Some properties of marrow derived adherent cells in tissue culture.

abstract：:Primary effusion lymphoma (PEL) is a rare B-cell malignancy that most often occurs in immunocompromised patients, such as HIV-infected individuals and patients receiving organ transplantation. The main characteristic of PEL is neoplastic effusions in body cavities without detectable tumor masses. The onset of the dise...

journal_title：Blood

authors： Shimada K,Hayakawa F,Kiyoi H

更新日期：2018-11-01 00:00:00

abstract：:Patients referred to tertiary care centers occasionally may have their diagnostic procedures repeated and have a final diagnosis that differs from that of the referring center. The aim of this study was to evaluate discordance rates and their clinical implications in the diagnosis of patients with myelodysplastic synd...

journal_title：Blood

authors： Naqvi K,Jabbour E,Bueso-Ramos C,Pierce S,Borthakur G,Estrov Z,Ravandi F,Faderl S,Kantarjian H,Garcia-Manero G

更新日期：2011-10-27 00:00:00

abstract：:In vitro agar culture patterns of bone marrow cells in acute myeloid leukemia may show several growth patterns, including cultures where no colonies or clusters develop, cultures with varying numbers of clusters and no colonies, or colony and cluster formation with an extremely high ratio of clusters to colonies. Twel...

journal_title：Blood

authors： McCarthy JH,Sullivan JR,Ungar B,Metcalf D

更新日期：1979-08-01 00:00:00

abstract：:Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is a treatment option for patients with hematopoietic malignancies that is hampered by treatment-related morbidity and mortality, in part the result of opportunistic infections, a direct consequence of delayed T-cell recovery. Thymic output can be imp...

journal_title：Blood

authors： Meek B,Cloosen S,Borsotti C,Van Elssen CH,Vanderlocht J,Schnijderberg MC,van der Poel MW,Leewis B,Hesselink R,Manz MG,Katsura Y,Kawamoto H,Germeraad WT,Bos GM

更新日期：2010-01-14 00:00:00

abstract：:Memory stem T cells (TSCM) have been proposed as key determinants of immunologic memory. However, their exact contribution to a mounting immune response, as well as the mechanisms and timing of their in vivo generation, are poorly understood. We longitudinally tracked TSCM dynamics in patients undergoing haploidentica...

journal_title：Blood

authors： Cieri N,Oliveira G,Greco R,Forcato M,Taccioli C,Cianciotti B,Valtolina V,Noviello M,Vago L,Bondanza A,Lunghi F,Marktel S,Bellio L,Bordignon C,Bicciato S,Peccatori J,Ciceri F,Bonini C

更新日期：2015-04-30 00:00:00

abstract：:Mutations of IDH1 and IDH2, which produce the oncometabolite 2-hydroxyglutarate (2HG), have been identified in several tumors, including acute myeloid leukemia. Recent studies have shown that expression of the IDH mutant enzymes results in high levels of 2HG and a block in cellular differentiation that can be reversed...

journal_title：Blood

authors： Kernytsky A,Wang F,Hansen E,Schalm S,Straley K,Gliser C,Yang H,Travins J,Murray S,Dorsch M,Agresta S,Schenkein DP,Biller SA,Su SM,Liu W,Yen KE

更新日期：2015-01-08 00:00:00

abstract：:Activated protein C (APC) resistance caused by the factor V Leiden mutation is associated with an increased risk of venous thrombosis. We investigated whether a reduced response to APC, not due to the factor V point mutation, is also a risk factor for venous thrombosis. For this analysis, we used the Leiden Thrombophi...

journal_title：Blood

authors： de Visser MC,Rosendaal FR,Bertina RM

更新日期：1999-02-15 00:00:00

abstract：:A series of monoclonal antibodies was used for the characterization of malignant T cells from 21 patients with lymphoblastic lymphoma (LL). The tumor population from these patients showed a marked degree of phenotypic heterogeneity and a proportion (one-third) of patients had tumor cells that did not conform exactly w...

