Hemoglobin level is linked to growth hormone-dependent proteins in short children.

abstract：:The interaction of von Willebrand factor (vWF) with the alpha v beta 3 integrin of human umbilical vein endothelial cells is dependent on the RGD sequence present at residues 1744-1746 of the mature vWF subunit. We compared vWF and its two dimeric fragments, SpIII (residues 1-1365) and SpII (residues 1366-2050), as ad...

journal_title：Blood

authors： Denis C,Williams JA,Lu X,Meyer D,Baruch D

更新日期：1993-12-15 00:00:00

abstract：:Human K562 erythroleukemia cells were transfected with human band 3 (anion exchanger 1 [AE1]) cDNA, using the pBabe retroviral vector. Stable K562 clones expressing band 3 were isolated by flow cytometry, and surface expression was quantified by immunoblotting. The function of band 3 expressed at the cell surface was ...

journal_title：Blood

authors： Beckmann R,Smythe JS,Anstee DJ,Tanner MJ

更新日期：1998-12-01 00:00:00

abstract：:Omenn syndrome (OS) is an inherited disorder characterized by an absence of circulating B cells and an infiltration of the skin and the intestine by activated oligoclonal T lymphocytes, indicating that a profound defect in the lymphoid developmental program could be accountable for this condition. Inherited mutations ...

journal_title：Blood

authors： Corneo B,Moshous D,Güngör T,Wulffraat N,Philippet P,Le Deist FL,Fischer A,de Villartay JP

更新日期：2001-05-01 00:00:00

abstract：:Severe congenital neutropenia (CN) is a preleukemic bone marrow failure syndrome with a 20% risk of evolving into leukemia or myelodysplastic syndrome (MDS). Patterns of acquisition of leukemia-associated mutations were investigated using next-generation deep-sequencing in 31 CN patients who developed leukemia or MDS....

journal_title：Blood

authors： Skokowa J,Steinemann D,Katsman-Kuipers JE,Zeidler C,Klimenkova O,Klimiankou M,Unalan M,Kandabarau S,Makaryan V,Beekman R,Behrens K,Stocking C,Obenauer J,Schnittger S,Kohlmann A,Valkhof MG,Hoogenboezem R,Göhring G,Rein

更新日期：2014-04-03 00:00:00

abstract：:Hydroxyl radical generation was demonstrated during heme-catalyzed decomposition of 15-hydroperoxy arachidonic acid. The hydroperoxide-mediated inactivation of prostacyclin synthetase seems to be related to the generation of this highly reactive species. A relationship between hydroperoxides and the hydroxyl radical m...

journal_title：Blood

authors： Weiss SJ,Turk J,Needleman P

更新日期：1979-06-01 00:00:00

abstract：:The interplay between bone marrow stromal cells (BMSCs) and multiple myeloma (MM) cells performs a crucial role in MM pathogenesis by secreting growth factors, cytokines, and extracellular vesicles. Exosomes are membranous vesicles 40 to 100 nm in diameter constitutively released by almost all cell types, and they med...

journal_title：Blood

authors： Wang J,Hendrix A,Hernot S,Lemaire M,De Bruyne E,Van Valckenborgh E,Lahoutte T,De Wever O,Vanderkerken K,Menu E

更新日期：2014-07-24 00:00:00

abstract：:Imatinib mesylate, a competitive inhibitor of Abl tyrosine kinase, is highly effective for the early stages of chronic myelogenous leukemia (CML), but remissions induced in advanced-phase CML and Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia tend to be relatively short-lived. Therefore, the searc...

journal_title：Blood

authors： Kuroda J,Kimura S,Segawa H,Kobayashi Y,Yoshikawa T,Urasaki Y,Ueda T,Enjo F,Tokuda H,Ottmann OG,Maekawa T

