Abstract:
:We determined that the molecular defect of 2 patients with hemoglobin (Hb) M-Kankakee [Hb M-Iwate, alpha87 (F8) His --> Tyr] resides in the alpha1-globin gene. The proportion of Hb M observed is higher than that predicted for an alpha1-globin variant. Our evidence suggests that the greater-than-expected proportion of Hb M-Kankakee results from preferential association of the electronegative beta-globin chains with the alpha(M)-globin chains that are more electropositive than normal alpha-globin chains.
journal_name
Bloodjournal_title
Bloodauthors
Ameri A,Fairbanks VF,Yanik GA,Mahdi F,Thibodeau SN,McCormick DJ,Boxer LA,McDonagh KTsubject
Has Abstractpub_date
1999-09-01 00:00:00pages
1825-6issue
5eissn
0006-4971issn
1528-0020journal_volume
94pub_type
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