journal_title：Blood

authors： Bernard A,Boumsell L,Reinherz EL,Nadler LM,Ritz J,Coppin H,Richard Y,Valensi F,Dausset J,Flandrin G,Lemerle J,Schlossman SF

更新日期：1981-06-01 00:00:00

abstract：:In individuals with sickle cell disease, a variable number of irreversibly sickled cells (ISC) is present that may contribute to the pathophysiology of sickle cell anemia. The present study was undertaken to determine the possible role of membrane lipid peroxidation in the genesis of ISC. After 24 hr of simple aerobic...

journal_title：Blood

authors： Jain SK,Shohet SB

更新日期：1984-02-01 00:00:00

abstract：:Retroviral gene therapy can restore immunity to infants with X-linked severe combined immunodeficiency (XSCID) caused by mutations in the IL2RG gene encoding the common gamma chain (gammac) of receptors for interleukins 2 (IL-2), -4, -7, -9, -15, and -21. We investigated the safety and efficacy of gene therapy as salv...

journal_title：Blood

authors： Chinen J,Davis J,De Ravin SS,Hay BN,Hsu AP,Linton GF,Naumann N,Nomicos EY,Silvin C,Ulrick J,Whiting-Theobald NL,Malech HL,Puck JM

更新日期：2007-07-01 00:00:00

abstract：:On 1 September 2017, the US Food and Drug Administration (FDA) approved gemtuzumab ozogamicin (GO) for the treatment of adults with newly diagnosed CD33+ acute myeloid leukemia and for patients aged ≥2 years with CD33+ acute myeloid leukemia who have experienced a relapse or who have not responded to initial treatment...

journal_title：Blood

authors： Appelbaum FR,Bernstein ID

更新日期：2017-11-30 00:00:00

abstract：:Antisense oligodeoxynucleotide (ODN) drugs might be more effective if their delivery was optimized and they were targeted to short-lived proteins encoded by messenger RNA (mRNA) species with equally short half-lives. To test this hypothesis, an ODN targeted to the c-myb proto-oncogene was developed and used to purge m...

journal_title：Blood

authors： Luger SM,O'Brien SG,Ratajczak J,Ratajczak MZ,Mick R,Stadtmauer EA,Nowell PC,Goldman JM,Gewirtz AM

更新日期：2002-02-15 00:00:00

abstract：:In mouse mid-gestational embryos, definitive hematopoietic stem progenitor cells are derived directly from a very small proportion of the arterial endothelium. However, the physiological mechanisms restraining excessive endothelial-hematopoietic transition remain elusive. We show here that genetic deletion of Smad4 fr...

journal_title：Blood

authors： Lan Y,He W,Li Z,Wang Y,Wang J,Gao J,Wang W,Cheng T,Liu B,Yang X

更新日期：2014-04-03 00:00:00

abstract：:Clonal hematopoiesis (CH) in aplastic anemia (AA) has been closely linked to the evolution of late clonal disorders, including paroxysmal nocturnal hemoglobinuria and myelodysplastic syndromes (MDS)/acute myeloid leukemia (AML), which are common complications after successful immunosuppressive therapy (IST). With the ...

journal_title：Blood

authors： Ogawa S

更新日期：2016-07-21 00:00:00

abstract：:We show the molecular and functional characterization of a novel population of lineage-negative CD34-negative (Lin(-)CD34(-)) hematopoietic stem cells from chronic myelogenous leukemia (CML) patients at diagnosis. Molecular karyotyping and quantitative analysis of BCR-ABL transcript demonstrated that approximately one...

journal_title：Blood

authors： Lemoli RM,Salvestrini V,Bianchi E,Bertolini F,Fogli M,Amabile M,Tafuri A,Salati S,Zini R,Testoni N,Rabascio C,Rossi L,Martin-Padura I,Castagnetti F,Marighetti P,Martinelli G,Baccarani M,Ferrari S,Manfredini R