更新日期：2003-09-15 00:00:00

abstract：UNLABELLED:Better methods to characterize normal human hematopoietic cells with short-term repopulating activity cells (STRCs) are needed to facilitate improving recovery rates in transplanted patients.We now show that 5-fold more human myeloid cells are produced in sublethally irradiated NOD/SCID-IL-2Receptor-γchain-n...

journal_title：Blood

authors： Miller PH,Cheung AM,Beer PA,Knapp DJ,Dhillon K,Rabu G,Rostamirad S,Humphries RK,Eaves CJ

更新日期：2013-01-31 00:00:00

abstract：:The association of thrombosis and gestational morbidity with antiphospholipid antibodies is termed antiphospholipid syndrome (APS). Annexin 2 (A2) is a profibrinolytic endothelial cell surface receptor that binds plasminogen, its tissue activator (tPA), and beta(2)-glycoprotein I (beta2GPI), the main antigen for antip...

journal_title：Blood

authors： Cesarman-Maus G,Ríos-Luna NP,Deora AB,Huang B,Villa R,Cravioto Mdel C,Alarcón-Segovia D,Sánchez-Guerrero J,Hajjar KA

更新日期：2006-06-01 00:00:00

abstract：:Cytomegalovirus (CMV) has been a major cause of morbidity and mortality after allogeneic stem cell transplantation (SCT). The importance of the recipient's serologic status is paramount. However, the importance of the donor's serologic status in CMV-seropositive recipients is controversial. We analyzed the influence o...

journal_title：Blood

authors： Ljungman P,Brand R,Einsele H,Frassoni F,Niederwieser D,Cordonnier C

更新日期：2003-12-15 00:00:00

abstract：:The pattern of expression of several protein kinase C (PKC) isoforms (alpha, betaI, delta, epsilon, eta, and zeta) during the course of hematopoietic development was investigated using primary human CD34(+) hematopoietic cells and stable cell lines subcloned from the growth factor-dependent 32D murine hematopoietic ce...

journal_title：Blood

authors： Bassini A,Zauli G,Migliaccio G,Migliaccio AR,Pascuccio M,Pierpaoli S,Guidotti L,Capitani S,Vitale M

更新日期：1999-02-15 00:00:00

abstract：:The primitive hematopoietic stem/progenitor cells (HSPCs) during embryonic hematopoiesis are thought to be short-lived (SL) with limited self-renewal potential. The fate and consequence of these short-lived HSPCs, once reprogrammed into "long-lived" in a living animal body, remain unknown. Here we show that targeted e...

journal_title：Blood

authors： Zhou T,Wang L,Zhu KY,Dong M,Xu PF,Chen Y,Chen SJ,Chen Z,Deng M,Liu TX

更新日期：2011-10-06 00:00:00

abstract：:Adult-onset hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening disease of immune hyperactivation. Unlike pediatric HLH, adult HLH is rarely driven by germline genetic variants. Although numerous precipitating etiologies have been identified, the reason that HLH occurs in only a subset of individuals ...

journal_title：Blood

authors： Miller PG,Sperling AS,Gibson CJ,Viswanathan K,Castellano C,McConkey M,Ceremsak J,Taylor MS,Birndt S,Perner F,Arnason J,Agrawal M,Schram AM,Nikiforow S,Pihan G,Hasserjian RP,Aster JC,La Rosée P,Morgan EA,Berliner N,

更新日期：2020-12-24 00:00:00

abstract：:Since the initial observations by Kaiser and Edelman, interest in the role of calcium in ACS-induced apoptosis has wavered, in part because of the fact that extracellular calcium is only necessary for induction of apoptosis in thymocytes, but not in peripheral lymphocytes or lymphoma cells. Now, as result of molecular...

journal_title：Blood

authors： Distelhorst CW,Dubyak G

更新日期：1998-02-01 00:00:00

abstract：:Cryoprecipitate has been demonstrated to correct the bleeding abnormality of patients with some congenital (storage pool disease) and acquired (uremia) platelet abnormalities, but the reason for this effect is unknown. We found significant platelet contamination in plasma harvested to prepare fresh frozen plasma and c...

