Identification of the molecular genetic defect of patients with methemoglobin M-Kankakee (M-Iwate), alpha87 (F8) His --> Tyr: evidence for an electrostatic model of alphaM hemoglobin assembly.

Abstract:

:We determined that the molecular defect of 2 patients with hemoglobin (Hb) M-Kankakee [Hb M-Iwate, alpha87 (F8) His --> Tyr] resides in the alpha1-globin gene. The proportion of Hb M observed is higher than that predicted for an alpha1-globin variant. Our evidence suggests that the greater-than-expected proportion of Hb M-Kankakee results from preferential association of the electronegative beta-globin chains with the alpha(M)-globin chains that are more electropositive than normal alpha-globin chains.

journal_name

Blood

journal_title

Blood

authors

Ameri A,Fairbanks VF,Yanik GA,Mahdi F,Thibodeau SN,McCormick DJ,Boxer LA,McDonagh KT

subject

Has Abstract

pub_date

1999-09-01 00:00:00

pages

1825-6

issue

5

eissn

0006-4971

issn

1528-0020

journal_volume

94

pub_type

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