更新日期：2009-12-10 00:00:00

abstract：:Fourteen patients with cytogenetic relapse of chronic myeloid leukemia (CML) after transplantation with unmanipulated bone marrow were treated with alpha-2a-interferon. There were eight men and six women, median age, 33 years. Twelve patients received marrow from a related allogeneic donor and two received marrow from...

journal_title：Blood

authors： Higano CS,Chielens D,Raskind W,Bryant E,Flowers ME,Radich J,Clift R,Appelbaum F

更新日期：1997-10-01 00:00:00

abstract：:Chronic granulomatous disease (CGD) is characterized by the absence of a respiratory burst in activated phagocytes. Defects in at least four different genes lead to CGD. Patients with the X-linked form of CGD have mutations in the gene for the beta-subunit of cytochrome b558 (gp91-phox). We studied the molecular defec...

journal_title：Blood

authors： de Boer M,Bolscher BG,Dinauer MC,Orkin SH,Smith CI,Ahlin A,Weening RS,Roos D

更新日期：1992-09-15 00:00:00

abstract：:Fanconi anemia (FA) is an autosomal recessive syndrome featuring diverse symptoms including progressive bone marrow failure and early occurrence of acute myeloid leukemia. Nine genetic subtypes have been described for FA (A, B, C, D1, D2, E, F, G, and L), all of which have been connected to distinct disease genes, exc...

journal_title：Blood

authors： Levitus M,Rooimans MA,Steltenpool J,Cool NF,Oostra AB,Mathew CG,Hoatlin ME,Waisfisz Q,Arwert F,de Winter JP,Joenje H

更新日期：2004-04-01 00:00:00

abstract：:Efficient clearance of apoptotic cells seems to be a prerequisite to prevent the development of autoimmunity. Here we identify that macrophage colony-stimulating factor (M-CSF)-driven macrophages (Mø2s) are potent phagocytes that have the unique capacity to preferentially bind and ingest early apoptotic cells. This ma...

journal_title：Blood

authors： Xu W,Roos A,Schlagwein N,Woltman AM,Daha MR,van Kooten C

更新日期：2006-06-15 00:00:00

abstract：:The introduction of agents targeted at specific molecular events is changing the treatment paradigms in a number of malignancies. Historically, we have relied entirely on DNA-interactive, cytotoxic drugs for treating patients with leukemia. Increased understanding of the leukemic cell biology and pathogenesis, and the...

journal_title：Blood

authors： Ravandi F

更新日期：2019-01-10 00:00:00

abstract：:One major obstacle to the effective treatment of cancer is to distinguish between tumor cells and normal cells. The chimeric molecules created by cancer-associated chromosomal abnormalities are ideal therapeutic targets because they are unique to the disease. We describe the use of a novel approach based on the cataly...

journal_title：Blood

authors： Cobaleda C,Sánchez-García I

更新日期：2000-02-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is an incurable adult disease of unknown etiology. Understanding the biology of CLL cells, particularly cell maturation and growth in vivo, has been impeded by lack of a reproducible adoptive transfer model. We report a simple, reproducible system in which primary CLL cells prolifera...

journal_title：Blood

authors： Bagnara D,Kaufman MS,Calissano C,Marsilio S,Patten PE,Simone R,Chum P,Yan XJ,Allen SL,Kolitz JE,Baskar S,Rader C,Mellstedt H,Rabbani H,Lee A,Gregersen PK,Rai KR,Chiorazzi N

更新日期：2011-05-19 00:00:00

abstract：:The reduced folate carrier (RFC) is involved in the transport of methotrexate (MTX) across the cell membrane. The RFC gene (SLC19A1) is located on chromosome 21, and we hypothesized that the RFC80 G>A polymorphism would affect outcome and toxicity in childhood leukemia and that this could interact with chromosome 21 c...

journal_title：Blood

authors： Gregers J,Christensen IJ,Dalhoff K,Lausen B,Schroeder H,Rosthoej S,Carlsen N,Schmiegelow K,Peterson C