journal_title：Blood

authors： George JN,Pickett EB,Heinz R

更新日期：1986-07-01 00:00:00

abstract：:Low-grade follicular non-Hodgkin's lymphomas are characterized by the presence of a t(14;18) chromosomal translocation that results in deregulation of the B-cell lymphoma (Bcl-2) gene. Studies in cell lines and transgenic animal models have suggested that this results in the suppression of apoptotic cell death in germ...

journal_title：Blood

authors： Johnson PW,Watt SM,Betts DR,Davies D,Jordan S,Norton AJ,Lister TA

更新日期：1993-09-15 00:00:00

abstract：:The human erythrocyte blood group system Cromer consists of high-incidence and low-incidence antigens that reside on decay-accelerating factor (DAF; CD55), a glycosyl-phosphatidylinositol-anchored membrane protein that regulates complement activation on cell surfaces. In the Cromer phenotypes Dr(a-) and Inab there is ...

journal_title：Blood

authors： Lublin DM,Mallinson G,Poole J,Reid ME,Thompson ES,Ferdman BR,Telen MJ,Anstee DJ,Tanner MJ

更新日期：1994-08-15 00:00:00

abstract：:Current dendritic cell (DC)-based vaccines are based on ex vivo-generated autologous DCs loaded with antigen prior to readministration into patients. A more direct and less laborious strategy is to target antigens to DCs in vivo via specific surface receptors. Therefore, we developed a humanized antibody, hD1V1G2/G4 (...

journal_title：Blood

authors： Tacken PJ,de Vries IJ,Gijzen K,Joosten B,Wu D,Rother RP,Faas SJ,Punt CJ,Torensma R,Adema GJ,Figdor CG

更新日期：2005-08-15 00:00:00

abstract：:Val34Leu polymorphism of the A subunit of coagulation factor XIII (FXIII-A) is located in the activation peptide (AP) just 3 amino acids away from the thrombin cleavage site. This mutation has been associated with a protective effect against occlusive arterial diseases and venous thrombosis; however, its biochemical c...

journal_title：Blood

authors： Balogh I,Szôke G,Kárpáti L,Wartiovaara U,Katona E,Komáromi I,Haramura G,Pfliegler G,Mikkola H,Muszbek L

更新日期：2000-10-01 00:00:00

abstract：:Caspases are cysteine proteases involved in apoptosis and cytokine maturation. In erythroblasts, keratinocytes, and lens epithelial cells undergoing differentiation, enucleation has been regarded as a caspase-mediated incomplete apoptotic process. Here, we show that several caspases are activated in human peripheral b...

journal_title：Blood

authors： Sordet O,Rébé C,Plenchette S,Zermati Y,Hermine O,Vainchenker W,Garrido C,Solary E,Dubrez-Daloz L

更新日期：2002-12-15 00:00:00

abstract：:Thalassemia is a congenital hemolytic disorder caused by a partial or complete deficiency of alpha- or beta-globin chain synthesis. Homozygous carriers of beta-globin gene defects suffer from severe anemia and other serious complications from early childhood. The disease is treated by chronic blood transfusion. Howeve...

journal_title：Blood

authors： Eldor A,Rachmilewitz EA

更新日期：2002-01-01 00:00:00

abstract：:We show further differences between two clinically related entities, T-cell acute lymphoblastic leukemia (T-ALL) and lymphoblastic lymphoma (T-LL), by using several monoclonal antibodies (MoAbs) reacting with either constant or variable regions of T-cell receptors (TcR) alpha beta and gamma delta or with various CD mo...

journal_title：Blood

authors： Gouttefangeas C,Bensussan A,Boumsell L

更新日期：1990-02-15 00:00:00

abstract：:Stimulators of human erythroid burst-forming units (BFU-E) and multipotential colony-forming cells (CFU-GEMM) can be produced by a number of different cell types. A product of human peripheral blood monocytes, interleukin 1 (IL-1), was evaluated for its ability to stimulate fibroblast cultures to produce stimulators o...

