Variable heavy chain gene analysis of follicular lymphomas: correlation between heavy chain isotype expression and somatic mutation load.

abstract：:Adaptive immunity is triggered at the immune synapse, where peptide-major histocompatibility complexes and costimulatory molecules expressed by dendritic cells (DCs) are physically presented to T cells. Here we describe transmission of the inflammatory monoamine serotonin (5-hydroxytryptamine [5-HT]) between these cel...

journal_title：Blood

authors： O'Connell PJ,Wang X,Leon-Ponte M,Griffiths C,Pingle SC,Ahern GP

更新日期：2006-02-01 00:00:00

abstract：:To further unravel the molecular pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL), we performed high-resolution array comparative genomic hybridization on diagnostic specimens from 47 children with T-ALL and identified monoallelic or biallelic LEF1 microdeletions in 11% (5 of 47) of these primary samples. A...

journal_title：Blood

authors： Gutierrez A,Sanda T,Ma W,Zhang J,Grebliunaite R,Dahlberg S,Neuberg D,Protopopov A,Winter SS,Larson RS,Borowitz MJ,Silverman LB,Chin L,Hunger SP,Jamieson C,Sallan SE,Look AT

更新日期：2010-04-08 00:00:00

abstract：:The CD31 monoclonal antibody, LYP21, binds to the CD31 domain 6 and inhibits the human mixed-lymphocyte reaction (MLR) in a specific and dose-dependent fashion. A synthetic CD31 peptide based on human CD31 epitope (amino acids 551 to 574) recognized by LYP21 is equally effective in inhibiting the MLR. In this study, w...

journal_title：Blood

authors： Chen Y,Schlegel PG,Tran N,Thompson D,Zehnder JL,Chao NJ

更新日期：1997-02-15 00:00:00

abstract：:Recombinant gibbon interleukin-3 (IL-3) is a multilineage hematopoietic colony-stimulating factor (CSF) that recently was cloned and found to be highly homologous with human IL-3. Gibbon IL-3, as well as human granulocyte-CSF (G-CSF) and human granulocyte-macrophage CSF (GM-CSF), stimulated normal human bone marrow ce...

journal_title：Blood

authors： Paquette RL,Zhou JY,Yang YC,Clark SC,Koeffler HP

更新日期：1988-06-01 00:00:00

abstract：:The mechanisms by which hematopoietic progenitor cells become lineage-committed remain poorly understood. A cloned subline of the AML14 cell line (AML14.3D10) that spontaneously differentiates to eosinophilic myelocytes in the absence of cytokine stimulation was obtained by limiting dilution. This subline exhibits aug...

journal_title：Blood

authors： Paul CC,Mahrer S,Tolbert M,Elbert BL,Wong I,Ackerman SJ,Baumann MA

更新日期：1995-11-15 00:00:00

abstract：:The generation of Ab-secreting plasma cells depends critically on CD4 T-follicular helper (TFH) cells during the germinal center reaction. Germinal center TFH cells share functional properties with circulating CXCR5(+) CD4 T cells, referred to herein as peripheral TFH (pTFH) cells. Because deficient Ab production and ...

journal_title：Blood

authors： Pallikkuth S,Parmigiani A,Silva SY,George VK,Fischl M,Pahwa R,Pahwa S

更新日期：2012-08-02 00:00:00

abstract：:The use of 8-methoxypsoralen (8-MOP) and UV-A irradiation to inactivate contaminating donor leukocytes in platelet concentrates and to prevent primary alloimmunization against donor class I major histocompatibility (MHC) antigens in mice was investigated. CBA/CaH-T6J mice with the H2k haplotype and BALB/cByJ mice with...

journal_title：Blood

authors： Grana NH,Kao KJ

更新日期：1991-06-01 00:00:00

abstract：:Although an increase in protein phosphorylation on tyrosine was first noted as a result of cell transformation or the application of growth factors to cells, recent reports have shown high levels of tyrosine kinases in nondividing tissues. For that reason, we have investigated whether normal human polymorphonuclear le...

