Abstract:
:Multiple myeloma is a clonal plasma cell malignancy that accounts for slightly more than 10% of all hematologic cancers. In this paper, we present a historically focused review of the disease, from the description of the first case in 1844 to the present. The evolution of drug therapy and stem-cell transplantation for the treatment of myeloma, as well as the development of new agents, is discussed. We also provide an update on current concepts of diagnosis and therapy, with an emphasis on how treatments have emerged from a historical perspective after certain important discoveries and the results of experimental studies.
journal_name
Bloodjournal_title
Bloodauthors
Kyle RA,Rajkumar SVdoi
10.1182/blood-2007-10-078022subject
Has Abstractpub_date
2008-03-15 00:00:00pages
2962-72issue
6eissn
0006-4971issn
1528-0020pii
111/6/2962journal_volume
111pub_type
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