Efficacy of the farnesyl transferase inhibitor R115777 in chronic myeloid leukemia and other hematologic malignancies.

abstract：:Current treatment strategies for Hodgkin lymphoma result in excellent survival but often confer significant long-term toxicity. We designed ABVE-PC (doxorubicin, bleomycin, vincristine, etoposide, prednisone, cyclophosphamide) to (1) enhance treatment efficacy by dose-dense drug delivery and (2) reduce risk of long-te...

journal_title：Blood

authors： Schwartz CL,Constine LS,Villaluna D,London WB,Hutchison RE,Sposto R,Lipshultz SE,Turner CS,deAlarcon PA,Chauvenet A

更新日期：2009-09-03 00:00:00

abstract：:Myeloperoxidase (MPO) is a heme containing enzyme involved in the oxygen-dependent microbicidal activity of human polymorphonuclear leukocytes (PMN). Complete hereditary and acquired MPO deficiencies are defined as lack of peroxidase activity in PMN. Using this criterion, we studied a patient with complete hereditary ...

journal_title：Blood

authors： Tobler A,Selsted ME,Miller CW,Johnson KR,Novotny MJ,Rovera G,Koeffler HP

更新日期：1989-05-15 00:00:00

abstract：:In this issue of Blood, Mayer et al describe a new method of generating high numbers of Batf3- and Irf8-dependent CD103+ conventional dendritic cells (cDCs), providing new opportunities to study this subset of antigen-presenting cells specialized in crosspresentation. ...

journal_title：Blood

authors： van de Laar L,Lambrecht BN

更新日期：2014-11-13 00:00:00

abstract：:We genotyped 370 subjects with primary myelofibrosis (PMF) and 148 with postpolycythemia vera/postessential thrombocythemia (PPV/PET) MF for mutations of EZH2. Mutational status at diagnosis was correlated with hematologic parameters, clinical manifestations, and outcome. A total of 25 different EZH2 mutations were de...

journal_title：Blood

authors： Guglielmelli P,Biamonte F,Score J,Hidalgo-Curtis C,Cervantes F,Maffioli M,Fanelli T,Ernst T,Winkelman N,Jones AV,Zoi K,Reiter A,Duncombe A,Villani L,Bosi A,Barosi G,Cross NC,Vannucchi AM

更新日期：2011-11-10 00:00:00

abstract：:Dendritic cells (DCs) represent a small and heterogeneous fraction of the hematopoietic system, specialized in antigen capture, processing, and presentation. The different DC subsets act as sentinels throughout the body and perform a key role in the induction of immunogenic as well as tolerogenic immune responses. Bec...

journal_title：Blood

authors： van de Laar L,Coffer PJ,Woltman AM

更新日期：2012-04-12 00:00:00

abstract：:Low-density lipoprotein (LDL) receptor (LDLR) and LDLR-related protein (LRP) are members of the LDLR family of endocytic receptors. LRP recognizes a wide spectrum of structurally and functionally unrelated ligands, including coagulation factor VIII (FVIII). In contrast, the ligand specificity of LDLR is restricted to ...

journal_title：Blood

authors： Bovenschen N,Mertens K,Hu L,Havekes LM,van Vlijmen BJ

更新日期：2005-08-01 00:00:00

abstract：:Interaction between human platelets and bacterial endotoxin was studied in vitro with transmission and scanning electron microscopy. Washed human platelets, whose aggregation was blocked with apyrase, were incubated in a plasma-free medium containing crude endotoxin that had previously been complexed with copper. Thir...

journal_title：Blood

authors： Ausprunk DH,Das J

更新日期：1978-03-01 00:00:00

abstract：:Cells derived from human cord blood were recently used instead of bone marrow (BM) for transplantation. However, several questions concerning the potential of these cells to reconstitute the hematopoietic and immunologic system of the recipient and to induce a graft-versus-host disease (GVHD) remain unanswered. Here w...

journal_title：Blood

authors： de La Selle V,Gluckman E,Bruley-Rosset M

更新日期：1996-05-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is one of the most aggressive lymphoid neoplasms whose pathogenesis is not fully understood. The neural transcription factor SOX11 is overexpressed in most MCL but is not detected in other mature B-cell lymphomas or normal lymphoid cells. The specific expression of SOX11 in MCL suggests that...

journal_title：Blood

authors： Vegliante MC,Palomero J,Pérez-Galán P,Roué G,Castellano G,Navarro A,Clot G,Moros A,Suárez-Cisneros H,Beà S,Hernández L,Enjuanes A,Jares P,Villamor N,Colomer D,Martín-Subero JI,Campo E,Amador V

更新日期：2013-03-21 00:00:00

abstract：:Acute myeloid leukemia (AML) cells are characterized by unlimited self-renewal and an impaired capacity to undergo terminal differentiation. The MUC1 oncoprotein is aberrantly expressed in AML cells; however, there has been no evidence for involvement of MUC1 in myeloid leukemogenesis. Cell-penetrating peptide inhibit...