journal_title：Blood

authors： Kraft AS,Berkow RL

更新日期：1987-08-01 00:00:00

abstract：:Toll-like receptors orchestrate rapid local protective innate-immune responses to invading pathogens and optimize leukocyte priming of subsequent adaptive responses. Paradoxically, systemic excess of the TLR2 ligand, bacterial lipoprotein (BLP), suppresses peripheral inflammatory responses. Here, we demonstrate that t...

journal_title：Blood

authors： McKimmie CS,Moore M,Fraser AR,Jamieson T,Xu D,Burt C,Pitman NI,Nibbs RJ,McInnes IB,Liew FY,Graham GJ

更新日期：2009-04-30 00:00:00

abstract：:A patient, CAL, with gamma heavy chain disease is presented who has had a complete remission lasting over 2 yr with combination chemotherapy consisting of pulsatile cyclophosphamide and prednisone. The patient exhibited many features of an atuoimmune process including a vasculitis, low serum complement levels, a posit...

journal_title：Blood

authors： Lyons RM,Chaplin H,Tillack TW,Majerus PW

更新日期：1975-07-01 00:00:00

abstract：:Cervical internal carotid artery (cICA) occlusion is a recognized cause of acute ischemic stroke (AIS) in sickle cell disease (SCD), but the associated clinical and radiologic features are not well described. We reviewed data on cervical magnetic resonance angiography (cMRA) performed prospectively in 67 patients (55 ...

journal_title：Blood

authors： Telfer PT,Evanson J,Butler P,Hemmaway C,Abdulla C,Gadong N,Whitmarsh S,Kaya B,Kirkham FJ

更新日期：2011-12-01 00:00:00

abstract：:Variations of the partial thromboplastin time (PTT) were tested to determine the best screening method for detection of inhibitors of factor VIII. Variables tested included the duration of preincubation of a mixture of patient plasma and factor VIII source (normal plasma), the ratio of the patient plasma to the normal...

journal_title：Blood

authors： Lossing TS,Kasper CK,Feinstein DI

更新日期：1977-05-01 00:00:00

abstract：:Advances in fluorescence-activated cell sorter technology have brought about multicolor analysis of cell phenotypes. To clarify the phenotypes of human hematopoietic stem cells (HSCs), we initially prepared novel antibodies against CD34 and labeled one of them (4A1) with allophycocyanin (APC). With this, we analyzed t...

journal_title：Blood

authors： Gunji Y,Nakamura M,Hagiwara T,Hayakawa K,Matsushita H,Osawa H,Nagayoshi K,Nakauchi H,Yanagisawa M,Miura Y

更新日期：1992-07-15 00:00:00

abstract：:Human early thymic precursors have the potential to differentiate into multiple cell lineages, including T cells and plasmacytoid dendritic cells (pDCs). This decision is guided by the induction or silencing of lineage-specific transcription factors. The ETS family member Spi-B is a key regulator of pDC development, w...

journal_title：Blood

authors： Dontje W,Schotte R,Cupedo T,Nagasawa M,Scheeren F,Gimeno R,Spits H,Blom B

更新日期：2006-03-15 00:00:00

abstract：:The inv(11)(p15q22) is a recurrent chromosomal abnormality associated with de novo and therapy-related myeloid malignancies. Here we report the molecular definition of this chromosomal aberration in four patients. Positional cloning showed the consistent rearrangement of the DDX10 gene on chromosome 11q22, which encod...

journal_title：Blood

authors： Arai Y,Hosoda F,Kobayashi H,Arai K,Hayashi Y,Kamada N,Kaneko Y,Ohki M

更新日期：1997-06-01 00:00:00

abstract：:Intravascular hemolysis describes the relocalization of heme and hemoglobin (Hb) from erythrocytes to plasma. We investigated the concept that erythrocyte membrane microparticles (MPs) concentrate cell-free heme in human hemolytic diseases, and that heme-laden MPs have a physiopathological impact. Up to one-third of c...