journal_title：Blood

authors： Zucali JR,Broxmeyer HE,Dinarello CA,Gross MA,Weiner RS

更新日期：1987-01-01 00:00:00

abstract：:One hundred forty-two patients between the ages of 1 and 17 years who survived disease-free more than 1 year after marrow transplantation for hematologic malignancy had growth and development evaluations from one to 14 years posttransplant (median 4 years). Prior to transplant all children received multiagent chemothe...

journal_title：Blood

authors： Sanders JE,Pritchard S,Mahoney P,Amos D,Buckner CD,Witherspoon RP,Deeg HJ,Doney KC,Sullivan KM,Appelbaum FR

更新日期：1986-11-01 00:00:00

abstract：:Chromosome 11q deletions are frequently observed in chronic lymphocytic leukemia (CLL) in association with progressive disease and a poor prognosis. A minimal region of deletion has been assigned to 11q22-q23. Trinucleotide repeats have been associated with anticipation in disease, and evidence of anticipation has bee...

journal_title：Blood

authors： Auer RL,Jones C,Mullenbach RA,Syndercombe-Court D,Milligan DW,Fegan CD,Cotter FE

更新日期：2001-01-15 00:00:00

abstract：:Many surface receptors and signaling molecules are thought to associate with unique membrane microdomains termed lipid rafts. We examined the involvement of lipid rafts in the activation of leukocyte function-associated antigen-1 (LFA-1). Depletion or sequestration of cholesterol with methyl-beta-cyclodextrin (MCD) or...

journal_title：Blood

authors： Marwali MR,Rey-Ladino J,Dreolini L,Shaw D,Takei F

更新日期：2003-07-01 00:00:00

abstract：:The Wiskott-Aldrich syndrome (WAS) is a severe immunodeficiency and platelet deficiency disease arising from mutation(s) in the WASP gene, which in normal cells encodes an intracellular protein able to interact with other proteins relevant to the control of cytoskeleton organization. Immunodeficiency is mainly due to ...

journal_title：Blood

authors： Gallego MD,Santamaría M,Peña J,Molina IJ

更新日期：1997-10-15 00:00:00

abstract：:The combination of cyclophosphamide, vincristine, and prednisone (CVP) is one of several standard treatment options for advanced follicular lymphoma. This, like similar chemotherapeutic regimens, induces response rates of 60% to 80%, with a median response duration of under 2 years. Rituximab, a chimeric monoclonal an...

journal_title：Blood

authors： Marcus R,Imrie K,Belch A,Cunningham D,Flores E,Catalano J,Solal-Celigny P,Offner F,Walewski J,Raposo J,Jack A,Smith P

更新日期：2005-02-15 00:00:00

abstract：:Bcr-abl fusion peptide-specific CD4+ T-lymphocyte clones have recently been shown to augment colony formation by chronic myelogenous leukemia (CML) cells in a bcr-abl type-specific and HLA class II-restricted manner without addition of exogenous antigen. These findings suggest that CML cells can naturally process and ...

journal_title：Blood

authors： Yasukawa M,Ohminami H,Kojima K,Hato T,Hasegawa A,Takahashi T,Hirai H,Fujita S

更新日期：2001-09-01 00:00:00

abstract：:Airway dendritic cells (DCs) are held responsible for inducing sensitization to inhaled antigen, leading to eosinophilic airway inflammation, typical of asthma. However, less information is available about the role of these cells in ongoing inflammation. In a mouse model of asthma, sensitization to ovalbumin (OVA) was...

journal_title：Blood

authors： van Rijt LS,Prins JB,Leenen PJ,Thielemans K,de Vries VC,Hoogsteden HC,Lambrecht BN

更新日期：2002-11-15 00:00:00