journal_title：Blood

authors： Yin L,Wu Z,Avigan D,Rosenblatt J,Stone R,Kharbanda S,Kufe D

更新日期：2011-05-05 00:00:00

abstract：:Thrombopoietin (TPO) is a recently cloned cytokine that binds to its receptor, Mpl, and promotes hematopoietic expansion and maturation, primarily of the megakaryocyte lineage. The signaling pathways responsible for these events are thought to involve the Janus family of nonreceptor tyrosine kinases (JAKs) and the sig...

journal_title：Blood

authors： Drachman JG,Sabath DF,Fox NE,Kaushansky K

更新日期：1997-01-15 00:00:00

abstract：:The long form of B-cell lymphoma-x (Bcl-x(L)), an outer mitochondrial membrane protein, has been proposed to mediate the antiapoptotic action of erythropoietin on erythroid progenitor cells and to be necessary for heme synthesis in erythroblasts. Mice with conditional knockout of Bcl-x(L) (conditional bcl-x(-/-) mice)...

journal_title：Blood

authors： Rhodes MM,Kopsombut P,Bondurant MC,Price JO,Koury MJ

更新日期：2005-09-01 00:00:00

abstract：:Residual vein thrombosis (RVT) indicates a prothrombotic state and is useful for evaluating the optimal duration of oral anticoagulant treatment (OAT). Patients with a first episode of deep vein thrombosis, treated with OAT for 3 months, were managed according to RVT findings. Those with RVT were randomized to either ...

journal_title：Blood

authors： Siragusa S,Malato A,Anastasio R,Cigna V,Milio G,Amato C,Bellisi M,Attanzio MT,Cormaci O,Pellegrino M,Dolce A,Casuccio A,Bajardi G,Mariani G

更新日期：2008-08-01 00:00:00

abstract：:Targeted sequencing of 103 leukemia-associated genes in leukemia cells from 841 treatment-naive patients with chronic lymphocytic leukemia (CLL) identified 89 (11%) patients as having CLL cells with mutations in genes encoding proteins that putatively are involved in hedgehog (Hh) signaling. Consistent with this findi...

journal_title：Blood

authors： Ghia EM,Rassenti LZ,Neuberg DS,Blanco A,Yousif F,Smith EN,McPherson JD,Hudson TJ,HALT Pan-Leukemia Gene Panel Consortium.,Harismendy O,Frazer KA,Kipps TJ

更新日期：2019-06-20 00:00:00

abstract：:Interleukin (IL)-32 was originally identified in natural killer cells and IL-2-activated human T lymphocytes. As T cells are activated in allogeneic transplantation, we determined the role of IL-32 in human mixed lymphocyte cultures (MLCs) and GVHD. In allogeneic MLCs, IL-32 increased two-fold in responding T cells, a...

journal_title：Blood

authors： Marcondes AM,Li X,Tabellini L,Bartenstein M,Kabacka J,Sale GE,Hansen JA,Dinarello CA,Deeg HJ

更新日期：2011-11-03 00:00:00

abstract：:To investigate underlying mechanisms of thrombocytopenia in myelodysplastic syndrome (MDS), radiolabeled platelet studies were performed in 30 MDS patients with platelet counts less than 100 x 10(9)/L. Furthermore, plasma thrombopoietin and glycocalicin index (a parameter of platelet or megakaryocyte destruction) were...

journal_title：Blood

authors： Houwerzijl EJ,Blom NR,van der Want JJ,Louwes H,Esselink MT,Smit JW,Vellenga E,de Wolf JT

更新日期：2005-05-01 00:00:00

abstract：:It has previously been shown that monolayer cultures derived adherent cells (MDAC), apparently consisting of fibroblasts, macrophages, epithelioid cells, and fat cells, can support long-term stem cell proliferation in vitro. In the present study, the hematopoietic support capability of murine MDAC monolayers was confi...

journal_title：Blood

authors： Bentley SA,Foidart JM

更新日期：1980-12-01 00:00:00

abstract：:Little is known about the molecular characteristics of alloantigens recognized by alloreactive T cells mediating hematologic stem cell graft rejection. In particular, it has never been shown that such alloantigens can be encoded by HLA-DP beta alleles. Indeed, matching for HLA-DP antigens is generally not considered t...

journal_title：Blood

authors： Fleischhauer K,Zino E,Mazzi B,Sironi E,Servida P,Zappone E,Benazzi E,Bordignon C

更新日期：2001-08-15 00:00:00

abstract：:The large granular lymphocyte (LGL) population, which effects a natural killer (NK) function, consists of cells whose lineage derivation has not been clearly established on the basis of phenotypic and functional properties. To clarify the relationship of LGL/NK cells to T cells we studied patterns of rearrangement and...

journal_title：Blood

authors： Pelicci PG,Allavena P,Subar M,Rambaldi A,Pirelli A,Di Bello M,Barbui T,Knowles DM 2nd,Dalla-Favera R,Mantovani A

更新日期：1987-11-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is one of the most common acute leukemias in adults and children, yet significant numbers of patients relapse and die of disease. In this study, we identify the dependence of AML blasts on arginine for proliferation. We show that AML blasts constitutively express the arginine transporters ...