journal_title：Blood

authors： Camus SM,De Moraes JA,Bonnin P,Abbyad P,Le Jeune S,Lionnet F,Loufrani L,Grimaud L,Lambry JC,Charue D,Kiger L,Renard JM,Larroque C,Le Clésiau H,Tedgui A,Bruneval P,Barja-Fidalgo C,Alexandrou A,Tharaux PL,Boulanger CM

更新日期：2015-06-11 00:00:00

abstract：:We have investigated the clonality of Ph1-negative hemopoietic progenitor cells appearing in long-term marrow cultures established with cells from a mosaic Turner syndrome patient (46,XX/45,X) with Ph1-positive chronic myeloid leukemia (CML). The Ph1-positive clone had been shown previously to have arisen from a cell ...

journal_title：Blood

authors： Dubé ID,Arlin ZA,Kalousek DK,Eaves CJ,Eaves AC

更新日期：1984-12-01 00:00:00

abstract：:In a phase I/II study, 19 patients with advanced tumors but normal hematopoiesis and nine patients with bone marrow failure and prolonged severe cytopenias were treated with recombinant human interleukin-3 (rhIL-3) to assess the toxicity and biological effects of this multipotential hematopoietic growth factor. Doses ...

journal_title：Blood

authors： Ganser A,Lindemann A,Seipelt G,Ottmann OG,Herrmann F,Eder M,Frisch J,Schulz G,Mertelsmann R,Hoelzer D

更新日期：1990-08-15 00:00:00

abstract：:The development of peroxidase (PO) reaction in the nuclear envelope (NE) and endoplasmic reticulum (ER) of monocytes differentiating in vitro and its relationship with arachidonic acid metabolism were studied. The PO, as visualized by the diaminobenzidine (DAB) technique, appeared in the NE and ER of the majority of m...

journal_title：Blood

authors： Deimann W,Seitz M,Gemsa D,Fahimi HD

更新日期：1984-08-01 00:00:00

abstract：:In this issue of Blood, the findings of Chakraborty et al and Emile et al support a model in which the mitogen-activated protein kinase (MAPK) and PI3K/AKT pathways are critical in the pathogenesis of 2 of the most common histiocytoses—Langerhans cell histiocytosis (LCH) and Erdheim-Chester disease (ECD)—whereas their...

journal_title：Blood

authors： Prince HM

更新日期：2014-11-06 00:00:00

abstract：:This study demonstrates that the human platelet F11 receptor (F11R) functions as an adhesion molecule, and this finding is confirmed by the structure of the protein as revealed by molecular cloning. The F11R is a 32-/35-kd protein duplex that serves as the binding site through which a stimulatory monoclonal antibody c...

journal_title：Blood

authors： Sobocka MB,Sobocki T,Banerjee P,Weiss C,Rushbrook JI,Norin AJ,Hartwig J,Salifu MO,Markell MS,Babinska A,Ehrlich YH,Kornecki E

更新日期：2000-04-15 00:00:00

abstract：:In utero transplantation (IUT) is becoming a viable option for the treatment of various immune and metabolic disorders diagnosed early in gestation. In this study, donor fetal liver cells had a 10-fold competitive engraftment advantage relative to adult bone marrow in allogeneic fetal severe combined immunodeficient (...

journal_title：Blood

authors： Taylor PA,McElmurry RT,Lees CJ,Harrison DE,Blazar BR

更新日期：2002-03-01 00:00:00

abstract：:Pediatric-type follicular lymphoma (PTFL) is a variant of follicular lymphoma (FL) with distinctive clinicopathological features. Patients are predominantly young males presenting with localized lymphadenopathy; the tumor shows high-grade cytology and lacks both BCL2 expression and t(14;18) translocation. The genetic ...

