary leak syndrome characterized by edema, weight gain, and oliguria. We studied five patients with advanced malignancy treated with IL-2. Eosinophilia was ...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1991-09-15 00:00:00
abstract：:In patients with common variable immunodeficiency (CVI), we have previously defined a subgroup of patients (CVIHyper) characterized by decreased numbers of CD4+ lymphocytes in peripheral blood, splenomegaly, and persistent immune activation in vivo, particularly of monocytes/macrophages. To further characterize this h...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1996-01-15 00:00:00
abstract：:Forty patients with refractory Hodgkin's disease (24 patients) or non-Hodgkin's lymphoma (16 patients) who were considered for high-dose therapy but not for autologous bone marrow transplantation (ABMT) due to BM metastases, previous pelvic irradiation, a history of marrow involvement by tumor or hypocellular marrow i...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1989-09-01 00:00:00
abstract：:Phosphatidylserine (PS) is normally confined to the cytoplasmic leaflet of the red blood cell (RBC) membrane, but some sickle RBCs expose PS in the outer leaflet (PS+ cells). This study examined the relationships among PS externalization, fetal hemoglobin content, hydration state, and cell age. Sickle RBCs exhibit a w...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2002-11-3416
更新日期：2003-07-01 00:00:00
abstract：:Erythropoiesis was investigated in 32 children wih short stature and in eight children with skeletal dysplasia by studying blood hemoglobin in relation to growth and to serum concentrations of insulin-like growth factor I (IGF-I), IGF binding protein-3 (IGFBP-3), and erythropoietin (EPO) before, during, and after 12 m...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1996-03-01 00:00:00
abstract：:Patients with PNH may be treated with a number of known agents. As in all patients with a chronic disease, a regimen tolerable over a long period of time must be selected. Knowledge and anticipation of complications and their proper treatment are essential parts in the treatment. When these principals are used, many p...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1982-07-01 00:00:00
abstract：:We conducted a genome-wide association study to identify novel associations between genetic variants and circulating plasminogen activator inhibitor-1 (PAI-1) concentration, and examined functional implications of variants and genes that were discovered. A discovery meta-analysis was performed in 19 599 subjects, foll...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2012-06-436188
更新日期：2012-12-06 00:00:00
abstract：:In this issue of Blood, Bachanova et al describe how modulation of the inhibitory tumor environment may enhance natural killer (NK) cell clinical activity and produce encouraging results in the treatment of refractory acute myeloid leukemia (AML). NK cells are highly proliferative, early responders of the innate immun...
journal_title：Blood
pub_type： 评论,杂志文章
doi：10.1182/blood-2014-05-570291
更新日期：2014-06-19 00:00:00
abstract：:Cultured mononuclear phagocytes produce soluble factors that stimulate endothelial cells to release GM-colony-stimulating activity (GM-CSA). One such factor was recently identified as interleukin 1 (IL 1). Studies were designed to determine which types of granulopoietic factors are released by IL 1-stimulated endothel...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:The mechanical properties of sickle erythrocyte membranes were evaluated in the ektacytometer. When ghosts from the total red blood cell population were examined, the rigidity of the resealed ghosts and their rate of fragmentation by shear stress (t1/2) were normal. However, fractionation on Stractan density gradients...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1990-04-15 00:00:00
abstract：:Conventional assays evaluating antitumor activity of immune effector cells have limitations that preclude their high-throughput application. We adapted the recently developed Compartment-Specific Bioluminescence Imaging (CS-BLI) technique to perform high-throughput quantification of innate antitumor activity and to sh...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2011-04-348490
更新日期：2012-04-12 00:00:00
abstract：:Rituximab is a chimeric monoclonal antibody directed at CD20 with significant activity in non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL). A variety of pathways of tumor cytotoxicity different from cytotoxic chemotherapy have been proposed for this therapeutic antibody including antibody-dependent ce...
journal_title：Blood
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1182/blood.v99.3.1038
更新日期：2002-02-01 00:00:00
abstract：:Human and rhesus monkey platelets secrete at least two antiheparin proteins: platelet factor 4 (PF4) and low affinity platelet factor 4 (LA-PF4). Neither of these proteins showed species-related antigenic differences. As determined by radioimmunoassay, the levels of PF4 and LA-PF4 antigen per 10(9) monkey platelets am...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1980-10-01 00:00:00
abstract：:The CXC-chemokines interleukin-8 (IL-8), neutrophil-activating peptide-2 (NAP-2), and melanoma growth-stimulatory activity (MGSA) are chemoattractants with high selectivity for neutrophils. Although IL-8 has been shown to act as an extremely potent mediator, reports on NAP-2 and MGSA are still contradictory. Here we s...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1997-12-01 00:00:00
abstract：:Blood-borne lymphocyte trafficking to peripheral lymph nodes (PLNs) depends on the successful initiation of rolling interactions mediated by L-selectin binding to sialomucin ligands in high endothelial venules (HEVs). Biochemical analysis of purified L-selectin ligands has identified posttranslational modifications me...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2004-05-1986
更新日期：2004-12-15 00:00:00
abstract：:In this issue of Blood, Rowley et al report that noncoding RNAs precisely regulate the messenger RNA (mRNA) profile in platelets. Interfering in this process using genetically engineered mice affects hemostatic and thrombotic functions of platelets. ...
journal_title：Blood
pub_type： 评论,杂志文章
doi：10.1182/blood-2016-01-694893
更新日期：2016-04-07 00:00:00
abstract：:In this issue of Blood, Willems et al describe the dependence of acute myeloid leukemia (AML) cells on glutamine for maintaining protein synthesis downstream of mammalian target of rapamycin (mTOR) and show that the enzyme asparaginase can be used to target this dependence. Using various AML cell lines, primary sample...
journal_title：Blood
pub_type： 评论,杂志文章
doi：10.1182/blood-2013-09-526392
更新日期：2013-11-14 00:00:00
abstract：:We determined that the molecular defect of 2 patients with hemoglobin (Hb) M-Kankakee [Hb M-Iwate, alpha87 (F8) His --> Tyr] resides in the alpha1-globin gene. The proportion of Hb M observed is higher than that predicted for an alpha1-globin variant. Our evidence suggests that the greater-than-expected proportion of ...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：:Hemoglobin Ohio [beta 142 (H20) Ala replaced by Asp] was found in three members of a white family, all of whom showed erythrocytosis. The variant hemoglobin has a high oxygen affinity, a reduced Bohr effect, and diminished cooperativity. The functional abnormalities of Hb Ohio are explained by the proximity of the sub...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1980-08-01 00:00:00
abstract：:Some multilineage hemopoietic colonies contain, in addition to myeloid cells, T lymphocytes. These proliferate extensively in liquid suspension culture under the influence of a T cell growth factor provided by phytohemagglutinin-T cell-conditioned medium (PHA-TCM). The clonal origin of these myeloid and lymphoid compo...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1984-06-01 00:00:00
abstract：:One hundred twenty-five cases of Hodgkin's disease from the United States (79), Mexico City (31), and Costa Rica (15) were analyzed for the presence of Epstein-Barr virus (EBV) by in situ hybridization to EBER1 transcripts. EBV was more frequently detected in the Reed-Sternberg (RS) cells of mixed cellularity Hodgkin'...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1994-03-15 00:00:00