更新日期：2010-06-10 00:00:00

abstract：:A distinct pathologic entity (ALK+ lymphoma) that is characterized by expression of the anaplastic lymphoma kinase (ALK) protein has recently emerged within the heterogeneous group of CD30(+) anaplastic large-cell lymphomas. Information on clinical findings and treatment outcome of ALK+ lymphoma is still limited, and ...

journal_title：Blood

authors： Falini B,Pileri S,Zinzani PL,Carbone A,Zagonel V,Wolf-Peeters C,Verhoef G,Menestrina F,Todeschini G,Paulli M,Lazzarino M,Giardini R,Aiello A,Foss HD,Araujo I,Fizzotti M,Pelicci PG,Flenghi L,Martelli MF,Santucci A

更新日期：1999-04-15 00:00:00

abstract：:Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL) is a high-risk subtype of ALL in children. There are conflicting data on the incidence and prognosis of Ph-like ALL in adults. Patients with newly diagnosed B-cell ALL (B-ALL) who received frontline chemotherapy at MD Anderson Cancer Center underwent...

journal_title：Blood

authors： Jain N,Roberts KG,Jabbour E,Patel K,Eterovic AK,Chen K,Zweidler-McKay P,Lu X,Fawcett G,Wang SA,Konoplev S,Harvey RC,Chen IM,Payne-Turner D,Valentine M,Thomas D,Garcia-Manero G,Ravandi F,Cortes J,Kornblau S,O'Brien

更新日期：2017-02-02 00:00:00

abstract：:Using highly sensitive 2-site immunoradiometric assays, we examined the relationship between iron absorption from closed intestinal loops and transferrin and ferritin concentrations in isolated duodenal mucosal cells. As in prior studies, mucosal ferritin correlates inversely with iron absorption and directly with bod...

journal_title：Blood

authors： Savin MA,Cook JD

更新日期：1980-12-01 00:00:00

abstract：:Autologous T cells engineered to express a CD19-specific chimeric antigen receptor (CAR) have produced impressive minimal residual disease-negative (MRD-negative) complete remission (CR) rates in patients with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL). However, the factors associated with durable...

journal_title：Blood

authors： Hay KA,Gauthier J,Hirayama AV,Voutsinas JM,Wu Q,Li D,Gooley TA,Cherian S,Chen X,Pender BS,Hawkins RM,Vakil A,Steinmetz RN,Schoch G,Chapuis AG,Till BG,Kiem HP,Ramos JD,Shadman M,Cassaday RD,Acharya UH,Riddell SR

更新日期：2019-04-11 00:00:00

abstract：:In previous experimental animal studies it has been demonstrated that antibody depletion is not followed by increased antibody synthesis. To assess whether these results are conferrable to antibody-depleted humans, we measured free light chains (flcs) as markers of current antibody synthesis in 8 patients treated with...

journal_title：Blood

authors： Goldammer A,Derfler K,Herkner K,Bradwell AR,Hörl WH,Haas M

更新日期：2002-07-01 00:00:00

abstract：:Human bone marrow (BM) cells contain low levels of the DNA repair protein, O6-alkylguanine-DNA alkyltransferase, which may explain their susceptibility to nitrosourea-induced cytotoxicity and the development of secondary leukemia after nitrosourea treatment. Isolated CD34+ myeloid progenitors were also found to have l...

journal_title：Blood

authors： Gerson SL,Phillips W,Kastan M,Dumenco LL,Donovan C

更新日期：1996-09-01 00:00:00

abstract：:2-Chlorodeoxyadenosine, a new lymphocyte-selective, anti-neoplastic drug was administered to 18 patients with advanced chronic lymphocytic leukemia of B-cell origin. All patients were resistant to conventional treatment. A total of 44 courses of 2-chlorodeoxyadenosine were completed with minimal toxicity. An overall r...

journal_title：Blood

authors： Piro LD,Carrera CJ,Beutler E,Carson DA

更新日期：1988-09-01 00:00:00