journal_title：Blood

authors： Mussai F,Egan S,Higginbotham-Jones J,Perry T,Beggs A,Odintsova E,Loke J,Pratt G,U KP,Lo A,Ng M,Kearns P,Cheng P,De Santo C

更新日期：2015-04-09 00:00:00

abstract：:We used the polymerase chain reaction (PCR) to determine the frequency of silent human immunodeficiency virus type 1 (HIV-1) infections in seronegative high-risk individuals with hemophilia who had been exposed to contaminated blood products more than 3 years previously. In a cross-sectional study of a cohort of 57 pr...

journal_title：Blood

authors： Gibbons J,Cory JM,Hewlett IK,Epstein JS,Eyster ME

更新日期：1990-11-15 00:00:00

abstract：:To elucidate the pathways by which nitric oxide (NO) influences macrophage iron metabolism, the uptake, release, and intracellular distribution of iron in the murine macrophage cell line J774 has been investigated, together with transferrin receptor (TfR) expression and iron-regulatory protein (IRP1 and IRP2) activity...

journal_title：Blood

authors： Mulero V,Brock JH

更新日期：1999-10-01 00:00:00

abstract：:Development of inhibitory antibodies is a serious complication of treatment with repeated factor IX infusions in a minority of patients with hemophilia B. Such antibodies detected in 8 patients have been characterized. Typing studies revealed that patients' immune response toward factor IX is highly heterogeneous and ...

journal_title：Blood

authors： Christophe OD,Lenting PJ,Cherel G,Boon-Spijker M,Lavergne JM,Boertjes R,Briquel ME,de Goede-Bolder A,Goudemand J,Gaillard S,d'Oiron R,Meyer D,Mertens K

更新日期：2001-09-01 00:00:00

abstract：:Cholesterol, in addition to providing rigidity to the fluid membrane, plays a critical role in receptor function, endocytosis, recycling, and signal transduction. In the present study, we examined the effect of membrane cholesterol on functional expression of tissue factor (TF), a cellular receptor for clotting factor...

journal_title：Blood

authors： Mandal SK,Iakhiaev A,Pendurthi UR,Rao LV

更新日期：2005-01-01 00:00:00

abstract：:The Wiskott-Aldrich syndrome (WAS) is a severe immunodeficiency and platelet deficiency disease arising from mutation(s) in the WASP gene, which in normal cells encodes an intracellular protein able to interact with other proteins relevant to the control of cytoskeleton organization. Immunodeficiency is mainly due to ...

journal_title：Blood

authors： Gallego MD,Santamaría M,Peña J,Molina IJ

更新日期：1997-10-15 00:00:00

abstract：:Chronic graft-versus-host disease (cGVHD) is characterized by a state of profound immunodeficiency in association with alloreactive and autoimmune phenomena. These observations indicate an impairment of immunologic tolerance that could involve both central and peripheral mechanisms. Defective thymic function may contr...

journal_title：Blood

authors： Clark FJ,Gregg R,Piper K,Dunnion D,Freeman L,Griffiths M,Begum G,Mahendra P,Craddock C,Moss P,Chakraverty R

更新日期：2004-03-15 00:00:00

abstract：:The cells and mechanisms involved in blood clot resorption are only partially known. We show that regulatory T (Treg) cells accumulate in venous blood clots and regulate thrombolysis by controlling the recruitment, differentiation and matrix metalloproteinase (MMP) activity of monocytes. We describe a clot Treg popula...

journal_title：Blood

authors： Shahneh F,Alexandra G,Klein M,Frauhammer F,Bopp T,Schäfer K,Raker V,Becker C

更新日期：2020-09-15 00:00:00

abstract：:Thrombin Metz and normal thrombin, resulting from activation of the respective prothrombins by factor Xa in the presence of calcium, phospholipid, and factor Va, were purified by chromatography on sulfopropyl Sephadex. By physicochemical criteria, thrombin Metz is identical to normal thrombin. Its functional propertie...

journal_title：Blood

authors： Rabiet MJ,Jandrot-Perrus M,Boissel JP,Elion J,Josso F

更新日期：1984-04-01 00:00:00

abstract：:Although numerous studies have shown a higher risk of acquiring HIV infection in the presence of other sexually transmitted diseases, the biologic mechanisms responsible for enhanced HIV acquisition are unclear. Because Langerhans cells (LCs) are suspected to be the initial HIV targets after sexual exposure, we studie...

journal_title：Blood

authors： Ogawa Y,Kawamura T,Kimura T,Ito M,Blauvelt A,Shimada S

更新日期：2009-05-21 00:00:00

abstract：:The expansion of follicular lymphomas (FLs) resembles, both morphologically and functionally, normal germinal center B-cell growth. The tumor cells proliferate in networks of follicular dendritic cells and are believed to be capable of somatic hypermutation and isotype switching. To investigate the relation between so...

journal_title：Blood

authors： Aarts WM,Bende RJ,Steenbergen EJ,Kluin PM,Ooms EC,Pals ST,van Noesel CJ

更新日期：2000-05-01 00:00:00