journal_title：Blood

authors： Schmidt J,Gong S,Marafioti T,Mankel B,Gonzalez-Farre B,Balagué O,Mozos A,Cabeçadas J,van der Walt J,Hoehn D,Rosenwald A,Ott G,Dojcinov S,Egan C,Nadeu F,Ramis-Zaldívar JE,Clot G,Bárcena C,Pérez-Alonso V,Endris V,Pe

更新日期：2016-08-25 00:00:00

abstract：:Severe congenital neutropenia (CN) is a preleukemic bone marrow failure syndrome with a 20% risk of evolving into leukemia or myelodysplastic syndrome (MDS). Patterns of acquisition of leukemia-associated mutations were investigated using next-generation deep-sequencing in 31 CN patients who developed leukemia or MDS....

journal_title：Blood

authors： Skokowa J,Steinemann D,Katsman-Kuipers JE,Zeidler C,Klimenkova O,Klimiankou M,Unalan M,Kandabarau S,Makaryan V,Beekman R,Behrens K,Stocking C,Obenauer J,Schnittger S,Kohlmann A,Valkhof MG,Hoogenboezem R,Göhring G,Rein

更新日期：2014-04-03 00:00:00

abstract：:In animal models, tissue stem cells were proposed to exhibit an unexpected level of plasticity, although issues on cell fusions have lead to some controversies. Only transplantation experiments using genetically distinct recipients and donors can unequivocally show these changes in cell fate. We have analyzed oral squ...

journal_title：Blood

authors： Janin A,Murata H,Leboeuf C,Cayuela JM,Gluckman E,Legrès L,Desveaux A,Varna M,Ratajczak P,Soulier J,de Thé H,Bertheau P,Socié G

更新日期：2009-02-19 00:00:00

abstract：:The extended use of brentuximab-vedotin was reported for CD30(+) nonanaplastic peripheral T-cell lymphomas (PTCLs) with promising efficacy. CD30 status assessment is thus a critical factor for therapeutic decision, but the reliability of immunohistochemistry (IHC) in evaluating its expression remains to be defined. Th...

journal_title：Blood

authors： Bossard C,Dobay MP,Parrens M,Lamant L,Missiaglia E,Haioun C,Martin A,Fabiani B,Delarue R,Tournilhac O,Delorenzi M,Gaulard P,de Leval L

更新日期：2014-11-06 00:00:00

abstract：:Patients with immune thrombocytopenia (ITP) commonly have antiplatelet antibodies that cause thrombocytopenia through Fcγ receptors (FcγRs). Antibodies specific for FcγRs, designed to inhibit antibody-FcγR interaction, had been shown to improve ITP in refractory human patients. However, the development of such FcγR-sp...

journal_title：Blood

authors： Yu X,Menard M,Prechl J,Bhakta V,Sheffield WP,Lazarus AH

更新日期：2016-01-07 00:00:00

abstract：:High molecular weight (HMW) kininogen, the cofactor for activation of the contact system of plasma proteolysis, transports and optimally positions prekallikrein and factor XI on a negatively charged surface, allowing those zymogens to be activated by surface-bound factor XIIa. HMW kininogen circulates in plasma as a p...

journal_title：Blood

authors： Chang JJ,Scott CF,Colman RW

更新日期：1986-03-01 00:00:00

abstract：:Multiple myeloma is a clonal plasma cell malignancy that accounts for slightly more than 10% of all hematologic cancers. In this paper, we present a historically focused review of the disease, from the description of the first case in 1844 to the present. The evolution of drug therapy and stem-cell transplantation for...

journal_title：Blood

authors： Kyle RA,Rajkumar SV

更新日期：2008-03-15 00:00:00

abstract：:Cellular interleukin 6 (IL-6) is an important growth factor for Kaposi sarcoma- associated herpesvirus (KSHV)-associated neoplasms, which include human immunodeficiency virus (HIV)-related and -unrelated cases of Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). Increased ...

journal_title：Blood

authors： An J,Lichtenstein AK,Brent G,Rettig MB

更新日期：2002-01-15 00:00:00