Abstract:
:The cells and mechanisms involved in blood clot resorption are only partially known. We show that regulatory T (Treg) cells accumulate in venous blood clots and regulate thrombolysis by controlling the recruitment, differentiation and matrix metalloproteinase (MMP) activity of monocytes. We describe a clot Treg population that forms the matricellular acid- and cysteine-rich protein (SPARC), show that SPARC enhances monocyte MMP activity and that SPARC+ Treg are crucial for blood clot resorption. By comparing different treatment times, we define a therapeutic window of Treg expansion that accelerates clot resorption.
journal_name
Bloodjournal_title
Bloodauthors
Shahneh F,Alexandra G,Klein M,Frauhammer F,Bopp T,Schäfer K,Raker V,Becker Cdoi
10.1182/blood.2020005407subject
Has Abstractpub_date
2020-09-15 00:00:00eissn
0006-4971issn
1528-0020pii
463762pub_type
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